KR900001688A - 벤조디아제핀 유도체 - Google Patents

벤조디아제핀 유도체 Download PDF

Info

Publication number
KR900001688A
KR900001688A KR1019890009654A KR890009654A KR900001688A KR 900001688 A KR900001688 A KR 900001688A KR 1019890009654 A KR1019890009654 A KR 1019890009654A KR 890009654 A KR890009654 A KR 890009654A KR 900001688 A KR900001688 A KR 900001688A
Authority
KR
South Korea
Prior art keywords
alkyl
hydrogen
halogen
compound
amino
Prior art date
Application number
KR1019890009654A
Other languages
English (en)
Inventor
요시나리 사토
테루아키 마투오
Original Assignee
후지사와 도모키치로
후지사와 야쿠힌 고오교오 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888816207A external-priority patent/GB8816207D0/en
Priority claimed from GB888820560A external-priority patent/GB8820560D0/en
Priority claimed from GB888823660A external-priority patent/GB8823660D0/en
Application filed by 후지사와 도모키치로, 후지사와 야쿠힌 고오교오 가부시기가이샤 filed Critical 후지사와 도모키치로
Publication of KR900001688A publication Critical patent/KR900001688A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

벤조디아제핀 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 구조식(I)의 화합물 및 그의 약학적 허용염.
    상기식에서, R1은 할로겐, 하나 또는 그 이상의 적합한 치환체를 지닌 헤테로 시클릭기, 하나 또는 그 이상의 적합한 치환체를 지닌 아릴, -NH-R5(R5는 할로겐, 저급 알카노일 또는 히드록시(저급)알킬임), -S-R6(R6는 저급 알킬, 카르복시 및 아미노로 치환된 저급알킬, 보호된 카르복시 및 보호된 아미노로 치환된 저급알킬 또는 피리딜임), -O-R7(R7은 수소, 히드록시 보호기, 저급 알킬, 저급 알케닐, 아르(저급)알킬, 할로(저급)알킬, 아미노(저급)알킬, 보호된 아미노(저급)알킬 또는 저급 알킬을 지닌 피페라지닐(저급)알킬임), -CONH-R8(R8은 시아노, 카르바모일(저급)알킬, 카르복시(저급)알킬, 보호된 카르복시(저급)알킬, 보호된 카르복시(저급)알킬, 또는 카르바모일 및 아릴로 치환된 저급 알킬), 또는 -Z-R9[R9는 수소 또는 저급 알킬이고, Z는(R10은 히드록시, 저급 알콕시 또는 아미노) 또는(R11은 카르복시 또는 보호된 카르복시이고, R12는 수소이고; 혹은 R11은 할로겐이고, R12는 할로게임)]이며 R12는 하나 또는 그 이상의 적합한 치환체를 지닌 아릴이며, R3는 수소, 또는 할로겐이며, R4는 수소 할로겐 또는 저급 알콕시이며, A는 저급 알킬렌임.
  2. 제 1 항에 있어서, R12는 하나 또는 그 이상의 적합한 치환체를 지니는 헤테로 시클릭기인 화합물.
  3. 제 2 항에 있어서, R1은 저급 알킬 또는 아미노 보호기를 지닌 2 또는 3의 질소 원자를 함유한 5-원 헤테로 모노 시클릭기이고, R2는 할로겐 원자를 지닌 페닐기인 화합물.
  4. 제 3 항에 있어서, R1은 이미다졸일, 피라졸일 또는 트리아졸일이며, 그 각각은 저급 알킬 및 이미노 보호기 또는 저급 알킬 또는 이미노 보호기를 지니는 화합물.
  5. 제 4 항에 있어서, R1은 가급 알킬기를 지니는 이미다졸일이고, R3는 수소이고, R4는 수소이고, A는 C1-C3알킬렌인 화합물.
  6. 제 5 항에 있어서, (3S)-1,3-디하이드로-1-(4-이미다졸일메틸)-3-(2-인돌일카르보닐아미노)-5-(2-플루오로페닐)-2H-1,4-벤조 디아제핀-2-온인 화합물.
  7. (1)하기식(II)의 화합물 또는 그 염을 하기식(III)의 화합물 또는 그 염과 반응시켜 하기식(I)의 화합물 또는 그 염을 제조하고, 또는 (2) 하기식(IV)의 화합물 또는 아미노기에서의 그의 반응성 유도체 또는 그 염을 하기식(V)의 화합물 또는 카르복실기에서의 그의 반응성 유도체 또는 그 염을 반응시켜 하기식(I)의 화합물 또는 그 염을 제조하고, 또는 (3) 하기식(I1) 또는 그 염을 이미노 보호기의 제거반응에 수반시켜 하기식(Im) 또는 그 염을 제조하는 것을 포함하는 하기식(I)의 화합물 또는 그 염을 제조하는 방법.
    상기식에서, R1은 할로겐, 하나 또는 그 이상의 적합한 치환체를 지닌 헤테로 시클릭기, 하나 또는 그 이상의 적합한 치환체를 지닌 아릴,-NH-R5(R5는 할로겐, 저급 알카노일 또는 히드록시(저급)알킬임), -S-R6(R6는 저급알킬, 카르복시 및 아미노로 치환된 저급알킬, 보호된 카르복시 및 보호된 아미노로 치환된 저급알킬 또는 피리딜임), -O-R7(R7은 수소, 히드록시 보호기, 저급 알킬, 저급 알케닐, 아르(저급)알킬, 할로(저급)알킬, 아미노(저급)알킬, 보호된 아미노(저급)알킬 또는 저급 알킬을 지닌 피페라지닐(저급)알킬임), -CONH-R8(R8은 시아노, 카르바모일(저급)알킬, 카르복시(저급)알킬, 보호된 카르복시(저급)알킬, 또는 카르바모일 및 아릴로 치환된 저급 알킬), 또는 -Z-R9(R9는 수소 또는 저급 알킬이고, Z는(R10은 히드록시, 저급 알콕시 또는 아미노)또는(R11은 카르복시 또는 보호된 카르복시이고, R12는 수소이고; 혹은 R11은 할로겐이고, R12는 할로겐임)]이며, R2는 하나 또는 그 이상의 적합한 치환체를 지닌 알릴이며, R3는 수소 또는 할로겐이며, R4는 수소, 할로겐 또는 저급 알콕시이며, A는 저급 알킬렌이며, X는 할로겐이며, R14는 수소 또는 저급 알킬이며, R15는 이미노 보호기이며, J는 CH 또는 N이며, Q는 CH 또는 N임.
  8. 활성 성분으로서의 제 1 항의 화합물 또는 그의 약학적 허용염과, 이와 혼합되는 약학적 허용 담체를 포함하는 약학적 조성물.
  9. 제 1 항의 화합물 또는 그의 약학적 허용염을 콜레시스토키닌 길항질로서 사용하는 방법.
  10. 제 1 항의 화합물 또는 그의 약학적 허용염을 사람 또는 동물에게 투여하는 것을 포함하는 구토 또는 췌장염의 치료 또는 예방방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009654A 1988-07-07 1989-07-06 벤조디아제핀 유도체 KR900001688A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP8816207.8 1988-07-07
GB888816207A GB8816207D0 (en) 1988-07-07 1988-07-07 Benzodiazepine derivatives
JP8820560.4 1988-08-31
GB888820560A GB8820560D0 (en) 1988-08-31 1988-08-31 Benzodiazepine derivatives
GB888823660A GB8823660D0 (en) 1988-10-07 1988-10-07 Benzodiazepine derivatives
JP8823660.9 1988-10-07

Publications (1)

Publication Number Publication Date
KR900001688A true KR900001688A (ko) 1990-02-27

Family

ID=27263983

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890009654A KR900001688A (ko) 1988-07-07 1989-07-06 벤조디아제핀 유도체

Country Status (17)

Country Link
US (1) US4970207A (ko)
EP (1) EP0349949B1 (ko)
JP (2) JP2536160B2 (ko)
KR (1) KR900001688A (ko)
CN (1) CN1041941A (ko)
AT (1) ATE147403T1 (ko)
AU (1) AU3785989A (ko)
CA (1) CA1334589C (ko)
DE (1) DE68927620T2 (ko)
DK (1) DK336589A (ko)
ES (1) ES2095833T3 (ko)
FI (1) FI95699C (ko)
GR (1) GR3022239T3 (ko)
HU (1) HUT50331A (ko)
IL (1) IL90830A (ko)
NO (1) NO173014C (ko)
PT (1) PT91092B (ko)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211939A (ja) * 1988-02-18 1989-08-25 Nec Kyushu Ltd イオン注入装置
US5264433A (en) * 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
GB9015879D0 (en) * 1990-07-19 1990-09-05 Fujisawa Pharmaceutical Co Benzodiazepine derivatives
AU654140B2 (en) * 1990-07-31 1994-10-27 Lilly Industries Limited N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
CA2071181A1 (en) * 1991-06-14 1992-12-15 Roger M. Freidinger Benzodiazepine analogs
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5583130A (en) * 1992-09-25 1996-12-10 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5317017A (en) * 1992-09-30 1994-05-31 Merck & Co., Inc. N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release
WO1994018229A1 (en) * 1993-02-03 1994-08-18 Fisons Corporation 1,2,4-triazinone derivatives and their use in therapy
US5284841A (en) * 1993-02-04 1994-02-08 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
JPH10504545A (ja) * 1994-07-29 1998-05-06 藤沢薬品工業株式会社 ベンゾジアゼピン誘導体
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
CA2257948A1 (en) * 1996-06-28 1998-01-08 Merck & Co., Inc. Antiarrhythmic combinations of selective iks antagonists with beta-adenergic blocking agents
US5929071A (en) * 1996-07-02 1999-07-27 Merck & Co., Inc. Method for the treatment of preterm labor
WO1998000406A1 (en) * 1996-07-02 1998-01-08 Merck & Co., Inc. Method for the treatment of preterm labor
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
ATE290545T1 (de) * 1996-12-06 2005-03-15 Vertex Pharma Inhibitoren des interleukin-1beta konvertierenden enzyms
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
DE60007960T2 (de) * 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
US6558690B2 (en) 2000-12-15 2003-05-06 Pacific Health Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
US6458795B1 (en) * 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
CN1812982B (zh) * 2003-06-26 2010-10-27 默沙东公司 苯并二氮杂*cgrp受体拮抗剂
JP2008528448A (ja) * 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
EP1893218A4 (en) 2005-06-01 2011-01-12 Univ Michigan NON-SOLVATED BENZODIAZEPINE PREPARATIONS AND METHODS
EP1948191B1 (en) 2005-11-01 2013-01-16 The Regents of the University of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (en) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders
CA2680017C (en) 2007-03-09 2013-11-12 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
CA2698248C (en) 2007-09-14 2017-08-29 The Regents Of The University Of Michigan Phenyl acyl guanidine derivatives as f1f0-atpase inhibitors and the use thereof
CA2703005A1 (en) 2007-11-06 2009-05-14 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US8497307B2 (en) 2008-09-11 2013-07-30 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
EP2470020A4 (en) 2009-09-18 2013-03-13 Univ Michigan BENZODIAZEPINONE COMPOUNDS AND TREATMENT METHODS THEREWITH
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
AU2010322287B2 (en) 2009-11-17 2014-04-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
CA2780333C (en) 2009-11-17 2016-05-24 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
EP2953484B1 (en) 2013-02-05 2019-01-16 Ludwig Stocker Hofpfisterei GmbH Use of microorganisms for the prevention and treatment of intestinal diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines

Also Published As

Publication number Publication date
FI893226A (fi) 1990-01-08
CA1334589C (en) 1995-02-28
FI95699B (fi) 1995-11-30
PT91092B (pt) 1995-05-04
JPH0256481A (ja) 1990-02-26
ES2095833T3 (es) 1997-03-01
DE68927620D1 (de) 1997-02-20
CN1041941A (zh) 1990-05-09
NO173014C (no) 1993-10-13
ATE147403T1 (de) 1997-01-15
EP0349949A3 (en) 1991-09-04
IL90830A (en) 1995-06-29
NO173014B (no) 1993-07-05
JP2536160B2 (ja) 1996-09-18
EP0349949A2 (en) 1990-01-10
DK336589A (da) 1990-01-08
GR3022239T3 (en) 1997-04-30
IL90830A0 (en) 1990-01-18
JPH07224060A (ja) 1995-08-22
AU3785989A (en) 1990-01-11
FI893226A0 (fi) 1989-07-03
US4970207A (en) 1990-11-13
FI95699C (fi) 1996-03-11
NO892799L (no) 1990-01-08
PT91092A (pt) 1990-02-08
EP0349949B1 (en) 1997-01-08
NO892799D0 (no) 1989-07-06
DK336589D0 (da) 1989-07-06
DE68927620T2 (de) 1997-04-24
HUT50331A (en) 1990-01-29

Similar Documents

Publication Publication Date Title
KR900001688A (ko) 벤조디아제핀 유도체
DE69230163T2 (de) Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
KR930010039A (ko) 인돌로피롤로카르바졸 유도체
DE69021472D1 (de) Pyrazolderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellung.
HUT62892A (en) Process for producing iso-and heterocyclic compounds furnished with imidazole ring and pharmaceutical compositions comprising same as active ingredient
IL107426A0 (en) Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same
KR910011895A (ko) 약제
KR930701446A (ko) 트리사이클릭 벤조디아제핀 유도체, 그의 제조방법 및 이를 함유하는 약제학적 조성물
KR930703292A (ko) 신규 퀴놀론 유도체 또는 그의 염 및 이 화합물을 함유하는 항균제
KR880006231A (ko) 이미다졸리디논 화합물 및 그의 제조 방법
KR890016013A (ko) 이환식 아민화합물 및 그 제조방법
KR930006024A (ko) 이미다조 인돌리진 유도체 및 그의 제조방법
IL148196A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
IL103826A0 (en) Thiazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ATE716T1 (de) Cytostatisch wirkende arzneimittel bzw. pharmazeutische zubereitungen.
KR900004717A (ko) 이미다졸 부정맥증 치료제
IL83216A (en) 1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
KR880011141A (ko) 신규한 화합물
KR930703275A (ko) 벤조옥사디논유도체
KR910007901A (ko) 5-{2-[(2-아미노-2-옥소에틸)(메틸)아미노] 에틸}-2,3-디히드로-3-히드록시-2-(4-메톡시페닐)-1,5(5h)-벤조티아제핀-4-온 유도체. 그의 제조 및 치료에 있어서의 그의 이용
KR950032159A (ko) 티아디아지논 유도체
TH44255B (th) สารสำหรับยับยั้งการผลิตไซโทไคน์ และสารสำหรับยับยั้งการจับเกาะเซลล์
TH36095A (th) สารสำหรับยับยั้งการผลิตไซโทไคน์ และสารสำหรับยับยั้งการจับเกาะเซลล์
KR920016405A (ko) 판토텐산 유도체
KR890013003A (ko) 벤즈이미다졸 카르바메이트 유도체

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application