AR121692A1 - Moléculas de unión a antígeno multiespecíficas activadoras de la inmunidad y usos de estas - Google Patents
Moléculas de unión a antígeno multiespecíficas activadoras de la inmunidad y usos de estasInfo
- Publication number
- AR121692A1 AR121692A1 ARP210100788A ARP210100788A AR121692A1 AR 121692 A1 AR121692 A1 AR 121692A1 AR P210100788 A ARP210100788 A AR P210100788A AR P210100788 A ARP210100788 A AR P210100788A AR 121692 A1 AR121692 A1 AR 121692A1
- Authority
- AR
- Argentina
- Prior art keywords
- binding
- antigen
- molecule
- multispecific antigen
- gpc3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Una molécula de unión a antígeno que comprende una primera porción de unión a antígeno que es capaz de unirse a CD3 y CD137 (4-1BB), pero no se une a CD3 y CD137 al mismo tiempo (es decir, se une doblemente a CD3 y CD137 pero no simultáneamente); y se proporciona una segunda porción de unión a antígeno capaz de unirse a una molécula expresada específicamente en un tejido canceroso, específicamente Glypican-3 (GPC3). Debido a la unión dual a CD3 y CD137 pero no simultáneamente y con cinética de unión ajustada, y la unión a GPC3, la molécula multiespecífica de unión al antígeno expresa una fuerte actividad citotóxica para las células cancerosas con efectos adversos reducidos. Además, mediante la adaptación de tecnologías de ingeniería de anticuerpos y un diseño de formato molecular (incluidas mutaciones cargadas en la región marco y/o región constante, intercambio VH / VL y selección de la región Fc), la molécula multiespecífica de unión al antígeno con estabilidad, capacidad de fabricación / capacidad de producción favorables y se proporciona homogeneidad estructural.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020062357 | 2020-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR121692A1 true AR121692A1 (es) | 2022-06-29 |
Family
ID=77928944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210100788A AR121692A1 (es) | 2020-03-31 | 2021-03-30 | Moléculas de unión a antígeno multiespecíficas activadoras de la inmunidad y usos de estas |
Country Status (9)
Country | Link |
---|---|
US (1) | US20230147840A1 (es) |
EP (1) | EP4126958A4 (es) |
JP (1) | JP2021175391A (es) |
KR (1) | KR20220161156A (es) |
CN (1) | CN115315447A (es) |
AR (1) | AR121692A1 (es) |
SG (1) | SG11202105566TA (es) |
TW (1) | TW202204410A (es) |
WO (1) | WO2021200896A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI652279B (zh) | 2013-11-11 | 2019-03-01 | 中外製藥股份有限公司 | 含改變的抗體可變區之抗原結合分子 |
US11952422B2 (en) | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
CN115960242B (zh) * | 2021-09-09 | 2023-10-17 | 广东东阳光药业股份有限公司 | 抗癌结合分子及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2647707B1 (en) | 2010-11-30 | 2018-09-12 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
TWI726842B (zh) | 2014-04-07 | 2021-05-11 | 日商中外製藥股份有限公司 | 免疫活化抗原結合分子 |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
US11952422B2 (en) * | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
SG11202101912UA (en) * | 2018-09-28 | 2021-04-29 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecules capable of binding cd3 and cd137 but not simultaneously |
KR20210068061A (ko) * | 2018-09-28 | 2021-06-08 | 추가이 세이야쿠 가부시키가이샤 | 개변된 항체 가변 영역을 포함하는 항원 결합 분자 |
-
2021
- 2021-03-30 EP EP21780692.6A patent/EP4126958A4/en active Pending
- 2021-03-30 KR KR1020217031417A patent/KR20220161156A/ko unknown
- 2021-03-30 AR ARP210100788A patent/AR121692A1/es unknown
- 2021-03-30 JP JP2021056390A patent/JP2021175391A/ja active Pending
- 2021-03-30 US US17/914,855 patent/US20230147840A1/en active Pending
- 2021-03-30 CN CN202180020903.4A patent/CN115315447A/zh active Pending
- 2021-03-30 SG SG11202105566TA patent/SG11202105566TA/en unknown
- 2021-03-30 TW TW110111557A patent/TW202204410A/zh unknown
- 2021-03-30 WO PCT/JP2021/013456 patent/WO2021200896A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220161156A (ko) | 2022-12-06 |
SG11202105566TA (en) | 2021-11-29 |
EP4126958A4 (en) | 2024-07-24 |
TW202204410A (zh) | 2022-02-01 |
US20230147840A1 (en) | 2023-05-11 |
WO2021200896A1 (en) | 2021-10-07 |
JP2021175391A (ja) | 2021-11-04 |
CN115315447A (zh) | 2022-11-08 |
EP4126958A1 (en) | 2023-02-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR121692A1 (es) | Moléculas de unión a antígeno multiespecíficas activadoras de la inmunidad y usos de estas | |
Singh et al. | Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells | |
Mulder et al. | Visualizing ribosome biogenesis: parallel assembly pathways for the 30 S subunit | |
Qin et al. | ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation | |
Muda et al. | Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono-and bispecific antibodies | |
CO2021005528A2 (es) | Moléculas de unión a antígeno capaces de unirse al cúmulo de diferenciación 3 (cd3) y al cúmulo de diferenciación 137 (cd137) pero no simultáneamente | |
AR069776A1 (es) | Anticuerpos bivalentes biespecificos | |
Chess et al. | Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells | |
Heads et al. | Relative stabilities of IgG1 and IgG4 Fab domains: Influence of the light–heavy interchain disulfide bond architecture | |
Kida et al. | Cell surface-fluorescence immunosorbent assay for real-time detection of hybridomas with efficient antibody secretion at the single-cell level | |
Zavoiura et al. | Nanobody–siRNA conjugates for targeted delivery of siRNA to cancer cells | |
BR112022021426A2 (pt) | Anticorpo biespecífico anti-cd73/anti-pd-1, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para preparar o anticorpo biespecífico anti-cd73/anti-pd-1, conjugado, kit, usos do anticorpo biespecífico anti-cd73/anti-pd-1, composição farmacêutica, método in vitro, linhagem celular de hibridoma e anticorpo monoclonal anti-cd73 | |
Do et al. | Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras | |
Dippong et al. | Hapten-specific single-cell selection of hybridoma clones by fluorescence-activated cell sorting for the generation of monoclonal antibodies | |
Belaadi et al. | SUN2 regulates mitotic duration in response to extracellular matrix rigidity | |
Shi et al. | Bioanalysis in the age of new drug modalities | |
Ito et al. | Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics | |
Lakomek et al. | HIV-1 envelope protein gp41: an NMR study of dodecyl phosphocholine embedded gp41 reveals a dynamic prefusion intermediate conformation | |
Yang et al. | Constructing GFP-based reporter to study back splicing and translation of circular RNA | |
Copur et al. | Novel strategies in nephrology: what to expect from the future? | |
Ding et al. | Discovery of novel d-(+)-biotin-conjugated resorcinol dibenzyl ether-based PD-L1 inhibitors for targeted cancer immunotherapy | |
Etersque et al. | Regulation of eDHFR-tagged proteins with trimethoprim PROTACs | |
Wu et al. | Molecular Snuggle and Stretch of a Tetraammonium Chain in the Construction of a Hetero-[4] pseudorotaxane with CyclopentanoQ [6] and Classical Q [7] | |
Hou et al. | Iron-catalyzed fluoroalkylative alkylsulfonylation of alkenes via radical-anion relay | |
Takahashi et al. | Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |