PT91092A - Processo para a preparacao de novos derivados de benzodiazepina - Google Patents
Processo para a preparacao de novos derivados de benzodiazepinaInfo
- Publication number
- PT91092A PT91092A PT91092A PT9109289A PT91092A PT 91092 A PT91092 A PT 91092A PT 91092 A PT91092 A PT 91092A PT 9109289 A PT9109289 A PT 9109289A PT 91092 A PT91092 A PT 91092A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- hydrogen
- carboxy
- halogen
- amino
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888816207A GB8816207D0 (en) | 1988-07-07 | 1988-07-07 | Benzodiazepine derivatives |
| GB888820560A GB8820560D0 (en) | 1988-08-31 | 1988-08-31 | Benzodiazepine derivatives |
| GB888823660A GB8823660D0 (en) | 1988-10-07 | 1988-10-07 | Benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT91092A true PT91092A (pt) | 1990-02-08 |
| PT91092B PT91092B (pt) | 1995-05-04 |
Family
ID=27263983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT91092A PT91092B (pt) | 1988-07-07 | 1989-07-07 | Processo para a preparacao de novos derivados de benzodiazepina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4970207A (pt) |
| EP (1) | EP0349949B1 (pt) |
| JP (2) | JP2536160B2 (pt) |
| KR (1) | KR900001688A (pt) |
| CN (1) | CN1041941A (pt) |
| AT (1) | ATE147403T1 (pt) |
| AU (1) | AU3785989A (pt) |
| CA (1) | CA1334589C (pt) |
| DE (1) | DE68927620T2 (pt) |
| DK (1) | DK336589A (pt) |
| ES (1) | ES2095833T3 (pt) |
| FI (1) | FI95699C (pt) |
| GR (1) | GR3022239T3 (pt) |
| HU (1) | HUT50331A (pt) |
| IL (1) | IL90830A (pt) |
| NO (1) | NO173014C (pt) |
| PT (1) | PT91092B (pt) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01211939A (ja) * | 1988-02-18 | 1989-08-25 | Nec Kyushu Ltd | イオン注入装置 |
| US5264433A (en) * | 1988-07-07 | 1993-11-23 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| US4994258A (en) * | 1990-03-05 | 1991-02-19 | Merck & Co., Inc. | Gamma emitting, CCK-A antagonists for pancreatic imaging |
| GB9015879D0 (en) * | 1990-07-19 | 1990-09-05 | Fujisawa Pharmaceutical Co | Benzodiazepine derivatives |
| AU654140B2 (en) * | 1990-07-31 | 1994-10-27 | Lilly Industries Limited | N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them |
| US5206238A (en) * | 1990-11-13 | 1993-04-27 | Merck & Co., Inc. | Cholecystokinin antagonists |
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| US5218114A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
| EP0523845A3 (en) * | 1991-06-14 | 1993-11-18 | Merck & Co Inc | New benzodiazepine analogs |
| US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| US5583130A (en) * | 1992-09-25 | 1996-12-10 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| US5317017A (en) * | 1992-09-30 | 1994-05-31 | Merck & Co., Inc. | N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release |
| WO1994018229A1 (en) * | 1993-02-03 | 1994-08-18 | Fisons Corporation | 1,2,4-triazinone derivatives and their use in therapy |
| US5284841A (en) * | 1993-02-04 | 1994-02-08 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| EP0804425A2 (en) * | 1994-07-29 | 1997-11-05 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US5776930A (en) * | 1996-06-28 | 1998-07-07 | Merck & Company, Inc. | Pharmaceutical preparation |
| CA2257948A1 (en) * | 1996-06-28 | 1998-01-08 | Merck & Co., Inc. | Antiarrhythmic combinations of selective iks antagonists with beta-adenergic blocking agents |
| US5929071A (en) * | 1996-07-02 | 1999-07-27 | Merck & Co., Inc. | Method for the treatment of preterm labor |
| AU3591697A (en) * | 1996-07-02 | 1998-01-21 | Merck & Co., Inc. | Method for the treatment of preterm labor |
| AUPO284396A0 (en) | 1996-10-08 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| ATE290545T1 (de) * | 1996-12-06 | 2005-03-15 | Vertex Pharma | Inhibitoren des interleukin-1beta konvertierenden enzyms |
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
| US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| IL146222A0 (en) | 1999-04-30 | 2002-07-25 | Univ Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US20060025388A1 (en) | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
| US7276348B2 (en) | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
| US6207638B1 (en) | 2000-02-23 | 2001-03-27 | Pacifichealth Laboratories, Inc. | Nutritional intervention composition for enhancing and extending satiety |
| US6558690B2 (en) | 2000-12-15 | 2003-05-06 | Pacific Health Laboratories, Inc. | Nutritional composition for improving the efficacy of a lipase inhibitor |
| US6429190B1 (en) | 2000-12-15 | 2002-08-06 | Pacifichealth Laboratories, Inc. | Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK) |
| US6458795B1 (en) * | 2001-11-15 | 2002-10-01 | University Of Florida | Method and composition for treatment of irritable bowel disease |
