AU3343093A - Pellets containing peptide drugs, their manufacture and use - Google Patents

Pellets containing peptide drugs, their manufacture and use

Info

Publication number
AU3343093A
AU3343093A AU33430/93A AU3343093A AU3343093A AU 3343093 A AU3343093 A AU 3343093A AU 33430/93 A AU33430/93 A AU 33430/93A AU 3343093 A AU3343093 A AU 3343093A AU 3343093 A AU3343093 A AU 3343093A
Authority
AU
Australia
Prior art keywords
containing peptide
pellets containing
manufacture
peptide drugs
pellets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU33430/93A
Inventor
Jurgen Freidenreich
Ursula Schick
Jurgen Werry
Jens-Christian Wunderlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Alfatec Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4201179A external-priority patent/DE4201179A1/en
Application filed by Alfatec Pharma GmbH filed Critical Alfatec Pharma GmbH
Publication of AU3343093A publication Critical patent/AU3343093A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Abstract

Described are pellets containing peptide drugs incorporated in a matrix consisting of gelatin or fractionated gelatin and plasticizers, the pellets having a semi-solid to gel-like consistency. Such drug forms exhibit, after application, bioadhesive properties and, by virtue of the matrix materials specified, allow or enhance the resorption of the peptide drug by the body.
AU33430/93A 1992-01-17 1993-01-18 Pellets containing peptide drugs, their manufacture and use Abandoned AU3343093A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4201179A DE4201179A1 (en) 1992-01-17 1992-01-17 Granulates or pellets comprising dispersion of active agent in hydrophilic macromolecules - are e.g. for treatment of depression, hypertension, rheumatism, etc.
DE4201179 1992-01-17
US87686592A 1992-04-30 1992-04-30
US876865 1992-04-30

Publications (1)

Publication Number Publication Date
AU3343093A true AU3343093A (en) 1993-08-03

Family

ID=25911046

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33430/93A Abandoned AU3343093A (en) 1992-01-17 1993-01-18 Pellets containing peptide drugs, their manufacture and use

Country Status (8)

Country Link
EP (1) EP0621775B1 (en)
AT (1) ATE156350T1 (en)
AU (1) AU3343093A (en)
DE (1) DE59307073D1 (en)
DK (1) DK0621775T3 (en)
ES (1) ES2108258T3 (en)
GR (1) GR3024529T3 (en)
WO (1) WO1993013753A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2128244C (en) 1992-01-17 1998-09-22 Jens-Christian Wunderlich Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
WO1995018602A1 (en) * 1994-01-11 1995-07-13 Alkermes Controlled Therapeutics, Inc. ORAL DOSAGE FORM OF DESMOPRESSIN (dDAVP)
CA2164262A1 (en) * 1995-12-01 1997-06-02 Charles J. Doillon Biostable porous material comprising composite biopolymers
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
KR20000010591A (en) * 1996-04-22 2000-02-15 피터 알. 로쓰쉴드 Stabilized tablet of anti-hepatitis type b
IT1293087B1 (en) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital MICROPARTICLES BASED ON HYBRID POLYMER MATERIALS FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE MOLECULES, PROCEDURE FOR THE
WO1999024019A1 (en) * 1997-11-06 1999-05-20 Orbon Corporation Stabilized, dry pharmaceutical compositions for drug delivery and methods of preparing same
DE19821951A1 (en) * 1998-05-15 1999-11-18 Basf Ag Orally administered solid or liquid cyclosporin compositions
DE10332160A1 (en) * 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multiparticulate dosage form containing mucoadhesively formulated peptide or protein active substances, and a method for producing the dosage form
DE102005054938A1 (en) * 2005-11-17 2007-05-24 Gelita Ag Shaped body based on a crosslinked, gelatin-containing material, process for their preparation and their use
DE102005054937A1 (en) * 2005-11-17 2007-05-24 Gelita Ag Angiogenesis promoting substrate
JP2010523554A (en) 2007-04-04 2010-07-15 シグモイド・ファーマ・リミテッド Pharmaceutical composition of tacrolimus
EP2061587A1 (en) 2007-04-26 2009-05-27 Sigmoid Pharma Limited Manufacture of multiple minicapsules
DK2471518T3 (en) * 2009-05-18 2017-12-04 Sigmoid Pharma Ltd COMPOSITION INCLUDING OIL DROPS
EP2464341B1 (en) 2009-08-12 2022-07-06 Sublimity Therapeutics Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
BR112012021445B8 (en) * 2010-02-25 2022-07-05 Evonik Roehm Gmbh pharmaceutical or neutroceutical formulation, and use of a bioavailability promoting agent
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
GB201319792D0 (en) * 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
PL3215127T3 (en) 2014-11-07 2021-05-17 Sublimity Therapeutics Limited Compositions comprising cyclosporin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB887901A (en) * 1960-04-13 1900-01-01
US3312594A (en) * 1963-06-21 1967-04-04 Squibb & Sons Inc Longlasting troche
GB8514090D0 (en) * 1985-06-04 1985-07-10 Sandoz Ltd Organic compounds
DE3486029T2 (en) * 1983-10-14 1993-05-13 Sumitomo Pharma IFN PREPARATION WITH DELAYED DELIVERY FOR PARENTAL ADMINISTRATION.
EP0179904A1 (en) * 1984-05-09 1986-05-07 Medaphore Inc. Oral insulin and a method of making the same
CA1277601C (en) * 1985-12-27 1990-12-11 Shigeji Sato Method for producing sustained release formulation
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution

Also Published As

Publication number Publication date
DK0621775T3 (en) 1997-10-06
EP0621775A1 (en) 1994-11-02
WO1993013753A1 (en) 1993-07-22
GR3024529T3 (en) 1997-12-31
ES2108258T3 (en) 1997-12-16
DE59307073D1 (en) 1997-09-11
ATE156350T1 (en) 1997-08-15
EP0621775B1 (en) 1997-08-06

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