ZA200506254B - HIV inhibiting 1,2,4-triazines - Google Patents
HIV inhibiting 1,2,4-triazines Download PDFInfo
- Publication number
- ZA200506254B ZA200506254B ZA200506254A ZA200506254A ZA200506254B ZA 200506254 B ZA200506254 B ZA 200506254B ZA 200506254 A ZA200506254 A ZA 200506254A ZA 200506254 A ZA200506254 A ZA 200506254A ZA 200506254 B ZA200506254 B ZA 200506254B
- Authority
- ZA
- South Africa
- Prior art keywords
- recess
- crown
- segment
- annular
- electrode
- Prior art date
Links
- 150000003920 1,2,4-triazines Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000002093 peripheral effect Effects 0.000 claims description 27
- 230000014759 maintenance of location Effects 0.000 claims description 18
- 230000008878 coupling Effects 0.000 claims description 10
- 238000010168 coupling process Methods 0.000 claims description 10
- 238000005859 coupling reaction Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000000725 suspension Substances 0.000 claims description 5
- 239000002184 metal Substances 0.000 description 3
- 238000002955 isolation Methods 0.000 description 2
- 229920000271 Kevlar® Polymers 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical group [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 239000004761 kevlar Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0301289 | 2003-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200506254B true ZA200506254B (en) | 2008-02-27 |
Family
ID=32892827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200506254A ZA200506254B (en) | 2003-02-07 | 2005-08-04 | HIV inhibiting 1,2,4-triazines |
Country Status (20)
Country | Link |
---|---|
US (1) | US7585861B2 (de) |
EP (1) | EP1597242B1 (de) |
JP (1) | JP4783725B2 (de) |
KR (1) | KR20050105190A (de) |
CN (2) | CN1747941A (de) |
AP (1) | AP2005003365A0 (de) |
AT (1) | ATE402152T1 (de) |
AU (1) | AU2004213173B2 (de) |
BR (1) | BRPI0407306A (de) |
CA (1) | CA2513123C (de) |
DE (1) | DE602004015254D1 (de) |
EA (1) | EA010379B1 (de) |
ES (1) | ES2311146T3 (de) |
HR (1) | HRP20050690A2 (de) |
IL (1) | IL170120A (de) |
MX (1) | MXPA05008368A (de) |
NO (1) | NO20054127L (de) |
PL (1) | PL232814B1 (de) |
WO (1) | WO2004074266A1 (de) |
ZA (1) | ZA200506254B (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2567574C (en) | 2004-04-08 | 2013-01-08 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
US7923554B2 (en) * | 2004-08-10 | 2011-04-12 | Janssen Pharmaceutica N.V. | HIV inhibiting 1,2,4-triazin-6-one derivatives |
NZ553492A (en) | 2004-08-25 | 2010-11-26 | Targegen Inc | Triazole derivatives and methods of use |
CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
EP2289510A1 (de) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten |
WO2006034440A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
EP2316458A1 (de) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas |
MX2007003321A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
CN101208089A (zh) | 2005-06-03 | 2008-06-25 | 泽农医药公司 | 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂 |
US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
PT1951684T (pt) | 2005-11-01 | 2016-10-13 | Targegen Inc | Inibidores de cinases de tipo biaril-meta-pirimidina |
JP2010518014A (ja) * | 2007-01-31 | 2010-05-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用な2−アミノピリジン誘導体 |
DK2300013T3 (en) | 2008-05-21 | 2017-12-04 | Ariad Pharma Inc | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS |
MX2011000837A (es) | 2008-07-23 | 2011-04-05 | Vertex Pharma | Inhibidores de pirazolpiridina cinasa triciclica. |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
JP2011529062A (ja) | 2008-07-23 | 2011-12-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | ピラゾロピリジンキナーゼ阻害剤 |
AU2009279611A1 (en) | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
CA2760705A1 (en) | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
CN102869663A (zh) | 2010-01-27 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 吡唑并吡嗪激酶抑制剂 |
WO2011094290A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
EP2528917B1 (de) | 2010-01-27 | 2016-10-19 | Vertex Pharmaceuticals Incorporated | Zur behandlung von autoimmun-, entzündlichen oder (hyper)proliferativen erkrankungen geeignete pyrazolopyridine |
AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
