KR930703275A - 벤조옥사디논유도체 - Google Patents

벤조옥사디논유도체

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Publication number
KR930703275A
KR930703275A KR1019930702219A KR930702219A KR930703275A KR 930703275 A KR930703275 A KR 930703275A KR 1019930702219 A KR1019930702219 A KR 1019930702219A KR 930702219 A KR930702219 A KR 930702219A KR 930703275 A KR930703275 A KR 930703275A
Authority
KR
South Korea
Prior art keywords
single bond
hydrogen atom
group
lower alkyl
serine protease
Prior art date
Application number
KR1019930702219A
Other languages
English (en)
Other versions
KR960008242B1 (ko
Inventor
고바야시 코지
마나베 슈니치
와타나베 요시히로
하야가와 가주히데
우치다 이츠오
Original Assignee
시게루 미즈노
재팬-타바코 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시게루 미즈노, 재팬-타바코 인코퍼레이티드 filed Critical 시게루 미즈노
Publication of KR930703275A publication Critical patent/KR930703275A/ko
Application granted granted Critical
Publication of KR960008242B1 publication Critical patent/KR960008242B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

일반식
〔식중, R, R1, R3은 동일 또는 상이하며, 수소원자 또는 저급알킬기이며 A는 할로겐원자로 치환되어도 좋은 페닐기, 헤테로고리 또는 아다만티기이며, B는 수소원자, 할로겐원자로 치환되어도 좋은 페닐기 또는 헤케로고리이며, U는 =CH-,=C 또는 =N-이며, V는 -O-,-CH2-,=N-,-NH- 또는 단일결합이며, X는 -O-,=CH-,-CH2- 또는 단일결합이며, Y는 -CH2-,-NH-,-O- 또는 단일결합이며, Z는 -CO- 또는 -CH2-이며, 1은 0내지 3의 정수이다〕로 표시되는 벤조옥사디논유도체 또는 약학적으로 허용되는 그것들의 산부가염, 상기 벤조옥사디논유도체[I]를 유효성분으로서 함유하는 항염증제 및 호중구침윤억제제 및 세린프로테아제 저해제에 관한 것이다.
본 발명 화합물은 뛰어난 프로테아제 저해활성, 호중구 주화억제활성 및 카라게닌유도공기주머니에의 호중구침운억제제 및 세린프로테아제 저해제로서 유용하다.

Description

벤조옥사디논유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 일반식
    〔식중, R은 수소원자 또는 저급알킬이며, R1은 수소원자 또는 저급알킬기이며, R2은 수소원자 또는 저급알킬기이며, R3는 수소원자 또는 저급알킬기이며, A는 할로겐원자로 치환되어도 좋은 페닐기, 헤테르고리 또는 아다민틸기이며, B는 할로겐원자로 치환되어도 좋은 페닐기, 또는 헤케로구리이며, U는이며 V는-O-,-CH2-,=N-,-NH-,-CH= 또는 단일결합이며,Y는 -CH2-,-NH-,-O- 또는 단일결합이며, Z는 -CO- 또는 -CH2-이며,…는 이중결합 또는 1중결합이며, 1은 0내지 3의 정수이다〕로 표시되는 벤조옥사디논유도체 또는 약리학적으로 허용되는 그것들의 산부가염.
  2. 의약으로서 적당한 담체 및 청구항 1기재의 화합물을 항염증작용을 나타내는데 유효한 양을 함유하는 항염증제.
  3. 의약으로서 적당한 담체 및 청구항 1기재의 화합물을 호중구침윤억제작용을 나타내는데 유효한 양을 함유하는 호중구침윤억제제.
  4. 의약으로서 적당한 담체 및 청구항 1기재의 화합물을 세린로테아제저해작용을 나타내는데 유효한 양을 함유하는 세린프로테아제저해제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930702219A 1991-11-28 1992-11-27 벤조옥사디논유도체 KR960008242B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP91-337901 1991-11-28
JP3337901A JPH05148249A (ja) 1991-11-28 1991-11-28 ベンゾオキサジノン誘導体
PCT/JP1992/001550 WO1993011121A1 (fr) 1991-11-28 1992-11-27 Derive de benzoxazinone

Publications (2)

Publication Number Publication Date
KR930703275A true KR930703275A (ko) 1993-11-29
KR960008242B1 KR960008242B1 (ko) 1996-06-21

Family

ID=18313071

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930702219A KR960008242B1 (ko) 1991-11-28 1992-11-27 벤조옥사디논유도체

Country Status (5)

Country Link
EP (1) EP0569598A1 (ko)
JP (1) JPH05148249A (ko)
KR (1) KR960008242B1 (ko)
CA (1) CA2101428A1 (ko)
WO (1) WO1993011121A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3339797A (en) * 1996-06-20 1998-01-07 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
WO2007086584A1 (ja) * 2006-01-30 2007-08-02 Meiji Seika Kaisha, Ltd. 新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤
US20210128699A1 (en) 2017-01-13 2021-05-06 Tobishi Pharmaceutical Co., Ltd. Neutrophil activation regulator

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332734A (en) * 1991-04-10 1994-07-26 Japan Tobacco, Incorporated Oxazinone derivative

Also Published As

Publication number Publication date
WO1993011121A1 (fr) 1993-06-10
JPH05148249A (ja) 1993-06-15
KR960008242B1 (ko) 1996-06-21
EP0569598A1 (en) 1993-11-18
CA2101428A1 (en) 1993-05-29
EP0569598A4 (ko) 1994-04-20

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