ATE228115T1 - Bizyklische fibrinogenantagonisten - Google Patents
Bizyklische fibrinogenantagonistenInfo
- Publication number
- ATE228115T1 ATE228115T1 AT92914832T AT92914832T ATE228115T1 AT E228115 T1 ATE228115 T1 AT E228115T1 AT 92914832 T AT92914832 T AT 92914832T AT 92914832 T AT92914832 T AT 92914832T AT E228115 T1 ATE228115 T1 AT E228115T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- substituted
- optionally
- date
- 4alkynyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/10—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72300991A | 1991-06-28 | 1991-06-28 | |
PCT/US1992/005463 WO1993000095A2 (en) | 1991-06-28 | 1992-06-26 | Bicyclic fibrinogen antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE228115T1 true ATE228115T1 (de) | 2002-12-15 |
Family
ID=24904429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92914832T ATE228115T1 (de) | 1991-06-28 | 1992-06-26 | Bizyklische fibrinogenantagonisten |
Country Status (15)
Country | Link |
---|---|
US (1) | US5693636A (de) |
EP (1) | EP0593603B1 (de) |
JP (1) | JP3497164B2 (de) |
KR (1) | KR940701259A (de) |
AT (1) | ATE228115T1 (de) |
AU (1) | AU666318B2 (de) |
CA (1) | CA2112360A1 (de) |
DE (1) | DE69232854T2 (de) |
ES (1) | ES2190428T3 (de) |
IE (1) | IE922087A1 (de) |
NZ (1) | NZ243326A (de) |
PT (1) | PT100631B (de) |
TW (1) | TW218018B (de) |
WO (1) | WO1993000095A2 (de) |
ZA (1) | ZA924760B (de) |
Families Citing this family (95)
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US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6017877A (en) * | 1990-04-06 | 2000-01-25 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
EP0570493B1 (de) * | 1991-02-08 | 2000-01-05 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5693636A (en) * | 1991-06-28 | 1997-12-02 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5674863A (en) * | 1991-10-18 | 1997-10-07 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
SG90035A1 (en) * | 1992-12-21 | 2002-07-23 | Smithkline Beecham Corp | Bicyclic fibrinogen antagonists |
US5441952A (en) * | 1993-04-05 | 1995-08-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
SG49788A1 (en) * | 1993-04-08 | 1998-06-15 | Diatide Inc | Radiolabeled compounds for thrombus imaging |
EP0698015A1 (de) | 1993-05-14 | 1996-02-28 | Genentech, Inc. | Inhibitoren der farnesyl protein-transferase |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US6448269B1 (en) | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US6403578B1 (en) | 1993-12-21 | 2002-06-11 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
EP0762882A4 (de) * | 1994-06-29 | 2002-09-11 | Smithkline Beecham Corp | Vibronectin-rezeptor-antagonisten |
US6458784B1 (en) * | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
BR9508178A (pt) * | 1994-06-29 | 1997-11-18 | Smithkline Beecham Corp | Antagonistas de receptor de vitronectina |
US6008214A (en) * | 1994-08-22 | 1999-12-28 | Smithkline Beecham Corporation | Bicyclic compounds |
WO1996017833A1 (en) * | 1994-12-09 | 1996-06-13 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
WO1996018602A1 (en) * | 1994-12-13 | 1996-06-20 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
WO1996026190A1 (en) * | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
DE19516483A1 (de) | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
EP0895475A4 (de) * | 1995-12-29 | 2000-08-23 | Smithkline Beecham Corp | Vitronectin rezeptor antagonisten |
ZA9610853B (en) | 1995-12-29 | 1998-04-06 | Smithkline Beecham Corp | Processes and intermediates for preparing pharmaceuticals. |
US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
BR9710570A (pt) * | 1996-07-25 | 2005-06-28 | Biogen Inc | Inibidor de adesão de células |
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DE69723873T2 (de) | 1996-09-03 | 2004-04-22 | Smithkline Beecham Corp. | Kristallines pharmazeutisches produkt |
US20030125317A1 (en) | 1996-10-02 | 2003-07-03 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
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US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
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CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
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TWI549944B (zh) * | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
EP2708535A1 (de) | 2012-05-11 | 2014-03-19 | Les Laboratoires Servier | Mittel zur Behandlung von Erkrankungen durch Modulation von Ryanodin-Rezeptoren |
EP3218371B1 (de) * | 2014-11-14 | 2018-09-26 | Boehringer Ingelheim International GmbH | Aryl- und heteroarylkondensierte tetrahydro-1,4-oxazepinamide als somatostatinrezeptorsubtyp 4 (sstr4)-agonisten |
CN105348148B (zh) * | 2015-11-30 | 2017-12-26 | 山东新华制药股份有限公司 | 制备达比加群酯中间体缩合物的杂质的草酸盐的方法 |
EP3521269A1 (de) | 2018-02-06 | 2019-08-07 | Clariant Plastics & Coatings Ltd | Verfahren zur herstellung von 1-nitrobenzol-2-alkyloxycarbonyl-5-carboxylsäure |
CN110845308A (zh) * | 2019-10-24 | 2020-02-28 | 扬州工业职业技术学院 | 一种辣椒素的制备工艺 |
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JPH04211071A (ja) * | 1990-03-05 | 1992-08-03 | Hokuriku Seiyaku Co Ltd | 多環式化合物 |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
IL99539A0 (en) * | 1990-09-27 | 1992-08-18 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
NZ239876A (en) * | 1990-09-27 | 1993-12-23 | Merck & Co Inc | Glycyl-b-alanine derivatives and pharmaceutical compositions thereof. |
US5470849A (en) * | 1990-11-01 | 1995-11-28 | Smithkline Beecham Corp. | γ-turn peptidomimetics as fibrinogen antagonists |
AU9122391A (en) * | 1990-11-30 | 1992-06-25 | Smithkline Beecham Corporation | Hiv protease inhibitors |
TW198715B (de) * | 1991-04-19 | 1993-01-21 | Dtsuka Seiyaku Kk | |
CA2071181A1 (en) * | 1991-06-14 | 1992-12-15 | Roger M. Freidinger | Benzodiazepine analogs |
US5693636A (en) * | 1991-06-28 | 1997-12-02 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
US5241065A (en) * | 1992-02-25 | 1993-08-31 | Schering Corporation | 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity |
CZ288595B6 (cs) * | 1992-11-09 | 2001-07-11 | The Boots Company Plc | Farmaceutické prostředky obsahující deriváty 2,3,4,5-tetrahydro-1,4-benzothiazepinů, tyto deriváty a způsob jejich výroby |
SG90035A1 (en) * | 1992-12-21 | 2002-07-23 | Smithkline Beecham Corp | Bicyclic fibrinogen antagonists |
US5493020A (en) * | 1993-07-29 | 1996-02-20 | Genentech, Inc. | Tricyclic inhibitors of the GPIIb IIIa receptor |
-
1992
- 1992-06-26 US US07/923,794 patent/US5693636A/en not_active Expired - Fee Related
- 1992-06-26 PT PT100631A patent/PT100631B/pt not_active IP Right Cessation
- 1992-06-26 CA CA002112360A patent/CA2112360A1/en not_active Abandoned
- 1992-06-26 NZ NZ243326A patent/NZ243326A/en unknown
- 1992-06-26 JP JP50170293A patent/JP3497164B2/ja not_active Expired - Fee Related
- 1992-06-26 ZA ZA924760A patent/ZA924760B/xx unknown
- 1992-06-26 DE DE69232854T patent/DE69232854T2/de not_active Expired - Fee Related
- 1992-06-26 WO PCT/US1992/005463 patent/WO1993000095A2/en active IP Right Grant
- 1992-06-26 EP EP92914832A patent/EP0593603B1/de not_active Expired - Lifetime
- 1992-06-26 AU AU22711/92A patent/AU666318B2/en not_active Ceased
- 1992-06-26 ES ES92914832T patent/ES2190428T3/es not_active Expired - Lifetime
- 1992-06-26 AT AT92914832T patent/ATE228115T1/de not_active IP Right Cessation
- 1992-06-26 KR KR1019930704088A patent/KR940701259A/ko not_active Application Discontinuation
- 1992-07-01 IE IE208792A patent/IE922087A1/en not_active Application Discontinuation
- 1992-08-01 TW TW081106117A patent/TW218018B/zh active
Also Published As
Publication number | Publication date |
---|---|
ZA924760B (en) | 1993-03-31 |
EP0593603B1 (de) | 2002-11-20 |
TW218018B (de) | 1993-12-21 |
CA2112360A1 (en) | 1993-12-23 |
PT100631A (pt) | 1993-09-30 |
US5693636A (en) | 1997-12-02 |
WO1993000095A2 (en) | 1993-01-07 |
PT100631B (pt) | 1999-06-30 |
NZ243326A (en) | 1995-10-26 |
EP0593603A1 (de) | 1994-04-27 |
KR940701259A (ko) | 1994-05-28 |
JP3497164B2 (ja) | 2004-02-16 |
ES2190428T3 (es) | 2003-08-01 |
EP0593603A4 (de) | 1994-03-07 |
DE69232854D1 (de) | 2003-01-02 |
AU666318B2 (en) | 1996-02-08 |
JPH06509074A (ja) | 1994-10-13 |
WO1993000095A3 (en) | 1993-02-18 |
IE922087A1 (en) | 1992-12-30 |
DE69232854T2 (de) | 2003-09-04 |
AU2271192A (en) | 1993-01-25 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |