JP2013521279A5 - - Google Patents

Info

Publication number

JP2013521279A5

JP2013521279A5 JP2012556049A JP2012556049A JP2013521279A5 JP 2013521279 A5 JP2013521279 A5 JP 2013521279A5 JP 2012556049 A JP2012556049 A JP 2012556049A JP 2012556049 A JP2012556049 A JP 2012556049A JP 2013521279 A5 JP2013521279 A5 JP 2013521279A5

Authority

JP

Japan

Prior art keywords

hcv

composition

interferon

compound

group

Prior art date

2010-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 8
• 239000003795 chemical substances by application Substances 0.000 claims 6
• 108010047761 Interferon-alpha Proteins 0.000 claims 4
• 102000006992 Interferon-alpha Human genes 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 108010050904 Interferons Proteins 0.000 claims 3
• 102000014150 Interferons Human genes 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 229940079322 interferon Drugs 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• HLQXYDHLDZTWDW-KAWPREARSA-N (2r,4s,5r)-1-(4-tert-butyl-3-methoxybenzoyl)-4-(methoxymethyl)-2-(pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid Chemical compound C([C@]1(C[C@@H]([C@@H](N1C(=O)C=1C=C(OC)C(=CC=1)C(C)(C)C)C=1SC=CN=1)COC)C(O)=O)N1C=CC=N1 HLQXYDHLDZTWDW-KAWPREARSA-N 0.000 claims 1
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
• UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 1
• 108020005544 Antisense RNA Proteins 0.000 claims 1
• 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 1
• 102100040018 Interferon alpha-2 Human genes 0.000 claims 1
• 108010079944 Interferon-alpha2b Proteins 0.000 claims 1
• 102000013462 Interleukin-12 Human genes 0.000 claims 1
• 108010065805 Interleukin-12 Proteins 0.000 claims 1
• 102000000588 Interleukin-2 Human genes 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 102000004889 Interleukin-6 Human genes 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 102000005741 Metalloproteases Human genes 0.000 claims 1
• 108010006035 Metalloproteases Proteins 0.000 claims 1
• 108060004795 Methyltransferase Proteins 0.000 claims 1
• 101800001019 Non-structural protein 4B Proteins 0.000 claims 1
• 101800001014 Non-structural protein 5A Proteins 0.000 claims 1
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
• 102000012479 Serine Proteases Human genes 0.000 claims 1
• 108010022999 Serine Proteases Proteins 0.000 claims 1
• 230000005867 T cell response Effects 0.000 claims 1
• DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical group C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
• 229960003805 amantadine Drugs 0.000 claims 1
• -1 amino, hydroxy, protected amino Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 229910021386 carbon form Inorganic materials 0.000 claims 1
• 239000003184 complementary RNA Substances 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• ZVTDLPBHTSMEJZ-JSZLBQEHSA-N danoprevir Chemical compound O=C([C@@]12C[C@H]1\C=C/CCCCC[C@@H](C(N1C[C@@H](C[C@H]1C(=O)N2)OC(=O)N1CC2=C(F)C=CC=C2C1)=O)NC(=O)OC(C)(C)C)NS(=O)(=O)C1CC1 ZVTDLPBHTSMEJZ-JSZLBQEHSA-N 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
• 229960002751 imiquimod Drugs 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 239000002348 inosinate dehydrogenase inhibitor Substances 0.000 claims 1
• 230000002452 interceptive effect Effects 0.000 claims 1
• 229940117681 interleukin-12 Drugs 0.000 claims 1
• 229940100601 interleukin-6 Drugs 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 239000002777 nucleoside Substances 0.000 claims 1
• 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 229960000329 ribavirin Drugs 0.000 claims 1
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
• 229960000888 rimantadine Drugs 0.000 claims 1