FR2814073B1 - Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition - Google Patents

Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition

Info

Publication number
FR2814073B1
FR2814073B1 FR0012050A FR0012050A FR2814073B1 FR 2814073 B1 FR2814073 B1 FR 2814073B1 FR 0012050 A FR0012050 A FR 0012050A FR 0012050 A FR0012050 A FR 0012050A FR 2814073 B1 FR2814073 B1 FR 2814073B1
Authority
FR
France
Prior art keywords
composition
antifungal
active ingredients
indole derivatives
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0012050A
Other languages
English (en)
Other versions
FR2814073A1 (fr
Inventor
Borgne Marc Le
Young Min Na
Fabrice Pagniez
Baut Guillaume Le
Pape Patrice Le
Hiam Abdala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yang Ji Chemical Co Ltd
Original Assignee
Yang Ji Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0012050A priority Critical patent/FR2814073B1/fr
Application filed by Yang Ji Chemical Co Ltd filed Critical Yang Ji Chemical Co Ltd
Priority to US10/381,293 priority patent/US20040067998A1/en
Priority to EP01972184A priority patent/EP1322638A1/fr
Priority to CA002423151A priority patent/CA2423151A1/fr
Priority to JP2002529095A priority patent/JP2004509886A/ja
Priority to AU2001291973A priority patent/AU2001291973A1/en
Priority to PCT/FR2001/002950 priority patent/WO2002024685A1/fr
Priority to KR1020037004417A priority patent/KR20030046472A/ko
Priority to CNA01818555XA priority patent/CN1473160A/zh
Publication of FR2814073A1 publication Critical patent/FR2814073A1/fr
Application granted granted Critical
Publication of FR2814073B1 publication Critical patent/FR2814073B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR0012050A 2000-09-21 2000-09-21 Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition Expired - Fee Related FR2814073B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR0012050A FR2814073B1 (fr) 2000-09-21 2000-09-21 Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition
EP01972184A EP1322638A1 (fr) 2000-09-21 2001-09-21 Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires
CA002423151A CA2423151A1 (fr) 2000-09-21 2001-09-21 Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires
JP2002529095A JP2004509886A (ja) 2000-09-21 2001-09-21 抗真菌及び／又は抗寄生虫用薬学的組成物、及びその組成物の活性成分としての新規のインドール誘導体
US10/381,293 US20040067998A1 (en) 2000-09-21 2001-09-21 Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition
AU2001291973A AU2001291973A1 (en) 2000-09-21 2001-09-21 Indole derivatives and their use as antifungal and/or antiparasitic agents
PCT/FR2001/002950 WO2002024685A1 (fr) 2000-09-21 2001-09-21 Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires
KR1020037004417A KR20030046472A (ko) 2000-09-21 2001-09-21 항진균 및/또는 항기생충 약학적 조성물 및 이러한조성물의 활성 성분으로서의 신규한 인돌 유도체
CNA01818555XA CN1473160A (zh) 2000-09-21 2001-09-21 抗真菌和/或抗寄生虫的药物组合物以及作为该组合物活性组分的新的吲哚衍生物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0012050A FR2814073B1 (fr) 2000-09-21 2000-09-21 Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition

Publications (2)

Publication Number Publication Date
FR2814073A1 FR2814073A1 (fr) 2002-03-22
FR2814073B1 true FR2814073B1 (fr) 2005-06-24

Family

ID=8854543

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0012050A Expired - Fee Related FR2814073B1 (fr) 2000-09-21 2000-09-21 Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition

Country Status (9)

Country Link
US (1) US20040067998A1 (fr)
EP (1) EP1322638A1 (fr)
JP (1) JP2004509886A (fr)
KR (1) KR20030046472A (fr)
CN (1) CN1473160A (fr)
AU (1) AU2001291973A1 (fr)
CA (1) CA2423151A1 (fr)
FR (1) FR2814073B1 (fr)
WO (1) WO2002024685A1 (fr)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
WO2004108671A1 (fr) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
AU2005250116B2 (en) 2004-06-01 2011-01-20 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor
WO2006109933A1 (fr) 2005-03-30 2006-10-19 Daewoong Pharmaceutical Co., Ltd. Derives de triazole antifongiques
ES2329413T3 (es) 2005-11-30 2009-11-25 F. Hoffmann-La Roche Ag 3-amino-2-arilpropil azaindoles y usos de los mismos.
CA2631048A1 (fr) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag Procede de synthese de 3-amino-1-arylpropyle indoles
AU2006319231A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
ES2594156T3 (es) 2006-01-06 2016-12-16 Sunovion Pharmaceuticals Inc. Cicloalquilaminas como inhibidores de la recaptación de monoaminas
CN101918360A (zh) * 2007-09-24 2010-12-15 阿勒根公司 具有1-磷酸-鞘氨醇(s1p)受体生物学活性的带芳基或者杂芳基基团的吲哚化合物
ME01838B (me) 2009-06-29 2014-12-20 Lncyte Holdings Corp Pirimidinoni kao inhibitori pi3k
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
EP2558463A1 (fr) 2010-04-14 2013-02-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de i3
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2655374B1 (fr) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(phényl substitué)éthyl)-9h-purin-6-amines en tant qu'inhibiteurs de pi3k
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (fr) 2011-03-25 2012-10-04 Incyte Corporation Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k
KR102371532B1 (ko) 2011-09-02 2022-03-07 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
WO2016040764A1 (fr) * 2014-09-12 2016-03-17 Spero Therapeutics, Inc. N-benzimidazoles hétéroaryles bicycliques liés à du carbonyle et analogues utilisés en tant qu'inhibiteurs de tolérance aux antibiotiques
NZ734993A (en) 2015-02-27 2024-03-22 Incyte Holdings Corp Salts of pi3k inhibitor and processes for their preparation
WO2016144706A2 (fr) * 2015-03-11 2016-09-15 Pharmakea, Inc. Composés inhibiteurs de l'autotaxine et leurs utilisations
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
ES2708900A1 (es) * 2017-10-10 2019-04-11 Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa Nuevos derivados de gramina con efecto protector de la actividad fosfatasa, y su aplicacion en el tratamiento de enfermedades humanas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140858A (en) * 1977-12-19 1979-02-20 Warner-Lambert Company 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production
GR75101B (fr) * 1980-10-23 1984-07-13 Pfizer
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW297813B (fr) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
WO2002024685A8 (fr) 2002-09-26
US20040067998A1 (en) 2004-04-08
EP1322638A1 (fr) 2003-07-02
FR2814073A1 (fr) 2002-03-22
WO2002024685A1 (fr) 2002-03-28
JP2004509886A (ja) 2004-04-02
CA2423151A1 (fr) 2002-03-28
AU2001291973A1 (en) 2002-04-02
CN1473160A (zh) 2004-02-04
KR20030046472A (ko) 2003-06-12

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20060531