EA201992253A1 - Новые гетероциклические производные, применимые в качестве ингибиторов shp2 - Google Patents

Новые гетероциклические производные, применимые в качестве ингибиторов shp2

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Publication number
EA201992253A1
EA201992253A1 EA201992253A EA201992253A EA201992253A1 EA 201992253 A1 EA201992253 A1 EA 201992253A1 EA 201992253 A EA201992253 A EA 201992253A EA 201992253 A EA201992253 A EA 201992253A EA 201992253 A1 EA201992253 A1 EA 201992253A1
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EA
Eurasian Patent Office
Prior art keywords
shp2
shp2 inhibitors
heterocyclic derivatives
new heterocyclic
derivatives applicable
Prior art date
Application number
EA201992253A
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English (en)
Inventor
Цуньбо МА
Паньлян Гао
Шаоцзин Ху
Цзылун Сюй
Хуэйфэн Хань
Синьпин У
Ди Кан
Original Assignee
Джакобио Фармасьютикалс Ко., Лтд.
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Application filed by Джакобио Фармасьютикалс Ко., Лтд. filed Critical Джакобио Фармасьютикалс Ко., Лтд.
Publication of EA201992253A1 publication Critical patent/EA201992253A1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к определенным новым производным пиразина (формула I) в качестве ингибиторов SHP2, которые представлены формулой I, к их синтезу и их применению для лечения SHP2-опосредованного нарушения. Более конкретно, настоящее изобретение направлено на производные в виде конденсированных гетероциклических групп, применимые в качестве ингибиторов SHP2, на способы получения таких соединений и способы лечения SHP2-опосредованного нарушения.
EA201992253A 2017-03-23 2018-03-23 Новые гетероциклические производные, применимые в качестве ингибиторов shp2 EA201992253A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2017051690 2017-03-23
PCT/IB2018/051973 WO2018172984A1 (en) 2017-03-23 2018-03-23 Novel heterocyclic derivatives useful as shp2 inhibitors

Publications (1)

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EA201992253A1 true EA201992253A1 (ru) 2020-03-31

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EA201992253A EA201992253A1 (ru) 2017-03-23 2018-03-23 Новые гетероциклические производные, применимые в качестве ингибиторов shp2
EA202190196A EA202190196A1 (ru) 2017-03-23 2018-03-23 Новые гетероциклические производные, применимые в качестве ингибиторов shp2

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US (1) US10988466B2 (ru)
EP (1) EP3601239A4 (ru)
JP (3) JP6878615B2 (ru)
KR (4) KR102317480B1 (ru)
AU (3) AU2018239542C1 (ru)
CA (1) CA3057582C (ru)
CL (2) CL2019002698A1 (ru)
CO (1) CO2019011678A2 (ru)
EA (2) EA201992253A1 (ru)
MA (1) MA49013A (ru)
MX (4) MX2019011330A (ru)
NZ (1) NZ758458A (ru)
PH (1) PH12019502175A1 (ru)
SG (1) SG11201908820VA (ru)
TW (1) TWI664175B (ru)
WO (1) WO2018172984A1 (ru)

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