ES8801808A1 - Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona - Google Patents

Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Info

Publication number
ES8801808A1
ES8801808A1 ES557732A ES557732A ES8801808A1 ES 8801808 A1 ES8801808 A1 ES 8801808A1 ES 557732 A ES557732 A ES 557732A ES 557732 A ES557732 A ES 557732A ES 8801808 A1 ES8801808 A1 ES 8801808A1
Authority
ES
Spain
Prior art keywords
carbon atoms
lower alkyl
halo
image
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557732A
Other languages
English (en)
Other versions
ES557732A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES557732A0 publication Critical patent/ES557732A0/es
Publication of ES8801808A1 publication Critical patent/ES8801808A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA 2-OXI-4H-3,1-BENZOXACIN-4-ONA (I) SE OBTIENE A PARTIR DE COMPUESTOS (II) DONDE A ES 1 O 2 Y LOS RADICALES SON ALQUILO INFERIOR ENTRE OTROS; MEDIANTE UNA CICLACION DE ESTOS ULTIMOS. APLICABLE EN FARMACIA POR SU ACCION INHIBITORIA DE LAS PROTEASAS SERINICAS.
ES557732A 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona Expired ES8801808A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/748,631 US4665070A (en) 1985-06-25 1985-06-25 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use

Publications (2)

Publication Number Publication Date
ES557732A0 ES557732A0 (es) 1988-03-01
ES8801808A1 true ES8801808A1 (es) 1988-03-01

Family

ID=25010264

Family Applications (4)

Application Number Title Priority Date Filing Date
ES556514A Expired ES8802223A1 (es) 1985-06-25 1986-06-24 Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona
ES557731A Expired ES8801807A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557730A Expired ES8801806A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557732A Expired ES8801808A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES556514A Expired ES8802223A1 (es) 1985-06-25 1986-06-24 Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona
ES557731A Expired ES8801807A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557730A Expired ES8801806A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Country Status (13)

Country Link
US (1) US4665070A (es)
EP (1) EP0206323A1 (es)
JP (1) JPS6230770A (es)
KR (1) KR900004319B1 (es)
AU (2) AU599320B2 (es)
CA (1) CA1270487A (es)
DK (1) DK297486A (es)
ES (4) ES8802223A1 (es)
FI (1) FI862691A (es)
HU (1) HU196772B (es)
IL (1) IL79222A0 (es)
NO (1) NO163486C (es)
ZA (1) ZA864715B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
CA2056453A1 (en) * 1990-03-30 1991-10-01 Koji Kobayashi 4h-3, 1-benzoxazin-4-one derivative
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
FR2763944B1 (fr) * 1997-06-03 2000-12-15 Centre Nat Rech Scient Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
WO1999048878A1 (en) * 1998-03-24 1999-09-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
US6180625B1 (en) 1998-03-24 2001-01-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
AU1375000A (en) * 1998-11-26 2000-06-13 Novo Nordisk A/S Heterocyclic compounds regulating clotting
GB9900416D0 (en) 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
JP2003509538A (ja) * 1999-09-10 2003-03-11 ザ、プロクター、エンド、ギャンブル、カンパニー 酵素インヒビター
WO2004101742A2 (en) * 2003-05-06 2004-11-25 Cytovia, Inc Protease inhibitors for coronaviruses and sars-cov and the use thereof
EP2103601B1 (en) * 2006-11-22 2012-03-14 Ajinomoto Co., Inc. Process for production of phenylalanine derivatives having quinazolinedione skeletons and intermediates for the production
JP2010254623A (ja) * 2009-04-24 2010-11-11 Takeda Chem Ind Ltd ベンゾオキサジノン化合物の結晶

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173974B (hu) * 1971-08-30 1979-10-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija proizvodnykh 3,1-benzoksazin-4-ona

Also Published As

Publication number Publication date
IL79222A0 (en) 1986-09-30
AU4912090A (en) 1990-05-31
HU196772B (en) 1989-01-30
KR900004319B1 (ko) 1990-06-22
ES556514A0 (es) 1988-05-01
ES557731A0 (es) 1988-03-01
ZA864715B (en) 1988-02-24
NO163486C (no) 1990-06-13
FI862691A0 (fi) 1986-06-24
ES8802223A1 (es) 1988-05-01
AU5915086A (en) 1987-01-08
NO163486B (no) 1990-02-26
ES557730A0 (es) 1988-03-01
NO862534L (no) 1986-12-29
ES8801807A1 (es) 1988-03-01
ES8801806A1 (es) 1988-03-01
DK297486A (da) 1986-12-26
ES557732A0 (es) 1988-03-01
CA1270487A (en) 1990-06-19
DK297486D0 (da) 1986-06-24
FI862691A (fi) 1986-12-26
AU599320B2 (en) 1990-07-19
EP0206323A1 (en) 1986-12-30
JPS6230770A (ja) 1987-02-09
HUT41750A (en) 1987-05-28
KR870000310A (ko) 1987-02-17
NO862534D0 (no) 1986-06-24
US4665070A (en) 1987-05-12

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