PL2228370T3 - N-{1-[3-(2-etoksy-5-(4-etylopiperazynylo)benzenosulfonylo)-4,5-dihydro-5-okso-1,2,4-triazyn-6-yl]etylo}butyroamid, sposób jego wytwarzania i zastosowanie - Google Patents
N-{1-[3-(2-etoksy-5-(4-etylopiperazynylo)benzenosulfonylo)-4,5-dihydro-5-okso-1,2,4-triazyn-6-yl]etylo}butyroamid, sposób jego wytwarzania i zastosowanieInfo
- Publication number
- PL2228370T3 PL2228370T3 PL07855873T PL07855873T PL2228370T3 PL 2228370 T3 PL2228370 T3 PL 2228370T3 PL 07855873 T PL07855873 T PL 07855873T PL 07855873 T PL07855873 T PL 07855873T PL 2228370 T3 PL2228370 T3 PL 2228370T3
- Authority
- PL
- Poland
- Prior art keywords
- ethylpiperazinyl
- butyramide
- triazin
- benzenesulfonyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07855873A EP2228370B1 (en) | 2007-12-28 | 2007-12-28 | N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof |
PCT/CN2007/003872 WO2009082845A1 (en) | 2007-12-28 | 2007-12-28 | N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2228370T3 true PL2228370T3 (pl) | 2012-10-31 |
Family
ID=40823747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL07855873T PL2228370T3 (pl) | 2007-12-28 | 2007-12-28 | N-{1-[3-(2-etoksy-5-(4-etylopiperazynylo)benzenosulfonylo)-4,5-dihydro-5-okso-1,2,4-triazyn-6-yl]etylo}butyroamid, sposób jego wytwarzania i zastosowanie |
Country Status (7)
Country | Link |
---|---|
US (1) | US8410098B2 (pl) |
EP (1) | EP2228370B1 (pl) |
JP (1) | JP5411161B2 (pl) |
BR (1) | BRPI0722222A2 (pl) |
ES (1) | ES2388371T3 (pl) |
PL (1) | PL2228370T3 (pl) |
WO (1) | WO2009082845A1 (pl) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2448938T3 (pl) | 2009-06-29 | 2014-11-28 | Incyte Holdings Corp | Pirymidynony jako inhibitory PI3K |
US20120190849A1 (en) * | 2009-08-07 | 2012-07-26 | Ranbaxy Laboratories Limited | Processes for the preparation of vardenafil |
US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
JP5961187B2 (ja) | 2010-12-20 | 2016-08-02 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pi3k阻害剤としてのn−(1−(置換フェニル)エチル)−9h−プリン−6−アミン |
HUE030869T2 (en) | 2011-09-02 | 2017-06-28 | Incyte Holdings Corp | Heterocyclic amines as inhibitors of PI3K |
AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
CZ303877B6 (cs) | 2011-11-24 | 2013-06-05 | Zentiva, K.S. | Zpusob prípravy a izolace solí vardenafilu s kyselinami |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
AU2016222556B2 (en) | 2015-02-27 | 2020-08-27 | Incyte Holdings Corporation | Salts of Pl3K inhibitor and processes for their preparation |
WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
CN107445964A (zh) * | 2017-07-29 | 2017-12-08 | 合肥创新医药技术有限公司 | 一种盐酸伐地那非杂质的合成方法 |
CN115785101B (zh) * | 2022-11-23 | 2023-10-13 | 西安市食品药品检验所 | 一种含有苯基哌嗪结构的那非类化合物及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE213246T1 (de) | 1997-11-12 | 2002-02-15 | 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren | |
YU93902A (sh) * | 2000-06-22 | 2005-11-28 | Pfizer Products Inc. | Postupak za pripremanje pirazolopirimidinona |
US6667398B2 (en) * | 2000-06-22 | 2003-12-23 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
DE10063106A1 (de) | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von 2-(2-Ethoxyphenyl)-substituierten Imidazotriazinonen |
DE10063108A1 (de) | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
WO2006127368A2 (en) | 2005-05-20 | 2006-11-30 | Lexicon Genetics Incorporated | Methods for synthesizing imidazotriazinones |
JP2013543512A (ja) * | 2010-10-11 | 2013-12-05 | アクシキン ファーマシューティカルズ インコーポレーテッド | アリールスルホンアミドccr3アンタゴニストの塩 |
-
2007
- 2007-12-28 US US12/810,898 patent/US8410098B2/en not_active Expired - Fee Related
- 2007-12-28 JP JP2010539986A patent/JP5411161B2/ja not_active Expired - Fee Related
- 2007-12-28 EP EP07855873A patent/EP2228370B1/en not_active Not-in-force
- 2007-12-28 WO PCT/CN2007/003872 patent/WO2009082845A1/zh active Application Filing
- 2007-12-28 ES ES07855873T patent/ES2388371T3/es active Active
- 2007-12-28 PL PL07855873T patent/PL2228370T3/pl unknown
- 2007-12-28 BR BRPI0722222-0A patent/BRPI0722222A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2011511761A (ja) | 2011-04-14 |
BRPI0722222A2 (pt) | 2015-06-16 |
EP2228370B1 (en) | 2012-05-23 |
ES2388371T3 (es) | 2012-10-15 |
US20110190495A1 (en) | 2011-08-04 |
EP2228370A4 (en) | 2011-06-08 |
WO2009082845A1 (en) | 2009-07-09 |
JP5411161B2 (ja) | 2014-02-12 |
EP2228370A1 (en) | 2010-09-15 |
US8410098B2 (en) | 2013-04-02 |
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