JP5677425B2 - Ｐｉ３ｋ阻害剤としてのピリミジノン - Google Patents

Ｐｉ３ｋ阻害剤としてのピリミジノン Download PDF

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Publication number
JP5677425B2
JP5677425B2 JP2012518563A JP2012518563A JP5677425B2 JP 5677425 B2 JP5677425 B2 JP 5677425B2 JP 2012518563 A JP2012518563 A JP 2012518563A JP 2012518563 A JP2012518563 A JP 2012518563A JP 5677425 B2 JP5677425 B2 JP 5677425B2
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thiazolo
methyl
pyrimidin
ethyl
purin
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JP2012532131A5 (enExample
JP2012532131A (ja
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ユン−ロン・リ
ブライアン・ダブリュー・メトカーフ
アンドリュー・ピー・クームズ
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2012518563A 2009-06-29 2010-06-28 Ｐｉ３ｋ阻害剤としてのピリミジノン Expired - Fee Related JP5677425B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22116009P 2009-06-29 2009-06-29
US61/221,160 2009-06-29
US25976509P 2009-11-10 2009-11-10
US61/259,765 2009-11-10
PCT/US2010/040150 WO2011008487A1 (en) 2009-06-29 2010-06-28 Pyrimidinones as pi3k inhibitors

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JP2014223540A Division JP2015042673A (ja) 2009-06-29 2014-10-31 Ｐｉ３ｋ阻害剤としてのピリミジノン

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JP2012532131A JP2012532131A (ja) 2012-12-13
JP2012532131A5 JP2012532131A5 (enExample) 2013-08-15
JP5677425B2 true JP5677425B2 (ja) 2015-02-25

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JP2012518563A Expired - Fee Related JP5677425B2 (ja) 2009-06-29 2010-06-28 Ｐｉ３ｋ阻害剤としてのピリミジノン
JP2014223540A Pending JP2015042673A (ja) 2009-06-29 2014-10-31 Ｐｉ３ｋ阻害剤としてのピリミジノン

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US (6) US8940752B2 (enExample)
EP (2) EP2448938B9 (enExample)
JP (2) JP5677425B2 (enExample)
KR (1) KR101763656B1 (enExample)
CN (2) CN102482278B (enExample)
AR (1) AR077280A1 (enExample)
AU (2) AU2010273816B2 (enExample)
BR (1) BRPI1015135B1 (enExample)
CA (1) CA2766100C (enExample)
CL (1) CL2011003346A1 (enExample)
CO (1) CO6440529A2 (enExample)
CR (1) CR20110686A (enExample)
DK (1) DK2448938T5 (enExample)
EA (1) EA021595B1 (enExample)
ES (1) ES2486715T3 (enExample)
HK (1) HK1208224A1 (enExample)
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MX (1) MX2011013816A (enExample)
MY (1) MY162507A (enExample)
NZ (1) NZ597050A (enExample)
PE (1) PE20120493A1 (enExample)
PH (1) PH12015501221A1 (enExample)
PL (1) PL2448938T3 (enExample)
PT (1) PT2448938E (enExample)
RS (1) RS53494B9 (enExample)
SG (1) SG177384A1 (enExample)
SI (1) SI2448938T1 (enExample)
SM (1) SMT201400116B (enExample)
TW (2) TWI490219B (enExample)
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JP5961187B2 (ja) 2010-12-20 2016-08-02 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン
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TWI662030B (zh) 2013-01-15 2019-06-11 英塞特控股公司 適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物
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WO2015192761A1 (zh) * 2014-06-17 2015-12-23 辰欣药业股份有限公司 作为mTOR/PI3K抑制剂的吡啶并[1,2-a]嘧啶酮类似物
EA201692557A1 (ru) * 2014-07-04 2017-05-31 Люпин Лимитед Хинолизиноновые производные в качестве ингибиторов pi3k
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