JP4887139B2 - ジペプチジルペプチダーゼインヒビター - Google Patents
ジペプチジルペプチダーゼインヒビター Download PDFInfo
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- JP4887139B2 JP4887139B2 JP2006509315A JP2006509315A JP4887139B2 JP 4887139 B2 JP4887139 B2 JP 4887139B2 JP 2006509315 A JP2006509315 A JP 2006509315A JP 2006509315 A JP2006509315 A JP 2006509315A JP 4887139 B2 JP4887139 B2 JP 4887139B2
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- Prior art keywords
- amino
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- alkyl
- phenyl
- oxo
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- CNYHXCROGLKAFF-UHFFFAOYSA-N CC(C)Nc(nc(N)nc1Cl)c1N Chemical compound CC(C)Nc(nc(N)nc1Cl)c1N CNYHXCROGLKAFF-UHFFFAOYSA-N 0.000 description 1
- GOXIUQBNDATVMB-UHFFFAOYSA-N CC(C)[n]1c(N=C(N(Cc2ccccc2C#N)C2=O)Br)c2nc1C(F)(F)F Chemical compound CC(C)[n]1c(N=C(N(Cc2ccccc2C#N)C2=O)Br)c2nc1C(F)(F)F GOXIUQBNDATVMB-UHFFFAOYSA-N 0.000 description 1
- WAGOURVKFTZAPV-UHFFFAOYSA-N CCC[n](cn1)c(C(N2)=O)c1N=C2Cl Chemical compound CCC[n](cn1)c(C(N2)=O)c1N=C2Cl WAGOURVKFTZAPV-UHFFFAOYSA-N 0.000 description 1
- MEUAHQGXXXZIGQ-UHFFFAOYSA-N COc(cc(c(N=C(N1Cc2ccccc2C#N)Cl)c2)C1=O)c2F Chemical compound COc(cc(c(N=C(N1Cc2ccccc2C#N)Cl)c2)C1=O)c2F MEUAHQGXXXZIGQ-UHFFFAOYSA-N 0.000 description 1
- PHJKYNSEJIZCAD-UHFFFAOYSA-N COc(cc(c(N=C(N1Cc2ccccc2C#N)N(CCC2)CC2N)c2)C1=O)c2OC Chemical compound COc(cc(c(N=C(N1Cc2ccccc2C#N)N(CCC2)CC2N)c2)C1=O)c2OC PHJKYNSEJIZCAD-UHFFFAOYSA-N 0.000 description 1
- RZBPTLOVZCUBRS-UHFFFAOYSA-N COc(cc1C(N2)=O)ccc1N=C2Cl Chemical compound COc(cc1C(N2)=O)ccc1N=C2Cl RZBPTLOVZCUBRS-UHFFFAOYSA-N 0.000 description 1
- KMMSRPSEYSNHKS-UHFFFAOYSA-N C[n](nc1C(N2Cc3ccccc3C#N)=O)nc1N=C2Cl Chemical compound C[n](nc1C(N2Cc3ccccc3C#N)=O)nc1N=C2Cl KMMSRPSEYSNHKS-UHFFFAOYSA-N 0.000 description 1
- YNXUTUJCKRGCDF-UHFFFAOYSA-N Clc1c2nc[n](COCc3ccccc3)c2nc(Cl)n1 Chemical compound Clc1c2nc[n](COCc3ccccc3)c2nc(Cl)n1 YNXUTUJCKRGCDF-UHFFFAOYSA-N 0.000 description 1
- XMOSOHDOZCRMML-UHFFFAOYSA-N NC(CCC1)CN1C(N(Cc(cccc1)c1C#N)C(c1c2)=O)=Nc1ccc2F Chemical compound NC(CCC1)CN1C(N(Cc(cccc1)c1C#N)C(c1c2)=O)=Nc1ccc2F XMOSOHDOZCRMML-UHFFFAOYSA-N 0.000 description 1
- LGQVNFUOFPCSSQ-QGZVFWFLSA-N N[C@H](CCC1)CN1C(N(Cc1ccccc1C#N)C(c1c2)=O)=Nc1ccc2Cl Chemical compound N[C@H](CCC1)CN1C(N(Cc1ccccc1C#N)C(c1c2)=O)=Nc1ccc2Cl LGQVNFUOFPCSSQ-QGZVFWFLSA-N 0.000 description 1
- QVEOGGYGCHHHHK-OAHLLOKOSA-N N[C@H](CCC1)CN1C(N(Cc1ccccc1C(F)(F)F)C(c1c2)=O)=Nc1ccc2F Chemical compound N[C@H](CCC1)CN1C(N(Cc1ccccc1C(F)(F)F)C(c1c2)=O)=Nc1ccc2F QVEOGGYGCHHHHK-OAHLLOKOSA-N 0.000 description 1
- CNGRGEDXKHIFIL-UHFFFAOYSA-N O=C1NC(Cl)=Nc2ccccc12 Chemical compound O=C1NC(Cl)=Nc2ccccc12 CNGRGEDXKHIFIL-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45778503P | 2003-03-25 | 2003-03-25 | |
US60/457,785 | 2003-03-25 | ||
PCT/US2004/009217 WO2004087053A2 (en) | 2003-03-25 | 2004-03-24 | Dipeptidyl peptidase inhibitors |
Publications (2)
Publication Number | Publication Date |
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JP2007524600A JP2007524600A (ja) | 2007-08-30 |
JP4887139B2 true JP4887139B2 (ja) | 2012-02-29 |
Family
ID=33131718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006509315A Expired - Fee Related JP4887139B2 (ja) | 2003-03-25 | 2004-03-24 | ジペプチジルペプチダーゼインヒビター |
Country Status (7)
Families Citing this family (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4887139B2 (ja) | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
EP1911754B1 (en) * | 2003-08-13 | 2013-10-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
RU2006107553A (ru) | 2003-08-13 | 2007-09-20 | Такеда Фармасьютикал Компани Лимитед (Jp) | Производные 4-пиримидона и их применение в качестве ингибиторов пептидилпептидаз |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1699777B1 (en) | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
NZ549716A (en) | 2004-03-15 | 2010-04-30 | Takeda Pharmaceutical | Pyrimidin-dione derivatives as dipeptidyl peptidase inhibitors |
WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
AR051596A1 (es) * | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
JP2008520744A (ja) | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
AU2011201488B2 (en) * | 2004-11-29 | 2011-11-17 | Merck Sharp & Dohme Corp. | Fused aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
WO2006068978A2 (en) * | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
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US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
JP5075125B2 (ja) | 2005-08-26 | 2012-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療又は予防用ジペプチジルペプチダーゼiv阻害剤としての縮合アミノピペリジン |
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BR112012025592A2 (pt) | 2010-04-06 | 2019-09-24 | Arena Pharm Inc | moduladores do receptor de gpr119 e o tratamento de distúrbios relacionados com os mesmos |
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CN102311448B (zh) * | 2010-07-07 | 2014-02-19 | 中国科学院广州生物医药与健康研究院 | 噻吩并嘧啶酮类dpp-iv抑制剂 |
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CA2518465A1 (en) | 2004-10-14 |
EP1608317B1 (en) | 2012-09-26 |
US7550590B2 (en) | 2009-06-23 |
US20040242566A1 (en) | 2004-12-02 |
US20040242568A1 (en) | 2004-12-02 |
EP1608317A2 (en) | 2005-12-28 |
KR20050122220A (ko) | 2005-12-28 |
WO2004087053A3 (en) | 2006-08-31 |
WO2004087053A2 (en) | 2004-10-14 |
EP1608317A4 (en) | 2006-12-27 |
WO2004087053A9 (en) | 2004-11-11 |
CN1894234A (zh) | 2007-01-10 |
US20040259870A1 (en) | 2004-12-23 |
JP2007524600A (ja) | 2007-08-30 |
US20050004117A1 (en) | 2005-01-06 |
US7687625B2 (en) | 2010-03-30 |
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