JP2010523555A5 - - Google Patents
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- JP2010523555A5 JP2010523555A5 JP2010501662A JP2010501662A JP2010523555A5 JP 2010523555 A5 JP2010523555 A5 JP 2010523555A5 JP 2010501662 A JP2010501662 A JP 2010501662A JP 2010501662 A JP2010501662 A JP 2010501662A JP 2010523555 A5 JP2010523555 A5 JP 2010523555A5
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- 239000000203 mixture Substances 0.000 claims 51
- 239000007787 solid Substances 0.000 claims 15
- 239000013543 active substance Substances 0.000 claims 13
- 239000007788 liquid Substances 0.000 claims 11
- 238000001816 cooling Methods 0.000 claims 8
- 238000013270 controlled release Methods 0.000 claims 7
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 210000001072 colon Anatomy 0.000 claims 6
- 239000010410 layer Substances 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 6
- 238000001125 extrusion Methods 0.000 claims 5
- 239000003018 immunosuppressive agent Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 210000003405 ileum Anatomy 0.000 claims 3
- 229960003444 immunosuppressant agent Drugs 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229930105110 Cyclosporin A Natural products 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 229940122439 Hydroxylase inhibitor Drugs 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000007903 gelatin capsule Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000003349 gelling agent Substances 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 229940125721 immunosuppressive agent Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 229960001967 tacrolimus Drugs 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 108010014632 NF-kappa B kinase Proteins 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 239000000227 bioadhesive Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- BNJOZDZCRHCODO-UHFFFAOYSA-N dimethyloxalylglycine Chemical compound COC(=O)CNC(=O)C(=O)OC BNJOZDZCRHCODO-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 238000001879 gelation Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000004347 intestinal mucosa Anatomy 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90749007P | 2007-04-04 | 2007-04-04 | |
| US649808P | 2008-01-16 | 2008-01-16 | |
| PCT/IE2008/000040 WO2008122967A2 (en) | 2007-04-04 | 2008-04-04 | An oral pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014149027A Division JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523555A JP2010523555A (ja) | 2010-07-15 |
| JP2010523555A5 true JP2010523555A5 (enExample) | 2012-06-07 |
Family
ID=39745242
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501662A Pending JP2010523555A (ja) | 2007-04-04 | 2008-04-04 | 「経口医薬組成物」 |
| JP2010501660A Expired - Fee Related JP5553747B2 (ja) | 2007-04-04 | 2008-04-04 | シクロスポリン医薬組成物 |
| JP2010501661A Withdrawn JP2010523554A (ja) | 2007-04-04 | 2008-04-04 | タクロリムスの医薬組成物 |
| JP2014149027A Expired - Fee Related JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
| JP2015221221A Active JP6149090B2 (ja) | 2007-04-04 | 2015-11-11 | 「経口医薬組成物」 |
| JP2017091572A Pending JP2017160241A (ja) | 2007-04-04 | 2017-05-02 | 「経口医薬組成物」 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501660A Expired - Fee Related JP5553747B2 (ja) | 2007-04-04 | 2008-04-04 | シクロスポリン医薬組成物 |
| JP2010501661A Withdrawn JP2010523554A (ja) | 2007-04-04 | 2008-04-04 | タクロリムスの医薬組成物 |
| JP2014149027A Expired - Fee Related JP6059688B2 (ja) | 2007-04-04 | 2014-07-22 | 「経口医薬組成物」 |
| JP2015221221A Active JP6149090B2 (ja) | 2007-04-04 | 2015-11-11 | 「経口医薬組成物」 |
| JP2017091572A Pending JP2017160241A (ja) | 2007-04-04 | 2017-05-02 | 「経口医薬組成物」 |
Country Status (11)
| Country | Link |
|---|---|
| US (11) | US8911777B2 (enExample) |
| EP (5) | EP2380564B1 (enExample) |
| JP (6) | JP2010523555A (enExample) |
| CN (6) | CN101677964A (enExample) |
| CA (3) | CA2683409A1 (enExample) |
| CY (1) | CY1113882T1 (enExample) |
| DK (1) | DK2079456T3 (enExample) |
| ES (3) | ES2524345T3 (enExample) |
| HR (1) | HRP20130173T1 (enExample) |
| PT (1) | PT2079456E (enExample) |
| WO (3) | WO2008122966A2 (enExample) |
Families Citing this family (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2922402B2 (ja) | 1993-10-14 | 1999-07-26 | 住友重機械工業株式会社 | 熱成形方法及びその熱成形装置 |
| EP2380564B1 (en) | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| JP2010527285A (ja) | 2007-04-26 | 2010-08-12 | シグモイド・ファーマ・リミテッド | 複数のミニカプセルの製造 |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| AU2009225434B2 (en) | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| RS56049B1 (sr) * | 2008-11-13 | 2017-09-29 | Nogra Pharma Ltd | Antisens kompozicije i postupci za pripremu i upotrebu istih |
| CN105213318A (zh) | 2009-05-18 | 2016-01-06 | 希格默伊德药业有限公司 | 包含油滴的组合物 |
| CN102573802A (zh) * | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| US20170079962A1 (en) | 2009-11-11 | 2017-03-23 | Rapamycin Holdings, Llc | Oral Rapamycin Preparation and Use for Stomatitus |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| KR101245078B1 (ko) * | 2010-11-11 | 2013-03-18 | 부산대학교 산학협력단 | 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물 |
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- 2008-04-04 CN CN200880016191A patent/CN101677964A/zh active Pending
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- 2008-04-04 EP EP08719897A patent/EP2061440A2/en not_active Withdrawn
- 2008-04-04 WO PCT/IE2008/000039 patent/WO2008122966A2/en not_active Ceased
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