DE69911557D1 - Imidazoline Derivate,ihre Herstellung und pharmazeutische Zusammensetzungen die sie enthalten - Google Patents

Imidazoline Derivate,ihre Herstellung und pharmazeutische Zusammensetzungen die sie enthalten

Info

Publication number
DE69911557D1
DE69911557D1 DE69911557T DE69911557T DE69911557D1 DE 69911557 D1 DE69911557 D1 DE 69911557D1 DE 69911557 T DE69911557 T DE 69911557T DE 69911557 T DE69911557 T DE 69911557T DE 69911557 D1 DE69911557 D1 DE 69911557D1
Authority
DE
Germany
Prior art keywords
alkyl
imidazoline derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69911557T
Other languages
English (en)
Other versions
DE69911557T2 (de
Inventor
Alex Cordi
Jean-Michel Lacoste
Mark Millan
Adrian Newman-Tancredi
Alain Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Application granted granted Critical
Publication of DE69911557D1 publication Critical patent/DE69911557D1/de
Publication of DE69911557T2 publication Critical patent/DE69911557T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C07D233/10—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69911557T 1998-12-18 1999-12-17 Imidazoline Derivate,ihre Herstellung und pharmazeutische Zusammensetzungen die sie enthalten Expired - Lifetime DE69911557T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9815999 1998-12-18
FR9815999A FR2787451B1 (fr) 1998-12-18 1998-12-18 Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE69911557D1 true DE69911557D1 (de) 2003-10-30
DE69911557T2 DE69911557T2 (de) 2004-06-17

Family

ID=9534132

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69911557T Expired - Lifetime DE69911557T2 (de) 1998-12-18 1999-12-17 Imidazoline Derivate,ihre Herstellung und pharmazeutische Zusammensetzungen die sie enthalten

Country Status (22)

Country Link
US (1) US6127396A (de)
EP (1) EP1010693B1 (de)
JP (1) JP3526800B2 (de)
KR (1) KR100492160B1 (de)
CN (1) CN1183907C (de)
AT (1) ATE250586T1 (de)
AU (1) AU767856B2 (de)
BR (1) BR9907497A (de)
CA (1) CA2292927C (de)
DE (1) DE69911557T2 (de)
DK (1) DK1010693T3 (de)
EA (1) EA004536B1 (de)
ES (1) ES2209362T3 (de)
FR (1) FR2787451B1 (de)
HK (1) HK1027573A1 (de)
HU (1) HUP9904628A3 (de)
NO (1) NO314544B1 (de)
NZ (1) NZ501785A (de)
PL (1) PL202198B1 (de)
PT (1) PT1010693E (de)
SI (1) SI1010693T1 (de)
ZA (1) ZA997734B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA981080B (en) * 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
NZ501822A (en) * 1997-10-02 2001-12-21 Yukijirushi Nyugyo Kabushiki K Therapeutic agents for male and female sex hormone dependent diseases
US6559157B2 (en) 1997-10-02 2003-05-06 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalene compounds
AU2001296542B2 (en) * 2000-10-02 2007-10-25 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
CA2589363A1 (en) * 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
BRPI0812833A2 (pt) * 2007-07-03 2014-12-09 Hoffmann La Roche 4-imidazolinas e seu uso como antidepressivos
WO2009089285A2 (en) * 2008-01-07 2009-07-16 Emory University Branched diepoxide compounds for the treatment of inflammatory disorders
US20100298305A1 (en) * 2008-11-26 2010-11-25 The United States Government, As Represented By The Department Of Veterans Affairs Tizanidine for the treatment of post-traumatic stress disorder and nightmares
US8771391B2 (en) 2011-02-22 2014-07-08 Baker Hughes Incorporated Methods of forming polycrystalline compacts
JP6692162B2 (ja) * 2014-01-17 2020-05-13 キッセイ薬品工業株式会社 α−置換グリシンアミド誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3367391D1 (en) * 1982-12-23 1986-12-11 Ici America Inc Chroman compounds
US4540705A (en) * 1983-03-14 1985-09-10 Sterling Drug Inc. Antidepressant imidazolines and related compounds
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent
DE3583900D1 (de) * 1984-06-06 1991-10-02 Abbott Lab Adrenergische verbindungen.
JPH01242571A (ja) * 1988-03-22 1989-09-27 Mitsui Petrochem Ind Ltd イミダゾール誘導体の製造方法
US5151526A (en) * 1990-10-11 1992-09-29 The United States Of America As Represented By The Secretary Of The Army 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic
KR920008026A (ko) * 1990-10-24 1992-05-27 오노 화아마슈티칼 캄파니 리미팃드 이소퀴놀리논 유도체 또는 이의 무독성 산부가염 또는 이의 수화물, 이의 제조방법 및 이를 포함하는 약제 조성물
WO1994007866A1 (en) * 1992-10-06 1994-04-14 Tokyo Tanabe Company Limited Aromatase inhibitor
DE19605400A1 (de) * 1996-02-14 1997-08-21 Bayer Ag Salze von Imidazolin-Derivaten
FR2756560A1 (fr) * 1996-12-04 1998-06-05 Adir Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
SI1010693T1 (en) 2004-02-29
BR9907497A (pt) 2000-09-26
JP3526800B2 (ja) 2004-05-17
EA199901050A3 (ru) 2000-10-30
PL337196A1 (en) 2000-06-19
EA004536B1 (ru) 2004-06-24
NO314544B1 (no) 2003-04-07
KR20000052509A (ko) 2000-08-25
CN1183907C (zh) 2005-01-12
ZA997734B (en) 2000-06-29
AU6529099A (en) 2000-06-22
HUP9904628A2 (hu) 2000-08-28
ATE250586T1 (de) 2003-10-15
NZ501785A (en) 2001-01-26
DK1010693T3 (da) 2004-02-09
JP2000178255A (ja) 2000-06-27
HU9904628D0 (en) 2000-02-28
EP1010693B1 (de) 2003-09-24
CA2292927A1 (fr) 2000-06-18
HK1027573A1 (en) 2001-01-19
CN1257864A (zh) 2000-06-28
FR2787451B1 (fr) 2001-01-26
US6127396A (en) 2000-10-03
DE69911557T2 (de) 2004-06-17
KR100492160B1 (ko) 2005-06-02
EP1010693A1 (de) 2000-06-21
FR2787451A1 (fr) 2000-06-23
PL202198B1 (pl) 2009-06-30
NO996284L (no) 2000-06-19
AU767856B2 (en) 2003-11-27
CA2292927C (fr) 2005-09-13
EA199901050A2 (ru) 2000-06-26
PT1010693E (pt) 2003-12-31
NO996284D0 (no) 1999-12-17
HUP9904628A3 (en) 2001-02-28
ES2209362T3 (es) 2004-06-16

Similar Documents

Publication Publication Date Title
EA200400432A1 (ru) Производные мочевины
IL114894A (en) Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
DK0928788T3 (da) Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler
PT992509E (pt) Novos derivados macrolidos
DE69911557D1 (de) Imidazoline Derivate,ihre Herstellung und pharmazeutische Zusammensetzungen die sie enthalten
CA2119662A1 (fr) Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69330601D1 (de) Serotoninergische ergolin derivate
ES2071786T3 (es) Compuestos bloqueadores de nmda, composiciones farmaceuticas, su preparacion y su uso.
MX9206930A (es) Nuevos compuestos
DE69910156D1 (de) Spiroimidazolinderivate und ihre Verwendung als alpha2-Adrenorezeptor-Antagonisten und Monoamino-Wiederaufnahme-Blocker
HU9602534D0 (en) Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
ATE258934T1 (de) Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
IL83216A (en) 1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
ATE228359T1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
ATE96144T1 (de) 2-aminoacetamid derivate.
DK0952157T3 (da) 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
DE69407227D1 (de) Die Verwendung von 2-Phenylmethylene-1-3'-(amino)-2-(hydroxy)-propoxy-imino-cyclohexane-Derivaten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition