AU2001291973A1 - Indole derivatives and their use as antifungal and/or antiparasitic agents - Google Patents

Indole derivatives and their use as antifungal and/or antiparasitic agents

Info

Publication number
AU2001291973A1
AU2001291973A1 AU2001291973A AU9197301A AU2001291973A1 AU 2001291973 A1 AU2001291973 A1 AU 2001291973A1 AU 2001291973 A AU2001291973 A AU 2001291973A AU 9197301 A AU9197301 A AU 9197301A AU 2001291973 A1 AU2001291973 A1 AU 2001291973A1
Authority
AU
Australia
Prior art keywords
antifungal
indole derivatives
antiparasitic agents
antiparasitic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001291973A
Inventor
Hiam Abdala
Guillaume Le Baut
Marc Le Borgne
Patrice Le Pape
Young Min Na
Fabrice Pagniez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yang Ji Chemical Co Ltd
Original Assignee
Yang Ji Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yang Ji Chemical Co Ltd filed Critical Yang Ji Chemical Co Ltd
Publication of AU2001291973A1 publication Critical patent/AU2001291973A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2001291973A 2000-09-21 2001-09-21 Indole derivatives and their use as antifungal and/or antiparasitic agents Abandoned AU2001291973A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0012050A FR2814073B1 (en) 2000-09-21 2000-09-21 ANTIFUNGAL AND / OR ANTIPARASITIC PHARMACEUTICAL COMPOSITION AND NOVEL INDOLE DERIVATIVES AS ACTIVE INGREDIENTS OF SUCH A COMPOSITION
FR0012050 2000-09-21
PCT/FR2001/002950 WO2002024685A1 (en) 2000-09-21 2001-09-21 Indole derivatives and their use as antifungal and/or antiparasitic agents

Publications (1)

Publication Number Publication Date
AU2001291973A1 true AU2001291973A1 (en) 2002-04-02

Family

ID=8854543

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001291973A Abandoned AU2001291973A1 (en) 2000-09-21 2001-09-21 Indole derivatives and their use as antifungal and/or antiparasitic agents

Country Status (9)

Country Link
US (1) US20040067998A1 (en)
EP (1) EP1322638A1 (en)
JP (1) JP2004509886A (en)
KR (1) KR20030046472A (en)
CN (1) CN1473160A (en)
AU (1) AU2001291973A1 (en)
CA (1) CA2423151A1 (en)
FR (1) FR2814073B1 (en)
WO (1) WO2002024685A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
DE602005020280D1 (en) 2004-06-01 2010-05-12 Hoffmann La Roche 3-AMINO-1-ARYLPROPYL INDOLE AS A MONOAMINE RECOVERY INHIBITOR
KR101048535B1 (en) 2005-03-30 2011-07-11 주식회사 대웅제약 Antifungal Triazole Derivatives
CA2629962A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
DE602006009138D1 (en) 2005-11-30 2009-10-22 Hoffmann La Roche 3-AMINO-2-ARYLPROPYLAZAINDOLE AND APPLICATIONS THEREOF
ATE517086T1 (en) 2005-11-30 2011-08-15 Hoffmann La Roche METHOD FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYLINDOLES
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
AU2008304657B2 (en) * 2007-09-24 2013-09-05 Allergan, Inc. Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity
ES2486715T3 (en) 2009-06-29 2014-08-19 Incyte Corporation Pyrimidinones as PI3K inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR081823A1 (en) 2010-04-14 2012-10-24 Incyte Corp FUSIONATED DERIVATIVES AS PI3Kd INHIBITORS
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
ME02595B (en) 2011-09-02 2017-06-20 Incyte Holdings Corp Heterocyclylamines as pi3k inhibitors
AR090548A1 (en) 2012-04-02 2014-11-19 Incyte Corp BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
WO2016040764A1 (en) * 2014-09-12 2016-03-17 Spero Therapeutics, Inc. Carbonyl linked bicyclic heteroaryl n-benzimidazoles and analogs as antibiotic tolerance inhibitors
KR20170132185A (en) 2015-02-27 2017-12-01 인사이트 코포레이션 Salts of PI3K inhibitors and processes for their preparation
WO2016144706A2 (en) * 2015-03-11 2016-09-15 Pharmakea, Inc. Autotaxin inhibitor compounds and uses thereof
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
ES2708900A1 (en) * 2017-10-10 2019-04-11 Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa NEW GRAMINE DERIVATIVES WITH PROTECTIVE EFFECT OF PHOSPHATASE ACTIVITY, AND ITS APPLICATION IN THE TREATMENT OF HUMAN DISEASES (Machine-translation by Google Translate, not legally binding)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140858A (en) * 1977-12-19 1979-02-20 Warner-Lambert Company 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production
GR75101B (en) * 1980-10-23 1984-07-13 Pfizer
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW297813B (en) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
FR2814073B1 (en) 2005-06-24
EP1322638A1 (en) 2003-07-02
CN1473160A (en) 2004-02-04
US20040067998A1 (en) 2004-04-08
KR20030046472A (en) 2003-06-12
WO2002024685A1 (en) 2002-03-28
JP2004509886A (en) 2004-04-02
FR2814073A1 (en) 2002-03-22
WO2002024685A8 (en) 2002-09-26
CA2423151A1 (en) 2002-03-28

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