EA202090900A1 - Ингибиторы иммунопротеасом - Google Patents
Ингибиторы иммунопротеасомInfo
- Publication number
- EA202090900A1 EA202090900A1 EA202090900A EA202090900A EA202090900A1 EA 202090900 A1 EA202090900 A1 EA 202090900A1 EA 202090900 A EA202090900 A EA 202090900A EA 202090900 A EA202090900 A EA 202090900A EA 202090900 A1 EA202090900 A1 EA 202090900A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- inhibitors
- immunoproteasom
- immunoproteasomes
- immunoproteasome
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 101001136986 Homo sapiens Proteasome subunit beta type-8 Proteins 0.000 abstract 1
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 abstract 1
- 102100035760 Proteasome subunit beta type-8 Human genes 0.000 abstract 1
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
В настоящем документе предложены соединения, такие как соединение формулы (I) или его фармацевтически приемлемая соль, являющиеся ингибиторами иммунопротеасомы (такой как LMP2 и LMP7). Соединения, описанные в настоящем документе, можно использовать для лечения заболеваний, поддающихся лечению посредством ингибирования иммунопротеасом. Также в настоящем документе предложены фармацевтические композиции, содержащие такие соединения, и способы получения таких соединений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762587376P | 2017-11-16 | 2017-11-16 | |
PCT/US2018/061140 WO2019099582A1 (en) | 2017-11-16 | 2018-11-14 | Immunoproteasome inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090900A1 true EA202090900A1 (ru) | 2020-10-02 |
Family
ID=64746633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090900A EA202090900A1 (ru) | 2017-11-16 | 2018-11-14 | Ингибиторы иммунопротеасом |
Country Status (17)
Country | Link |
---|---|
US (2) | US11225493B2 (ru) |
EP (1) | EP3710458A1 (ru) |
JP (1) | JP7277457B2 (ru) |
KR (1) | KR102625984B1 (ru) |
AU (1) | AU2018367515B2 (ru) |
CA (1) | CA3080949C (ru) |
CL (1) | CL2020001244A1 (ru) |
CO (1) | CO2020007150A2 (ru) |
EA (1) | EA202090900A1 (ru) |
IL (1) | IL274523B2 (ru) |
MA (1) | MA50906A (ru) |
MX (2) | MX2020005046A (ru) |
NZ (1) | NZ764393A (ru) |
PH (1) | PH12020550580A1 (ru) |
SG (1) | SG11202003867SA (ru) |
WO (1) | WO2019099582A1 (ru) |
ZA (1) | ZA202002531B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3571208T (pt) | 2017-01-18 | 2021-04-13 | Principia Biopharma Inc | Inibidores do imunoproteassoma |
NZ764393A (en) | 2017-11-16 | 2023-11-24 | Principia Biopharma Inc | Immunoproteasome inhibitors |
WO2024006337A1 (en) * | 2022-06-30 | 2024-01-04 | Principia Biopharma Inc. | Cyclic boronic esters and their uses |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
US4963655A (en) | 1988-05-27 | 1990-10-16 | Mayo Foundation For Medical Education And Research | Boron analogs of amino acid/peptide protease inhibitors |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
IL111175A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
RU2379315C2 (ru) | 2004-02-23 | 2010-01-20 | Трастиз Оф Тафтс Колледж | Ингибиторы дипептидилпептидазы iv |
