|
US3773719A
(en)
|
1966-12-06 |
1973-11-20 |
Hoffmann La Roche |
2-aminoxy-2'-acyl-acetanilide
|
|
SE370449B
(Direct)
|
1970-08-29 |
1974-10-14 |
Philips Nv |
|
|
JPS5334319B2
(Direct)
|
1971-12-28 |
1978-09-20 |
|
|
|
JPS5616428B2
(Direct)
|
1973-04-13 |
1981-04-16 |
|
|
|
JPS6048972B2
(ja)
|
1975-08-08 |
1985-10-30 |
株式会社日立製作所 |
方向比較搬送保護継電装置
|
|
JPS5816170B2
(ja)
|
1977-03-16 |
1983-03-30 |
旭化成株式会社 |
乾式画像形成材料
|
|
US4208479A
(en)
|
1977-07-14 |
1980-06-17 |
Syva Company |
Label modified immunoassays
|
|
JPS5970B2
(ja)
|
1978-02-10 |
1984-01-05 |
エプソン株式会社 |
小型プリンタの紙送り機構
|
|
JPS55134615A
(en)
|
1979-04-05 |
1980-10-20 |
Ishigaki Kiko Kk |
Removing device for cake in filter press
|
|
JPS5912436B2
(ja)
|
1980-08-05 |
1984-03-23 |
ファナック株式会社 |
工業用ロボットの安全機構
|
|
JPS6022444B2
(ja)
|
1980-11-08 |
1985-06-01 |
日立化成工業株式会社 |
集成マイカ材料,集成マイカプリプレグ材料及び集成マイカ製品
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
ATE87659T1
(de)
|
1986-09-02 |
1993-04-15 |
Enzon Lab Inc |
Bindungsmolekuele mit einzelpolypeptidkette.
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US6121424A
(en)
|
1991-11-25 |
2000-09-19 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
|
IL89491A0
(en)
|
1988-11-17 |
1989-09-10 |
Hybritech Inc |
Bifunctional chimeric antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
DE68928946T2
(de)
|
1989-12-11 |
1999-10-21 |
Immunomedics, Inc. |
Verfahren zum aufspüren von diagnostischen oder therapeutischen mitteln durch antikörper
|
|
TW212184B
(Direct)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
|
JPH04228089A
(ja)
|
1990-05-15 |
1992-08-18 |
Kanegafuchi Chem Ind Co Ltd |
高カルシウム血症治療・予防剤
|
|
JPH05184383A
(ja)
|
1990-06-19 |
1993-07-27 |
Dainabotsuto Kk |
二重特異性抗体
|
|
EP0585287B1
(en)
|
1990-07-10 |
1999-10-13 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
JPH05199894A
(ja)
|
1990-08-20 |
1993-08-10 |
Takeda Chem Ind Ltd |
二重特異性抗体および抗体含有薬剤
|
|
DE69127627T2
(de)
|
1990-08-29 |
1998-02-19 |
Genpharm Int |
Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
|
|
AU668349B2
(en)
|
1991-04-25 |
1996-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human interleukin 6 receptor
|
|
JPH04336051A
(ja)
|
1991-05-10 |
1992-11-24 |
Toshiba Corp |
超音波診断装置
|
|
JPH05304992A
(ja)
|
1991-06-20 |
1993-11-19 |
Takeda Chem Ind Ltd |
ハイブリッド・モノクローナル抗体および抗体含有薬剤
|
|
CA2119930C
(en)
|
1991-09-23 |
2002-10-01 |
Hendricus R. J. M. Hoogenboom |
Production of chimeric antibodies - a combinatorial approach
|
|
WO1993011161A1
(en)
|
1991-11-25 |
1993-06-10 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
CA2124967C
(en)
|
1991-12-17 |
2008-04-08 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
JPH05203652A
(ja)
|
1992-01-28 |
1993-08-10 |
Fuji Photo Film Co Ltd |
抗体酵素免疫分析法
|
|
JPH05213775A
(ja)
|
1992-02-05 |
1993-08-24 |
Otsuka Pharmaceut Co Ltd |
Bfa抗体
|
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
|
CA2131151A1
(en)
|
1992-03-24 |
1994-09-30 |
Kevin S. Johnson |
Methods for producing members of specific binding pairs
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US5744446A
(en)
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
|
EP0640094A1
(en)
|
1992-04-24 |
1995-03-01 |
The Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
EP0652950B1
(en)
|
1992-07-24 |
2007-12-19 |
Amgen Fremont Inc. |
Generation of xenogeneic antibodies
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
|
US5648267A
(en)
|
1992-11-13 |
1997-07-15 |
Idec Pharmaceuticals Corporation |
Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
|
|
EP0754225A4
(en)
|
1993-04-26 |
2001-01-31 |
Genpharm Int |
HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
US6214973B1
(en)
|
1993-11-19 |
2001-04-10 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human antibody to human medulloblastoma cells
|
|
CA2177988A1
(en)
|
1993-12-03 |
1995-06-08 |
Kazuo Higuchi |
Expression vector for preparing an anti-body-variable-region library
|
|
JPH09506508A
(ja)
|
1993-12-03 |
1997-06-30 |
メディカル リサーチ カウンシル |
組換え結合タンパク質およびペプチド
|
|
JP3485266B2
(ja)
|
1994-05-20 |
2004-01-13 |
松下電器産業株式会社 |
プロセッサ
|
|
DE122009000068I2
(de)
|
1994-06-03 |
2011-06-16 |
Ascenion Gmbh |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
|
US5622701A
(en)
|
1994-06-14 |
1997-04-22 |
Protein Design Labs, Inc. |
Cross-reacting monoclonal antibodies specific for E- and P-selectin
|
|
HU221385B1
(en)
|
1994-07-13 |
2002-09-28 |
Chugai Pharmaceutical Co Ltd |
Reconstituted human antibody against human interleukin-8
|
|
JP3053873B2
(ja)
|
1994-08-12 |
2000-06-19 |
イムノメディクス,インコーポレイテッド |
B細胞リンパ腫細胞および白血病細胞に特異的な免疫結合体およびヒト化抗体
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
CN101601861A
(zh)
|
1994-10-07 |
2009-12-16 |
中外制药株式会社 |
以il-6拮抗剂作为有效成分治疗慢性类风湿性关节炎
|
|
EP0791359A4
(en)
|
1994-10-21 |
2002-09-11 |
Chugai Pharmaceutical Co Ltd |
MEDICINE AGAINST IL-6 PRODUCTION IN DISEASES
|
|
CA2207869A1
(en)
|
1994-12-02 |
1996-06-06 |
Chiron Corporation |
Method of promoting an immune response with a bispecific antibody
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
DK0812136T3
(da)
|
1995-02-28 |
2001-02-19 |
Procter & Gamble |
Fremgangsmåde til fremstilling af ikke-kulsyreholdige læskedrikke med bedre mikrobiel stabilitet
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
KR100654645B1
(ko)
|
1995-04-27 |
2007-04-04 |
아브게닉스, 인크. |
면역화된 제노마우스 유래의 인간 항체
|
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69633973T2
(de)
|
1995-09-11 |
2005-12-22 |
Kyowa Hakko Kogyo Co., Ltd. |
Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor
|
|
MA24512A1
(fr)
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
|
WO1998003546A1
(en)
|
1996-07-19 |
1998-01-29 |
Amgen Inc. |
Analogs of cationic proteins
|
|
EP0962467A4
(en)
|
1996-09-26 |
2002-10-30 |
Chugai Pharmaceutical Co Ltd |
Antibody against human parathormone related peptides
|
|
JP3587664B2
(ja)
|
1996-10-04 |
2004-11-10 |
中外製薬株式会社 |
再構成ヒト抗hm1.24抗体
|
|
UA76934C2
(en)
|
1996-10-04 |
2006-10-16 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
JPH10165184A
(ja)
|
1996-12-16 |
1998-06-23 |
Tosoh Corp |
抗体、遺伝子及びキメラ抗体の製法
|
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
|
JP4228089B2
(ja)
|
1997-03-11 |
2009-02-25 |
株式会社ニコン |
過電流検知機構およびそれを用いた電子閃光装置
|
|
JPH10256223A
(ja)
|
1997-03-11 |
1998-09-25 |
Super Silicon Kenkyusho:Kk |
ウェーハ面取り部の枚葉処理装置
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US7365166B2
(en)
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
DE19725586C2
(de)
|
1997-06-17 |
1999-06-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper
|
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
|
US6617156B1
(en)
|
1997-08-15 |
2003-09-09 |
Lynn A. Doucette-Stamm |
Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics
|
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
US7361336B1
(en)
|
1997-09-18 |
2008-04-22 |
Ivan Bergstein |
Methods of cancer therapy targeted against a cancer stem line
|
|
KR100473836B1
(ko)
|
1997-10-03 |
2005-03-07 |
츄가이 세이야꾸 가부시키가이샤 |
천연 인간형화 항체
|
|
JPH11118775A
(ja)
|
1997-10-09 |
1999-04-30 |
Canon Inc |
超音波検査装置
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
CA2325346A1
(en)
|
1998-04-03 |
1999-10-14 |
Chugai Seiyaku Kabushiki Kaisha |
Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody
|
|
DK2180007T4
(da)
|
1998-04-20 |
2017-11-27 |
Roche Glycart Ag |
Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
JP3445153B2
(ja)
|
1998-06-04 |
2003-09-08 |
富士通株式会社 |
電話番号一時的使用装置及び方法
|
|
WO2000009560A2
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
WO2000018806A1
(de)
|
1998-09-25 |
2000-04-06 |
Horst Lindhofer |
Bispezifische und trispezifische antikörper, die spezifisch mit induzierbaren oberflächenantigenen als operationelle zielstrukturen reagieren
|
|
CA2346264A1
(en)
|
1998-10-16 |
2000-04-27 |
Regents Of The University Of California |
Glypicans for the detection and treatment of human carcinoma
|
|
KR100483494B1
(ko)
|
1998-12-01 |
2005-04-15 |
프로테인 디자인 랩스 인코포레이티드 |
감마 인터페론에 대한 인간화 항체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
MX353234B
(es)
|
1999-01-15 |
2018-01-08 |
Genentech Inc |
Variantes de polipeptidos con función efectora alterada.
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6972125B2
(en)
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
|
ATE412433T1
(de)
|
1999-02-12 |
2008-11-15 |
Scripps Research Inst |
Methoden zur behandlung von tumoren und metastasen unter verwendung einer anti-angiogenen und immun-therapien
|
|
DK1176195T3
(da)
|
1999-04-09 |
2013-06-24 |
Kyowa Hakko Kirin Co Ltd |
Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
ES2307526T3
(es)
|
1999-08-23 |
2008-12-01 |
Chugai Seiyaku Kabushiki Kaisha |
Potenciadores de la expresion del antigeno hm1.24.
|
|
AT411997B
(de)
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
|
JP3606132B2
(ja)
|
1999-10-14 |
2005-01-05 |
Jfeエンジニアリング株式会社 |
超音波探傷方法およびその装置
|
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
|
PL366025A1
(en)
|
2000-05-03 |
2005-01-24 |
Munich Biotech Ag |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
|
EP1299419A2
(en)
|
2000-05-24 |
2003-04-09 |
Imclone Systems, Inc. |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
GB0017635D0
(en)
|
2000-07-18 |
2000-09-06 |
Pharmacia & Upjohn Spa |
Antitumor combined therapy
|
|
JP2002048867A
(ja)
|
2000-08-07 |
2002-02-15 |
Mitsubishi Heavy Ind Ltd |
音響探査装置
|
|
DE60128817T2
(de)
|
2000-09-12 |
2008-02-07 |
Union Carbide Chemicals & Plastics Technology Corp., Danbury |
Polymerische mischungen enthaltend ethylenoxid-copolymere
|
|
EA013224B1
(ru)
|
2000-10-06 |
2010-04-30 |
Киова Хакко Кирин Ко., Лтд. |
Клетки, продуцирующие композиции антител
|
|
WO2002040545A2
(en)
|
2000-11-17 |
2002-05-23 |
The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services |
Reduction of the nonspecific animal toxicity of immunotoxins by mutating the framework regions of the fv to lower the isoelectric point
|
|
US7361343B2
(en)
|
2003-01-21 |
2008-04-22 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of CD63
|
|
DE60143544D1
(de)
|
2000-12-12 |
2011-01-05 |
Medimmune Llc |
Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung
|
|
AU2002307037B2
(en)
|
2001-04-02 |
2008-08-07 |
Biogen Idec Inc. |
Recombinant antibodies coexpressed with GnTIII
|
|
EP1250023A1
(en)
|
2001-04-11 |
2002-10-16 |
Alcatel |
Provision of subscriber QoS guarantees to roaming subscribers
|
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
|
HUP0402250A3
(en)
|
2001-04-13 |
2007-06-28 |
Biogen Idec Inc |
Antibodies to vla-1
|
|
JP3642316B2
(ja)
|
2001-06-15 |
2005-04-27 |
日本電気株式会社 |
化学増幅レジスト用単量体、化学増幅レジスト用重合体、化学増幅レジスト組成物、パターン形成方法
|
|
US20040236080A1
(en)
|
2001-06-22 |
2004-11-25 |
Hiroyuki Aburatani |
Cell proliferation inhibitors containing anti-glypican 3 antibody
|
|
DE10136273A1
(de)
|
2001-07-25 |
2003-02-13 |
Sabine Debuschewitz |
Molekulare Marker beim hepatozellulären Karzinom
|
|
WO2003011878A2
(en)
|
2001-08-03 |
2003-02-13 |
Glycart Biotechnology Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
|
DE60216305T2
(de)
|
2001-10-03 |
2007-07-05 |
Celator Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur Abgabe von Arzneimittelkombinationen
|
|
US7850990B2
(en)
|
2001-10-03 |
2010-12-14 |
Celator Pharmaceuticals, Inc. |
Compositions for delivery of drug combinations
|
|
CA2463879C
(en)
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
|
JP3961359B2
(ja)
|
2002-07-18 |
2007-08-22 |
株式会社東芝 |
超音波画像化装置
|
|
JP4087098B2
(ja)
|
2001-11-14 |
2008-05-14 |
株式会社東芝 |
超音波検査装置
|
|
KR100559808B1
(ko)
|
2001-11-14 |
2006-03-15 |
가부시끼가이샤 도시바 |
검사 장치 및 초음파 검사 장치
|
|
JP2003157075A
(ja)
|
2001-11-22 |
2003-05-30 |
Kawai Musical Instr Mfg Co Ltd |
電子楽器のパラメータ入力装置
|
|
WO2003057881A1
(en)
|
2001-12-28 |
2003-07-17 |
Chugai Seiyaku Kabushiki Kaisha |
Method of stabilizing protein
|
|
EP1573002A4
(en)
|
2002-02-11 |
2008-07-16 |
Genentech Inc |
ANTIBODY VARIANTS WITH FASTER ANTIGEN ASSOCIATION SPEEDS
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US20040110226A1
(en)
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
JPWO2003085119A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物のFcγ受容体IIIaに対する結合活性を高める方法
|
|
EP1500665B1
(en)
|
2002-04-15 |
2011-06-15 |
Chugai Seiyaku Kabushiki Kaisha |
METHODS FOR CONSTRUCTING scDb LIBRARIES
|
|
AU2003235833A1
(en)
|
2002-04-26 |
2003-11-10 |
Chugai Seiyaku Kabushiki Kaisha |
Method of screening agonistic antibody
|
|
DE60326567D1
(de)
|
2002-05-23 |
2009-04-23 |
Sunnybrook & Womens College |
Diagnose von hepatozellulärem karzinom
|
|
US20060088899A1
(en)
|
2002-05-31 |
2006-04-27 |
Alvarez Vernon L |
Combination chemotherapy with chlorotoxin
|
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
|
US20050130224A1
(en)
|
2002-05-31 |
2005-06-16 |
Celestar Lexico- Sciences, Inc. |
Interaction predicting device
|
|
WO2003104453A1
(ja)
|
2002-06-05 |
2003-12-18 |
中外製薬株式会社 |
抗体作製方法
|
|
AU2003244817B2
(en)
|
2002-06-28 |
2010-08-26 |
Domantis Limited |
Antigen-binding immunoglobulin single variable domains and dual-specific constructs
|
|
ES2442615T5
(es)
|
2002-07-18 |
2023-03-16 |
Merus Nv |
Producción recombinante de mezclas de anticuerpos
|
|
AU2003264009A1
(en)
|
2002-08-15 |
2004-03-03 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
|
JP4406607B2
(ja)
|
2002-08-26 |
2010-02-03 |
オンコセラピー・サイエンス株式会社 |
ペプチド及びこれを含む医薬
|
|
AU2002330482A1
(en)
|
2002-09-04 |
2004-03-29 |
Perseus Proteomics Inc. |
Method of diagnosing cancer by detecting gpc3
|
|
AU2002338020A1
(en)
|
2002-09-04 |
2004-03-29 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody against blood-solubilized n-terminal peptide in gpc3
|
|
WO2004022595A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
MRL/lprマウスを用いた抗体の作製
|
|
ATE541857T1
(de)
|
2002-09-27 |
2012-02-15 |
Xencor Inc |
Optimierte fc-varianten und herstellungsverfahren dafür
|
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
DK1562972T3
(da)
|
2002-10-15 |
2010-12-06 |
Facet Biotech Corp |
Modifikation af FcRn-bindingsaffiniteter eller serumhalveringstider for antistoffer ved mutagenese
|
|
ES2524694T3
(es)
|
2002-10-17 |
2014-12-11 |
Genmab A/S |
Anticuerpos monoclonales humanos contra CD20
|
|
ATE431423T1
(de)
|
2003-01-21 |
2009-05-15 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening der leichten kette eines antikörpers
|
|
EP1608684A2
(en)
|
2003-02-07 |
2005-12-28 |
Protein Design Labs, Inc. |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
AU2004227401A1
(en)
|
2003-04-02 |
2004-10-21 |
Celator Pharmaceuticals, Inc. |
Methods to individualize combination therapy
|
|
GB2400851B
(en)
|
2003-04-25 |
2004-12-15 |
Bioinvent Int Ab |
Identifying binding of a polypeptide to a polypeptide target
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
KR100973564B1
(ko)
|
2003-05-02 |
2010-08-03 |
젠코어 인코포레이티드 |
최적화된 Fc 변이체 및 그의 제조 방법
|
|
US6921978B2
(en)
|
2003-05-08 |
2005-07-26 |
International Business Machines Corporation |
Method to generate porous organic dielectric
|
|
US20050186208A1
(en)
|
2003-05-30 |
2005-08-25 |
Genentech, Inc. |
Treatment with anti-VEGF antibodies
|
|
AU2004256042A1
(en)
|
2003-06-05 |
2005-01-20 |
Genentech, Inc. |
BlyS antagonists and uses thereof
|
|
WO2004111233A1
(ja)
|
2003-06-11 |
2004-12-23 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の製造方法
|
|
JP2005053541A
(ja)
|
2003-08-05 |
2005-03-03 |
Toppan Printing Co Ltd |
紙容器用積層材料及びそれを用いた紙容器
|
|
US20080008710A1
(en)
|
2003-09-04 |
2008-01-10 |
Hiroyuki Aburatani |
Therapeutic Agent And Diagnostic Agent For Cholangiocarcinoma
|
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
EP1693448A4
(en)
|
2003-10-14 |
2008-03-05 |
Chugai Pharmaceutical Co Ltd |
DOUBLE SPECIFIC ANTIBODIES AS REPLACEMENT FOR FUNCTIONAL PROTEIN
|
|
EP2385069A3
(en)
|
2003-11-12 |
2012-05-30 |
Biogen Idec MA Inc. |
Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
|
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
|
IN2009KN02655A
(Direct)
|
2003-12-10 |
2015-10-23 |
Medarex Inc |
|
|
US20050136051A1
(en)
|
2003-12-22 |
2005-06-23 |
Bernard Scallon |
Methods for generating multimeric molecules
|
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
|
PT2177537E
(pt)
|
2004-01-09 |
2011-12-13 |
Pfizer |
Anticorpos contra madcam
|
|
ITBO20040008U1
(it)
|
2004-02-03 |
2004-05-03 |
Tonazzi S R L |
Macchina per il riempimento e la chiusura di tubetti
|
|
EP2053062A1
(en)
|
2004-03-24 |
2009-04-29 |
Xencor, Inc. |
Immunoglobin variants outside the Fc region
|
|
JP4223981B2
(ja)
|
2004-03-24 |
2009-02-12 |
学校法人東海大学 |
ホルムアルデヒド検知材料およびその製造方法
|
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
|
JP4658926B2
(ja)
|
2004-04-28 |
2011-03-23 |
株式会社ペルセウスプロテオミクス |
肝癌治療後の再発予測判定薬
|
|
JP5139800B2
(ja)
|
2004-06-03 |
2013-02-06 |
ノビミューン エスアー |
抗cd3抗体およびその使用方法
|
|
BRPI0511065A
(pt)
|
2004-06-04 |
2007-12-26 |
Pfizer Prod Inc |
método para tratar crescimento de célula anormal
|
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
AU2005259992A1
(en)
|
2004-06-25 |
2006-01-12 |
Medimmune, Llc |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
|
DE102004032634A1
(de)
|
2004-07-06 |
2006-02-16 |
Sms Demag Ag |
Verfahren und Einrichtung zum Messen und Regeln der Planheit und/oder der Bandspannungen eines Edelstahlbandes oder einer Edelstahlfolie beim Kaltwalzen in einem Vielwalzengerüst, insbesondere in einem 20-Walzen-Sendizimir-Walzwerk
|
|
CN102702353A
(zh)
|
2004-07-09 |
2012-10-03 |
中外制药株式会社 |
抗-磷脂酰肌醇蛋白聚糖3抗体
|
|
JP4331227B2
(ja)
|
2004-07-09 |
2009-09-16 |
中外製薬株式会社 |
抗グリピカン3抗体
|
|
DK2471813T3
(en)
|
2004-07-15 |
2015-03-02 |
Xencor Inc |
Optimized Fc variants
|
|
PL2213683T3
(pl)
|
2004-08-04 |
2013-10-31 |
Mentrik Biotech Llc |
WARIANTY REGIONÓW Fc
|
|
EP1778726A4
(en)
|
2004-08-16 |
2009-03-18 |
Medimmune Inc |
INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY
|
|
WO2006022407A1
(ja)
|
2004-08-24 |
2006-03-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗グリピカン3抗体を用いたアジュバント療法
|
|
US20060204493A1
(en)
|
2004-09-02 |
2006-09-14 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
US7572456B2
(en)
|
2004-09-13 |
2009-08-11 |
Macrogenics, Inc. |
Humanized antibodies against West Nile Virus and therapeutic and prophylactic uses thereof
|
|
US20060074225A1
(en)
|
2004-09-14 |
2006-04-06 |
Xencor, Inc. |
Monomeric immunoglobulin Fc domains
|
|
CA2580319A1
(en)
|
2004-09-14 |
2006-03-23 |
National Institute For Biological Standards And Control |
Vaccine
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
UA93488C2
(uk)
|
2004-10-26 |
2011-02-25 |
Чугаі Сейяку Кабусікі Кайся |
Композиція анти-гліпікан 3-антитіл, що мають модифікований цукровий ланцюг
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
AR051800A1
(es)
|
2004-12-15 |
2007-02-07 |
Wyeth Corp |
Anticuerpos a beta usados en mejorar la cognicion
|
|
US20090061485A1
(en)
|
2004-12-22 |
2009-03-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
|
|
KR20070100346A
(ko)
|
2005-01-05 |
2007-10-10 |
바이오겐 아이덱 엠에이 인코포레이티드 |
크립토 결합 분자
|
|
WO2006076594A2
(en)
|
2005-01-12 |
2006-07-20 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
|
US20060263357A1
(en)
|
2005-05-05 |
2006-11-23 |
Tedder Thomas F |
Anti-CD19 antibody therapy for autoimmune disease
|
|
WO2006096653A2
(en)
|
2005-03-04 |
2006-09-14 |
Biogen Idec Ma Inc. |
Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues
|
|
CA2602663A1
(en)
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
TWI671403B
(zh)
|
2005-03-31 |
2019-09-11 |
中外製藥股份有限公司 |
控制組裝之多肽的製造方法
|
|
EP1870458B1
(en)
|
2005-03-31 |
2018-05-09 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2 STRUCTURAL ISOMERS
|
|
TW200714313A
(en)
|
2005-04-08 |
2007-04-16 |
Chugai Pharmaceutical Co Ltd |
Antibodies that substitute for coagulation factor VIII
|
|
CA2610987C
(en)
|
2005-06-10 |
2013-09-10 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
WO2006132352A1
(ja)
|
2005-06-10 |
2006-12-14 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2を含有する医薬組成物
|
|
EP1900814A4
(en)
|
2005-06-10 |
2010-07-21 |
Chugai Pharmaceutical Co Ltd |
SCREED SC (FV) 2-MUTANTE
|
|
WO2007005612A2
(en)
|
2005-07-01 |
2007-01-11 |
Medimmune, Inc. |
An integrated approach for generating multidomain protein therapeutics
|
|
JP5072595B2
(ja)
|
2005-08-05 |
2012-11-14 |
中外製薬株式会社 |
マルチキナーゼ阻害剤
|
|
WO2007024535A2
(en)
|
2005-08-19 |
2007-03-01 |
Wyeth |
Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders
|
|
WO2007030531A2
(en)
|
2005-09-06 |
2007-03-15 |
Molecular Image Inc. |
Reagents for testing and molecular imaging of liver cancer
|
|
JP2007093274A
(ja)
|
2005-09-27 |
2007-04-12 |
Perseus Proteomics Inc |
癌の診断方法および治療薬
|
|
US20070087005A1
(en)
|
2005-10-14 |
2007-04-19 |
Lazar Gregory A |
Anti-glypican-3 antibody
|
|
CA2627873A1
(en)
|
2005-10-31 |
2007-05-10 |
Scott Wilhelm |
Treatment of cancer with sorafenib
|
|
US20070185069A1
(en)
|
2005-11-14 |
2007-08-09 |
Plum Stacy M |
Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
KR20080090406A
(ko)
|
2005-11-28 |
2008-10-08 |
젠맵 에이/에스 |
재조합 1가 항체 및 그의 제조 방법
|
|
US7723043B2
(en)
|
2006-01-04 |
2010-05-25 |
Picobella, Lp |
Methods for screening for prostate cancer
|
|
TW200800181A
(en)
|
2006-02-09 |
2008-01-01 |
Sankyo Co |
Pharmaceutical composition for anticancer
|
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
|
TW200745163A
(en)
|
2006-02-17 |
2007-12-16 |
Syntonix Pharmaceuticals Inc |
Peptides that block the binding of IgG to FcRn
|
|
WO2007099988A1
(ja)
|
2006-02-28 |
2007-09-07 |
Kyowa Hakko Kogyo Co., Ltd. |
α-1,6-フコシルトランスフェラーゼ変異体とその用途
|
|
JP2007256063A
(ja)
|
2006-03-23 |
2007-10-04 |
Seiko Epson Corp |
表示装置、および、電子機器
|
|
PT1999154E
(pt)
|
2006-03-24 |
2013-01-24 |
Merck Patent Gmbh |
Domínios proteicos heterodiméricos modificados
|
|
DK2009101T3
(en)
|
2006-03-31 |
2018-01-15 |
Chugai Pharmaceutical Co Ltd |
Antibody modification method for purification of a bispecific antibody
|
|
DK3056568T3
(da)
|
2006-03-31 |
2021-11-01 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik
|
|
WO2007137170A2
(en)
|
2006-05-20 |
2007-11-29 |
Seattle Genetics, Inc. |
Anti-glypican-3 antibody drug conjugates
|
|
US20090258001A1
(en)
|
2006-06-06 |
2009-10-15 |
Paul Ponath |
Administration of anti-CD3 antibodies in the treatment of autoimmune diseases
|
|
RU2511406C2
(ru)
|
2006-06-08 |
2014-04-10 |
Чугаи Сейяку Кабусики Кайся |
Профилактическое или лекарственное средство для воспалительного заболевания
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
GB2440721A
(en)
|
2006-08-11 |
2008-02-13 |
Univ Cambridge Tech |
Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier
|
|
JP4463793B2
(ja)
|
2006-10-10 |
2010-05-19 |
浜松ホトニクス株式会社 |
光検出装置
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
EP2107115A1
(en)
|
2007-01-24 |
2009-10-07 |
Kyowa Hakko Kirin Co., Ltd. |
Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
|
|
US8114967B2
(en)
*
|
2007-03-27 |
2012-02-14 |
Sea Lane Biotechnologies Llc |
Constructs and libraries comprising antibody surrogate light chain sequences
|
|
CA2681974C
(en)
|
2007-03-29 |
2019-12-31 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
WO2009011941A2
(en)
|
2007-04-04 |
2009-01-22 |
The Government Of U.S.A., As Represented By The Secretary, Departmetnt Of Health & Human Services |
Monoclonal antibodies against dengue and other viruses with deletion in fc region
|
|
EP2666787B1
(en)
|
2007-05-31 |
2022-02-09 |
Genmab A/S |
STABLE IgG4 ANTIBODIES
|
|
AU2008270710A1
(en)
|
2007-06-29 |
2009-01-08 |
Merck Sharp & Dohme Corp. |
MDL-1 uses
|
|
AU2008275985B2
(en)
|
2007-07-17 |
2013-09-19 |
E. R. Squibb & Sons, L.L.C. |
Monoclonal antibodies against Glypican-3
|
|
KR102467302B1
(ko)
|
2007-09-26 |
2022-11-14 |
추가이 세이야쿠 가부시키가이샤 |
항체 정상영역 개변체
|
|
MX2010003329A
(es)
|
2007-09-26 |
2010-04-27 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-receptor de il-6.
|
|
EP3689912A1
(en)
|
2007-09-26 |
2020-08-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substitution in cdr
|
|
EP2584043A3
(en)
|
2007-09-28 |
2013-10-02 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-glypican 3 antibody having improved kinetics in plasma
|
|
AU2008314697B2
(en)
|
2007-10-22 |
2013-08-29 |
Merck Serono S.A. |
Single IFN-beta fused to a mutated lgG Fc fragment
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
JP5619603B2
(ja)
|
2008-03-17 |
2014-11-05 |
国立大学法人宮崎大学 |
抗グリピカン3抗体を用いる肝癌細胞の検出法
|
|
AU2009228158B2
(en)
|
2008-03-27 |
2014-02-27 |
Zymogenetics, Inc. |
Compositions and methods for inhibiting PDGFRbeta and VEGF-A
|
|
CL2009000647A1
(es)
|
2008-04-04 |
2010-06-04 |
Chugai Pharmaceutical Co Ltd |
Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
CN101377506A
(zh)
|
2008-04-16 |
2009-03-04 |
北京科美东雅生物技术有限公司 |
磷脂酰肌醇蛋白聚糖-3化学发光免疫分析测定试剂盒及其制备方法
|
|
AU2009241589B2
(en)
|
2008-04-29 |
2013-10-10 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
US9109026B2
(en)
|
2008-06-03 |
2015-08-18 |
Abbvie, Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
DE102008042377A1
(de)
|
2008-09-25 |
2010-04-01 |
Robert Bosch Gmbh |
Audioverstärker mit Lastanpassung sowie Verfahren zur Lastanpassung des Audioverstärkers
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
CN102164960A
(zh)
|
2008-09-26 |
2011-08-24 |
罗氏格黎卡特股份公司 |
双特异性抗-egfr/抗-igf-1r抗体
|
|
US20110217302A1
(en)
*
|
2008-10-10 |
2011-09-08 |
Emergent Product Development Seattle, Llc |
TCR Complex Immunotherapeutics
|
|
DE202008016028U1
(de)
|
2008-12-04 |
2010-04-15 |
Melitta Haushaltsprodukte Gmbh & Co. Kg |
Behälter zur Aufbewahrung von Gegenständen
|
|
EP2389192A4
(en)
|
2009-01-23 |
2013-01-16 |
Biogen Idec Inc |
STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE
|
|
RU2011140335A
(ru)
|
2009-03-05 |
2013-04-10 |
Эбботт Лэборетриз |
Связывающие il-17 белки
|
|
US9228017B2
(en)
|
2009-03-19 |
2016-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
EP3674317B1
(en)
|
2009-03-19 |
2024-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
SG174992A1
(en)
|
2009-04-01 |
2011-11-28 |
Genentech Inc |
Anti-fcrh5 antibodies and immunoconjugates and methods of use
|
|
EP2417156B1
(en)
|
2009-04-07 |
2015-02-11 |
Roche Glycart AG |
Trivalent, bispecific antibodies
|
|
AU2010245011B2
(en)
|
2009-04-27 |
2015-09-03 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
EP2975051B1
(en)
|
2009-06-26 |
2021-04-14 |
Regeneron Pharmaceuticals, Inc. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
AU2010286518C1
(en)
|
2009-08-29 |
2015-08-27 |
Abbvie Inc. |
Therapeutic DLL4 binding proteins
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
US10053513B2
(en)
|
2009-11-30 |
2018-08-21 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
JP2011118775A
(ja)
|
2009-12-04 |
2011-06-16 |
Sony Corp |
検索装置、検索方法、及び、プログラム
|
|
BR112012017124C1
(pt)
|
2009-12-25 |
2021-08-31 |
Chugai Pharmaceutical Co Ltd |
Método para produzir e para purificar um multímero polipeptídico
|
|
US20120021409A1
(en)
*
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
EP2543727B1
(en)
|
2010-03-02 |
2016-08-31 |
Kyowa Hakko Kirin Co., Ltd. |
Modified antibody composition
|
|
AU2011225716A1
(en)
|
2010-03-11 |
2012-09-27 |
Pfizer Inc. |
Antibodies with pH dependent antigen binding
|
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
LT2560993T
(lt)
|
2010-04-20 |
2024-10-10 |
Genmab A/S |
Baltymai, kurių sudėtyje yra heterodimerinio antikūno fc, ir jų gamybos būdai
|
|
BR112012027001A2
(pt)
|
2010-04-23 |
2016-07-19 |
Genentech Inc |
produção de proteínas heteromultiméricas
|
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
|
JP6320753B2
(ja)
|
2010-05-27 |
2018-05-09 |
ゲンマブ エー/エス |
Her2に対するモノクローナル抗体
|
|
EP2603526A1
(en)
|
2010-08-13 |
2013-06-19 |
Medimmune Limited |
Monomeric polypeptides comprising variant fc regions and methods of use
|
|
CN103261220B
(zh)
|
2010-08-16 |
2016-06-15 |
诺夫免疫股份有限公司 |
用于生成多特异性和多价抗体的方法
|
|
MX352929B
(es)
|
2010-11-05 |
2017-12-13 |
Zymeworks Inc |
DISEÑO DE ANTICUERPOS HETERODIMÉRICOS ESTABLES CON MUTACIONES EN EL DOMINIO Fc.
