|
CA2263479A1
(en)
|
1996-09-25 |
1998-04-02 |
Zeneca Limited |
Quinoline derivatives inhibiting the effect of growth factors such as vegf
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
DE69838172T2
(de)
|
1997-08-22 |
2008-04-10 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
KR100609646B1
(ko)
|
1998-08-18 |
2006-08-04 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
Egf-r 길항물질의 투여에 의한 기도 점액생산의 방지
|
|
CN1165532C
(zh)
*
|
1998-09-29 |
2004-09-08 |
惠氏控股有限公司 |
作为蛋白质酪氨酸激酶抑制剂的取代的3-氰基喹啉
|
|
PT2253620E
(pt)
*
|
1998-09-29 |
2014-04-15 |
Wyeth Holdings Llc |
3-cianoquinolinas substituídas como inibidores de proteínas tirosinas quinases
|
|
AU2004200300A1
(en)
*
|
1998-09-29 |
2004-02-19 |
Wyeth Holdings Corporation |
Substituted 3-cyanoquinolines as Protein Tyrosine Kinases Inhibitors
|
|
US6297258B1
(en)
|
1998-09-29 |
2001-10-02 |
American Cyanamid Company |
Substituted 3-cyanoquinolines
|
|
US6288082B1
(en)
|
1998-09-29 |
2001-09-11 |
American Cyanamid Company |
Substituted 3-cyanoquinolines
|
|
GB9904103D0
(en)
|
1999-02-24 |
1999-04-14 |
Zeneca Ltd |
Quinoline derivatives
|
|
WO2000051991A1
(en)
*
|
1999-02-27 |
2000-09-08 |
Boehringer Ingelheim Pharma Kg |
4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES
|
|
US6548496B2
(en)
|
1999-04-21 |
2003-04-15 |
American Cyanamid Company |
Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
|
|
ATE264328T1
(de)
*
|
1999-04-21 |
2004-04-15 |
Wyeth Corp |
Substituierte 3-cyano-(1.7), (1.5) und (1.8)naphthyridininhibitoren von tyrosin kinasen
|
|
US6355636B1
(en)
|
1999-04-21 |
2002-03-12 |
American Cyanamid Company |
Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
|
|
GB9910579D0
(en)
*
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
GB9910580D0
(en)
*
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
GB9910577D0
(en)
*
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
MEP45508A
(en)
|
1999-06-21 |
2011-02-10 |
Boehringer Ingelheim Pharma |
Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
|
|
US6927203B1
(en)
|
1999-08-17 |
2005-08-09 |
Purdue Research Foundation |
Treatment of metastatic disease
|
|
US7192698B1
(en)
|
1999-08-17 |
2007-03-20 |
Purdue Research Foundation |
EphA2 as a diagnostic target for metastatic cancer
|
|
IL149034A0
(en)
|
1999-11-05 |
2002-11-10 |
Astrazeneca Ab |
Quinazoline derivatives as vegf inhibitors
|
|
CA2396579A1
(en)
*
|
1999-12-29 |
2001-07-05 |
Wyeth |
Tricyclic protein kinase inhibitors
|
|
US6638929B2
(en)
|
1999-12-29 |
2003-10-28 |
Wyeth |
Tricyclic protein kinase inhibitors
|
|
KR100817423B1
(ko)
*
|
2000-03-13 |
2008-03-27 |
와이어쓰 홀딩스 코포레이션 |
시아노퀴놀린을 포함하는 결장 폴립의 치료 또는 억제를 위한 약제학적 조성물
|
|
US6384051B1
(en)
|
2000-03-13 |
2002-05-07 |
American Cyanamid Company |
Method of treating or inhibiting colonic polyps
|
|
US6521618B2
(en)
|
2000-03-28 |
2003-02-18 |
Wyeth |
3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
|
|
AR035851A1
(es)
*
|
2000-03-28 |
2004-07-21 |
Wyeth Corp |
3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas
|
|
US6608048B2
(en)
|
2000-03-28 |
2003-08-19 |
Wyeth Holdings |
Tricyclic protein kinase inhibitors
|
|
SI1274692T1
(sl)
|
2000-04-07 |
2006-12-31 |
Astrazeneca Ab |
Kinazolinske spojine
|
|
JP4939716B2
(ja)
*
|
2000-04-08 |
2012-05-30 |
ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト |
二環式複素環化合物、これらの化合物を含む医薬組成物、それらの使用及びそれらの調製方法
|
|
US6627634B2
(en)
|
2000-04-08 |
2003-09-30 |
Boehringer Ingelheim Pharma Kg |
Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them
|
|
AU2002216758A1
(en)
*
|
2000-07-03 |
2002-01-14 |
Astrazeneca Ab |
Quinazolines with therapeutic use
|
|
US6576644B2
(en)
*
|
2000-09-06 |
2003-06-10 |
Bristol-Myers Squibb Co. |
Quinoline inhibitors of cGMP phosphodiesterase
|
|
US7101976B1
(en)
|
2000-09-12 |
2006-09-05 |
Purdue Research Foundation |
EphA2 monoclonal antibodies and methods of making and using same
|
|
JP2004514718A
(ja)
*
|
2000-11-02 |
2004-05-20 |
アストラゼネカ アクチボラグ |
抗癌剤としての置換キノリン類
|
|
US7253184B2
(en)
|
2000-11-02 |
2007-08-07 |
Astrazeneca Ab |
4-Substituted quinolines as antitumor agents
|
|
US7019012B2
(en)
|
2000-12-20 |
2006-03-28 |
Boehringer Ingelheim International Pharma Gmbh & Co. Kg |
Quinazoline derivatives and pharmaceutical compositions containing them
|
|
CN100457719C
(zh)
|
2000-12-29 |
2009-02-04 |
惠氏公司 |
区域选择性制备取代的苯并[g]喹啉-3-腈和苯并[g]喹唑啉的方法
|
|
SE0101675D0
(sv)
|
2001-05-11 |
2001-05-11 |
Astrazeneca Ab |
Novel composition
|
|
US6713462B2
(en)
*
|
2001-06-21 |
2004-03-30 |
Ariad Pharmaceuticals, Inc. |
Quinolinones and uses thereof
|
|
US6706699B2
(en)
|
2001-06-21 |
2004-03-16 |
Ariad Pharmaceuticals, Inc. |
Quinolines and uses thereof
|
|
ES2272737T3
(es)
*
|
2001-07-16 |
2007-05-01 |
Astrazeneca Ab |
Derivados de quinolina y su uso como inhibidores de tirosina quinasas.
|
|
UA77200C2
(en)
|
2001-08-07 |
2006-11-15 |
Wyeth Corp |
Antineoplastic combination of cci-779 and bkb-569
|
|
AU2002359489B2
(en)
*
|
2001-11-27 |
2008-10-30 |
Wyeth Holdings Corporation |
3-cyanoquinolines as inhibitors of EGF-R and Her2 kinases
|
|
WO2003047584A1
(en)
*
|
2001-12-05 |
2003-06-12 |
Astrazeneca Ab |
Quinoline derivatives
|
|
WO2003048159A1
(en)
*
|
2001-12-05 |
2003-06-12 |
Astrazeneca Ab |
Quinoline derivatives
|
|
WO2003047582A1
(en)
*
|
2001-12-05 |
2003-06-12 |
Astrazeneca Ab |
Quinoline derivatives as antitumour agents
|
|
GB0129099D0
(en)
*
|
2001-12-05 |
2002-01-23 |
Astrazeneca Ab |
Chemical compounds
|
|
DE60328461D1
(de)
*
|
2002-01-28 |
2009-09-03 |
Ube Industries |
Verfahren zur herstellung eines chinazolin-4-onderivats
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
MXPA04008893A
(es)
|
2002-03-13 |
2005-06-20 |
Array Biopharma Inc |
Derivados de bencimidazol n3 alquilados como inhibidores de mek.
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
JP2005536462A
(ja)
*
|
2002-04-30 |
2005-12-02 |
ユン ジン ファーマスーチカル インダストリーズ カンパニー リミテッド |
カスパーゼ−3阻害剤としてのキノリン誘導体、この製造方法及びこれを含む薬剤学的組成物
|
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
|
DE10221018A1
(de)
|
2002-05-11 |
2003-11-27 |
Boehringer Ingelheim Pharma |
Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
|
|
JP4703183B2
(ja)
|
2002-07-15 |
2011-06-15 |
シンフォニー エボルーション, インク. |
受容体型キナーゼモジュレーターおよびその使用方法
|
|
ATE535254T1
(de)
|
2002-07-15 |
2011-12-15 |
Genentech Inc |
Behandlung von krebs mit dem anti-erbb2- antikörper rhumab 2c4
|
|
EP3321282A1
(en)
|
2002-09-27 |
2018-05-16 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
GB0225579D0
(en)
|
2002-11-02 |
2002-12-11 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2004060400A1
(ja)
*
|
2003-01-06 |
2004-07-22 |
Mitsubishi Pharma Corp |
上皮成長因子受容体を分子標的とする抗精神病薬
|
|
CL2004000016A1
(es)
|
2003-01-21 |
2005-04-15 |
Wyeth Corp |
Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
|
|
WO2004069250A1
(en)
*
|
2003-02-03 |
2004-08-19 |
Astrazeneca Ab |
3-cyano-quinoline derivatives as non-receptor tyrosine kinase inhibitors
|
|
WO2004069827A1
(en)
*
|
2003-02-03 |
2004-08-19 |
Astrazeneca Ab |
Quinoline derivatives and use thereof as antitumor agents
|
|
WO2004069249A1
(en)
*
|
2003-02-03 |
2004-08-19 |
Astrazeneca Ab |
3-cyano-quinoline derivatives as non-receptor tyrosine kinase inhibitors
|
|
US7223749B2
(en)
|
2003-02-20 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US7135575B2
(en)
|
2003-03-03 |
2006-11-14 |
Array Biopharma, Inc. |
P38 inhibitors and methods of use thereof
|
|
US7381410B2
(en)
|
2003-03-12 |
2008-06-03 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
JP4762889B2
(ja)
|
2003-03-12 |
2011-08-31 |
バスジーン セラピューティクス,インコーポレイテッド |
血管形成及び腫瘍成長を阻止するための核酸化合物
|
|
UA80607C2
(en)
*
|
2003-04-09 |
2007-10-10 |
White Holdings Corp |
Process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolines
|
|
WO2004108703A1
(en)
*
|
2003-06-05 |
2004-12-16 |
Astrazeneca Ab |
Pyrazinyl 3-cyanoquinoline derivatives for use in the treatment of tumours
|
|
WO2004108704A1
(en)
*
|
2003-06-05 |
2004-12-16 |
Astrazeneca Ab |
Pyrimidin-4-yl 3-cyanoquinoline derivatives for use in the treatment of tumours
|
|
US8309562B2
(en)
|
2003-07-03 |
2012-11-13 |
Myrexis, Inc. |
Compounds and therapeutical use thereof
|
|
NZ544472A
(en)
|
2003-07-03 |
2009-04-30 |
Myriad Genetics Inc |
Compounds and therapeutical use thereof
|
|
WO2006074147A2
(en)
|
2005-01-03 |
2006-07-13 |
Myriad Genetics, Inc. |
Nitrogen containing bicyclic compounds and therapeutical use thereof
|
|
WO2005009969A1
(en)
|
2003-07-31 |
2005-02-03 |
Sanofi-Aventis |
Aminoquinoline derivatives and their use as adenosine a3 ligands
|
|
RU2317290C2
(ru)
*
|
2003-07-31 |
2008-02-20 |
Санофи-Авентис |
Производные аминохинолина и их применение в качестве лигандов аденозина а3
|
|
JP2007502819A
(ja)
*
|
2003-08-19 |
2007-02-15 |
ワイス・ホールディングズ・コーポレイション |
4−アミノ−3−キノリンカルボニトリルの調製方法
|
|
US7538120B2
(en)
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7399865B2
(en)
*
|
2003-09-15 |
2008-07-15 |
Wyeth |
Protein tyrosine kinase enzyme inhibitors
|
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
ES2651730T3
(es)
|
2003-09-26 |
2018-01-29 |
Exelixis, Inc. |
Moduladores c-Met y métodos de uso
|
|
US7456189B2
(en)
|
2003-09-30 |
2008-11-25 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
|
|
DE10349113A1
(de)
|
2003-10-17 |
2005-05-12 |
Boehringer Ingelheim Pharma |
Verfahren zur Herstellung von Aminocrotonylverbindungen
|
|
CN104998273A
(zh)
|
2003-11-06 |
2015-10-28 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
WO2005047259A1
(en)
*
|
2003-11-06 |
2005-05-26 |
Wyeth |
4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (cml)
|
|
US7517994B2
(en)
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7732616B2
(en)
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
BRPI0416692A
(pt)
|
2003-11-19 |
2007-01-30 |
Array Biopharma Inc |
inibidores heterocìclicos de mek e métodos de emprego destes
|
|
CN102786482A
(zh)
|
2003-11-21 |
2012-11-21 |
阿雷生物药品公司 |
Akt蛋白激酶抑制剂
|
|
DE602004023876D1
(de)
*
|
2003-12-18 |
2009-12-10 |
Janssen Pharmaceutica Nv |
3-cyano-chinolin-derivate mit antiproliferativer wirkung
|
|
CA2549869C
(en)
|
2003-12-18 |
2015-05-05 |
Janssen Pharmaceutica N.V. |
Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents
|
|
CA2553729A1
(en)
|
2004-01-16 |
2005-08-04 |
Wyeth |
Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
|
|
SE0400284D0
(sv)
*
|
2004-02-10 |
2004-02-10 |
Astrazeneca Ab |
Novel compounds
|
|
TW200529846A
(en)
|
2004-02-20 |
2005-09-16 |
Wyeth Corp |
3-quinolinecarbonitrile protein kinase inhibitors
|
|
DE602005025459D1
(de)
|
2004-03-12 |
2011-02-03 |
Vasgene Therapeutics Inc |
Ephb4-bindende antikörper zur inhibierung von angiogenese und tumorwachstum
|
|
EP2287194B1
(en)
|
2004-03-12 |
2016-10-26 |
Vasgene Therapeutics, Inc. |
Antibodies binding to EphB4 for inhibiting angiogenesis and tumor growth
|
|
KR101289774B1
(ko)
|
2004-03-31 |
2013-08-07 |
다나-파버 캔서 인스티튜트 인크. |
표피성장인자 수용체를 표적으로 하는 치료에 대한 암의반응성을 결정하는 방법
|
|
RS52119B
(sr)
|
2004-05-06 |
2012-08-31 |
Warner-Lambert Company Llc |
4-fenilamino-hinazolin-6-il-amidi
|
|
CA2567520A1
(en)
|
2004-06-01 |
2005-12-15 |
Genentech, Inc. |
Maytansinoid-antibody conjugates
|
|
DK2471813T3
(en)
|
2004-07-15 |
2015-03-02 |
Xencor Inc |
Optimized Fc variants
|
|
EP3088004B1
(en)
|
2004-09-23 |
2018-03-28 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
US20060204512A1
(en)
|
2004-09-23 |
2006-09-14 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
KR101318012B1
(ko)
|
2004-10-20 |
2013-10-14 |
메르크 세로노 에스.에이. |
3-아릴아미노 피리딘 유도체
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
CN102746404B
(zh)
|
2004-11-12 |
2016-01-20 |
赞科股份有限公司 |
对FcRn的结合被改变的Fc变体
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
HUP0402371A2
(en)
*
|
2004-11-15 |
2006-09-28 |
Sanofi Aventis |
Novel 125-i-labeled amino-quinoline derivatives
|
|
NI200700147A
(es)
|
2004-12-08 |
2019-05-10 |
Janssen Pharmaceutica Nv |
Derivados de quinazolina inhibidores de cinasas dirigidos a multip
|
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
CN102580084B
(zh)
|
2005-01-21 |
2016-11-23 |
健泰科生物技术公司 |
Her抗体的固定剂量给药
|
|
CN113952459B
(zh)
|
2005-02-03 |
2025-02-11 |
综合医院公司 |
治疗吉非替尼耐药性癌症的方法
|
|
MX2007009889A
(es)
|
2005-02-23 |
2007-09-07 |
Genentech Inc |
Alargar el tiempo hasta la progresion de la enfermedad o la supervivencia de los pacientes de cancer.
