JP2004517047A5 - - Google Patents
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- Publication number
- JP2004517047A5 JP2004517047A5 JP2002523884A JP2002523884A JP2004517047A5 JP 2004517047 A5 JP2004517047 A5 JP 2004517047A5 JP 2002523884 A JP2002523884 A JP 2002523884A JP 2002523884 A JP2002523884 A JP 2002523884A JP 2004517047 A5 JP2004517047 A5 JP 2004517047A5
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- effective amount
- pharmaceutically effective
- interleukin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010050904 Interferons Proteins 0.000 description 10
- 102000014150 Interferons Human genes 0.000 description 10
- 229940079322 interferon Drugs 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 208000005176 Hepatitis C Diseases 0.000 description 2
- 102100040018 Interferon alpha-2 Human genes 0.000 description 2
- 108010047761 Interferon-alpha Proteins 0.000 description 2
- 102000006992 Interferon-alpha Human genes 0.000 description 2
- 108010079944 Interferon-alpha2b Proteins 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 108700027921 interferon tau Proteins 0.000 description 2
- 208000017830 lymphoblastoma Diseases 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 description 1
- HAEJPQIATWHALX-KQYNXXCUSA-N ITP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 HAEJPQIATWHALX-KQYNXXCUSA-N 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000004889 Interleukin-6 Human genes 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
- 229960002751 imiquimod Drugs 0.000 description 1
- 229940117681 interleukin-12 Drugs 0.000 description 1
- 229940100601 interleukin-6 Drugs 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 229960000888 rimantadine Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22939800P | 2000-08-31 | 2000-08-31 | |
| US60/229,398 | 2000-08-31 | ||
| US27764101P | 2001-03-21 | 2001-03-21 | |
| US60/277,641 | 2001-03-21 | ||
| PCT/US2001/026008 WO2002018369A2 (en) | 2000-08-31 | 2001-08-31 | Peptidomimetic protease inhibitors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007143124A Division JP2007284444A (ja) | 2000-08-31 | 2007-05-30 | ペプチド模倣プロテアーゼインヒビター |
| JP2010238165A Division JP5269035B2 (ja) | 2000-08-31 | 2010-10-25 | ペプチド模倣プロテアーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517047A JP2004517047A (ja) | 2004-06-10 |
| JP2004517047A5 true JP2004517047A5 (enExample) | 2008-02-07 |
| JP4689938B2 JP4689938B2 (ja) | 2011-06-01 |
Family
ID=26923261
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002523884A Expired - Lifetime JP4689938B2 (ja) | 2000-08-31 | 2001-08-31 | ペプチド模倣プロテアーゼインヒビター |
| JP2007143124A Pending JP2007284444A (ja) | 2000-08-31 | 2007-05-30 | ペプチド模倣プロテアーゼインヒビター |
| JP2010238165A Expired - Fee Related JP5269035B2 (ja) | 2000-08-31 | 2010-10-25 | ペプチド模倣プロテアーゼインヒビター |
| JP2012120678A Pending JP2012197289A (ja) | 2000-08-31 | 2012-05-28 | ペプチド模倣プロテアーゼインヒビター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007143124A Pending JP2007284444A (ja) | 2000-08-31 | 2007-05-30 | ペプチド模倣プロテアーゼインヒビター |
| JP2010238165A Expired - Fee Related JP5269035B2 (ja) | 2000-08-31 | 2010-10-25 | ペプチド模倣プロテアーゼインヒビター |
| JP2012120678A Pending JP2012197289A (ja) | 2000-08-31 | 2012-05-28 | ペプチド模倣プロテアーゼインヒビター |
Country Status (36)
Families Citing this family (241)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA79749C2 (en) * | 1996-10-18 | 2007-07-25 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
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| ATE297946T1 (de) * | 2000-04-03 | 2005-07-15 | Vertex Pharma | Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CZ301182B6 (cs) | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| CN1498224A (zh) | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| WO2002008187A1 (en) | 2000-07-21 | 2002-01-31 | Schering Corporation | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| GB2368339B (en) | 2000-10-26 | 2002-09-18 | Yissum Res Dev Co | Complex incorporating a plurality of antioxidants |
| ATE539744T1 (de) * | 2001-10-24 | 2012-01-15 | Vertex Pharma | Hemmer von serin-protease, insbesondere von hepatitis-c-virus-ns3-ns4a-protease, mit einem kondensierten ringsystem |
| US7119072B2 (en) | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
| US7091184B2 (en) | 2002-02-01 | 2006-08-15 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
| US6642204B2 (en) | 2002-02-01 | 2003-11-04 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor tri-peptides |
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| CN1852920B (zh) | 2003-07-18 | 2010-12-15 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
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