DK107688D0 - Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner - Google Patents
Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepinerInfo
- Publication number
- DK107688D0 DK107688D0 DK107688A DK107688A DK107688D0 DK 107688 D0 DK107688 D0 DK 107688D0 DK 107688 A DK107688 A DK 107688A DK 107688 A DK107688 A DK 107688A DK 107688 D0 DK107688 D0 DK 107688D0
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- halogen
- formula
- ring
- chem
- Prior art date
Links
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 title 1
- 229940112021 centrally acting muscle relaxants carbamic acid ester Drugs 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- -1 CN R<4> is H Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 1
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical group C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK107688A DK107688D0 (da) | 1988-03-01 | 1988-03-01 | Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner |
| IL89207A IL89207A0 (en) | 1988-03-01 | 1989-02-07 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepines,their preparation and pharmaceutical compositions containing them |
| IE42089A IE64247B1 (en) | 1988-03-01 | 1989-02-10 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines |
| CA000590992A CA1312863C (en) | 1988-03-01 | 1989-02-14 | Carbamic acid esters of benzazepines |
| PH38219A PH26368A (en) | 1988-03-01 | 1989-02-20 | Carbamic acid esters of benzazepines |
| FI890841A FI94955C (fi) | 1988-03-01 | 1989-02-22 | Menetelmä uusien terapeuttisesti aktiivisten substituoitujen 7-hydroksi-2,3,4,5-tetrahydro-1H-3-bentsatsepiinien karbamiinihappoestereiden valmistamiseksi |
| DK87689A DK162228C (da) | 1988-03-01 | 1989-02-24 | Substituerede 7-aminocarbonyloxy-2,3,4,5-tetrahydro-1h-3-benzazepiner, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
| KR1019890002236A KR0126473B1 (ko) | 1988-03-01 | 1989-02-25 | 치환된 7-하이드록시-2,3,4,5-테트라하이드로-1h-3-벤즈아제핀의 카밤산 에스테르, 이의 제조방법 및 이의 용도 |
| NZ228151A NZ228151A (en) | 1988-03-01 | 1989-02-27 | Carbamic acid esters of 7-hydroxy-2,3,4,5 tetrahydro-1h- 3-benzazepines and pharmaceutical compositions |
| ES89103531T ES2059592T3 (es) | 1988-03-01 | 1989-02-28 | Esteres de acidos carbamicos de 7-hidroxi-2,3,4,5-tetrahidro-1h-3-benzazepinas sustituidas. |
| DE89103531T DE68909448T2 (de) | 1988-03-01 | 1989-02-28 | Carbaminsäureester von substituierten 7-Hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepinen. |
| US07/317,016 US5017571A (en) | 1988-03-01 | 1989-02-28 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines |
| EP89103531A EP0331130B1 (en) | 1988-03-01 | 1989-02-28 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepines |
| ZA891537A ZA891537B (en) | 1988-03-01 | 1989-02-28 | Carbamic acid esters of benzazepines |
| AT89103531T ATE95179T1 (de) | 1988-03-01 | 1989-02-28 | Carbaminsaeureester von substituierten 7-hydroxy2,3,4,5-tetrahydro-1h-3-benzazepinen. |
| NO890857A NO173825C (no) | 1988-03-01 | 1989-02-28 | Analogifremgangsmaate for fremstilling av terapeutisk aktive carbaminsyreestere av substituerte 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepiner |
| JP1046695A JPH01254679A (ja) | 1988-03-01 | 1989-03-01 | 置換された７‐ヒドロキシ‐２，３，４，５‐ テトラヒドロ‐１ｈ‐３‐ ベンズアゼピンのカルバミン酸エステル |
| AU30907/89A AU613716B2 (en) | 1988-03-01 | 1989-03-01 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5- tetrahydro-1h-3-benzazepines |
| PT89887A PT89887B (pt) | 1988-03-01 | 1989-03-01 | Processo para a preparacao de esteres de acido carbamico e 7-hidroxi-2,3,4,5-tetra-hidro-1h-3-benzazepinas e de composicoes farmaceuticas que os contem |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK107688A DK107688D0 (da) | 1988-03-01 | 1988-03-01 | Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK107688D0 true DK107688D0 (da) | 1988-03-01 |
Family
ID=8100728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK107688A DK107688D0 (da) | 1988-03-01 | 1988-03-01 | Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5017571A (da) |
| EP (1) | EP0331130B1 (da) |
| JP (1) | JPH01254679A (da) |
| KR (1) | KR0126473B1 (da) |
| AT (1) | ATE95179T1 (da) |
| AU (1) | AU613716B2 (da) |
| CA (1) | CA1312863C (da) |
| DE (1) | DE68909448T2 (da) |
| DK (1) | DK107688D0 (da) |
| ES (1) | ES2059592T3 (da) |
| FI (1) | FI94955C (da) |
| IE (1) | IE64247B1 (da) |
| IL (1) | IL89207A0 (da) |
| NO (1) | NO173825C (da) |
| NZ (1) | NZ228151A (da) |
| PH (1) | PH26368A (da) |
| PT (1) | PT89887B (da) |
| ZA (1) | ZA891537B (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK67489D0 (da) * | 1989-02-14 | 1989-02-14 | Novo Industri As | Nye benzazepinderivater |
| ES2190428T3 (es) * | 1991-06-28 | 2003-08-01 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogeno. |
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5470850A (en) * | 1992-02-24 | 1995-11-28 | Novo Nordisk A/S | 2,3,4,5-tetrahydro-1H-3-benzazepines |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| US20030125317A1 (en) * | 1996-10-02 | 2003-07-03 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| AU2004253888B2 (en) | 2003-06-17 | 2010-11-11 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases |
| WO2005042491A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| SI1833473T1 (sl) | 2004-12-23 | 2010-01-29 | Arena Pharm Inc | Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe |
| JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법 |
| CA2808890A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to individuals with renal impairment |
| JP6272695B2 (ja) | 2010-09-01 | 2018-01-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形 |
| WO2012030938A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
| SG188361A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
| JP2015534563A (ja) | 2012-10-09 | 2015-12-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 体重管理の方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
| US3609138A (en) * | 1967-12-22 | 1971-09-28 | Ciba Geigy Corp | 1-aryl-3-benzazepines |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
| ZA792043B (en) * | 1978-05-08 | 1980-05-28 | Scherico Ltd | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them |
| US4284555A (en) * | 1979-04-27 | 1981-08-18 | Schering Corporation | 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
| PH27337A (en) * | 1987-03-27 | 1993-06-08 | Schering Corp | Substituted benzazepines their preparation and pharmaceutical compositions containing them |
-
1988
- 1988-03-01 DK DK107688A patent/DK107688D0/da not_active Application Discontinuation
-
1989
- 1989-02-07 IL IL89207A patent/IL89207A0/xx not_active IP Right Cessation
- 1989-02-10 IE IE42089A patent/IE64247B1/en not_active IP Right Cessation
- 1989-02-14 CA CA000590992A patent/CA1312863C/en not_active Expired - Fee Related
- 1989-02-20 PH PH38219A patent/PH26368A/en unknown
- 1989-02-22 FI FI890841A patent/FI94955C/fi not_active IP Right Cessation
- 1989-02-25 KR KR1019890002236A patent/KR0126473B1/ko not_active Expired - Fee Related
- 1989-02-27 NZ NZ228151A patent/NZ228151A/xx unknown
- 1989-02-28 DE DE89103531T patent/DE68909448T2/de not_active Expired - Fee Related
- 1989-02-28 US US07/317,016 patent/US5017571A/en not_active Expired - Fee Related
- 1989-02-28 AT AT89103531T patent/ATE95179T1/de not_active IP Right Cessation
- 1989-02-28 NO NO890857A patent/NO173825C/no unknown
- 1989-02-28 ZA ZA891537A patent/ZA891537B/xx unknown
- 1989-02-28 ES ES89103531T patent/ES2059592T3/es not_active Expired - Lifetime
- 1989-02-28 EP EP89103531A patent/EP0331130B1/en not_active Expired - Lifetime
- 1989-03-01 AU AU30907/89A patent/AU613716B2/en not_active Ceased
- 1989-03-01 JP JP1046695A patent/JPH01254679A/ja active Pending
- 1989-03-01 PT PT89887A patent/PT89887B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01254679A (ja) | 1989-10-11 |
| KR0126473B1 (ko) | 1997-12-24 |
| FI94955C (fi) | 1995-11-27 |
| PT89887B (pt) | 1994-05-31 |
| FI890841A0 (fi) | 1989-02-22 |
| IL89207A0 (en) | 1989-09-10 |
| NO890857L (no) | 1989-09-04 |
| NO890857D0 (no) | 1989-02-28 |
| CA1312863C (en) | 1993-01-19 |
| NZ228151A (en) | 1991-08-27 |
| FI890841A7 (fi) | 1989-09-02 |
| KR890014494A (ko) | 1989-10-24 |
| AU613716B2 (en) | 1991-08-08 |
| EP0331130B1 (en) | 1993-09-29 |
| NO173825C (no) | 1994-02-09 |
| FI94955B (fi) | 1995-08-15 |
| AU3090789A (en) | 1989-09-07 |
| IE890420L (en) | 1989-09-01 |
| US5017571A (en) | 1991-05-21 |
| IE64247B1 (en) | 1995-07-26 |
| DE68909448D1 (de) | 1993-11-04 |
| EP0331130A1 (en) | 1989-09-06 |
| PH26368A (en) | 1992-06-01 |
| ATE95179T1 (de) | 1993-10-15 |
| ZA891537B (en) | 1989-11-29 |
| NO173825B (no) | 1993-11-01 |
| DE68909448T2 (de) | 1994-02-10 |
| ES2059592T3 (es) | 1994-11-16 |
| PT89887A (pt) | 1989-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |