ES8801806A1 - Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona - Google Patents

Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Info

Publication number
ES8801806A1
ES8801806A1 ES557730A ES557730A ES8801806A1 ES 8801806 A1 ES8801806 A1 ES 8801806A1 ES 557730 A ES557730 A ES 557730A ES 557730 A ES557730 A ES 557730A ES 8801806 A1 ES8801806 A1 ES 8801806A1
Authority
ES
Spain
Prior art keywords
carbon atoms
lower alkyl
halo
image
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557730A
Other languages
English (en)
Other versions
ES557730A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES557730A0 publication Critical patent/ES557730A0/es
Publication of ES8801806A1 publication Critical patent/ES8801806A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA 2-OXI-4H-3,1-BENZOXACIN-ONA (I) SE OBTIENE A PARTIR DE COMPUESTOS (II) DONDE A ES 1 O 2 Y LOS RADICALES SON ALQUILO INFERIOR ENTRE OTROS; ESTOS ULTIMOS (II) SE PREPARAN POR HIDROLISIS DE COMPUESTOS (III). APLICABLE EN FARMACIAPOR SU ACCION INHIBITORIA DE LAS PROTEASAS SERINICAS.
ES557730A 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona Expired ES8801806A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/748,631 US4665070A (en) 1985-06-25 1985-06-25 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use

Publications (2)

Publication Number Publication Date
ES557730A0 ES557730A0 (es) 1988-03-01
ES8801806A1 true ES8801806A1 (es) 1988-03-01

Family

ID=25010264

Family Applications (4)

Application Number Title Priority Date Filing Date
ES556514A Expired ES8802223A1 (es) 1985-06-25 1986-06-24 Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona
ES557732A Expired ES8801808A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557730A Expired ES8801806A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES557731A Expired ES8801807A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES556514A Expired ES8802223A1 (es) 1985-06-25 1986-06-24 Procedimiento para la preparacion de derivados de 2-oxi-4h-3, 1-benzoxazin-4-ona
ES557732A Expired ES8801808A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557731A Expired ES8801807A1 (es) 1985-06-25 1987-09-16 Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona

Country Status (13)

Country Link
US (1) US4665070A (es)
EP (1) EP0206323A1 (es)
JP (1) JPS6230770A (es)
KR (1) KR900004319B1 (es)
AU (2) AU599320B2 (es)
CA (1) CA1270487A (es)
DK (1) DK297486A (es)
ES (4) ES8802223A1 (es)
FI (1) FI862691A (es)
HU (1) HU196772B (es)
IL (1) IL79222A0 (es)
NO (1) NO163486C (es)
ZA (1) ZA864715B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
KR920701200A (ko) * 1990-03-30 1992-08-11 미즈노 시게루 신규의 4h-3,1-벤조옥사진-4-온 유도체
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
FR2763944B1 (fr) * 1997-06-03 2000-12-15 Centre Nat Rech Scient Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
US6180625B1 (en) 1998-03-24 2001-01-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
AU2826099A (en) * 1998-03-24 1999-10-18 Novo Nordisk A/S Heterocyclic compounds regulating clotting
WO2000030646A1 (en) * 1998-11-26 2000-06-02 Novo Nordisk A/S Heterocyclic compounds regulating clotting
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
WO2001018181A2 (en) * 1999-09-10 2001-03-15 The Procter & Gamble Company Enzyme inhibitors
US7504382B2 (en) * 2003-05-06 2009-03-17 Cytovia, Inc. Protease inhibitors for coronaviruses and SARS-CoV and the use thereof
EP2103601B1 (en) * 2006-11-22 2012-03-14 Ajinomoto Co., Inc. Process for production of phenylalanine derivatives having quinazolinedione skeletons and intermediates for the production
JP2010254623A (ja) * 2009-04-24 2010-11-11 Takeda Chem Ind Ltd ベンゾオキサジノン化合物の結晶

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173974B (hu) * 1971-08-30 1979-10-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija proizvodnykh 3,1-benzoksazin-4-ona

Also Published As

Publication number Publication date
CA1270487A (en) 1990-06-19
AU5915086A (en) 1987-01-08
ES8801808A1 (es) 1988-03-01
HUT41750A (en) 1987-05-28
JPS6230770A (ja) 1987-02-09
NO163486C (no) 1990-06-13
AU599320B2 (en) 1990-07-19
KR900004319B1 (ko) 1990-06-22
US4665070A (en) 1987-05-12
FI862691A (fi) 1986-12-26
DK297486D0 (da) 1986-06-24
FI862691A0 (fi) 1986-06-24
EP0206323A1 (en) 1986-12-30
ES8801807A1 (es) 1988-03-01
KR870000310A (ko) 1987-02-17
ES8802223A1 (es) 1988-05-01
NO862534L (no) 1986-12-29
ES557732A0 (es) 1988-03-01
ES557730A0 (es) 1988-03-01
HU196772B (en) 1989-01-30
ES556514A0 (es) 1988-05-01
ZA864715B (en) 1988-02-24
NO862534D0 (no) 1986-06-24
NO163486B (no) 1990-02-26
IL79222A0 (en) 1986-09-30
AU4912090A (en) 1990-05-31
DK297486A (da) 1986-12-26
ES557731A0 (es) 1988-03-01

Similar Documents

Publication Publication Date Title
TW330202B (en) Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals
MX9306831A (es) Nuevos compuestos heterociclicos.
ES8801807A1 (es) Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
IL103944A (en) Piperazine derivatives, their preparation and pharmaceutical compositions containing them
DE69431974T2 (de) Benzamid-Derivate und ihre Verwendung als Vasopressin-Antagonisten
ES8703410A1 (es) Procedimiento para preparar guanidinas anti-inflamatorias
EP0322738A3 (en) Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells
IL105372A0 (en) 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutical compositions containing them
EA200000614A1 (ru) 2,3-замещенные соединения индола в качестве ингибиторов сох-2
GR3027694T3 (en) Naphthyloxyacetic acid derivatives as PGE2 agonists and antagonists.
HUP0100184A2 (hu) Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények
MY129935A (en) Dihydropyridine derivatives useful in antitumor therapy
FI881018A (fi) Heterocykliska foereningar.
ES2010284A6 (es) Procedimiento para preparar derivados de tiourea.
ES8200887A1 (es) Procedimiento para la preparacion de nuevas 2-(perhi- dro-1,4-diazino)-pirimido(5,4-d)pirimidinas
MY118844A (en) 2,4,4-trisubstituted-1,3-dioxolane antifungals
NZ194777A (en) N-aminoalkyl-n'-(2-chloroethyl)-n'-nitroso-ureas and pharmaceutical compositions
ATE215075T1 (de) Hydroxylamin-derivate mit anti-ischämischer wirkung und pharmazeutische zusammensetzungen diese enthaltend
DE3864336D1 (en) Aromatische thioaether.
DE60111653D1 (de) Aminoflavonverbindungen, zusammensetzungen und ihre verwendung
SE7902264L (sv) N,n'-bis(fenylkarbamoylmetyl)amidiner och sett for framstellning derav
ES8500620A1 (es) Procedimiento para la preparacion de derivados e-homo-eburnanos racemicos u opticamente activos y de sus sales de adicion acidas.