|
|
NZ563707A
(en)
|
2005-05-18 |
2011-01-28 |
Array Biopharma Inc |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
WO2006124692A2
(en)
*
|
2005-05-18 |
2006-11-23 |
Wyeth |
3-cyanoquinoline inhibitors of tpl2 kinase and methods of making and using the same
|
|
KR20080016671A
(ko)
*
|
2005-05-25 |
2008-02-21 |
와이어쓰 |
치환된 3-시아노퀴놀린 및 그것의 중간체를 합성하는 방법
|
|
WO2007008943A2
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc. |
Optimized anti-ep-cam antibodies
|
|
EP1931709B1
(en)
|
2005-10-03 |
2016-12-07 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
|
AU2006306991A1
(en)
|
2005-10-28 |
2007-05-03 |
Takeda Pharmaceutical Company Limited |
Heterocyclic amide compound and use thereof
|
|
CN103110948A
(zh)
|
2005-11-04 |
2013-05-22 |
惠氏公司 |
mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合
|
|
EP3173084B1
(en)
|
2005-11-11 |
2019-10-23 |
Boehringer Ingelheim International GmbH |
Quinazoline derivatives for the treatment of cancer diseases
|
|
JP5131990B2
(ja)
|
2006-01-31 |
2013-01-30 |
アレイ バイオファーマ、インコーポレイテッド |
キナーゼ阻害剤およびその使用方法
|
|
JP5231411B2
(ja)
|
2006-07-06 |
2013-07-10 |
アレイ バイオファーマ、インコーポレイテッド |
Aktプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
|
|
ATE493418T1
(de)
|
2006-07-06 |
2011-01-15 |
Array Biopharma Inc |
Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
|
|
ES2372955T3
(es)
|
2006-07-06 |
2012-01-30 |
Array Biopharma, Inc. |
Ciclopenta[d]pirimidinas como inhibidores de la proteína cinasa akt.
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
ES2569428T3
(es)
|
2006-07-13 |
2016-05-10 |
Janssen Pharmaceutica Nv |
Derivados de quinazolina como MTKI
|
|
HRP20140331T1
(hr)
|
2006-08-14 |
2014-05-09 |
Xencor, Inc. |
Optimizirana antitijela usmjerena na cd19
|
|
ES2372217T3
(es)
|
2006-09-12 |
2012-01-17 |
Genentech, Inc. |
Procedimientos y composiciones para el diagnóstico y tratamiento del cáncer de pulmón utilizando el gen de pdgfra, kit o kdr como marcador genético.
|
|
SI2068880T1
(sl)
|
2006-09-18 |
2012-08-31 |
Boehringer Ingelheim Int |
Postopek za zdravljenje raka, ki vsebuje mutacije EGFR
|
|
EP1921070A1
(de)
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
|
|
WO2008095847A1
(de)
|
2007-02-06 |
2008-08-14 |
Boehringer Ingelheim International Gmbh |
Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
|
|
ES2477497T3
(es)
|
2007-03-02 |
2014-07-17 |
Genentech, Inc. |
Predicción de la respuesta a un inhibidor de la dimerización de HER basado en la expresión de HER3 bajo
|
|
EP3392273A1
(en)
|
2007-05-30 |
2018-10-24 |
Xencor, Inc. |
Methods and compositions for inhibiting cd32b expressing cells
|
|
CA3006428A1
(en)
|
2007-06-08 |
2008-12-18 |
Genentech, Inc. |
Gene expression markers of tumor resistance to her2 inhibitor treatment
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
NZ582692A
(en)
|
2007-07-05 |
2012-05-25 |
Array Biopharma Inc |
Pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
US8377937B2
(en)
|
2007-07-05 |
2013-02-19 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
AU2008281849B2
(en)
|
2007-07-27 |
2013-11-28 |
Janssen Pharmaceutica Nv |
Pyrrolopyrimidines
|
|
CA2696164C
(en)
|
2007-08-13 |
2018-06-12 |
Vasgene Therapeutics, Inc. |
Cancer treatment using humanized antibodies that bind to ephb4
|
|
CN101148439B
(zh)
*
|
2007-09-14 |
2011-06-22 |
东南大学 |
一种吉非替尼的制备方法
|
|
US8022216B2
(en)
|
2007-10-17 |
2011-09-20 |
Wyeth Llc |
Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
|
|
HRP20150279T1
(hr)
|
2007-12-26 |
2015-05-08 |
Xencor, Inc. |
Fc inaäśice s promijenjenim vezanjem na fcrn
|
|
CA2711692A1
(en)
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
|
|
WO2009089459A1
(en)
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
|
WO2009098061A1
(de)
|
2008-02-07 |
2009-08-13 |
Boehringer Ingelheim International Gmbh |
Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
|
|
DE102008009609A1
(de)
|
2008-02-18 |
2009-08-20 |
Freie Universität Berlin |
Substituierte 4-(Indol-3-yl)chinazoline und deren Verwendung und Herstellung
|
|
US12492253B1
(en)
|
2008-02-25 |
2025-12-09 |
Xencor, Inc. |
Anti-human C5 antibodies
|
|
EP2288727B1
(en)
|
2008-05-14 |
2013-07-10 |
Genomic Health, Inc. |
Predictors of patient response to treatment with egf receptor inhibitors
|
|
CN102641270A
(zh)
|
2008-06-17 |
2012-08-22 |
惠氏有限责任公司 |
含有hki-272和长春瑞滨的抗肿瘤组合
|
|
HUE032958T2
(hu)
|
2008-08-04 |
2017-11-28 |
Wyeth Llc |
4-Anilino-3-ciano-kinolinok és capecitabin antineoplasztikus kombinációi
|
|
WO2010017051A1
(en)
|
2008-08-04 |
2010-02-11 |
Merck Serono S.A. |
Novel phenylamino isonicotinamide compounds
|
|
US8648191B2
(en)
|
2008-08-08 |
2014-02-11 |
Boehringer Ingelheim International Gmbh |
Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
|
|
EP2346818B1
(en)
|
2008-11-10 |
2012-12-05 |
Bayer Intellectual Property GmbH |
Substituted sulphonamido phenoxybenzamides
|
|
AU2009314631B2
(en)
|
2008-11-12 |
2014-07-31 |
Takeda Pharmaceutical Company Limited |
Pyrazinopyrazines and derivatives as kinase inhibitors
|
|
CA2758030C
(en)
|
2009-01-16 |
2019-01-08 |
Exelixis, Inc. |
Malate salt of n-(4-{[6,7-bis(methyloxy)quin0lin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
|
|
LT3000467T
(lt)
|
2009-04-06 |
2023-04-11 |
Wyeth Llc |
Krūties vėžio gydymo schema naudojant neratinibą
|
|
HRP20191005T1
(hr)
|
2009-07-06 |
2019-08-23 |
Boehringer Ingelheim International Gmbh |
Postupak sušenja bibw2992, njegovih soli i čvrstih farmaceutskih formulacija koje sadrže taj djelatni sastojak
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
CN102020639A
(zh)
|
2009-09-14 |
2011-04-20 |
上海恒瑞医药有限公司 |
6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用
|
|
US20120269803A1
(en)
|
2009-10-21 |
2012-10-25 |
Bayer Intellectual Property Gmbh |
Substituted benzosulphonamides
|
|
CA2777304A1
(en)
|
2009-10-21 |
2011-04-28 |
Marion Hitchcock |
Substituted benzosulphonamides
|
|
WO2011047796A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted halophenoxybenzamide derivatives
|
|
US10584181B2
(en)
|
2009-12-04 |
2020-03-10 |
Genentech, Inc. |
Methods of making and using multispecific antibody panels and antibody analog panels
|
|
KR20140015162A
(ko)
|
2010-01-12 |
2014-02-06 |
에프. 호프만-라 로슈 아게 |
트라이사이클릭 헤테로사이클릭 화합물, 조성물 및 이의 사용 방법
|
|
CA2800230A1
(en)
|
2010-03-04 |
2011-09-09 |
Hospital District Of Southwest Finland |
Method for selecting patients for treatment with an egfr inhibitor
|
|
JP2013522267A
(ja)
|
2010-03-17 |
2013-06-13 |
エフ.ホフマン−ラ ロシュ アーゲー |
イミダゾピリジン化合物、組成物、および使用法
|
|
EP2552957A4
(en)
|
2010-03-29 |
2013-11-20 |
Zymeworks Inc |
ANTIBODIES WITH REINFORCED OR SUPPRESSIVE ACTIVE FUNCTION
|
|
KR20130058672A
(ko)
|
2010-04-16 |
2013-06-04 |
제넨테크, 인크. |
PI3K/AKT 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 FOXO3a
|
|
WO2011140442A1
(en)
*
|
2010-05-07 |
2011-11-10 |
Glaxo Group Limited |
Amino-quinolines as kinase inhibitors
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
AU2011264209B2
(en)
*
|
2010-06-09 |
2014-08-07 |
Tianjin Hemay Oncology Pharmaceutical Co., Ltd |
Cyanoquinoline derivatives
|
|
SG187064A1
(en)
*
|
2010-07-14 |
2013-02-28 |
Zhejiang Beta Pharma Inc |
NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS
|
|
UY33549A
(es)
*
|
2010-08-10 |
2012-01-31 |
Glaxo Group Ltd |
Quinolil aminas como agentes inhibidores de las quinasas
|
|
CN103209695A
(zh)
|
2010-09-15 |
2013-07-17 |
弗·哈夫曼-拉罗切有限公司 |
氮杂苯并噻唑化合物、组合物及应用方法
|
|
US9045429B2
(en)
|
2010-10-29 |
2015-06-02 |
Bayer Intellectual Property Gmbh |
Substituted phenoxypyridines
|
|
WO2012065161A2
(en)
|
2010-11-12 |
2012-05-18 |
Scott & White Healthcare |
Antibodies to tumor endothelial marker 8
|
|
JP2013542966A
(ja)
|
2010-11-19 |
2013-11-28 |
エフ.ホフマン−ラ ロシュ アーゲー |
ピラゾロピリジンならびにtyk2阻害剤としてのピラゾロピリジン及びそれらの使用
|
|
WO2012085176A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
|
|
ES2609578T3
(es)
|
2011-03-04 |
2017-04-21 |
Glaxosmithkline Intellectual Property Development Limited |
Amino-quinolinas como inhibidores de quinasa
|
|
WO2012122513A2
(en)
|
2011-03-10 |
2012-09-13 |
Omeros Corporation |
Generation of anti-fn14 monoclonal antibodies by ex-vivo accelerated antibody evolution
|
|
CN102675287A
(zh)
*
|
2011-03-11 |
2012-09-19 |
江苏恒瑞医药股份有限公司 |
(e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用
|
|
RS56759B2
(sr)
|
2011-04-01 |
2024-10-31 |
Genentech Inc |
Kombinacija akt inhibitor jedinjenja i abiraterona za upotrebu pri terapeutskim tretiranjima
|
|
CA2831932A1
(en)
|
2011-04-01 |
2012-10-04 |
Genentech, Inc. |
Combinations of akt and mek inhibitor compounds, and methods of use
|
|
US9833439B2
(en)
|
2011-05-25 |
2017-12-05 |
Universite Paris Descartes |
ERK inhibitors for use in treating spinal muscular atrophy
|
|
WO2013007765A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Fused tricyclic compounds for use as inhibitors of janus kinases
|
|
WO2013007768A1
(en)
|
2011-07-13 |
2013-01-17 |
F. Hoffmann-La Roche Ag |
Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
|
|
HK1199255A1
(en)
|
2011-08-12 |
2015-06-26 |
F. Hoffmann-La Roche Ag |
Indazole compounds, compositions and methods of use
|
|
JP5944994B2
(ja)
|
2011-08-12 |
2016-07-05 |
オメロス コーポレーション |
抗fzd10モノクローナル抗体およびそれらの使用方法
|
|
TWI547494B
(zh)
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
WO2013041539A1
(en)
|
2011-09-20 |
2013-03-28 |
F. Hoffmann-La Roche Ag |
Imidazopyridine compounds, compositions and methods of use
|
|
CA2849945A1
(en)
|
2011-11-04 |
2013-05-10 |
F.Hoffmann-La Roche Ag |
New aryl-quinoline derivatives
|
|
CN103204822B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途
|
|
NZ630020A
(en)
|
2012-03-08 |
2016-08-26 |
Halozyme Inc |
Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
|
|
CA2865082A1
(en)
|
2012-03-27 |
2013-10-03 |
Genentech, Inc. |
Diagnosis and treatments relating to her3 inhibitors
|
|
CN103539783A
(zh)
*
|
2012-07-12 |
2014-01-29 |
江苏恒瑞医药股份有限公司 |
一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法
|
|
TW201425307A
(zh)
|
2012-09-13 |
2014-07-01 |
Glaxosmithkline Llc |
作為激酶抑制劑之胺基-喹啉類
|
|
TWI592417B
(zh)
|
2012-09-13 |
2017-07-21 |
葛蘭素史克智慧財產發展有限公司 |
胺基喹唑啉激酶抑制劑之前藥
|
|
BR112015019624A2
(pt)
|
2013-02-21 |
2017-07-18 |
Glaxosmithkline Ip Dev Ltd |
quinazolinas como inibidores de quinase
|
|
US10035801B2
(en)
|
2013-03-13 |
2018-07-31 |
Genentech, Inc. |
Pyrazolo compounds and uses thereof
|
|
UY35464A
(es)
|
2013-03-15 |
2014-10-31 |
Araxes Pharma Llc |
Inhibidores covalentes de kras g12c.
