WO2002024685A8 - Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires - Google Patents
Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitairesInfo
- Publication number
- WO2002024685A8 WO2002024685A8 PCT/FR2001/002950 FR0102950W WO0224685A8 WO 2002024685 A8 WO2002024685 A8 WO 2002024685A8 FR 0102950 W FR0102950 W FR 0102950W WO 0224685 A8 WO0224685 A8 WO 0224685A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antifungal
- indole derivatives
- antiparasitic agents
- antiparasitic
- agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/381,293 US20040067998A1 (en) | 2000-09-21 | 2001-09-21 | Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition |
EP01972184A EP1322638A1 (fr) | 2000-09-21 | 2001-09-21 | Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires |
JP2002529095A JP2004509886A (ja) | 2000-09-21 | 2001-09-21 | 抗真菌及び/又は抗寄生虫用薬学的組成物、及びその組成物の活性成分としての新規のインドール誘導体 |
AU2001291973A AU2001291973A1 (en) | 2000-09-21 | 2001-09-21 | Indole derivatives and their use as antifungal and/or antiparasitic agents |
CA002423151A CA2423151A1 (fr) | 2000-09-21 | 2001-09-21 | Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0012050 | 2000-09-21 | ||
FR0012050A FR2814073B1 (fr) | 2000-09-21 | 2000-09-21 | Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002024685A1 WO2002024685A1 (fr) | 2002-03-28 |
WO2002024685A8 true WO2002024685A8 (fr) | 2002-09-26 |
Family
ID=8854543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2001/002950 WO2002024685A1 (fr) | 2000-09-21 | 2001-09-21 | Derives de l'indole et leur utilisation en tant qu'agents antifongiques et/ou antiparasitaires |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040067998A1 (fr) |
EP (1) | EP1322638A1 (fr) |
JP (1) | JP2004509886A (fr) |
KR (1) | KR20030046472A (fr) |
CN (1) | CN1473160A (fr) |
AU (1) | AU2001291973A1 (fr) |
CA (1) | CA2423151A1 (fr) |
FR (1) | FR2814073B1 (fr) |
WO (1) | WO2002024685A1 (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877975B2 (en) | 2006-01-06 | 2014-11-04 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
US8940752B2 (en) | 2009-06-29 | 2015-01-27 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
US9096600B2 (en) | 2010-12-20 | 2015-08-04 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
US9199982B2 (en) | 2011-09-02 | 2015-12-01 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
US9309251B2 (en) | 2012-04-02 | 2016-04-12 | Incyte Holdings Corporation | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors |
US9403847B2 (en) | 2009-12-18 | 2016-08-02 | Incyte Holdings Corporation | Substituted heteroaryl fused derivatives as P13K inhibitors |
US12024522B2 (en) | 2021-07-01 | 2024-07-02 | Incyte Corporation | Salts and processes of preparing a PI3K inhibitor |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004108671A1 (fr) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant |
EP1756054B1 (fr) | 2004-06-01 | 2010-03-31 | F.Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles utiles comme inhibiteurs de la reabsorption de la monoamine |
EP1871766A4 (fr) * | 2005-03-30 | 2010-07-21 | Dae Woong Pharma | Derives de triazole antifongiques |
WO2007062996A1 (fr) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles et indoles a substitution azo |
ATE442368T1 (de) | 2005-11-30 | 2009-09-15 | Hoffmann La Roche | 3-amino-2-arylpropylazaindole und anwendungen davon |
BRPI0619247A2 (pt) | 2005-11-30 | 2011-09-20 | Hoffmann La Roche | métodos para a sìntese de 3-amino-1-aril-propila indóis |
WO2009042485A1 (fr) * | 2007-09-24 | 2009-04-02 | Allergan, Inc. | Composés de type indole porteur de groupes hétéroaryles ayant une activité biologique de récepteur de la sphingosine-1-phosphate (s1p) |
WO2011163195A1 (fr) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k |
WO2015191677A1 (fr) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k |
WO2016040764A1 (fr) * | 2014-09-12 | 2016-03-17 | Spero Therapeutics, Inc. | N-benzimidazoles hétéroaryles bicycliques liés à du carbonyle et analogues utilisés en tant qu'inhibiteurs de tolérance aux antibiotiques |
NZ734993A (en) | 2015-02-27 | 2024-03-22 | Incyte Holdings Corp | Salts of pi3k inhibitor and processes for their preparation |
WO2016144706A2 (fr) * | 2015-03-11 | 2016-09-15 | Pharmakea, Inc. | Composés inhibiteurs de l'autotaxine et leurs utilisations |
US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
ES2708900A1 (es) * | 2017-10-10 | 2019-04-11 | Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa | Nuevos derivados de gramina con efecto protector de la actividad fosfatasa, y su aplicacion en el tratamiento de enfermedades humanas |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140858A (en) * | 1977-12-19 | 1979-02-20 | Warner-Lambert Company | 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production |
GR75101B (fr) * | 1980-10-23 | 1984-07-13 | Pfizer | |
GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
TW297813B (fr) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd |
-
2000
- 2000-09-21 FR FR0012050A patent/FR2814073B1/fr not_active Expired - Fee Related
-
2001
- 2001-09-21 WO PCT/FR2001/002950 patent/WO2002024685A1/fr not_active Application Discontinuation
- 2001-09-21 KR KR1020037004417A patent/KR20030046472A/ko not_active Application Discontinuation
- 2001-09-21 JP JP2002529095A patent/JP2004509886A/ja active Pending
- 2001-09-21 CA CA002423151A patent/CA2423151A1/fr not_active Abandoned
- 2001-09-21 US US10/381,293 patent/US20040067998A1/en not_active Abandoned
- 2001-09-21 CN CNA01818555XA patent/CN1473160A/zh active Pending
- 2001-09-21 AU AU2001291973A patent/AU2001291973A1/en not_active Abandoned
- 2001-09-21 EP EP01972184A patent/EP1322638A1/fr not_active Withdrawn
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877975B2 (en) | 2006-01-06 | 2014-11-04 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
US8940752B2 (en) | 2009-06-29 | 2015-01-27 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
US9434746B2 (en) | 2009-06-29 | 2016-09-06 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
US9403847B2 (en) | 2009-12-18 | 2016-08-02 | Incyte Holdings Corporation | Substituted heteroaryl fused derivatives as P13K inhibitors |
US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
US9096600B2 (en) | 2010-12-20 | 2015-08-04 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
US9527848B2 (en) | 2010-12-20 | 2016-12-27 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
US9199982B2 (en) | 2011-09-02 | 2015-12-01 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
US9309251B2 (en) | 2012-04-02 | 2016-04-12 | Incyte Holdings Corporation | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors |
US12024522B2 (en) | 2021-07-01 | 2024-07-02 | Incyte Corporation | Salts and processes of preparing a PI3K inhibitor |
Also Published As
Publication number | Publication date |
---|---|
EP1322638A1 (fr) | 2003-07-02 |
WO2002024685A1 (fr) | 2002-03-28 |
CN1473160A (zh) | 2004-02-04 |
FR2814073B1 (fr) | 2005-06-24 |
FR2814073A1 (fr) | 2002-03-22 |
CA2423151A1 (fr) | 2002-03-28 |
KR20030046472A (ko) | 2003-06-12 |
JP2004509886A (ja) | 2004-04-02 |
AU2001291973A1 (en) | 2002-04-02 |
US20040067998A1 (en) | 2004-04-08 |
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