JP2010509359A5 - - Google Patents
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- Publication number
- JP2010509359A5 JP2010509359A5 JP2009536467A JP2009536467A JP2010509359A5 JP 2010509359 A5 JP2010509359 A5 JP 2010509359A5 JP 2009536467 A JP2009536467 A JP 2009536467A JP 2009536467 A JP2009536467 A JP 2009536467A JP 2010509359 A5 JP2010509359 A5 JP 2010509359A5
- Authority
- JP
- Japan
- Prior art keywords
- carbamoyl
- methoxy
- prolinamide
- oxy
- isoquinolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 salt compound Chemical class 0.000 claims 105
- 125000000217 alkyl group Chemical group 0.000 claims 47
- 125000000753 cycloalkyl group Chemical group 0.000 claims 30
- 125000003545 alkoxy group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000005843 halogen group Chemical group 0.000 claims 17
- 125000001188 haloalkyl group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000003710 aryl alkyl group Chemical group 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000004438 haloalkoxy group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 108010050904 Interferons Proteins 0.000 claims 8
- 102000014150 Interferons Human genes 0.000 claims 8
- 229940079322 interferon Drugs 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229910052717 sulfur Chemical group 0.000 claims 6
- 239000011593 sulfur Chemical group 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 5
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229960000329 ribavirin Drugs 0.000 claims 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 2
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 2
- 108020005544 Antisense RNA Proteins 0.000 claims 2
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 2
- 108050006182 Inosine-5'-monophosphate dehydrogenases Proteins 0.000 claims 2
- 102000016600 Inosine-5'-monophosphate dehydrogenases Human genes 0.000 claims 2
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 2
- 102000013462 Interleukin-12 Human genes 0.000 claims 2
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- 101800001019 Non-structural protein 4B Proteins 0.000 claims 2
- 101800001014 Non-structural protein 5A Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 2
- 229960003805 amantadine Drugs 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 239000003184 complementary RNA Substances 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 2
- 229960002751 imiquimod Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000002452 interceptive effect Effects 0.000 claims 2
- 108700027921 interferon tau Proteins 0.000 claims 2
- 229940117681 interleukin-12 Drugs 0.000 claims 2
- 229940100601 interleukin-6 Drugs 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 229960000888 rimantadine Drugs 0.000 claims 2
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86503406P | 2006-11-09 | 2006-11-09 | |
| US11/934,840 US7772180B2 (en) | 2006-11-09 | 2007-11-05 | Hepatitis C virus inhibitors |
| PCT/US2007/084012 WO2008060927A2 (en) | 2006-11-09 | 2007-11-08 | Hepatitis c virus inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010509359A JP2010509359A (ja) | 2010-03-25 |
| JP2010509359A5 true JP2010509359A5 (enExample) | 2010-12-24 |
Family
ID=39304590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536467A Pending JP2010509359A (ja) | 2006-11-09 | 2007-11-08 | Ｃ型肝炎ウイルス阻害剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7772180B2 (enExample) |
| EP (1) | EP2086963B1 (enExample) |
| JP (1) | JP2010509359A (enExample) |
| KR (1) | KR20090082467A (enExample) |
| CN (1) | CN101541784B (enExample) |
| AR (1) | AR063653A1 (enExample) |
| AU (1) | AU2007319435A1 (enExample) |
| BR (1) | BRPI0718625A2 (enExample) |
| CA (1) | CA2669310A1 (enExample) |
| CL (1) | CL2007003250A1 (enExample) |
| EA (1) | EA200900676A1 (enExample) |
| IL (1) | IL198248A0 (enExample) |
| MX (1) | MX2009004888A (enExample) |
| NO (1) | NO20091591L (enExample) |
| NZ (1) | NZ576817A (enExample) |
| PE (1) | PE20081344A1 (enExample) |
| TW (1) | TW200826938A (enExample) |
| WO (1) | WO2008060927A2 (enExample) |
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| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| EP1831225A2 (en) | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Anti-inflammatory pyrazolopyrimidines |
| KR20150038395A (ko) | 2006-04-04 | 2015-04-08 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 키나제 길항물질 |
| EP2160392A2 (en) * | 2007-05-03 | 2010-03-10 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| BRPI0811447A2 (pt) * | 2007-05-10 | 2014-10-29 | Intermune Inc | Compostos, composição farmacêutica e métodos de inibição da atividade da protease ns3/ns4, de tratamento da fibrose hepática e de intensificação da função hepática num indivíduo tendo infecção de vírus da hepatite c. |
| US20090047252A1 (en) * | 2007-06-29 | 2009-02-19 | Gilead Sciences, Inc. | Antiviral compounds |
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| MX2010006738A (es) | 2007-12-21 | 2010-10-15 | Avila Therapeutics Inc | Inhibidores de proteasa del virus de la hepatitis c (hcv) y usos de los mismos. |
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- 2007-11-05 US US11/934,840 patent/US7772180B2/en active Active
- 2007-11-08 JP JP2009536467A patent/JP2010509359A/ja active Pending
- 2007-11-08 EP EP07864081.0A patent/EP2086963B1/en active Active
- 2007-11-08 MX MX2009004888A patent/MX2009004888A/es active IP Right Grant
- 2007-11-08 NZ NZ576817A patent/NZ576817A/en not_active IP Right Cessation
- 2007-11-08 KR KR1020097011785A patent/KR20090082467A/ko not_active Withdrawn
- 2007-11-08 EA EA200900676A patent/EA200900676A1/ru unknown
- 2007-11-08 CN CN2007800416231A patent/CN101541784B/zh not_active Expired - Fee Related
- 2007-11-08 AU AU2007319435A patent/AU2007319435A1/en not_active Abandoned
- 2007-11-08 CA CA002669310A patent/CA2669310A1/en not_active Abandoned
- 2007-11-08 BR BRPI0718625-8A patent/BRPI0718625A2/pt not_active IP Right Cessation
- 2007-11-08 WO PCT/US2007/084012 patent/WO2008060927A2/en not_active Ceased
- 2007-11-09 CL CL200703250A patent/CL2007003250A1/es unknown
- 2007-11-09 PE PE2007001545A patent/PE20081344A1/es not_active Application Discontinuation
- 2007-11-09 AR ARP070105019A patent/AR063653A1/es not_active Application Discontinuation
- 2007-11-09 TW TW096142550A patent/TW200826938A/zh unknown
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2009
- 2009-04-21 IL IL198248A patent/IL198248A0/en unknown
- 2009-04-22 NO NO20091591A patent/NO20091591L/no not_active Application Discontinuation