CA2669310A1 - Hepatitis c virus inhibitors - Google Patents

Hepatitis c virus inhibitors Download PDF

Info

Publication number
CA2669310A1
CA2669310A1 CA002669310A CA2669310A CA2669310A1 CA 2669310 A1 CA2669310 A1 CA 2669310A1 CA 002669310 A CA002669310 A CA 002669310A CA 2669310 A CA2669310 A CA 2669310A CA 2669310 A1 CA2669310 A1 CA 2669310A1
Authority
CA
Canada
Prior art keywords
carbamoyl
methoxy
prolinamide
oxy
vinylcyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002669310A
Other languages
English (en)
French (fr)
Inventor
Ny Sin
Brian Lee Venables
Li-Qiang Sun
Sing-Yuen Sit
Yan Chen
Paul Michael Scola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2669310A1 publication Critical patent/CA2669310A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002669310A 2006-11-09 2007-11-08 Hepatitis c virus inhibitors Abandoned CA2669310A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86503406P 2006-11-09 2006-11-09
US60/865,034 2006-11-09
US11/934,840 US7772180B2 (en) 2006-11-09 2007-11-05 Hepatitis C virus inhibitors
US11/934,840 2007-11-05
PCT/US2007/084012 WO2008060927A2 (en) 2006-11-09 2007-11-08 Hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
CA2669310A1 true CA2669310A1 (en) 2008-05-22

Family

ID=39304590

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002669310A Abandoned CA2669310A1 (en) 2006-11-09 2007-11-08 Hepatitis c virus inhibitors

Country Status (18)

Country Link
US (1) US7772180B2 (enExample)
EP (1) EP2086963B1 (enExample)
JP (1) JP2010509359A (enExample)
KR (1) KR20090082467A (enExample)
CN (1) CN101541784B (enExample)
AR (1) AR063653A1 (enExample)
AU (1) AU2007319435A1 (enExample)
BR (1) BRPI0718625A2 (enExample)
CA (1) CA2669310A1 (enExample)
CL (1) CL2007003250A1 (enExample)
EA (1) EA200900676A1 (enExample)
IL (1) IL198248A0 (enExample)
MX (1) MX2009004888A (enExample)
NO (1) NO20091591L (enExample)
NZ (1) NZ576817A (enExample)
PE (1) PE20081344A1 (enExample)
TW (1) TW200826938A (enExample)
WO (1) WO2008060927A2 (enExample)

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US7772180B2 (en) 2010-08-10
EP2086963A2 (en) 2009-08-12
TW200826938A (en) 2008-07-01
AU2007319435A1 (en) 2008-05-22
EP2086963B1 (en) 2015-09-16
JP2010509359A (ja) 2010-03-25
NZ576817A (en) 2011-08-26
CL2007003250A1 (es) 2008-05-23
AR063653A1 (es) 2009-02-04
MX2009004888A (es) 2009-05-19
KR20090082467A (ko) 2009-07-30
CN101541784B (zh) 2013-04-24
US20080119461A1 (en) 2008-05-22
EA200900676A1 (ru) 2010-02-26
BRPI0718625A2 (pt) 2014-04-01
IL198248A0 (en) 2009-12-24
WO2008060927A2 (en) 2008-05-22
WO2008060927A3 (en) 2008-07-03

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