|
|
CN103275001B
(zh)
*
|
2013-06-14 |
2015-02-18 |
苏州明锐医药科技有限公司 |
4-氨基-3-喹啉甲腈衍生物的制备方法
|
|
CA2922925A1
(en)
|
2013-09-05 |
2015-03-12 |
Genentech, Inc. |
Antiproliferative compounds
|
|
EP3043822A1
(en)
|
2013-09-11 |
2016-07-20 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Compositions for preparing cardiomyocytes
|
|
KR20160055253A
(ko)
|
2013-09-12 |
2016-05-17 |
할로자임, 아이엔씨 |
변형된 항-상피세포 성장인자 수용체 항체 및 이의 사용 방법
|
|
KR20160055861A
(ko)
|
2013-09-17 |
2016-05-18 |
오비아이 파머 인코퍼레이티드 |
암치료에서 면역반응을 유도하기 위한 탄수화물 백신의 조성물
|
|
AR097894A1
(es)
|
2013-10-03 |
2016-04-20 |
Hoffmann La Roche |
Inhibidores terapéuticos de cdk8 o uso de los mismos
|
|
TWI659021B
(zh)
|
2013-10-10 |
2019-05-11 |
亞瑞克西斯製藥公司 |
Kras g12c之抑制劑
|
|
FI3083686T4
(fi)
|
2013-12-17 |
2023-05-09 |
|
Menetelmiä syöpien hoitamiseksi käyttäen pd-1-akselia sitovia antagonisteja ja taksaaneja
|
|
BR112016013963A2
(pt)
|
2013-12-17 |
2017-10-10 |
Genentech Inc |
terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1
|
|
US9242965B2
(en)
|
2013-12-31 |
2016-01-26 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
|
|
EP3094736A4
(en)
|
2014-01-14 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
JP6588461B2
(ja)
|
2014-03-31 |
2019-10-09 |
ジェネンテック, インコーポレイテッド |
抗血管新生剤及びox40結合アゴニストを含む併用療法
|
|
PE20161571A1
(es)
|
2014-03-31 |
2017-02-07 |
Genentech Inc |
Anticuerpos anti-ox40 y metodos de uso
|
|
CN107074823B
(zh)
|
2014-09-05 |
2021-05-04 |
基因泰克公司 |
治疗性化合物及其用途
|
|
CN107073125A
(zh)
|
2014-09-19 |
2017-08-18 |
基因泰克公司 |
Cbp/ep300和bet抑制剂用于治疗癌症的用途
|
|
US20170248603A1
(en)
|
2014-10-06 |
2017-08-31 |
Dana-Farber Cancer Institute, Inc. |
Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response
|
|
EP3204379B1
(en)
|
2014-10-10 |
2019-03-06 |
Genentech, Inc. |
Pyrrolidine amide compounds as histone demethylase inhibitors
|
|
CA2966523A1
(en)
|
2014-11-03 |
2016-05-12 |
Genentech, Inc. |
Assays for detecting t cell immune subsets and methods of use thereof
|
|
SG11201703521UA
(en)
|
2014-11-03 |
2017-05-30 |
Genentech Inc |
Methods and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment
|
|
KR20170072343A
(ko)
|
2014-11-06 |
2017-06-26 |
제넨테크, 인크. |
Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법
|
|
MA40940A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
MA40943A
(fr)
|
2014-11-10 |
2017-09-19 |
Constellation Pharmaceuticals Inc |
Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
|
|
EP3218376B1
(en)
|
2014-11-10 |
2019-12-25 |
Genentech, Inc. |
Bromodomain inhibitors and uses thereof
|
|
EP3221360A1
(en)
|
2014-11-17 |
2017-09-27 |
F. Hoffmann-La Roche AG |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
|
JP6771464B2
(ja)
|
2014-11-27 |
2020-10-21 |
ジェネンテック, インコーポレイテッド |
Cbpおよび/またはep300インヒビターとしての、4,5,6,7−テトラヒドロ−1h−ピラゾロ[4,3−c]ピリジン−3−アミン化合物
|
|
HK1243141A1
(zh)
|
2014-12-23 |
2018-07-06 |
豪夫迈.罗氏有限公司 |
用於治疗和诊断化学疗法抗性癌症的组合物和方法
|
|
JP2018503373A
(ja)
|
2014-12-30 |
2018-02-08 |
ジェネンテック, インコーポレイテッド |
がんの予後診断及び治療のための方法及び組成物
|
|
WO2016112251A1
(en)
|
2015-01-09 |
2016-07-14 |
Genentech, Inc. |
4,5-dihydroimidazole derivatives and their use as histone demethylase (kdm2b) inhibitors
|
|
JP6855379B2
(ja)
|
2015-01-09 |
2021-04-07 |
ジェネンテック, インコーポレイテッド |
癌の処置のためのヒストンデメチラーゼkdm2bのインヒビターとしての(ピペリジン−3−イル)(ナフタレン−2−イル)メタノン誘導体および関連化合物
|
|
JP6659703B2
(ja)
|
2015-01-09 |
2020-03-04 |
ジェネンテック, インコーポレイテッド |
ピリダジノン誘導体および癌の処置におけるそれらの使用
|
|
JP6709792B2
(ja)
|
2015-01-29 |
2020-06-17 |
ジェネンテック, インコーポレイテッド |
治療用化合物およびその使用
|
|
CN107438593B
(zh)
|
2015-01-30 |
2020-10-30 |
基因泰克公司 |
治疗化合物及其用途
|
|
MA41598A
(fr)
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
Composés thérapeutiques de pyridazine et leurs utilisations
|
|
MA41866A
(fr)
|
2015-03-31 |
2018-02-06 |
Massachusetts Gen Hospital |
Molécules à auto-assemblage pour l'administration ciblée de médicaments
|
|
KR20180002653A
(ko)
|
2015-04-07 |
2018-01-08 |
제넨테크, 인크. |
효능작용 활성을 갖는 항원 결합 복합체 및 사용 방법
|
|
EA201792214A1
(ru)
*
|
2015-04-10 |
2018-01-31 |
Араксис Фарма Ллк |
Соединения замещенного хиназолина
|
|
RS61152B2
(sr)
|
2015-05-12 |
2024-06-28 |