|
|
FI3434767T3
(fi)
|
2010-11-30 |
2026-02-12 |
Chugai Seiyaku Kk |
Sytotoksisuutta aiheuttava terapeuttinen aine
|
|
WO2012093704A1
(ja)
|
2011-01-07 |
2012-07-12 |
中外製薬株式会社 |
抗体の物性を改善させる方法
|
|
SG192945A1
(en)
|
2011-02-25 |
2013-09-30 |
Chugai Pharmaceutical Co Ltd |
Fcgriib-specific fc antibody
|
|
ES2666550T3
(es)
|
2011-04-19 |
2018-05-07 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anticuerpos monoclonales humanos específicos para glipicano 3 y uso de los mismos
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
PT2771364T
(pt)
|
2011-10-27 |
2019-09-10 |
Genmab As |
Produção de proteínas heterodiméricas
|
|
JP6371059B2
(ja)
|
2011-10-31 |
2018-08-08 |
中外製薬株式会社 |
重鎖と軽鎖の会合が制御された抗原結合分子
|
|
HUE056462T2
(hu)
|
2011-11-04 |
2022-02-28 |
Zymeworks Inc |
Stabil heterodimer antestest tervezés mutációkkal az FC domainben
|
|
EP2813568B1
(en)
|
2012-02-09 |
2025-04-23 |
Chugai Seiyaku Kabushiki Kaisha |
Modified fc region of antibody
|
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
|
CA2860369A1
(en)
|
2012-03-02 |
2013-09-06 |
Roche Glycart Ag |
Predicitive biomarker for cancer treatment with adcc enhanced antibodies
|
|
CN104487587A
(zh)
*
|
2012-04-20 |
2015-04-01 |
新兴产品开发西雅图有限公司 |
Cd3结合多肽
|
|
ES2740749T3
(es)
|
2012-04-20 |
2020-02-06 |
Merus Nv |
Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
|
|
EP2847230B1
(en)
|
2012-05-10 |
2020-08-12 |
Zymeworks Inc. |
Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain
|
|
WO2013181543A1
(en)
*
|
2012-06-01 |
2013-12-05 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
High-affinity monoclonal antibodies to glypican-3 and use thereof
|
|
CA2878587A1
(en)
|
2012-07-23 |
2014-01-30 |
Zymeworks Inc. |
Immunoglobulin constructs comprising selective pairing of the light and heavy chains
|
|
WO2014028354A1
(en)
|
2012-08-13 |
2014-02-20 |
Regeneron Pharmaceuticals, Inc. |
Anti-pcsk9 antibodies with ph-dependent binding characteristics
|
|
US10358492B2
(en)
*
|
2012-09-27 |
2019-07-23 |
Merus N.V. |
Bispecific IgG antibodies as T cell engagers
|
|
JP6273205B2
(ja)
|
2012-10-05 |
2018-01-31 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
|
EP2914634B1
(en)
|
2012-11-02 |
2017-12-06 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
|
CN103833852A
(zh)
*
|
2012-11-23 |
2014-06-04 |
上海市肿瘤研究所 |
针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体
|
|
TWI693073B
(zh)
|
2012-12-21 |
2020-05-11 |
日商中外製藥股份有限公司 |
對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑
|
|
EP3050896B1
(en)
|
2013-09-27 |
2021-07-07 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
|
BR112016006502A2
(pt)
|
2013-09-30 |
2017-09-19 |
Chugai Pharmaceutical Co Ltd |
Método para a produção de molécula de ligação de antígeno usando-se fago auxiliar modificado
|
|
TWI726842B
(zh)
|
2014-04-07 |
2021-05-11 |
日商中外製藥股份有限公司 |
免疫活化抗原結合分子
|
|
KR102409014B1
(ko)
|
2014-05-08 |
2022-06-14 |
추가이 세이야쿠 가부시키가이샤 |
Gpc3 표적 치료제 요법이 유효한 환자에게 투여되는 gpc3 표적 치료제
|
|
SG11201609370QA
(en)
|
2014-05-13 |
2016-12-29 |
Chugai Pharmaceutical Co Ltd |
T cell-redirected antigen-binding molecule for cells having immunosuppression function
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
EP4600372A3
(en)
|
2014-12-19 |
2025-11-19 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
|
|
BR112017011235A2
(pt)
|
2014-12-19 |
2018-02-06 |
Chugai Pharmaceutical Co Ltd |
anticorpos anti-c5 e métodos de uso
|
|
CN114773469B
(zh)
|
2015-02-05 |
2025-12-19 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
|
|
EP3279216A4
(en)
|
2015-04-01 |
2019-06-19 |
Chugai Seiyaku Kabushiki Kaisha |
PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER
|
|
BR112018068363A2
(pt)
*
|
2016-03-14 |
2019-01-15 |
Chugai Seiyaku Kabushiki Kaisha |
fármaco terapêutico indutor de dano celular para uso em terapia de câncer
|
|
CN117205314A
(zh)
|
2016-03-14 |
2023-12-12 |
中外制药株式会社 |
用于癌症治疗的诱导细胞损伤的治疗药物
|