|
EP0475255A3
(en)
|
1990-09-12 |
1993-04-14 |
F. Hoffmann-La Roche Ag |
Process for the preparation of optically pure (s)-alpha-((tert-butylsulfonyl)methyl)hydro cinnamic acid
|
|
DE69709671T2
(de)
|
1996-10-18 |
2002-08-22 |
Vertex Pharmaceuticals Inc., Cambridge |
Inhibitoren von serinproteasen, insbesondere von ns3-protease des hepatitis-c-virus
|
|
EP1003775B1
(en)
|
1997-08-11 |
2005-03-16 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor peptides
|
|
JP4452401B2
(ja)
|
1997-08-11 |
2010-04-21 |
ベーリンガー インゲルハイム (カナダ) リミテッド |
C型肝炎ウイルス阻害ペプチドアナログ
|
|
AR022061A1
(es)
|
1998-08-10 |
2002-09-04 |
Boehringer Ingelheim Ca Ltd |
Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
|
US7244721B2
(en)
|
2000-07-21 |
2007-07-17 |
Schering Corporation |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
ATE461207T1
(de)
|
2000-07-21 |
2010-04-15 |
Schering Corp |
Peptide als inhibitoren der ns3-serinprotease des hepatitis c virus
|
|
PE20020707A1
(es)
|
2000-11-20 |
2002-08-11 |
Bristol Myers Squibb Co |
Compuestos tripeptidicos como inhibidores de la proteasa ns3 del virus de hepatitis c
|
|
HUP0303436A2
(hu)
*
|
2000-12-12 |
2004-01-28 |
Schering Corp. |
Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
|
|
US6867185B2
(en)
|
2001-12-20 |
2005-03-15 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus
|
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
|
CA2370396A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
CA2369970A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US6828301B2
(en)
|
2002-02-07 |
2004-12-07 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for hepatitis C viral protease inhibitors
|
|
US20060199773A1
(en)
|
2002-05-20 |
2006-09-07 |
Sausker Justin B |
Crystalline forms of (1R,2S)-N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(6-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-cyclopropanecarboxamide, monopotassium salt
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
DE60324552D1
(en)
|
2002-05-20 |
2008-12-18 |
Bristol Myers Squibb Co |
Substituierte cycloalkyl p1' hepatitis c virus inhibitoren
|
|
DE60334205D1
(en)
|
2002-05-20 |
2010-10-28 |
Bristol Myers Squibb Co |
Heterocyclische sulfonamid-hepatitis-c-virus-hemmer
|
|
PL215228B1
(pl)
*
|
2002-05-20 |
2013-11-29 |
Bristol Myers Squibb Co |
Zwiazki tripeptydowe, ich zastosowanie i kompozycja farmaceutyczna je zawierajaca oraz jej zastosowanie
|
|
US20040033959A1
(en)
|
2002-07-19 |
2004-02-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pharmaceutical compositions for hepatitis C viral protease inhibitors
|
|
US20050075279A1
(en)
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
|
US7601709B2
(en)
|
2003-02-07 |
2009-10-13 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
|
CN1771050A
(zh)
|
2003-02-07 |
2006-05-10 |
益安药业 |
丙型肝炎丝氨酸蛋白酶的大环抑制剂
|
|
EP1599496B1
(en)
|
2003-03-05 |
2010-11-03 |
Boehringer Ingelheim International GmbH |
Hepatitis c inhibitor peptide analogs
|
|
WO2004101605A1
(en)
|
2003-03-05 |
2004-11-25 |
Boehringer Ingelheim International Gmbh |
Hepatitis c inhibiting compounds
|
|
KR20050108420A
(ko)
|
2003-04-02 |
2005-11-16 |
베링거 인겔하임 인터내셔날 게엠베하 |
C형 간염 바이러스 프로테아제 억제제를 위한 약제학적조성물
|
|
ATE422895T1
(de)
|
2003-04-16 |
2009-03-15 |
Bristol Myers Squibb Co |
Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus
|
|
EP2143727B1
(en)
|
2003-04-18 |
2015-01-21 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
|
EA009295B1
(ru)
|
2003-05-21 |
2007-12-28 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Соединения в качестве ингибиторов вируса гепатита с
|
|
WO2004113365A2
(en)
|
2003-06-05 |
2004-12-29 |
Enanta Pharmaceuticals, Inc. |
Hepatitis c serine protease tri-peptide inhibitors
|
|
US7125845B2
(en)
|
2003-07-03 |
2006-10-24 |
Enanta Pharmaceuticals, Inc. |
Aza-peptide macrocyclic hepatitis C serine protease inhibitors
|
|
RS20060197A
(sr)
|
2003-09-22 |
2008-09-29 |
Boehringer Ingelheim International Gmbh., |
Makrociklični peptidi koji su aktivni protiv hepatitisa c virusa
|
|
AU2004282148A1
(en)
|
2003-10-10 |
2005-04-28 |
Vertex Pharmaceuticals Incoporated |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
RS20110578A3
(en)
|
2003-10-14 |
2016-02-29 |
F. Hoffmann-La Roche Ltd |
MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULPHONAMIDES AS HCV REPLICATION INHIBITORS
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
CN1902216A
(zh)
|
2003-11-20 |
2007-01-24 |
先灵公司 |
丙肝病毒ns3蛋白酶的去肽化抑制剂
|
|
US7135462B2
(en)
|
2003-11-20 |
2006-11-14 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7309708B2
(en)
|
2003-11-20 |
2007-12-18 |
Birstol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
JP4682155B2
(ja)
|
2004-01-21 |
2011-05-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎ウイルスに対して活性な大環状ペプチド
|
|
DE602005017582D1
(en)
|
2004-01-30 |
2009-12-24 |
Medivir Ab |
Hcv ns-3 serine protease inhibitoren
|
|
BRPI0508867A
(pt)
|
2004-03-15 |
2007-09-04 |
Boehringer Ingelheim Int |
processo para a preparação de compostos macrocìclicos
|
|
BRPI0509467A
(pt)
|
2004-03-30 |
2007-09-11 |
Intermune Inc |
compostos macrocìclicos como inibidores de replicação viral
|
|
WO2006016930A2
(en)
|
2004-05-14 |
2006-02-16 |
Intermune, Inc. |
Methods for treating hcv infection
|
|
EP1753775B1
(en)
|
2004-05-25 |
2012-12-26 |
Boehringer Ingelheim International GmbH |
Process for preparing acyclic hcv protease inhibitors
|
|
EP1763531A4
(en)
|
2004-06-28 |
2009-07-01 |
Boehringer Ingelheim Int |
ANALOGUE OF HEPATITIS-C INHIBITING PEPTIDES
|
|
EP1778702B1
(en)
|
2004-07-16 |
2011-07-13 |
Gilead Sciences, Inc. |
Antiviral compounds
|
|
ATE512971T1
(de)
|
2004-07-20 |
2011-07-15 |
Boehringer Ingelheim Int |
Peptidanaloga als hepatitis c-hemmer
|
|
UY29016A1
(es)
|
2004-07-20 |
2006-02-24 |
Boehringer Ingelheim Int |
Analogos de dipeptidos inhibidores de la hepatitis c
|
|
CN101068828A
(zh)
|
2004-08-27 |
2007-11-07 |
先灵公司 |
用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的酰基磺酰胺化合物
|
|
JP2008513454A
(ja)
|
2004-09-17 |
2008-05-01 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
大環状hcvプロテアーゼインヒビターの調製方法
|
|
WO2007001406A2
(en)
|
2004-10-05 |
2007-01-04 |
Chiron Corporation |
Aryl-containing macrocyclic compounds
|
|
US20070249637A1
(en)
|
2004-10-21 |
2007-10-25 |
Collins Michael R |
Inhibitors Of Hepatitis C Virus Protease, And Compositions And Treatments Using The Same
|
|
US7323447B2
(en)
|
2005-02-08 |
2008-01-29 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
DK1863833T3
(da)
|
2005-03-08 |
2013-12-02 |
Boehringer Ingelheim Int |
Fremgangsmåde til fremstilling af makrocykliske forbindelser
|
|
JP4705164B2
(ja)
|
2005-05-02 |
2011-06-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Hcvns3プロテアーゼ阻害剤
|
|
US7592336B2
(en)
*
|
2005-05-10 |
2009-09-22 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
AR055198A1
(es)
|
2005-06-02 |
2007-08-08 |
Schering Corp |
Formulaciones farmaceuticas y metodos de tratamiento que las utilizan
|
|
US20060276405A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods for treating hepatitis C
|
|
EP1891089B1
(en)
|
2005-06-02 |
2014-11-05 |
Merck Sharp & Dohme Corp. |
HCV protease inhibitors in combination with food
|
|
US20060287248A1
(en)
|
2005-06-02 |
2006-12-21 |
Schering Corporation |
Asymmetric dosing methods
|
|
WO2006130666A2
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Medicaments and methods combining a hcv protease inhibitor and an akr competitor
|
|
US20060276407A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods of treating hepatitis C virus
|
|
US20070004635A1
(en)
|
2005-06-02 |
2007-01-04 |
Schering Corporation |
Method of treating interferon non-responders using HCV protease inhibitor
|
|
US20070021351A1
(en)
|
2005-06-02 |
2007-01-25 |
Schering Corporation |
Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
|
|
US20060281689A1
(en)
|
2005-06-02 |
2006-12-14 |
Schering Corporation |
Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
|
|
US20060276406A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods of treating hepatitis C virus
|
|
CA2611145A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Controlled-release formulation useful for treating disorders associated with hepatitis c virus
|
|
US7601686B2
(en)
|
2005-07-11 |
2009-10-13 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
TWI389908B
(zh)
|
2005-07-14 |
2013-03-21 |
Gilead Sciences Inc |
抗病毒化合物類
|
|
TW200738742A
(en)
|
2005-07-14 |
2007-10-16 |
Gilead Sciences Inc |
Antiviral compounds
|
|
JP2009501732A
(ja)
|
2005-07-20 |
2009-01-22 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎インヒビターペプチド類似体
|
|
TWI387603B
(zh)
|
2005-07-20 |
2013-03-01 |
Merck Sharp & Dohme |
Hcv ns3蛋白酶抑制劑
|
|
KR101294467B1
(ko)
|
2005-07-25 |
2013-09-09 |
인터뮨, 인크. |
C형 간염 바이러스 복제의 신규 거대고리형 억제제
|
|
PE20070343A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Inhibidores macrociclicos del virus de la hepatitis c
|
|
US8183277B2
(en)
|
2005-07-29 |
2012-05-22 |
Tibotec Pharmaceuticals Ltd. |
Macrocylic inhibitors of hepatitis C virus
|
|
AU2006274861B2
(en)
|
2005-07-29 |
2012-11-08 |
Medivir Ab |
Macrocyclic inhibitors of hepatitis C virus
|
|
PE20070210A1
(es)
|
2005-07-29 |
2007-04-16 |
Tibotec Pharm Ltd |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
|
ES2456617T3
(es)
|
2005-07-29 |
2014-04-23 |
Janssen R&D Ireland |
Inhibidores macrocíclicos del virus de la hepatitis C
|
|
ES2359939T3
(es)
|
2005-07-29 |
2011-05-30 |
Tibotec Pharmaceuticals |
Inhibidores macrocíclicos del virus de la hepatitis c.
|
|
JO2768B1
(en)
|
2005-07-29 |
2014-03-15 |
تيبوتيك فارماسيوتيكالز ليمتد |
Large cyclic inhibitors of hepatitis C virus
|
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
|
PT1912997E
(pt)
|
2005-07-29 |
2011-12-19 |
Tibotec Pharm Ltd |
Inibidores macrocíclicos do vírus da hepatite c
|
|
RU2419619C2
(ru)
|
2005-07-29 |
2011-05-27 |
Медивир Аб |
Макроциклические ингибиторы вируса гепатита с
|
|
RU2441870C2
(ru)
|
2005-07-29 |
2012-02-10 |
Тиботек Фармасьютикалз Лтд. |
Макроциклические ингибиторы вируса гепатита с
|
|
JP4705984B2
(ja)
|
2005-08-01 |
2011-06-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Hcvns3プロテアーゼ阻害剤としての大環状ペプチド
|
|
EP1915382A2
(en)
|
2005-08-01 |
2008-04-30 |
Phenomix Corporation |
Hepatitis c serine protease inhibitors and uses therefor
|
|
AR055395A1
(es)
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
|
|
DE602006019323D1
(de)
|
2005-10-11 |
2011-02-10 |
Intermune Inc |
Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus
|
|
US7772183B2
(en)
*
|
2005-10-12 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7741281B2
(en)
*
|
2005-11-03 |
2010-06-22 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US8268776B2
(en)
|
2006-06-06 |
2012-09-18 |
Enanta Pharmaceuticals, Inc. |
Macrocylic oximyl hepatitis C protease inhibitors
|
|
US7935670B2
(en)
*
|
2006-07-11 |
2011-05-03 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7635683B2
(en)
|
2006-08-04 |
2009-12-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl tripeptide hepatitis C virus inhibitors
|
|
US7605126B2
(en)
|
2006-08-11 |
2009-10-20 |
Enanta Pharmaceuticals, Inc. |
Acylaminoheteroaryl hepatitis C virus protease inhibitors
|
|
US7582605B2
(en)
|
2006-08-11 |
2009-09-01 |
Enanta Pharmaceuticals, Inc. |
Phosphorus-containing hepatitis C serine protease inhibitors
|
|
KR101615500B1
(ko)
|
2006-10-27 |
2016-04-27 |
머크 샤프 앤드 돔 코포레이션 |
Hcv ns3 프로테아제 억제제
|
|
US20080107623A1
(en)
*
|
2006-11-01 |
2008-05-08 |
Bristol-Myers Squibb Company |
Inhibitors of Hepatitis C Virus
|
|
US7763584B2
(en)
*
|
2006-11-16 |
2010-07-27 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7888464B2
(en)
*
|
2006-11-16 |
2011-02-15 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US20080279821A1
(en)
|
2007-04-26 |
2008-11-13 |
Deqiang Niu |
Arylpiperidinyl and arylpyrrolidinyl macrocyclic hepatitis c serine protease inhibitors
|
|
EP2178886A1
(en)
*
|
2007-07-17 |
2010-04-28 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic indole derivatives for the treatment of hepatitis c infections
|