AU2011223795B2 (en) | 2010-03-01 | 2015-11-05 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
KR20140114391A (ko) | 2011-12-22 | 2014-09-26 | 아레스 트레이딩 에스.에이. | 알파-아미노 보론산 유도체, 선택적 면역프로테아좀 저해인자 |
EP3157909B1 (en) | 2014-06-20 | 2021-04-07 | Principia Biopharma Inc. | Lmp7 inhibitors |
AU2015327345B9 (en) | 2014-10-01 | 2020-06-18 | Merck Patent Gmbh | Boronic acid derivatives |
CN106588965A (zh) | 2015-10-15 | 2017-04-26 | 北京大学 | 脲拟肽硼酸化合物及其药物组合物、制备方法和用途 |
PT3571208T (pt) * | 2017-01-18 | 2021-04-13 | Principia Biopharma Inc | Inibidores do imunoproteassoma |
HRP20221292T1 (hr) | 2017-11-16 | 2022-12-23 | Principia Biopharma Inc. | Inhibitori imunoproteazoma |
NZ764393A (en) | 2017-11-16 | 2023-11-24 | Principia Biopharma Inc | Immunoproteasome inhibitors |
-
2018
- 2018-11-14 NZ NZ764393A patent/NZ764393A/en unknown
- 2018-11-14 EP EP18822543.7A patent/EP3710458A1/en active Pending
- 2018-11-14 WO PCT/US2018/061140 patent/WO2019099582A1/en unknown
- 2018-11-14 EA EA202090900A patent/EA202090900A1/ru unknown
- 2018-11-14 MA MA050906A patent/MA50906A/fr unknown
- 2018-11-14 MX MX2020005046A patent/MX2020005046A/es unknown
- 2018-11-14 SG SG11202003867SA patent/SG11202003867SA/en unknown
- 2018-11-14 IL IL274523A patent/IL274523B2/en unknown
- 2018-11-14 JP JP2020527042A patent/JP7277457B2/ja active Active
- 2018-11-14 US US16/764,136 patent/US11225493B2/en active Active
- 2018-11-14 KR KR1020207017251A patent/KR102625984B1/ko active IP Right Grant
- 2018-11-14 CA CA3080949A patent/CA3080949C/en active Active
- 2018-11-14 AU AU2018367515A patent/AU2018367515B2/en active Active
-
2020
- 2020-05-07 PH PH12020550580A patent/PH12020550580A1/en unknown
- 2020-05-07 ZA ZA2020/02531A patent/ZA202002531B/en unknown
- 2020-05-12 CL CL2020001244A patent/CL2020001244A1/es unknown
- 2020-06-11 CO CONC2020/0007150A patent/CO2020007150A2/es unknown
- 2020-07-13 MX MX2022012825A patent/MX2022012825A/es unknown
-
2021
- 2021-11-16 US US17/527,514 patent/US11827656B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
NZ764393A (en) | 2023-11-24 |
CA3080949A1 (en) | 2019-05-23 |
AU2018367515A1 (en) | 2020-05-14 |
BR112020009516A2 (pt) | 2020-11-03 |
CA3080949C (en) | 2024-04-16 |
CN111491938A (zh) | 2020-08-04 |
CL2020001244A1 (es) | 2020-08-21 |
PH12020550580A1 (en) | 2021-04-26 |
EP3710458A1 (en) | 2020-09-23 |
KR102625984B1 (ko) | 2024-01-18 |
US11827656B2 (en) | 2023-11-28 |
MA50906A (fr) | 2020-09-23 |
IL274523B1 (en) | 2023-10-01 |
ZA202002531B (en) | 2023-10-25 |
WO2019099582A1 (en) | 2019-05-23 |
KR20200085868A (ko) | 2020-07-15 |
JP2021503471A (ja) | 2021-02-12 |
IL274523B2 (en) | 2024-02-01 |
MX2022012825A (es) | 2022-11-07 |
US20200277312A1 (en) | 2020-09-03 |
CO2020007150A2 (es) | 2020-06-19 |
US20220073538A1 (en) | 2022-03-10 |
MX2020005046A (es) | 2020-08-20 |
US11225493B2 (en) | 2022-01-18 |
IL274523A (en) | 2020-06-30 |
SG11202003867SA (en) | 2020-05-28 |
TW201930264A (zh) | 2019-08-01 |
JP7277457B2 (ja) | 2023-05-19 |
AU2018367515B2 (en) | 2023-04-27 |
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