DK0784054T3 - 1,2,3,4-tetrahydroquinoxalinderivater og deres anvendelse som glutamatreceptorantagonister - Google Patents
1,2,3,4-tetrahydroquinoxalinderivater og deres anvendelse som glutamatreceptorantagonisterInfo
- Publication number
- DK0784054T3 DK0784054T3 DK95932217T DK95932217T DK0784054T3 DK 0784054 T3 DK0784054 T3 DK 0784054T3 DK 95932217 T DK95932217 T DK 95932217T DK 95932217 T DK95932217 T DK 95932217T DK 0784054 T3 DK0784054 T3 DK 0784054T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- substituted
- carboxyl
- mono
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23190894 | 1994-09-27 | ||
JP5948295 | 1995-03-17 | ||
PCT/JP1995/001922 WO1996010023A1 (fr) | 1994-09-27 | 1995-09-25 | Derive de 1,2,3,4-tetrahydroquinoxalindione |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0784054T3 true DK0784054T3 (da) | 2002-03-25 |
Family
ID=26400527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95932217T DK0784054T3 (da) | 1994-09-27 | 1995-09-25 | 1,2,3,4-tetrahydroquinoxalinderivater og deres anvendelse som glutamatreceptorantagonister |
Country Status (16)
Country | Link |
---|---|
US (1) | US6096743A (da) |
EP (1) | EP0784054B1 (da) |
KR (1) | KR100392151B1 (da) |
CN (1) | CN1067387C (da) |
AT (1) | ATE209644T1 (da) |
CA (1) | CA2199468C (da) |
DE (1) | DE69524246T2 (da) |
DK (1) | DK0784054T3 (da) |
ES (1) | ES2168383T3 (da) |
HU (1) | HU223945B1 (da) |
MX (1) | MX9702244A (da) |
PL (1) | PL181532B1 (da) |
PT (1) | PT784054E (da) |
RU (1) | RU2149873C1 (da) |
UA (1) | UA44283C2 (da) |
WO (1) | WO1996010023A1 (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057304A (en) * | 1992-10-26 | 2000-05-02 | Schering Aktiengesellschaft | Quinoxaline-phosphonic acid derivatives |
DE19519979A1 (de) * | 1995-05-24 | 1996-11-28 | Schering Ag | Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln |
TW448171B (en) * | 1996-06-06 | 2001-08-01 | Yamanouchi Pharma Co Ltd | Imidazole-substituted quinoxalinedione derivatives |
DE69820048D1 (de) * | 1997-03-14 | 2004-01-08 | Meiji Seika Kaisha | Physiologisch aktive substanz pf1191 und verfahren zu ihrer herstellung |
DE19728326A1 (de) * | 1997-06-27 | 1999-01-07 | Schering Ag | Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln |
RU2217426C2 (ru) | 1998-06-01 | 2003-11-27 | Шионоги Энд Ко., Лтд. | Цианиминохиноксалиновые производные, способ их получения (варианты), промежуточные соединения и фармацевтическая композиция |
CA2362385C (en) | 1999-02-15 | 2009-08-11 | Eisai Co., Ltd. | Heterodiazinon compound |
US6599942B1 (en) | 1999-03-29 | 2003-07-29 | Novartis Ag | Thyromimetic organic compounds |
US6790978B2 (en) | 1999-03-29 | 2004-09-14 | Novartis Ag | Thyromimetic organic compounds |
US6709667B1 (en) | 1999-08-23 | 2004-03-23 | Conceptus, Inc. | Deployment actuation system for intrafallopian contraception |
ES2266214T3 (es) * | 2000-01-24 | 2007-03-01 | Neurosearch A/S | Derivados de isatina con actividad neurotrofica. |
DE60137426D1 (de) | 2000-06-12 | 2009-03-05 | Eisai R&D Man Co Ltd | 1,2-dihydropyridinverbindungen, verfahren zu deren herstellung und deren verwendung |
DE60114830T2 (de) * | 2000-06-28 | 2006-08-03 | Glycofi, Inc. | Verfahren zur herstellung modifizierter glycoproteine |
WO2002072542A2 (en) * | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
CA2479495A1 (en) * | 2002-03-29 | 2003-10-09 | Yamanouchi Pharmaceutical Co., Ltd. | Remedy for glioblastoma |
WO2003087091A1 (fr) * | 2002-04-17 | 2003-10-23 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau cristal d'anhydride de derive de quinoxalinedione |
WO2004002488A1 (ja) * | 2002-06-28 | 2004-01-08 | Yamanouchi Pharmaceutical Co., Ltd. | 脳出血治療剤 |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
GB0405034D0 (en) * | 2004-03-05 | 2004-04-07 | Novartis Ag | Organic compounds |
MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
AU2006232517A1 (en) * | 2005-04-04 | 2006-10-12 | Eisai R&D Management Co., Ltd. | Dihydropyridine compounds and compositions for headaches |
WO2007020521A1 (en) * | 2005-08-16 | 2007-02-22 | Pharmacia & Upjohn Company Llc | Pyridoyrazinones as pde-5 inhibitors |
ES2419239T3 (es) * | 2007-05-29 | 2013-08-20 | Santen Pharmaceutical Co., Ltd | Nuevo derivado de 1,2,3,4-tetrahidroquinoxalina que tiene como sustituyente un grupo fenilo con una estructura de éster de ácido sulfónico o una estructura de amida de ácido sulfónico introducida en el mismo y que tienen una actividad de unión al receptor de glucocorticoides |
US8420680B2 (en) | 2007-06-29 | 2013-04-16 | Emory University | NMDA receptor antagonists for neuroprotection |
WO2010053757A1 (en) * | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
MX2021006317A (es) | 2018-12-14 | 2021-08-11 | Eisai R&D Man Co Ltd | Formulaciones farmaceuticas de base acuosa de compuestos de 1,2-dihidropiridina. |
WO2023042888A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
JPWO2023042887A1 (da) | 2021-09-15 | 2023-03-23 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2550456B2 (ja) * | 1990-11-06 | 1996-11-06 | 山之内製薬株式会社 | 縮合ピラジン誘導体 |
PT101004B (pt) * | 1991-10-26 | 1999-10-29 | Schering Ag | Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem |
IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
JPH07165756A (ja) * | 1993-12-14 | 1995-06-27 | Yamanouchi Pharmaceut Co Ltd | ヒドロキシキノキサリンジオン誘導体 |
US5654303A (en) * | 1995-06-07 | 1997-08-05 | Warner-Lambert Company | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
-
1995
- 1995-09-25 ES ES95932217T patent/ES2168383T3/es not_active Expired - Lifetime
- 1995-09-25 PL PL95320059A patent/PL181532B1/pl not_active IP Right Cessation
- 1995-09-25 US US08/809,087 patent/US6096743A/en not_active Expired - Fee Related
- 1995-09-25 UA UA97031348A patent/UA44283C2/uk unknown
- 1995-09-25 PT PT95932217T patent/PT784054E/pt unknown
- 1995-09-25 DK DK95932217T patent/DK0784054T3/da active
- 1995-09-25 EP EP95932217A patent/EP0784054B1/en not_active Expired - Lifetime
- 1995-09-25 WO PCT/JP1995/001922 patent/WO1996010023A1/ja active IP Right Grant
- 1995-09-25 AT AT95932217T patent/ATE209644T1/de not_active IP Right Cessation
- 1995-09-25 DE DE69524246T patent/DE69524246T2/de not_active Expired - Fee Related
- 1995-09-25 MX MX9702244A patent/MX9702244A/es not_active IP Right Cessation
- 1995-09-25 CN CN95195237A patent/CN1067387C/zh not_active Expired - Fee Related
- 1995-09-25 RU RU97104870/04A patent/RU2149873C1/ru not_active IP Right Cessation
- 1995-09-25 CA CA002199468A patent/CA2199468C/en not_active Expired - Fee Related
- 1995-09-25 KR KR1019970701879A patent/KR100392151B1/ko not_active IP Right Cessation
- 1995-09-25 HU HU9702043A patent/HU223945B1/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE209644T1 (de) | 2001-12-15 |
KR100392151B1 (ko) | 2003-11-20 |
RU2149873C1 (ru) | 2000-05-27 |
WO1996010023A1 (fr) | 1996-04-04 |
PL320059A1 (en) | 1997-09-01 |
UA44283C2 (uk) | 2002-02-15 |
CN1168670A (zh) | 1997-12-24 |
HU223945B1 (hu) | 2005-03-29 |
US6096743A (en) | 2000-08-01 |
MX9702244A (es) | 1997-06-28 |
AU3533795A (en) | 1996-04-19 |
AU684392B2 (en) | 1997-12-11 |
PT784054E (pt) | 2002-05-31 |
PL181532B1 (pl) | 2001-08-31 |
CN1067387C (zh) | 2001-06-20 |
ES2168383T3 (es) | 2002-06-16 |
CA2199468A1 (en) | 1996-04-04 |
EP0784054A1 (en) | 1997-07-16 |
KR970706274A (ko) | 1997-11-03 |
DE69524246T2 (de) | 2002-06-27 |
EP0784054B1 (en) | 2001-11-28 |
HUT77442A (hu) | 1998-04-28 |
EP0784054A4 (en) | 1998-01-07 |
CA2199468C (en) | 2006-06-06 |
DE69524246D1 (de) | 2002-01-10 |
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