Hoffmann La Roche |
Terapeutski i dijagnostički postupci za lečenje raka
|
|
HK1248773A1
(zh)
|
2015-05-29 |
2018-10-19 |
豪夫迈‧罗氏有限公司 |
用於癌症的治疗和诊断方法
|
|
JP2018521019A
(ja)
|
2015-06-08 |
2018-08-02 |
ジェネンテック, インコーポレイテッド |
抗ox40抗体を使用して癌を治療する方法
|
|
JP2018518483A
(ja)
|
2015-06-08 |
2018-07-12 |
ジェネンテック, インコーポレイテッド |
抗ox40抗体及びpd−1軸結合アンタゴニストを使用して癌を治療する方法
|
|
IL256080B2
(en)
|
2015-06-17 |
2025-06-01 |
Genentech Inc |
Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes
|
|
PT3191470T
(pt)
*
|
2015-07-06 |
2019-06-05 |
Gilead Sciences Inc |
Moduladores de cot e métodos para a sua utilização
|
|
NZ738538A
(en)
|
2015-07-06 |
2019-06-28 |
Gilead Sciences Inc |
6-amino-quinoline-3-carbonitrils as cot modulators
|
|
JP6946270B2
(ja)
|
2015-08-26 |
2021-10-06 |
ファンダシオン デル セクトル プーブリコ エスタタル セントロ ナショナル デ インベスティゲーショネス オンコロジカス カルロス 3(エフ エス ピー クニオ) |
タンパク質キナーゼ阻害剤としての縮合三環化合物
|
|
KR20180050339A
(ko)
|
2015-09-04 |
2018-05-14 |
오비아이 파머 인코퍼레이티드 |
글리칸 어레이 및 사용 방법
|
|
KR20230125094A
(ko)
|
2015-09-25 |
2023-08-28 |
제넨테크, 인크. |
항-tigit 항체 및 이의 이용 방법
|
|
US10689356B2
(en)
|
2015-09-28 |
2020-06-23 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356347A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058915A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10882847B2
(en)
|
2015-09-28 |
2021-01-05 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
JP6740354B2
(ja)
|
2015-10-05 |
2020-08-12 |
ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク |
オートファジーの流れ及びホスホリパーゼd及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
|
|
CA3005089A1
(en)
|
2015-11-16 |
2017-05-26 |
Araxes Pharma Llc |
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
|
|
HRP20220227T1
(hr)
|
2015-12-16 |
2022-04-29 |
Genentech, Inc. |
Postupak priprave tricikličnih spojeva inhibitora p13k i postupci upotrebe navedenih spojeva u liječenju raka
|
|
ES2837428T3
(es)
|
2016-01-08 |
2021-06-30 |
Hoffmann La Roche |
Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3
|
|
KR102500659B1
(ko)
|
2016-02-29 |
2023-02-16 |
제넨테크, 인크. |
암에 대한 치료 및 진단 방법
|
|
US11041017B2
(en)
|
2016-03-29 |
2021-06-22 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
|
US10980894B2
(en)
|
2016-03-29 |
2021-04-20 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
|
JP7503887B2
(ja)
|
2016-04-15 |
2024-06-21 |
ジェネンテック, インコーポレイテッド |
がんを監視及び治療するための方法
|
|
WO2017180581A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
CA3020718A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Methods for monitoring and treating cancer
|
|
AU2017252128B2
(en)
|
2016-04-22 |
2024-06-06 |
Obi Pharma, Inc. |
Cancer immunotherapy by immune activation or immune modulation via Globo series antigens
|
|
US20190151346A1
(en)
|
2016-05-10 |
2019-05-23 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Combinations therapies for the treatment of cancer
|
|
WO2017205538A1
(en)
|
2016-05-24 |
2017-11-30 |
Genentech, Inc. |
Pyrazolopyridine derivatives for the treatment of cancer
|
|
WO2017205536A2
(en)
|
2016-05-24 |
2017-11-30 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
CN109312407A
(zh)
|
2016-06-08 |
2019-02-05 |
豪夫迈·罗氏有限公司 |
用于癌症的诊断和治疗方法
|
|
FI3468997T3
(fi)
|
2016-06-08 |
2023-10-31 |
Xencor Inc |
Igg4:ään liittyvien sairauksien hoito anti-cd19-vasta-aineilla, jotka ristisitoutuvat cd32b:een
|
|
EP3478674B1
(en)
|
2016-06-30 |
2020-05-13 |
Gilead Sciences, Inc. |
4,6-diaminoquinazolines as cot modulators and methods of use thereof
|
|
KR20230117482A
(ko)
|
2016-07-27 |
2023-08-08 |
오비아이 파머 인코퍼레이티드 |
면역원성/치료 글리칸 조성물 및 그의 용도
|
|
CN110062767B
(zh)
|
2016-07-29 |
2023-07-11 |
台湾浩鼎生技股份有限公司 |
人抗体、药物组合物和方法
|
|
JP2019530434A
(ja)
|
2016-08-05 |
2019-10-24 |
ジェネンテック, インコーポレイテッド |
アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法
|
|
JP7250674B2
(ja)
|
2016-08-08 |
2023-04-03 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
がんの治療及び診断方法
|
|
JP2019529484A
(ja)
|
2016-09-29 |
2019-10-17 |
アラクセス ファーマ エルエルシー |
Kras g12c変異体タンパク質の阻害剤
|
|
MX2019003934A
(es)
|
2016-10-06 |
2019-07-10 |
Genentech Inc |
Métodos terapéuticos y de diagnóstico para el cáncer.
