FR2814073B1 - Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition - Google Patents
Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle compositionInfo
- Publication number
- FR2814073B1 FR2814073B1 FR0012050A FR0012050A FR2814073B1 FR 2814073 B1 FR2814073 B1 FR 2814073B1 FR 0012050 A FR0012050 A FR 0012050A FR 0012050 A FR0012050 A FR 0012050A FR 2814073 B1 FR2814073 B1 FR 2814073B1
- Authority
- FR
- France
- Prior art keywords
- composition
- antifungal
- active ingredients
- indole derivatives
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0012050A FR2814073B1 (fr) | 2000-09-21 | 2000-09-21 | Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition |
EP01972184A EP1322638A1 (fr) | 2000-09-21 | 2001-09-21 | Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires |
CA002423151A CA2423151A1 (fr) | 2000-09-21 | 2001-09-21 | Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires |
JP2002529095A JP2004509886A (ja) | 2000-09-21 | 2001-09-21 | 抗真菌及び/又は抗寄生虫用薬学的組成物、及びその組成物の活性成分としての新規のインドール誘導体 |
US10/381,293 US20040067998A1 (en) | 2000-09-21 | 2001-09-21 | Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition |
AU2001291973A AU2001291973A1 (en) | 2000-09-21 | 2001-09-21 | Indole derivatives and their use as antifungal and/or antiparasitic agents |
PCT/FR2001/002950 WO2002024685A1 (fr) | 2000-09-21 | 2001-09-21 | Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires |
KR1020037004417A KR20030046472A (ko) | 2000-09-21 | 2001-09-21 | 항진균 및/또는 항기생충 약학적 조성물 및 이러한조성물의 활성 성분으로서의 신규한 인돌 유도체 |
CNA01818555XA CN1473160A (zh) | 2000-09-21 | 2001-09-21 | 抗真菌和/或抗寄生虫的药物组合物以及作为该组合物活性组分的新的吲哚衍生物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0012050A FR2814073B1 (fr) | 2000-09-21 | 2000-09-21 | Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2814073A1 FR2814073A1 (fr) | 2002-03-22 |
FR2814073B1 true FR2814073B1 (fr) | 2005-06-24 |
Family
ID=8854543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0012050A Expired - Fee Related FR2814073B1 (fr) | 2000-09-21 | 2000-09-21 | Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040067998A1 (fr) |
EP (1) | EP1322638A1 (fr) |
JP (1) | JP2004509886A (fr) |
KR (1) | KR20030046472A (fr) |
CN (1) | CN1473160A (fr) |
AU (1) | AU2001291973A1 (fr) |
CA (1) | CA2423151A1 (fr) |
FR (1) | FR2814073B1 (fr) |
WO (1) | WO2002024685A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004108671A1 (fr) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant |
AU2005250116B2 (en) | 2004-06-01 | 2011-01-20 | F. Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor |
WO2006109933A1 (fr) | 2005-03-30 | 2006-10-19 | Daewoong Pharmaceutical Co., Ltd. | Derives de triazole antifongiques |
ES2329413T3 (es) | 2005-11-30 | 2009-11-25 | F. Hoffmann-La Roche Ag | 3-amino-2-arilpropil azaindoles y usos de los mismos. |
CA2631048A1 (fr) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | Procede de synthese de 3-amino-1-arylpropyle indoles |
AU2006319231A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles and aza-substituted indoles |
ES2594156T3 (es) | 2006-01-06 | 2016-12-16 | Sunovion Pharmaceuticals Inc. | Cicloalquilaminas como inhibidores de la recaptación de monoaminas |
CN101918360A (zh) * | 2007-09-24 | 2010-12-15 | 阿勒根公司 | 具有1-磷酸-鞘氨醇(s1p)受体生物学活性的带芳基或者杂芳基基团的吲哚化合物 |
ME01838B (me) | 2009-06-29 | 2014-12-20 | Lncyte Holdings Corp | Pirimidinoni kao inhibitori pi3k |
US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
EP2558463A1 (fr) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Dérivés condensés en tant qu'inhibiteurs de i3 |
US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
EP2655374B1 (fr) | 2010-12-20 | 2019-10-23 | Incyte Holdings Corporation | N-(1-(phényl substitué)éthyl)-9h-purin-6-amines en tant qu'inhibiteurs de pi3k |
US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
WO2012135009A1 (fr) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k |
KR102371532B1 (ko) | 2011-09-02 | 2022-03-07 | 인사이트 홀딩스 코포레이션 | Pi3k 억제제로서 헤테로시클릴아민 |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
WO2016040764A1 (fr) * | 2014-09-12 | 2016-03-17 | Spero Therapeutics, Inc. | N-benzimidazoles hétéroaryles bicycliques liés à du carbonyle et analogues utilisés en tant qu'inhibiteurs de tolérance aux antibiotiques |
NZ734993A (en) | 2015-02-27 | 2024-03-22 | Incyte Holdings Corp | Salts of pi3k inhibitor and processes for their preparation |
WO2016144706A2 (fr) * | 2015-03-11 | 2016-09-15 | Pharmakea, Inc. | Composés inhibiteurs de l'autotaxine et leurs utilisations |
US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
ES2708900A1 (es) * | 2017-10-10 | 2019-04-11 | Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa | Nuevos derivados de gramina con efecto protector de la actividad fosfatasa, y su aplicacion en el tratamiento de enfermedades humanas |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140858A (en) * | 1977-12-19 | 1979-02-20 | Warner-Lambert Company | 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production |
GR75101B (fr) * | 1980-10-23 | 1984-07-13 | Pfizer | |
GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
TW297813B (fr) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd |
-
2000
- 2000-09-21 FR FR0012050A patent/FR2814073B1/fr not_active Expired - Fee Related
-
2001
- 2001-09-21 JP JP2002529095A patent/JP2004509886A/ja active Pending
- 2001-09-21 WO PCT/FR2001/002950 patent/WO2002024685A1/fr not_active Application Discontinuation
- 2001-09-21 CN CNA01818555XA patent/CN1473160A/zh active Pending
- 2001-09-21 US US10/381,293 patent/US20040067998A1/en not_active Abandoned
- 2001-09-21 EP EP01972184A patent/EP1322638A1/fr not_active Withdrawn
- 2001-09-21 KR KR1020037004417A patent/KR20030046472A/ko not_active Application Discontinuation
- 2001-09-21 AU AU2001291973A patent/AU2001291973A1/en not_active Abandoned
- 2001-09-21 CA CA002423151A patent/CA2423151A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002024685A8 (fr) | 2002-09-26 |
US20040067998A1 (en) | 2004-04-08 |
EP1322638A1 (fr) | 2003-07-02 |
FR2814073A1 (fr) | 2002-03-22 |
WO2002024685A1 (fr) | 2002-03-28 |
JP2004509886A (ja) | 2004-04-02 |
CA2423151A1 (fr) | 2002-03-28 |
AU2001291973A1 (en) | 2002-04-02 |
CN1473160A (zh) | 2004-02-04 |
KR20030046472A (ko) | 2003-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20060531 |