ES2071786T3 - Compuestos bloqueadores de nmda, composiciones farmaceuticas, su preparacion y su uso. - Google Patents

Compuestos bloqueadores de nmda, composiciones farmaceuticas, su preparacion y su uso.

Info

Publication number
ES2071786T3
ES2071786T3 ES90312147T ES90312147T ES2071786T3 ES 2071786 T3 ES2071786 T3 ES 2071786T3 ES 90312147 T ES90312147 T ES 90312147T ES 90312147 T ES90312147 T ES 90312147T ES 2071786 T3 ES2071786 T3 ES 2071786T3
Authority
ES
Spain
Prior art keywords
designates
preparation
chained
straight
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90312147T
Other languages
English (en)
Inventor
Yoel Kloog
Jeffery J Feigenbaum
Raphael Mechoulam
Mordechai Sokolowsky
Simon Benita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ramot at Tel Aviv University Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Ramot at Tel Aviv University Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ramot at Tel Aviv University Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Ramot at Tel Aviv University Ltd
Application granted granted Critical
Publication of ES2071786T3 publication Critical patent/ES2071786T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA UTILIZACION DEL COMPUESTO DE LA FORMULA: CON LA CONFIGURACION DE (3S, 4S) Y LIBRE ESENCIALMENTE DEL ENANTIOMERO (3R, 4R), DONDE A---B DESIGNAN UNA DOBLE UNION 1(2) O 6(1), R DESIGNA -CH SUB 3 O -CH SUB 2 OH, R ELEVADO 1 DESIGNA UN ATOMO DE HIDROGENO O UN GRUPO DE BAJO ACIL, Y R (AL CUADRADO) DESIGNA (A) UN RADICAL ALCALINO DE CADENA DIRECTA O RAMIFICADA C SUB 6-12; O (B) UN GRUPO RADICAL ALCALINO C SUB 5-9 DE CADENA DIRECTA O RAMIFICADA O UN RADICAL SUSTITUIDO EN EL ATOMO DE CARBONO TERMINAL POR UN GRUPO DE FENILO EN LA FABRICACION DE UN MEDICAMENTO PARA REDUCIR O PREVENIR LA NEUROTOXICIDAD GLUTAMATICA. ALGUNOS DE LOS COMPUESTOS ANTERIORES SON NUEVOS Y SE DESCRIBE SU PREPARACION.
ES90312147T 1989-11-07 1990-11-06 Compuestos bloqueadores de nmda, composiciones farmaceuticas, su preparacion y su uso. Expired - Lifetime ES2071786T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL9223889A IL92238A (en) 1989-11-07 1989-11-07 ADMN blocking product containing tetrahydrocannabinol history, several new tetrahydrocannabinol histories and process for their preparation

Publications (1)

Publication Number Publication Date
ES2071786T3 true ES2071786T3 (es) 1995-07-01

Family

ID=11060554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90312147T Expired - Lifetime ES2071786T3 (es) 1989-11-07 1990-11-06 Compuestos bloqueadores de nmda, composiciones farmaceuticas, su preparacion y su uso.

Country Status (11)

Country Link
EP (1) EP0427518B1 (es)
JP (1) JPH0768235B2 (es)
KR (1) KR950005914B1 (es)
AT (1) ATE119898T1 (es)
AU (1) AU631262B2 (es)
CA (1) CA2029419C (es)
DE (1) DE69017839T2 (es)
DK (1) DK0427518T3 (es)
ES (1) ES2071786T3 (es)
IL (1) IL92238A (es)
ZA (1) ZA908914B (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6413948B1 (en) 1996-09-27 2002-07-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706903A1 (de) 1997-02-21 1998-08-27 Bayer Ag Verwendung von bekannten Agonisten des zentralen Cannabinoid-Rezeptors CB 1
AU743788B2 (en) * 1997-05-07 2002-02-07 Unimed Pharmaceuticals, Inc. Method of improving disturbed behavior and elevating mood in humans
ATE367809T1 (de) 1998-04-21 2007-08-15 Us Health Cannabinoiden als antioxidantien und neuroschützende mittel
ZA200802767B (en) 2005-09-29 2009-09-30 Amr Technology Inc Process for production of delta-9-tetrahydrocannabinol
DE102015112092B4 (de) 2015-07-24 2022-03-10 Beko Technologies Gmbh Öl/Wasser-Trennvorrichtung mit Druckluftbeaufschlagung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48824A (en) * 1976-01-12 1980-05-30 Yissum Res Dev Co Pharmaceutical compositions containing (3s,js) tetrahydrocanabinol derivatives and some novel compounds of this type
US4133819A (en) * 1977-06-17 1979-01-09 Pfizer Inc. Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
US4209520A (en) * 1977-06-17 1980-06-24 Pfizer Inc. Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
IL80411A (en) * 1986-10-24 1991-08-16 Raphael Mechoulam Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US5985855A (en) 1996-09-27 1999-11-16 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using NAALADase inhibitors
US6004946A (en) 1996-09-27 1999-12-21 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6413948B1 (en) 1996-09-27 2002-07-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors

Also Published As

Publication number Publication date
IL92238A (en) 1995-07-31
CA2029419A1 (en) 1991-05-08
EP0427518B1 (en) 1995-03-15
IL92238A0 (es) 1990-07-26
EP0427518A1 (en) 1991-05-15
AU631262B2 (en) 1992-11-19
KR950005914B1 (ko) 1995-06-07
CA2029419C (en) 2004-05-25
DE69017839T2 (de) 1995-08-31
ZA908914B (en) 1991-09-25
JPH0768235B2 (ja) 1995-07-26
ATE119898T1 (de) 1995-04-15
DE69017839D1 (de) 1995-04-20
KR910009687A (ko) 1991-06-28
JPH03209377A (ja) 1991-09-12
AU6583490A (en) 1991-05-30
DK0427518T3 (da) 1995-07-24

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