JP2018513853A - 置換キナゾリン化合物およびその使用方法 - Google Patents

置換キナゾリン化合物およびその使用方法 Download PDF

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JP2018513853A
JP2018513853A JP2017552484A JP2017552484A JP2018513853A JP 2018513853 A JP2018513853 A JP 2018513853A JP 2017552484 A JP2017552484 A JP 2017552484A JP 2017552484 A JP2017552484 A JP 2017552484A JP 2018513853 A JP2018513853 A JP 2018513853A
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alkyl
compound
aminyl
compound according
cycloalkyl
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JP2018513853A5 (OSRAM
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リアンシェン リー，
リアンシェン リー，
フェン，　ジュン
ジュン フェン，
ユン オリバー ロング，
ユン オリバー ロング，
ユアン リウ，
ユアン リウ，
タオ ウー，
タオ ウー，
ピンダ レン，
ピンダ レン，
イー リウ，
イー リウ，
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アラクセス ファーマ エルエルシー
アラクセス ファーマ エルエルシー
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
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JP2017552484A 2015-04-10 2016-04-08 置換キナゾリン化合物およびその使用方法 Withdrawn JP2018513853A (ja)

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US201562145705P 2015-04-10 2015-04-10
US201562145818P 2015-04-10 2015-04-10
US62/145,818 2015-04-10
US62/145,705 2015-04-10
US201562255891P 2015-11-16 2015-11-16
US62/255,891 2015-11-16
US201562265316P 2015-12-09 2015-12-09
US201562265320P 2015-12-09 2015-12-09
US62/265,316 2015-12-09
US62/265,320 2015-12-09
PCT/US2016/026573 WO2016164675A1 (en) 2015-04-10 2016-04-08 Substituted quinazoline compounds and methods of use thereof

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KR (1) KR20180005178A (OSRAM)
CN (1) CN107849022A (OSRAM)
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BR (1) BR112017021869A2 (OSRAM)
CA (1) CA2981530A1 (OSRAM)
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Cited By (11)

* Cited by examiner, † Cited by third party
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JP2020504738A (ja) * 2016-12-22 2020-02-13 アムジエン・インコーポレーテツド 肺がん、膵臓がん、または大腸がんを治療するためのＫＲＡＳ Ｇ１２Ｃ阻害剤としての、ベンズイソチアゾール、イソチアゾロ［３，４−ｂ］ピリジン、キナゾリン、フタラジン、ピリド［２，３−ｄ］ピリダジンおよびピリド［２，３−ｄ］ピリミジン誘導体
JP2021526133A (ja) * 2018-06-11 2021-09-30 アムジエン・インコーポレーテツド がんを処置するためのｋｒａｓ ｇ１２ｃ阻害剤
JP2021532157A (ja) * 2018-08-01 2021-11-25 アラクセス ファーマ エルエルシー がんを処置するための複素環式スピロ化合物およびその使用方法
JP2022505835A (ja) * 2018-10-24 2022-01-14 アラクセス ファーマ エルエルシー 腫瘍転移を阻害するためのｇ１２ｃ変異体ｋｒａｓタンパク質の阻害剤としての２－（２－アクリロイル－２，６－ジアザスピロ［３．４］オクタン－６－イル）－６－（１ｈ－インダゾール－４－イル）－ベンゾニトリル誘導体および関連化合物
JP2022508494A (ja) * 2019-01-16 2022-01-19 シャンハイ インリー ファーマシューティカル カンパニー リミテッド モルホリノキナゾリン化合物の製造方法及びその中間体
JP2022508108A (ja) * 2017-11-15 2022-01-19 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｃ阻害剤
JP2022530383A (ja) * 2019-04-22 2022-06-29 貝達薬業股▲ふん▼有限公司 キナゾリン化合物及びその医薬上の使用
JP2023504178A (ja) * 2019-12-02 2023-02-01 シャンハイ インリー ファーマシューティカル カンパニー リミテッド 酸素含有複素環化合物、その製造方法及び使用
JP2023508482A (ja) * 2019-12-27 2023-03-02 ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド スピロ環含有キナゾリン化合物
JP2023519815A (ja) * 2020-03-25 2023-05-15 ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド スピロ環含有キナゾリン化合物
JP2023549055A (ja) * 2020-10-27 2023-11-22 アムジエン・インコーポレーテツド 複素環式スピロ化合物及びその使用方法

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US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049524A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
EA201792214A1 (ru) 2015-04-10 2018-01-31 Араксис Фарма Ллк Соединения замещенного хиназолина
EP3283462B1 (en) 2015-04-15 2020-12-02 Araxes Pharma LLC Fused-tricyclic inhibitors of kras and methods of use thereof
US10144724B2 (en) * 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356339A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10730867B2 (en) 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤をスクリーニングするための方法
TW201726656A (zh) * 2015-11-16 2017-08-01 亞瑞克西斯製藥公司 包含經取代雜環基團之２－經取代喹唑啉化合物及其使用方法
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
AU2016378723B2 (en) 2015-12-22 2021-09-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
KR102444509B1 (ko) 2016-05-18 2022-09-19 미라티 테라퓨틱스, 인크. Kras g12c 억제제
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
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