EP4108659A1 (de) | 2016-06-07 | 2022-12-28 | Jacobio Pharmaceuticals Co., Ltd. | Neuartige, als shp2-inhibitoren nützliche heterocyclische derivate |
AU2018239542C1 (en) | 2017-03-23 | 2021-02-11 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as SHP2 inhibitors |
WO2021071984A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
CN111333543B (zh) * | 2020-04-17 | 2022-09-16 | 武汉工程大学 | 一种利匹韦林中间体的合成方法 |
CN115745848A (zh) * | 2022-12-07 | 2023-03-07 | 上海优合生物科技有限公司 | 一种氨基胍的加工合成工艺 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
CZ154398A3 (cs) | 1995-11-23 | 1998-08-12 | Janssen Pharmaceutica N.V. | Pevné směsi cyklodextrinů připravené vytlačováním taveniny |
NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
DE69909455T2 (de) | 1998-03-27 | 2004-04-15 | Lg Life Sciences Ltd. | Polyethoxylierte ascorbinsäurederivate als neue antioxidantien und verfahren zu ihrer herstellung |
EP0945447A1 (de) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
ATE232521T1 (de) * | 1998-03-27 | 2003-02-15 | Janssen Pharmaceutica Nv | Hiv hemmende pyrimidin derivate |
BRPI9915552B8 (pt) * | 1998-11-10 | 2021-05-25 | Janssen Pharmaceutica Nv | pirimidinas inibidoras da reprodução do hiv |
EP1129079B1 (de) * | 1998-11-10 | 2006-01-04 | Janssen Pharmaceutica N.V. | 2,4-disubstierte triazinderivate mit anti-hiv aktivität |
EP1282606B1 (de) * | 2000-05-08 | 2015-04-22 | Janssen Pharmaceutica NV | Hiv replications hemmende pyrimidinen und triazinen |
ATE367814T1 (de) | 2001-03-15 | 2007-08-15 | Janssen Pharmaceutica Nv | Hiv hemmende pyrazinon-derivate |
JO3429B1 (ar) * | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
-
2004
- 2004-02-05 WO PCT/EP2004/050084 patent/WO2004074266A1/en active IP Right Grant
- 2004-02-05 CN CNA2004800035861A patent/CN1747941A/zh active Pending
- 2004-02-05 KR KR1020057013955A patent/KR20050105190A/ko not_active Application Discontinuation
- 2004-02-05 PL PL378107A patent/PL232814B1/pl unknown
- 2004-02-05 ES ES04708367T patent/ES2311146T3/es not_active Expired - Lifetime
- 2004-02-05 AU AU2004213173A patent/AU2004213173B2/en not_active Ceased
- 2004-02-05 US US10/544,584 patent/US7585861B2/en not_active Expired - Lifetime
- 2004-02-05 AP AP2005003365A patent/AP2005003365A0/xx unknown
- 2004-02-05 JP JP2006502005A patent/JP4783725B2/ja not_active Expired - Fee Related
- 2004-02-05 CN CN201110305993XA patent/CN102503903A/zh active Pending
- 2004-02-05 CA CA2513123A patent/CA2513123C/en not_active Expired - Fee Related
- 2004-02-05 EP EP04708367A patent/EP1597242B1/de not_active Expired - Lifetime
- 2004-02-05 DE DE602004015254T patent/DE602004015254D1/de not_active Expired - Lifetime
- 2004-02-05 BR BRPI0407306-1A patent/BRPI0407306A/pt not_active IP Right Cessation
- 2004-02-05 EA EA200501268A patent/EA010379B1/ru not_active IP Right Cessation
- 2004-02-05 AT AT04708367T patent/ATE402152T1/de not_active IP Right Cessation
- 2004-02-05 MX MXPA05008368A patent/MXPA05008368A/es active IP Right Grant
-
2005
- 2005-08-01 HR HR20050690A patent/HRP20050690A2/xx not_active Application Discontinuation
- 2005-08-04 IL IL170120A patent/IL170120A/en active IP Right Grant
- 2005-08-04 ZA ZA200506254A patent/ZA200506254B/en unknown
- 2005-09-05 NO NO20054127A patent/NO20054127L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN102503903A (zh) | 2012-06-20 |
KR20050105190A (ko) | 2005-11-03 |
JP2006516983A (ja) | 2006-07-13 |
HRP20050690A2 (en) | 2006-08-31 |
AP2005003365A0 (en) | 2005-09-30 |
AU2004213173B2 (en) | 2010-07-29 |
PL378107A1 (pl) | 2006-03-06 |
EP1597242B1 (de) | 2008-07-23 |
MXPA05008368A (es) | 2005-11-04 |
JP4783725B2 (ja) | 2011-09-28 |
PL232814B1 (pl) | 2019-07-31 |
CA2513123A1 (en) | 2004-09-02 |
NO20054127L (no) | 2005-09-05 |
CA2513123C (en) | 2013-04-23 |
BRPI0407306A (pt) | 2006-02-21 |
AU2004213173A1 (en) | 2004-09-02 |
EA200501268A1 (ru) | 2006-02-24 |
WO2004074266A1 (en) | 2004-09-02 |
EA010379B1 (ru) | 2008-08-29 |
EP1597242A1 (de) | 2005-11-23 |
ES2311146T3 (es) | 2009-02-01 |
ATE402152T1 (de) | 2008-08-15 |
US20070037811A1 (en) | 2007-02-15 |
IL170120A (en) | 2013-04-30 |
DE602004015254D1 (de) | 2008-09-04 |
US7585861B2 (en) | 2009-09-08 |
CN1747941A (zh) | 2006-03-15 |
WO2004074266A8 (en) | 2004-11-11 |
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