ES8802223A1 - Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona - Google Patents

Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona

Info

Publication number
ES8802223A1
ES8802223A1 ES556514A ES556514A ES8802223A1 ES 8802223 A1 ES8802223 A1 ES 8802223A1 ES 556514 A ES556514 A ES 556514A ES 556514 A ES556514 A ES 556514A ES 8802223 A1 ES8802223 A1 ES 8802223A1
Authority
ES
Spain
Prior art keywords
carbon atoms
lower alkyl
halo
image
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556514A
Other languages
English (en)
Other versions
ES556514A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8802223A1 publication Critical patent/ES8802223A1/es
Publication of ES556514A0 publication Critical patent/ES556514A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LOS DERIVADOS DE LA 2-OXI-4H-3,1-BENZOXCACIN-4-ONA (I), DONDE NO EXCLUSIVAMENTE, RK ES 1 INFERIOR, RL ACIL INFERIOR AMIDO O DI-(ALQUIL INFERIOR)-UREIDO, X ALQUILO OPCIONALMENTE SUSTITUIDO CON FENILO Y A VA DE 0 A 2; SE OBTIENEN CICLIZANDO UN COMPUESTO (II) CON UN HALOFORMIATO (III), POR EJEMPLO, EL CLOROFORMIATO, EN PIRIDINA ANHIDRA, A TEMPERATURA AMBIENTE Y CONDICIONES ANHIDRAS, DURANTE 15 MINUTOS, TRAS LO CUAL, SE SEPARA EL EXCESO DE PIRIDINA, A PRESION REDUCIDA Y 40JC; FINALMENTE SE PURIFICA CONCARBON ACTIVO Y OPCIONALMENTE SE SALIFICA. LOS COMPUESTOS (I) INHIBEN UNA VARIEDAD DE ENZIMAS FISIOLOGICAS COMO LAS PROTEASAS SERINICAS, ELASTASA DE LEUCOCITOS HUMANOS, TROMBINA HUMANA, UROQUINASA HUMANA, ACROSINA PORCINA, ELASTASA PANCREATICA PORCINA, CATEPSINA B BOVINA, ENTRE OTRAS , POR LO QUE ES APLICABLE PARA EL CONTROL DE LOS ESTADOS MORBOSOS EN LOS ANIMALES O EL HOMBRE O COMO ANTICONCEPTIVO.
ES556514A 1985-06-25 1986-06-24 Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona Expired ES8802223A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/748,631 US4665070A (en) 1985-06-25 1985-06-25 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use

Publications (2)

Publication Number Publication Date
ES8802223A1 true ES8802223A1 (es) 1988-05-01
ES556514A0 ES556514A0 (es) 1988-05-01

Family

ID=25010264

Family Applications (4)

Application Number Title Priority Date Filing Date
ES556514A Expired ES8802223A1 (es) 1985-06-25 1986-06-24 Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona
ES557731A Expired ES8801807A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557730A Expired ES8801806A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557732A Expired ES8801808A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES557731A Expired ES8801807A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557730A Expired ES8801806A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557732A Expired ES8801808A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Country Status (13)

Country Link
US (1) US4665070A (es)
EP (1) EP0206323A1 (es)
JP (1) JPS6230770A (es)
KR (1) KR900004319B1 (es)
AU (2) AU599320B2 (es)
CA (1) CA1270487A (es)
DK (1) DK297486A (es)
ES (4) ES8802223A1 (es)
FI (1) FI862691A (es)
HU (1) HU196772B (es)
IL (1) IL79222A0 (es)
NO (1) NO163486C (es)
ZA (1) ZA864715B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
WO1991015487A1 (fr) * 1990-03-30 1991-10-17 Japan Tobacco Inc. Nouveau derive de 4-1-benzoxazine-4h-3,1
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
FR2763944B1 (fr) * 1997-06-03 2000-12-15 Centre Nat Rech Scient Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
US6180625B1 (en) 1998-03-24 2001-01-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
WO1999048878A1 (en) * 1998-03-24 1999-09-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
WO2000030646A1 (en) * 1998-11-26 2000-06-02 Novo Nordisk A/S Heterocyclic compounds regulating clotting
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
EP1212098A2 (en) * 1999-09-10 2002-06-12 The Procter & Gamble Company Enzyme inhibitors
US7504382B2 (en) * 2003-05-06 2009-03-17 Cytovia, Inc. Protease inhibitors for coronaviruses and SARS-CoV and the use thereof
EP2103601B1 (en) * 2006-11-22 2012-03-14 Ajinomoto Co., Inc. Process for production of phenylalanine derivatives having quinazolinedione skeletons and intermediates for the production
JP2010254623A (ja) * 2009-04-24 2010-11-11 Takeda Chem Ind Ltd ベンゾオキサジノン化合物の結晶

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173974B (hu) * 1971-08-30 1979-10-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija proizvodnykh 3,1-benzoksazin-4-ona

Also Published As

Publication number Publication date
AU4912090A (en) 1990-05-31
ES557731A0 (es) 1988-03-01
IL79222A0 (en) 1986-09-30
AU5915086A (en) 1987-01-08
US4665070A (en) 1987-05-12
ES556514A0 (es) 1988-05-01
KR900004319B1 (ko) 1990-06-22
FI862691A (fi) 1986-12-26
HU196772B (en) 1989-01-30
JPS6230770A (ja) 1987-02-09
NO862534L (no) 1986-12-29
AU599320B2 (en) 1990-07-19
NO163486C (no) 1990-06-13
ES8801807A1 (es) 1988-03-01
ES557732A0 (es) 1988-03-01
ES557730A0 (es) 1988-03-01
FI862691A0 (fi) 1986-06-24
ZA864715B (en) 1988-02-24
DK297486A (da) 1986-12-26
CA1270487A (en) 1990-06-19
ES8801806A1 (es) 1988-03-01
NO163486B (no) 1990-02-26
NO862534D0 (no) 1986-06-24
EP0206323A1 (en) 1986-12-30
ES8801808A1 (es) 1988-03-01
HUT41750A (en) 1987-05-28
KR870000310A (ko) 1987-02-17
DK297486D0 (da) 1986-06-24

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