|
|
JP2019535250A
(ja)
|
2016-10-29 |
2019-12-12 |
ジェネンテック, インコーポレイテッド |
抗mic抗体及び使用方法
|
|
TWI822055B
(zh)
|
2016-11-21 |
2023-11-11 |
台灣浩鼎生技股份有限公司 |
共軛生物分子、醫藥組成物及方法
|
|
EP3573971A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
|
|
US11136308B2
(en)
|
2017-01-26 |
2021-10-05 |
Araxes Pharma Llc |
Substituted quinazoline and quinazolinone compounds and methods of use thereof
|
|
JP7327802B2
(ja)
|
2017-01-26 |
2023-08-16 |
アラクセス ファーマ エルエルシー |
縮合ヘテロ-ヘテロ二環式化合物およびその使用方法
|
|
US11274093B2
(en)
|
2017-01-26 |
2022-03-15 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
WO2018140599A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
ES2953595T3
(es)
|
2017-03-01 |
2023-11-14 |
Hoffmann La Roche |
Procedimientos diagnósticos y terapéuticos para el cáncer
|
|
BR112019021411A2
(pt)
|
2017-04-13 |
2020-05-05 |
Hoffmann La Roche |
métodos para tratar ou retardar a progressão do câncer e para melhorar a função, usos de um imunoconjugado, de um agonista, de um antagonista, composições, kit e invenção
|
|
US10745385B2
(en)
|
2017-05-25 |
2020-08-18 |
Araxes Pharma Llc |
Covalent inhibitors of KRAS
|
|
JP2020521740A
(ja)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体
|
|
TW201906832A
(zh)
|
2017-05-25 |
2019-02-16 |
美商亞瑞克西斯製藥公司 |
用於癌症治療之化合物及其使用方法
|
|
IL271888B2
(en)
|
2017-07-21 |
2024-09-01 |
Genentech Inc |
Therapeutic and diagnostic methods for cancer
|
|
CN111295394B
(zh)
|
2017-08-11 |
2024-06-11 |
豪夫迈·罗氏有限公司 |
抗cd8抗体及其用途
|
|
KR102811888B1
(ko)
|
2017-09-08 |
2025-05-27 |
에프. 호프만-라 로슈 아게 |
암의 진단 및 치료 방법
|
|
US11369608B2
(en)
|
2017-10-27 |
2022-06-28 |
University Of Virginia Patent Foundation |
Compounds and methods for regulating, limiting, or inhibiting AVIL expression
|
|
CA3077664A1
(en)
|
2017-11-06 |
2019-05-09 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
AU2019207535B2
(en)
|
2018-01-15 |
2021-12-23 |
Epiaxis Therapeutics Pty Ltd |
Agents and methods for predicting response to therapy
|
|
CA3088200A1
(en)
|
2018-01-26 |
2019-08-01 |
Exelixis, Inc. |
Compounds for the treatment of kinase-dependent disorders
|
|
AU2019212800B2
(en)
|
2018-01-26 |
2024-05-23 |
Exelixis, Inc. |
Compounds for the treatment of kinase-dependent disorders
|
|
CN112312909B
(zh)
|
2018-01-26 |
2024-07-02 |
埃克塞里艾克西斯公司 |
用于治疗激酶依赖性病症的化合物
|
|
CA3092108A1
(en)
|
2018-02-26 |
2019-08-29 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
JP2021524744A
(ja)
|
2018-05-21 |
2021-09-16 |
ナノストリング テクノロジーズ,インコーポレイティド |
分子遺伝子シグネチャーとその使用方法
|
|
AU2019288728A1
(en)
|
2018-06-23 |
2021-01-14 |
Genentech, Inc. |
Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
|
|
WO2020006176A1
(en)
|
2018-06-27 |
2020-01-02 |
Obi Pharma, Inc. |
Glycosynthase variants for glycoprotein engineering and methods of use
|
|
CN108752248A
(zh)
*
|
2018-07-17 |
2018-11-06 |
常州大学 |
一种合成1-(3-乙氧基-4-甲氧基)苯基-2-甲磺酰基乙胺的方法
|
|
TW202011991A
(zh)
|
2018-07-18 |
2020-04-01 |
美商建南德克公司 |
用pd-1軸結合拮抗劑、抗代謝劑及鉑劑治療肺癌之方法
|
|
BR112021001709A2
(pt)
|
2018-08-01 |
2021-05-04 |
Araxes Pharma Llc |
compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
|
|
TW202024023A
(zh)
|
2018-09-03 |
2020-07-01 |
瑞士商赫孚孟拉羅股份公司 |
治療性化合物及其使用方法
|
|
CN112955747A
(zh)
|
2018-09-19 |
2021-06-11 |
豪夫迈·罗氏有限公司 |
膀胱癌的治疗和诊断方法
|
|
ES2955032T3
(es)
|
2018-09-21 |
2023-11-28 |
Hoffmann La Roche |
Métodos de diagnóstico para el cáncer de mama triple negativo
|
|
AU2019362972A1
(en)
|
2018-10-17 |
2021-05-20 |
The University Of Queensland |
Epigenetic biomarker and uses therefor
|
|
AU2019361983A1
(en)
|
2018-10-18 |
2021-05-20 |
Genentech, Inc. |
Diagnostic and therapeutic methods for sarcomatoid kidney cancer
|
|
EP3921443A1
(en)
|
2019-02-08 |
2021-12-15 |
F. Hoffmann-La Roche AG |
Diagnostic and therapeutic methods for cancer
|
|
CA3131268A1
(en)
|
2019-02-27 |
2020-09-03 |
Epiaxis Therapeutics Pty Ltd |
Methods and agents for assessing t-cell function and predicting response to therapy
|
|
JP2022521773A
(ja)
|
2019-02-27 |
2022-04-12 |
ジェネンテック, インコーポレイテッド |
抗tigit抗体と抗cd20抗体又は抗cd38抗体とによる処置のための投薬
|
|
WO2020223233A1
(en)
|
2019-04-30 |
2020-11-05 |
Genentech, Inc. |
Prognostic and therapeutic methods for colorectal cancer
|
|
KR20220004744A
(ko)
|
2019-05-03 |
2022-01-11 |
제넨테크, 인크. |
항-pd-l1 항체를 이용하여 암을 치료하는 방법
|
|
TWI770527B
(zh)
|
2019-06-14 |
2022-07-11 |
美商基利科學股份有限公司 |
Cot 調節劑及其使用方法
|
|
CN112300279A
(zh)
|
2019-07-26 |
2021-02-02 |
上海复宏汉霖生物技术股份有限公司 |
针对抗cd73抗体和变体的方法和组合物
|
|
EP4025608A1
(en)
|
2019-09-04 |
2022-07-13 |
F. Hoffmann-La Roche AG |
Cd8 binding agents and uses thereof
|
|
TW202126651A
(zh)
|
2019-09-26 |
2021-07-16 |
美商艾克塞里克斯公司 |
吡啶酮化合物及使用方法
|
|
CR20220127A
(es)
|
2019-09-27 |
2022-05-27 |
Genentech Inc |
Administración de dosis para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1
|
|
CN114728936A
(zh)
|
2019-10-29 |
2022-07-08 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的双功能化合物
|
|
US20220389103A1
(en)
|
2019-11-06 |
2022-12-08 |
Genentech, Inc. |
Diagnostic and therapeutic methods for treatment of hematologic cancers
|
|
WO2021097110A1
(en)
|
2019-11-13 |
2021-05-20 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
KR20220113790A
(ko)
|
2019-12-13 |
2022-08-16 |
제넨테크, 인크. |
항-ly6g6d 항체 및 사용 방법
|
|
WO2021127404A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2021154761A1
(en)
|
2020-01-27 |
2021-08-05 |
Genentech, Inc. |
Methods for treatment of cancer with an anti-tigit antagonist antibody
|
|
WO2021194481A1
(en)
|
2020-03-24 |
2021-09-30 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
WO2022050954A1
(en)
|
2020-09-04 |
2022-03-10 |
Genentech, Inc. |
Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
|
|
WO2021177980A1
(en)
|
2020-03-06 |
2021-09-10 |
Genentech, Inc. |
Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist
|
|
KR20220161438A
(ko)
|
2020-03-30 |
2022-12-06 |
길리애드 사이언시즈, 인코포레이티드 |
Cot 억제제 화합물, (S)-6-(((1-(바이사이클로[1.1.1]펜탄-1-일)-1H-1,2,3-트라이아졸-4-일)2-메틸-1-옥소-1,2-다이하이드로아이소퀴놀린-5-일)메틸)))아미노8-클로로-(네오펜틸아미노)퀴놀린-3-카르보니트릴의 고체 형태
|
|
WO2021202688A1
(en)
|
2020-04-02 |
2021-10-07 |
Gilead Sciences, Inc. |
Process for preparing a cot inhibitor compound
|
|
WO2021202959A1
(en)
|
2020-04-03 |
2021-10-07 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
EP4143345A1
(en)
|
2020-04-28 |
2023-03-08 |
Genentech, Inc. |
Methods and compositions for non-small cell lung cancer immunotherapy
|
|
CA3181820A1
(en)
|
2020-06-16 |
2021-12-23 |
Genentech, Inc. |
Methods and compositions for treating triple-negative breast cancer
|
|
WO2021257124A1
(en)
|
2020-06-18 |
2021-12-23 |
Genentech, Inc. |
Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
|
|
JP7741831B2
(ja)
|
2020-06-30 |
2025-09-18 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
術前補助療法及び根治手術後の固形がんを患っている患者の再発及び/又は死亡のリスクを予測するための方法
|
|
CN115997123A
(zh)
|
2020-06-30 |
2023-04-21 |
国家医疗保健研究所 |
用于预测实体癌患者在术前辅助治疗后复发和/或死亡风险的方法
|
|
WO2022006386A1
(en)
*
|
2020-07-02 |
2022-01-06 |
Enliven Therapeutics, Inc. |
Alkyne quinazoline derivatives as inhibitors of erbb2
|
|
US11787775B2
(en)
|
2020-07-24 |
2023-10-17 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
WO2022031749A1
(en)
|
2020-08-03 |
2022-02-10 |
Genentech, Inc. |
Diagnostic and therapeutic methods for lymphoma
|
|
CN115803325B
(zh)
*
|
2020-08-10 |
2024-04-26 |
上海和誉生物医药科技有限公司 |
一种egfr抑制剂及其制备方法和应用
|
|
EP4196612A1
(en)
|
2020-08-12 |
2023-06-21 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
CN116847887A
(zh)
|
2020-08-27 |
2023-10-03 |
伊诺西治疗公司 |
治疗自身免疫性疾病和癌症的方法和组合物
|
|
MX2023003338A
(es)
|
2020-09-23 |
2023-06-14 |
Erasca Inc |
Piridonas y pirimidonas tricíclicas.
|
|
JP2023544407A
(ja)
|
2020-10-05 |
2023-10-23 |
ジェネンテック, インコーポレイテッド |
抗FcRH5/抗CD3二重特異性抗体による処置のための投与
|
|
US20230107642A1
(en)
|
2020-12-18 |
2023-04-06 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2022171745A1
(en)
|
2021-02-12 |
2022-08-18 |
F. Hoffmann-La Roche Ag |
Bicyclic tetrahydroazepine derivatives for the treatment of cancer
|
|
CA3211063A1
(en)
|
2021-02-19 |
2022-08-25 |
Exelixis, Inc. |
Pyridone compounds and methods of use
|
|
KR20240026948A
(ko)
|
2021-05-25 |
2024-02-29 |
에라스카, 아이엔씨. |
황 함유 헤테로방향족 트리사이클릭 kras 억제제
|
|
US20240293558A1
(en)
|
2021-06-16 |
2024-09-05 |
Erasca, Inc. |
Kras inhibitor conjugates
|
|
JP2024528697A
(ja)
|
2021-07-20 |
2024-07-30 |
エイジーエス・セラピューティクス・ソシエテ・パール・アクシオン・サンプリフィエ |
微細藻類由来の細胞外小胞、その調製および使用
|
|
EP4384522A1
(en)
|
2021-08-10 |
2024-06-19 |
Erasca, Inc. |
Selective kras inhibitors
|
|
JP2024541508A
(ja)
|
2021-11-24 |
2024-11-08 |
ジェネンテック, インコーポレイテッド |
治療用インダゾール化合物およびがんの治療における使用方法
|
|
US12275745B2
(en)
|
2021-11-24 |
2025-04-15 |
Genentech, Inc. |
Therapeutic compounds and methods of use
|
|
WO2023144127A1
(en)
|
2022-01-31 |
2023-08-03 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
|
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|
|
WO2023191816A1
(en)
|
2022-04-01 |
2023-10-05 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
CA3251472A1
(en)
|
2022-05-11 |
2023-11-16 |
Genentech, Inc. |
DOSAGE FOR TREATMENT WITH ANTI-FCRH5/ANTI-CD3 BISPECIFIC ANTIBODIES
|
|
KR20250022049A
(ko)
|
2022-06-07 |
2025-02-14 |
제넨테크, 인크. |
항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법
|
|
CN115057776B
(zh)
*
|
2022-06-15 |
2023-08-22 |
必维申瓯质量技术服务温州有限公司 |
2-萘甲酸乙酯衍生物的合成方法
|
|
CN119585308A
(zh)
|
2022-07-13 |
2025-03-07 |
基因泰克公司 |
针对用抗fcrh5/抗cd3双特异性抗体进行的治疗的给药
|
|
EP4558524A1
(en)
|
2022-07-19 |
2025-05-28 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
MA71727A
(fr)
|
2022-08-11 |
2025-05-30 |
F. Hoffmann-La Roche Ag |
Dérivés bicycliques de tétrahydrothiazépine
|
|
TW202417439A
(zh)
|
2022-08-11 |
2024-05-01 |
瑞士商赫孚孟拉羅股份公司 |
雙環四氫噻吖呯衍生物
|
|
KR20250048020A
(ko)
|
2022-08-11 |
2025-04-07 |
에프. 호프만-라 로슈 아게 |
바이시클릭 테트라히드로티아제핀 유도체
|
|
TW202417001A
(zh)
|
2022-08-11 |
2024-05-01 |
瑞士商赫孚孟拉羅股份公司 |
雙環四氫吖呯衍生物
|
|
WO2024085242A2
(en)
|
2022-10-21 |
2024-04-25 |
Kawasaki Institute Of Industrial Promotion |
Non-fouling or super stealth vesicle
|
|
EP4608424A1
(en)
|
2022-10-24 |
2025-09-03 |
AGS Therapeutics SAS |
Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof
|
|
WO2024091991A1
(en)
|
2022-10-25 |
2024-05-02 |
Genentech, Inc. |
Therapeutic and diagnostic methods for multiple myeloma
|
|
WO2024173842A1
(en)
|
2023-02-17 |
2024-08-22 |
Erasca, Inc. |
Kras inhibitors
|
|
AU2024270495A1
(en)
|
2023-05-05 |
2025-10-09 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
|
WO2024254455A1
(en)
|
2023-06-08 |
2024-12-12 |
Genentech, Inc. |
Macrophage signatures for diagnostic and therapeutic methods for lymphoma
|
|
WO2025024257A1
(en)
|
2023-07-21 |
2025-01-30 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
WO2025049277A1
(en)
|
2023-08-25 |
2025-03-06 |
Genentech, Inc. |
Methods and compositions for treating non-small cell lung cancer comprising an anti-tigit antagonist antibody and a pd-1 axis binding antagonist
|
|
WO2025176843A1
(en)
|
2024-02-21 |
2025-08-28 |
Ags Therapeutics Sas |
Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof
|