PT784054E - Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamato - Google Patents
Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamatoInfo
- Publication number
- PT784054E PT784054E PT95932217T PT95932217T PT784054E PT 784054 E PT784054 E PT 784054E PT 95932217 T PT95932217 T PT 95932217T PT 95932217 T PT95932217 T PT 95932217T PT 784054 E PT784054 E PT 784054E
- Authority
- PT
- Portugal
- Prior art keywords
- group
- substituted
- carboxyl
- mono
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23190894 | 1994-09-27 | ||
| JP5948295 | 1995-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT784054E true PT784054E (pt) | 2002-05-31 |
Family
ID=26400527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95932217T PT784054E (pt) | 1994-09-27 | 1995-09-25 | Derivados de tetraidroquinoxalinadiona 1,2,3,4 e sua utilizacao como antagonistas do receptor glutamato |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6096743A (pt) |
| EP (1) | EP0784054B1 (pt) |
| KR (1) | KR100392151B1 (pt) |
| CN (1) | CN1067387C (pt) |
| AT (1) | ATE209644T1 (pt) |
| CA (1) | CA2199468C (pt) |
| DE (1) | DE69524246T2 (pt) |
| DK (1) | DK0784054T3 (pt) |
| ES (1) | ES2168383T3 (pt) |
| HU (1) | HU223945B1 (pt) |
| MX (1) | MX9702244A (pt) |
| PL (1) | PL181532B1 (pt) |
| PT (1) | PT784054E (pt) |
| RU (1) | RU2149873C1 (pt) |
| UA (1) | UA44283C2 (pt) |
| WO (1) | WO1996010023A1 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057304A (en) * | 1992-10-26 | 2000-05-02 | Schering Aktiengesellschaft | Quinoxaline-phosphonic acid derivatives |
| DE19519979A1 (de) * | 1995-05-24 | 1996-11-28 | Schering Ag | Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln |
| TW448171B (en) * | 1996-06-06 | 2001-08-01 | Yamanouchi Pharma Co Ltd | Imidazole-substituted quinoxalinedione derivatives |
| EP0980865B1 (en) * | 1997-03-14 | 2003-11-26 | Meiji Seika Kaisha Ltd. | Physiologically active substance pf1191 and process for producing the same |
| DE19728326A1 (de) * | 1997-06-27 | 1999-01-07 | Schering Ag | Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln |
| US6525054B1 (en) * | 1998-06-01 | 2003-02-25 | Shionogi & Co., Ltd. | Cyanoiminoquinoxaline derivatives |
| DE60027546T2 (de) | 1999-02-15 | 2007-04-26 | Eisai Co., Ltd. | Heterodiazinon-derivate |
| US6790978B2 (en) | 1999-03-29 | 2004-09-14 | Novartis Ag | Thyromimetic organic compounds |
| US6599942B1 (en) | 1999-03-29 | 2003-07-29 | Novartis Ag | Thyromimetic organic compounds |
| US6709667B1 (en) | 1999-08-23 | 2004-03-23 | Conceptus, Inc. | Deployment actuation system for intrafallopian contraception |
| CN1298704C (zh) * | 2000-01-24 | 2007-02-07 | 神经研究公司 | 具有神经营养活性的靛红衍生物 |
| KR100850728B1 (ko) | 2000-06-12 | 2008-08-06 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 1,2-디하이드로피리딘 화합물, 그의 제조 방법 및 그의 용도 |
| DK1522590T3 (da) * | 2000-06-28 | 2009-12-21 | Glycofi Inc | Fremgangsmåde til fremstilling af modificerede glykoproteiner |
| EP1436258A4 (en) * | 2001-03-08 | 2005-03-23 | Univ Emory | ANTAGONISTS OF THE NMDA RECEPTOR DEPENDENT OF PH |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| MXPA04009496A (es) * | 2002-03-29 | 2005-01-25 | Yamanouchi Pharma Co Ltd | Remedio para glioblastoma. |
| WO2003087091A1 (fr) * | 2002-04-17 | 2003-10-23 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau cristal d'anhydride de derive de quinoxalinedione |
| JPWO2004002488A1 (ja) * | 2002-06-28 | 2005-10-27 | アステラス製薬株式会社 | 脳出血治療剤 |
| US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
| GB0405034D0 (en) * | 2004-03-05 | 2004-04-07 | Novartis Ag | Organic compounds |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| US20060270709A1 (en) * | 2005-04-04 | 2006-11-30 | Eisai Co. Ltd. | Dihydropyridine compounds and compositions for headaches |
| WO2007020521A1 (en) * | 2005-08-16 | 2007-02-22 | Pharmacia & Upjohn Company Llc | Pyridoyrazinones as pde-5 inhibitors |
| CN101679317B (zh) * | 2007-05-29 | 2012-10-31 | 参天制药株式会社 | 具有糖皮质激素受体结合活性且具有导入了磺酸酯或磺酰胺结构的苯基作为取代基的1，2，3，4-四氢喹喔啉衍生物 |
| CN101815518B (zh) * | 2007-06-29 | 2013-01-09 | 埃莫里大学 | 用于神经保护的nmda受体拮抗剂 |
| WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
| WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
| EP2338492A1 (en) * | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
| EP3893844A1 (en) | 2018-12-14 | 2021-10-20 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
| WO2023042887A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
| EP4403185A1 (en) | 2021-09-15 | 2024-07-24 | University of The Ryukyus | Pharmaceutical composition for treating cognitive decline or for treating overweightness or obesity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69132340T2 (de) * | 1990-11-06 | 2001-02-08 | Yamanouchi Pharmaceutical Co., Ltd. | Kondensiertes pyrazinderivat |
| PT101004B (pt) * | 1991-10-26 | 1999-10-29 | Schering Ag | Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem |
| IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| JPH07165756A (ja) * | 1993-12-14 | 1995-06-27 | Yamanouchi Pharmaceut Co Ltd | ヒドロキシキノキサリンジオン誘導体 |
| US5654303A (en) * | 1995-06-07 | 1997-08-05 | Warner-Lambert Company | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
-
1995
- 1995-09-25 WO PCT/JP1995/001922 patent/WO1996010023A1/ja active IP Right Grant
- 1995-09-25 HU HU9702043A patent/HU223945B1/hu not_active IP Right Cessation
- 1995-09-25 US US08/809,087 patent/US6096743A/en not_active Expired - Fee Related
- 1995-09-25 UA UA97031348A patent/UA44283C2/uk unknown
- 1995-09-25 CA CA002199468A patent/CA2199468C/en not_active Expired - Fee Related
- 1995-09-25 EP EP95932217A patent/EP0784054B1/en not_active Expired - Lifetime
- 1995-09-25 DK DK95932217T patent/DK0784054T3/da active
- 1995-09-25 RU RU97104870/04A patent/RU2149873C1/ru not_active IP Right Cessation
- 1995-09-25 KR KR1019970701879A patent/KR100392151B1/ko not_active IP Right Cessation
- 1995-09-25 PT PT95932217T patent/PT784054E/pt unknown
- 1995-09-25 PL PL95320059A patent/PL181532B1/pl not_active IP Right Cessation
- 1995-09-25 DE DE69524246T patent/DE69524246T2/de not_active Expired - Fee Related
- 1995-09-25 MX MX9702244A patent/MX9702244A/es not_active IP Right Cessation
- 1995-09-25 AT AT95932217T patent/ATE209644T1/de not_active IP Right Cessation
- 1995-09-25 CN CN95195237A patent/CN1067387C/zh not_active Expired - Fee Related
- 1995-09-25 ES ES95932217T patent/ES2168383T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0784054A1 (en) | 1997-07-16 |
| HU223945B1 (hu) | 2005-03-29 |
| WO1996010023A1 (fr) | 1996-04-04 |
| HUT77442A (hu) | 1998-04-28 |
| EP0784054B1 (en) | 2001-11-28 |
| DK0784054T3 (da) | 2002-03-25 |
| UA44283C2 (uk) | 2002-02-15 |
| CA2199468C (en) | 2006-06-06 |
| MX9702244A (es) | 1997-06-28 |
| DE69524246T2 (de) | 2002-06-27 |
| CN1168670A (zh) | 1997-12-24 |
| KR100392151B1 (ko) | 2003-11-20 |
| AU3533795A (en) | 1996-04-19 |
| DE69524246D1 (de) | 2002-01-10 |
| PL320059A1 (en) | 1997-09-01 |
| AU684392B2 (en) | 1997-12-11 |
| RU2149873C1 (ru) | 2000-05-27 |
| EP0784054A4 (en) | 1998-01-07 |
| ATE209644T1 (de) | 2001-12-15 |
| US6096743A (en) | 2000-08-01 |
| KR970706274A (ko) | 1997-11-03 |
| CA2199468A1 (en) | 1996-04-04 |
| PL181532B1 (pl) | 2001-08-31 |
| ES2168383T3 (es) | 2002-06-16 |
| CN1067387C (zh) | 2001-06-20 |
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