JP2004501642A - 改変された糖タンパク質を生成するための方法 - Google Patents

改変された糖タンパク質を生成するための方法 Download PDF

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JP2004501642A
JP2004501642A JP2002506194A JP2002506194A JP2004501642A JP 2004501642 A JP2004501642 A JP 2004501642A JP 2002506194 A JP2002506194 A JP 2002506194A JP 2002506194 A JP2002506194 A JP 2002506194A JP 2004501642 A JP2004501642 A JP 2004501642A
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ガーングロス，　ティルマン　ユー．
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グライコフィ，　インコーポレイテッド
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/2488—Mannanases
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)

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JP2002506194A 2000-06-28 2001-06-27 改変された糖タンパク質を生成するための方法 Pending JP2004501642A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21435800P 2000-06-28 2000-06-28
US21563800P 2000-06-30 2000-06-30
US27999701P 2001-03-30 2001-03-30
PCT/US2001/020553 WO2002000879A2 (en) 2000-06-28 2001-06-27 Methods for producing modified glycoproteins

Related Child Applications (1)

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JP2011059620A Division JP2011167194A (ja) 2000-06-28 2011-03-17 改変された糖タンパク質を生成するための方法

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JP2004501642A true JP2004501642A (ja) 2004-01-22

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JP2011059620A Pending JP2011167194A (ja) 2000-06-28 2011-03-17 改変された糖タンパク質を生成するための方法

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US (13) US7029872B2 (https=)
EP (5) EP2119793A1 (https=)
JP (2) JP2004501642A (https=)
KR (1) KR100787073B1 (https=)
AT (2) ATE440959T1 (https=)
AU (2) AU7684201A (https=)
CA (1) CA2412701A1 (https=)
CY (1) CY1109639T1 (https=)
DE (2) DE60114830T2 (https=)
DK (2) DK1522590T3 (https=)
ES (2) ES2252261T3 (https=)
MX (1) MXPA03000105A (https=)
NZ (1) NZ523476A (https=)
PT (1) PT1522590E (https=)
WO (1) WO2002000879A2 (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007529228A (ja) * 2004-03-17 2007-10-25 グライコフィ， インコーポレイテッド 真菌および酵母におけるシチジンモノホスフェート−シアル酸合成経路を操作する方法
JP2007534330A (ja) * 2004-04-29 2007-11-29 グライコフィ， インコーポレイテッド 糖タンパク質の作製においてアルファ−マンノシダーゼ抵抗性グリカンを減少させるか又は排除する方法
JP2009513131A (ja) * 2005-10-27 2009-04-02 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー ドリコールリン酸マンノース依存α−１，３−マンノシルトランスフェラーゼをコードするハンセヌラポリモルファ起源の新規遺伝子、および前記遺伝子が欠損したハンセヌラポリモルファ変異株を用いた組み換え糖タンパク質生産方法
JP2009528270A (ja) * 2006-01-26 2009-08-06 レコファーマ アーベー ウイルスの接着を阻害するための組成物および方法
WO2010038802A1 (ja) 2008-10-01 2010-04-08 旭硝子株式会社 宿主、形質転換体およびその製造方法、ならびにｏ－グリコシド型糖鎖含有異種蛋白質の製造方法
JP2010519930A (ja) * 2007-03-07 2010-06-10 グライコフィ， インコーポレイテッド 糖タンパク質の修飾フコシル化を用いる産生
JP2012503471A (ja) * 2008-05-30 2012-02-09 グライコフィ， インコーポレイテッド 末端アルファ−１，３−結合ガラクトースを有するタンパク質の製造のための酵母株
JP2012100664A (ja) * 2004-04-29 2012-05-31 Glycofi Inc 糖タンパク質の作製においてアルファ−マンノシダーゼ抵抗性グリカンを減少させるか又は排除する方法
JP2014138616A (ja) * 2011-10-03 2014-07-31 National Institute Of Advanced Industrial & Technology 複合型糖鎖加水分解酵素
JP2015532120A (ja) * 2012-10-22 2015-11-09 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｃｒｚ１突然変異真菌細胞

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