| GB0221923D0 (en) * | 2002-09-20 | 2002-10-30 | Arrow Therapeutics Ltd | Chemical compounds |
| US7196079B2 (en) * | 2003-06-26 | 2007-03-27 | Merck & Co, Inc. | Benzodiazepine CGRP receptor antagonists |
| US7638624B2 (en) | 2005-01-03 | 2009-12-29 | The Regents Of The University Of Michigan | Compositions and methods relating to novel benzodiazepine compounds and derivatives |
| EP1893218A4 (en) | 2005-06-01 | 2011-01-12 | Univ Michigan | UNLOCKED BENZODIAZEPINE COMPOSITIONS AND METHOD |
| CA2628193C (en) | 2005-11-01 | 2012-08-14 | The Regents Of The University Of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US7759338B2 (en) | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| EP2037741B1 (en) | 2006-06-09 | 2013-11-27 | The Regents Of The University Of Michigan | Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders |
| CN101662940A (zh) | 2007-03-09 | 2010-03-03 | 密执安州立大学董事会 | 与新化合物及其靶标有关的组合物和方法 |
| JP5416122B2 (ja) | 2007-09-14 | 2014-02-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ｆ１Ｆ０−ＡＴＰａｓｅインヒビターおよび関連の方法 |
| RU2010122902A (ru) | 2007-11-06 | 2011-12-20 | Дзе Риджентс оф дзе Юниверсити оф Мичиган (US) | Бензодиапениноновые соединения, применимые в лечении кожных состояний |
| JP5567573B2 (ja) | 2008-09-11 | 2014-08-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アリールグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびそれと関連する方法 |
| WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| US8673897B2 (en) | 2009-09-18 | 2014-03-18 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| CU20090172A7 (es) | 2009-10-09 | 2011-10-05 | Ct De Investigación Y Desarrollo De Medicamentos | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
| CN102753179A (zh) | 2009-11-17 | 2012-10-24 | 密执安大学评议会 | 具有治疗性能的1,4-苯并二氮杂*-2,5-二酮和相关化合物 |
| AU2010322287B2 (en) | 2009-11-17 | 2014-04-03 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| US20150374763A1 (en) | 2013-02-05 | 2015-12-31 | Ludwig Stocker Hofpfisterei Gmbh | Use of microorganisms for the prevention and treatment of intestinal diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| US4628084A (en) * | 1986-01-02 | 1986-12-09 | Merck & Co., Inc. | Process for 3-acylamino benzodiazepines |
-
1989
- 1989-06-29 US US07/373,171 patent/US4970207A/en not_active Expired - Lifetime
- 1989-06-30 IL IL9083089A patent/IL90830A/en not_active IP Right Cessation
- 1989-07-01 DE DE68927620T patent/DE68927620T2/de not_active Expired - Fee Related
- 1989-07-01 ES ES89112084T patent/ES2095833T3/es not_active Expired - Lifetime
- 1989-07-01 AT AT89112084T patent/ATE147403T1/de not_active IP Right Cessation
- 1989-07-01 EP EP89112084A patent/EP0349949B1/en not_active Expired - Lifetime
- 1989-07-03 FI FI893226A patent/FI95699C/fi not_active IP Right Cessation
- 1989-07-05 JP JP1176636A patent/JP2536160B2/ja not_active Expired - Lifetime
- 1989-07-05 AU AU37859/89A patent/AU3785989A/en not_active Abandoned
- 1989-07-06 KR KR1019890009654A patent/KR900001688A/ko not_active Ceased
- 1989-07-06 CN CN89104788A patent/CN1041941A/zh active Pending
- 1989-07-06 CA CA000604941A patent/CA1334589C/en not_active Expired - Fee Related
- 1989-07-06 DK DK336589A patent/DK336589A/da not_active Application Discontinuation
- 1989-07-06 NO NO892799A patent/NO173014C/no unknown
- 1989-07-06 HU HU893435A patent/HUT50331A/hu unknown
- 1989-07-07 PT PT91092A patent/PT91092B/pt not_active IP Right Cessation
-
1994
- 1994-03-08 JP JP6037275A patent/JPH07224060A/ja active Pending
-
1997
- 1997-01-09 GR GR960403582T patent/GR3022239T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2095833T3 (es) | 1997-03-01 |
| EP0349949A3 (en) | 1991-09-04 |
| JPH0256481A (ja) | 1990-02-26 |
| NO892799L (no) | 1990-01-08 |
| NO173014C (no) | 1993-10-13 |
| PT91092B (pt) | 1995-05-04 |
| KR900001688A (ko) | 1990-02-27 |
| CN1041941A (zh) | 1990-05-09 |
| AU3785989A (en) | 1990-01-11 |
| US4970207A (en) | 1990-11-13 |
| HUT50331A (en) | 1990-01-29 |
| EP0349949A2 (en) | 1990-01-10 |
| FI95699C (fi) | 1996-03-11 |
| NO892799D0 (no) | 1989-07-06 |
| NO173014B (no) | 1993-07-05 |
| DK336589D0 (da) | 1989-07-06 |
| JP2536160B2 (ja) | 1996-09-18 |
| IL90830A (en) | 1995-06-29 |
| DE68927620D1 (de) | 1997-02-20 |
| JPH07224060A (ja) | 1995-08-22 |
| FI95699B (fi) | 1995-11-30 |
| CA1334589C (en) | 1995-02-28 |
| DK336589A (da) | 1990-01-08 |
| GR3022239T3 (en) | 1997-04-30 |
| FI893226L (fi) | 1990-01-08 |
| EP0349949B1 (en) | 1997-01-08 |
| FI893226A0 (fi) | 1989-07-03 |
| IL90830A0 (en) | 1990-01-18 |
| ATE147403T1 (de) | 1997-01-15 |
| DE68927620T2 (de) | 1997-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19941003 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19990430 |