KR970706274A - 1,2,3,4-테트라하이드로퀴녹살린디온 유도체(1,2,3,4-Tetrahydroquinoxalinedione derivative) - Google Patents
1,2,3,4-테트라하이드로퀴녹살린디온 유도체(1,2,3,4-Tetrahydroquinoxalinedione derivative) Download PDFInfo
- Publication number
- KR970706274A KR970706274A KR1019970701879A KR19970701879A KR970706274A KR 970706274 A KR970706274 A KR 970706274A KR 1019970701879 A KR1019970701879 A KR 1019970701879A KR 19970701879 A KR19970701879 A KR 19970701879A KR 970706274 A KR970706274 A KR 970706274A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- salt
- substituted
- pharmaceutical composition
- carboxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
다음 화학식 (Ⅰ)의 1,2,3,4-테트라하이드로퀴녹살린디온 유도체 또는 이의 염 및 이를 함유하는 NMDA-글리신 수용체 및/또는 AMPA 수용체 길항제, 카이닌 신경세포 독성 작용 억제제. 또는 당해 화합물과 약제학적으로 허용되는 담체를 포함하는 약제 조성물.
상기 화학식 (Ⅰ)에서, X는 N 또는 CH이고, R은 이미다졸릴 그룹 또는 디-저급 알킬아미노 그룹이며, R1은 (1) 할로겐 원자, 니트로 그룹, 시아노 그룹, 카복실 그룹, 아미노 그룹, 모노- 또는 디-저급 알킬아미노 그룹, 저급 알카노일 그룹, 저급 알킬티오 그룹, 저급 알킬술피닐 그룹 또는 저급 알킬술포닐 그룹, 카바모일 그룹, (2) 할로겐 원자, 카복실 그룹 또는 아릴 그룹에 의해 치환될 수 있는 저급 알킬 그룹 또는 저급 알콕시 그룹 또는 (3) 저급 알콕시카보닐 그룹 또는 카복실 그룹에 의해 치환될 수 있는 페닐 옥시 그룹이고, R2는 하이드록실 그룹, 저급 알콕시 그룹, 아미노 그룹 또는 모노- 또는 디-저급 알킬아미노 그룹이며, A는 치환될 수 있는 저급 알킬렌 그룹 또는 화학식 -O-B-의 그룹이고, B는 저급 알킬렌 그룹이며, 단, R이 이미다졸 그룹이고 R1이 시아노 그룹이며 A가 에틸렌 그룹이고 R2가 하이드록실 그룹인 경우는 제외한다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 화학식 (Ⅰ)의 1,2,3,4-테트라하이드로퀴녹살린디온 유도체, 이의 토토머, 이의 염, 이의 수화물 또는 이의 용매화물.상기 화학식 (Ⅰ)에서, X는 질소원자 또는 화학식 CH의 그룹이고, R은 이미다졸릴 그룹 또는 디-저급 알킬아미노 그룹이며, R1은 (1) 할로겐 원자, 니트로 그룹, 시아노 그룹, 카복실 그룹, 아미노 그룹, 모노- 또는 디-저급 알킬아미노 그룹, 저급 알카노일 그룹, 저급 알킬티오 그룹, 저급 알킬술피닐 그룹 또는 저급 알킬술포닐 그룹, 카바모일 그룹, (2) 할로겐 원자, 카복실 그룹 또는 아릴 그룹에 의해 치환될 수 있는 저급 알킬 그룹 또는 저급 알콕시 그룹 또는 (3) 저급 알콕시카보닐 그룹 또는 카복실 그룹에 의해 치환될 수 있는 페닐옥시 그룹이고, R2는 하이드록실 그룹, 저급 알콕시 그룹, 아미노 그룹 또는 모노- 또는 디-저급 알킬아미노 그룹이며, A는 치환될 수 있는 저급 알킬렌 그룹 또는 화학식 -O-B-의 그룹이고, B는 저급 알킬렌 그룹이고, 단, R이 이미다졸 그룹이고 R1이 시아노 그룹이며 A가 에틸렌 그룹이고 R2가 하이드록실 그룹인 경우는 제외한다.
- 제1항에 있어서, R이 이미다졸릴 그룹이고, R1이 (1) 할로겐 원자, 니트로 그룹, 시아노 그룹, 카복실 그룹, 모노- 또는 디-저급 알킬아미노 그룹, 저급 알킬 술피닐 그룹, 저급 알킬술포닐 그룹 또는 카바모일 그룹, (2) 카복실 그룹 또는 아릴 그룹에 의해 치환될 수 있는 저급 알킬 그룹 또는 저급 알콕시 그룹 또는 (3) 저급 알콕시카보닐 그룹에 의해 치환될 수 있는 페닐옥시 그룹인 화학식 (Ⅰ)의 화합물 또는 이의 염.
- 제2항에 있어서, R이 1-이미다졸릴 그룹이고 X가 화학식 CH의 그룹이며 R1이 할로겐 원자, 니트로 그룹, 트리플루오로메틸 그룹, 시아노 그룹 또는 벤질옥시 그룹인 화학식 (Ⅰ)의 화합물 또는 이의 염.
- 2-[2,3-디옥소-7-(1H-이미다졸-1-일)-6-니트로-1,2,3,4-테트라하이드로퀴녹살린-1-일] 아세트산 또는 이의 염.
- 2-[2,3-디옥소-7-(1H-이미다졸-1-일)-6-트리플루오로메틸-1,2,3,4-테트라하이드로퀴녹살린-1-일]아세트산 또는 이의 염.
- 2-[6-벤질옥시-2,3-디옥소-7-(1H-이미다졸-1-일)-1,2,3,4-테트라하이드로퀴녹살린-1-일]아세트산 또는 이의 염.
- 제1항의 화합물 또는 약제학적으로 허용되는 이의 염과 약제학적으로 허용되는 담체를 포함하는 약제 조성물.
- 제7항에 있어서, 글루타메이트 수용체 길항제인 약제 조성물.
- 제7항 또는 제8항에 있어서, NMDA-글리신 수용체 길항제 및/또는 AMPA 수용체 길항제인 약제 조성물.
- 제7항 또는 제8항에 있어서, 카이닌산 신경세포 독성 억제제인 약제 조성물.
- 제7항 또는 제8항에 있어서, 향허혈약인 약제 조성물.
- 제7항 또는 제8항에 있어서, 향정신약인 약제 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23190894 | 1994-09-27 | ||
JP94-231908 | 1994-09-27 | ||
JP5948295 | 1995-03-17 | ||
JP95-059482 | 1995-03-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970706274A true KR970706274A (ko) | 1997-11-03 |
KR100392151B1 KR100392151B1 (ko) | 2003-11-20 |
Family
ID=26400527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970701879A KR100392151B1 (ko) | 1994-09-27 | 1995-09-25 | 1,2,3,4-테트라하이드로퀴녹살린디온유도체및이를포함하는약제학적조성물 |
Country Status (16)
Country | Link |
---|---|
US (1) | US6096743A (ko) |
EP (1) | EP0784054B1 (ko) |
KR (1) | KR100392151B1 (ko) |
CN (1) | CN1067387C (ko) |
AT (1) | ATE209644T1 (ko) |
CA (1) | CA2199468C (ko) |
DE (1) | DE69524246T2 (ko) |
DK (1) | DK0784054T3 (ko) |
ES (1) | ES2168383T3 (ko) |
HU (1) | HU223945B1 (ko) |
MX (1) | MX9702244A (ko) |
PL (1) | PL181532B1 (ko) |
PT (1) | PT784054E (ko) |
RU (1) | RU2149873C1 (ko) |
UA (1) | UA44283C2 (ko) |
WO (1) | WO1996010023A1 (ko) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057304A (en) * | 1992-10-26 | 2000-05-02 | Schering Aktiengesellschaft | Quinoxaline-phosphonic acid derivatives |
DE19519979A1 (de) * | 1995-05-24 | 1996-11-28 | Schering Ag | Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln |
TW448171B (en) * | 1996-06-06 | 2001-08-01 | Yamanouchi Pharma Co Ltd | Imidazole-substituted quinoxalinedione derivatives |
ATE255089T1 (de) * | 1997-03-14 | 2003-12-15 | Meiji Seika Kaisha | Physiologisch aktive substanz pf1191 und verfahren zu ihrer herstellung |
DE19728326A1 (de) * | 1997-06-27 | 1999-01-07 | Schering Ag | Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln |
NZ508280A (en) | 1998-06-01 | 2002-09-27 | Shionogi & Co | 2- or 3-cyanoiminoquinoxaline derivatives useful as glutamate receptor antagonists |
CA2362385C (en) | 1999-02-15 | 2009-08-11 | Eisai Co., Ltd. | Heterodiazinon compound |
US6790978B2 (en) | 1999-03-29 | 2004-09-14 | Novartis Ag | Thyromimetic organic compounds |
US6599942B1 (en) | 1999-03-29 | 2003-07-29 | Novartis Ag | Thyromimetic organic compounds |
US6709667B1 (en) | 1999-08-23 | 2004-03-23 | Conceptus, Inc. | Deployment actuation system for intrafallopian contraception |
WO2001055110A1 (en) * | 2000-01-24 | 2001-08-02 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
NZ522773A (en) | 2000-06-12 | 2005-06-24 | Eisai Co Ltd | 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof |
DE60139720D1 (de) * | 2000-06-28 | 2009-10-08 | Glycofi Inc | Verfahren für die Herstellung modifizierter Glykoproteine |
US7375136B2 (en) * | 2001-03-08 | 2008-05-20 | Emory University | pH-dependent NMDA receptor antagonists |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
MXPA04009496A (es) * | 2002-03-29 | 2005-01-25 | Yamanouchi Pharma Co Ltd | Remedio para glioblastoma. |
EP1496057A4 (en) * | 2002-04-17 | 2006-05-03 | Astellas Pharma Inc | NEW QUINOXALINEDIONE DERIVATIVE ANHYDRIDE CRYSTAL |
US20050234063A1 (en) * | 2002-06-28 | 2005-10-20 | Kazuhiro Terai | Therapeutic agent for brain hemorrhage |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
GB0405034D0 (en) * | 2004-03-05 | 2004-04-07 | Novartis Ag | Organic compounds |
MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
RS51822B (en) * | 2005-04-04 | 2012-02-29 | Eisai R. &D. Management Co. Ltd. | DIHYDROPYRIDINE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND Dementia |
WO2007020521A1 (en) * | 2005-08-16 | 2007-02-22 | Pharmacia & Upjohn Company Llc | Pyridoyrazinones as pde-5 inhibitors |
KR20100022456A (ko) * | 2007-05-29 | 2010-03-02 | 산텐 세이야꾸 가부시키가이샤 | 글루코코르티코이드 수용체 결합 활성을 갖는, 술폰산에스테르 또는 술폰산아미드 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2,3,4-테트라히드로퀴녹살린 유도체 |
US8420680B2 (en) * | 2007-06-29 | 2013-04-16 | Emory University | NMDA receptor antagonists for neuroprotection |
WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
EP2338492A1 (en) * | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
WO2020124090A1 (en) | 2018-12-14 | 2020-06-18 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
WO2023042887A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
WO2023042888A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2550456B2 (ja) * | 1990-11-06 | 1996-11-06 | 山之内製薬株式会社 | 縮合ピラジン誘導体 |
PT101004B (pt) * | 1991-10-26 | 1999-10-29 | Schering Ag | Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem |
IL109397A0 (en) * | 1993-04-28 | 1994-07-31 | Schering Ag | Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
JPH07165756A (ja) * | 1993-12-14 | 1995-06-27 | Yamanouchi Pharmaceut Co Ltd | ヒドロキシキノキサリンジオン誘導体 |
US5654303A (en) * | 1995-06-07 | 1997-08-05 | Warner-Lambert Company | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
-
1995
- 1995-09-25 US US08/809,087 patent/US6096743A/en not_active Expired - Fee Related
- 1995-09-25 WO PCT/JP1995/001922 patent/WO1996010023A1/ja active IP Right Grant
- 1995-09-25 HU HU9702043A patent/HU223945B1/hu not_active IP Right Cessation
- 1995-09-25 PL PL95320059A patent/PL181532B1/pl not_active IP Right Cessation
- 1995-09-25 DK DK95932217T patent/DK0784054T3/da active
- 1995-09-25 CN CN95195237A patent/CN1067387C/zh not_active Expired - Fee Related
- 1995-09-25 CA CA002199468A patent/CA2199468C/en not_active Expired - Fee Related
- 1995-09-25 RU RU97104870/04A patent/RU2149873C1/ru not_active IP Right Cessation
- 1995-09-25 UA UA97031348A patent/UA44283C2/uk unknown
- 1995-09-25 AT AT95932217T patent/ATE209644T1/de not_active IP Right Cessation
- 1995-09-25 MX MX9702244A patent/MX9702244A/es not_active IP Right Cessation
- 1995-09-25 PT PT95932217T patent/PT784054E/pt unknown
- 1995-09-25 EP EP95932217A patent/EP0784054B1/en not_active Expired - Lifetime
- 1995-09-25 ES ES95932217T patent/ES2168383T3/es not_active Expired - Lifetime
- 1995-09-25 DE DE69524246T patent/DE69524246T2/de not_active Expired - Fee Related
- 1995-09-25 KR KR1019970701879A patent/KR100392151B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2149873C1 (ru) | 2000-05-27 |
WO1996010023A1 (fr) | 1996-04-04 |
HU223945B1 (hu) | 2005-03-29 |
DE69524246T2 (de) | 2002-06-27 |
PL320059A1 (en) | 1997-09-01 |
DE69524246D1 (de) | 2002-01-10 |
EP0784054B1 (en) | 2001-11-28 |
PT784054E (pt) | 2002-05-31 |
DK0784054T3 (da) | 2002-03-25 |
ES2168383T3 (es) | 2002-06-16 |
UA44283C2 (uk) | 2002-02-15 |
KR100392151B1 (ko) | 2003-11-20 |
MX9702244A (es) | 1997-06-28 |
CN1168670A (zh) | 1997-12-24 |
AU684392B2 (en) | 1997-12-11 |
HUT77442A (hu) | 1998-04-28 |
ATE209644T1 (de) | 2001-12-15 |
CN1067387C (zh) | 2001-06-20 |
CA2199468A1 (en) | 1996-04-04 |
AU3533795A (en) | 1996-04-19 |
EP0784054A1 (en) | 1997-07-16 |
EP0784054A4 (en) | 1998-01-07 |
CA2199468C (en) | 2006-06-06 |
US6096743A (en) | 2000-08-01 |
PL181532B1 (pl) | 2001-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR970706274A (ko) | 1,2,3,4-테트라하이드로퀴녹살린디온 유도체(1,2,3,4-Tetrahydroquinoxalinedione derivative) | |
RU97104870A (ru) | 1,2,3,4-тетрагидрохиноксалиндионовое производное | |
IL95675A0 (en) | Pyrazole derivatives,processes for preparation thereof and pharmaceutical compositions containing the same | |
DE3684431D1 (de) | Derivate des ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2yl)methyl)-1h-imidazol und 1h-1,2,4-triazol. | |
IL104311A0 (en) | Pyrazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
KR880011131A (ko) | 치환된 트리아졸리논 | |
TW224464B (ko) | ||
KR900001688A (ko) | 벤조디아제핀 유도체 | |
AU6052594A (en) | New heterocyclic compounds | |
KR890000469A (ko) | (1h-아졸-1-일메틸)치환된 벤조트리아졸 유도체 | |
KR880007536A (ko) | 피롤로벤즈 이미다졸, 이들의 제조방법 및 이들을 함유하는 약리학적 조성물 | |
EP0299683A3 (en) | Heterocyclic olefinic compounds and their use as aromatase inhibitors | |
GR3021143T3 (en) | Imidazole derivatives and pharmaceutical compositions containing the same. | |
KR920012049A (ko) | 불소 화합물 | |
KR900014322A (ko) | 치환(퀴놀린-2-일-메톡시)페닐-n.n-술포닐우레아, 그의 제조방법 및 약물 용도 | |
KR900003143A (ko) | 시클로펜탄 유도체와 그의 제조방법 및 그를 포함하는 조성물 | |
NZ220703A (en) | Triazole and imidazole derivatives and pharmaceutical compositions | |
TW353012B (en) | Microbicide formulation for indoor use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20060626 Year of fee payment: 4 |
|
LAPS | Lapse due to unpaid annual fee |