HK1153754A1 - Nucleic acids and proteins from streptococcus groups a & b - Google Patents
Nucleic acids and proteins from streptococcus groups a & bInfo
- Publication number
- HK1153754A1 HK1153754A1 HK11107796.8A HK11107796A HK1153754A1 HK 1153754 A1 HK1153754 A1 HK 1153754A1 HK 11107796 A HK11107796 A HK 11107796A HK 1153754 A1 HK1153754 A1 HK 1153754A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- proteins
- streptococcus
- nucleic acids
- streptococcus groups
- group
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108091005461 Nucleic proteins Proteins 0.000 title 1
- 241000194017 Streptococcus Species 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000193985 Streptococcus agalactiae Species 0.000 abstract 1
- 241000193996 Streptococcus pyogenes Species 0.000 abstract 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 abstract 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C12N9/1088—Glutathione transferase (2.5.1.18)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01018—Glutathione transferase (2.5.1.18)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0026333A GB0026333D0 (en) | 2000-10-27 | 2000-10-27 | Streptococcus antigens |
GB0028727A GB0028727D0 (en) | 2000-11-24 | 2000-11-24 | Streptococcus antigens |
GB0105640A GB0105640D0 (en) | 2001-03-07 | 2001-03-07 | Streptococcus proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1153754A1 true HK1153754A1 (en) | 2012-04-05 |
Family
ID=27255953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11107796.8A HK1153754A1 (en) | 2000-10-27 | 2011-07-26 | Nucleic acids and proteins from streptococcus groups a & b |
Country Status (17)
Country | Link |
---|---|
US (10) | US7939087B2 (xx) |
EP (10) | EP2284183A1 (xx) |
JP (5) | JP4254931B1 (xx) |
AT (1) | ATE439372T1 (xx) |
AU (2) | AU2002214127B2 (xx) |
CA (2) | CA2881568C (xx) |
CY (1) | CY1110698T1 (xx) |
DE (1) | DE60139563D1 (xx) |
DK (1) | DK1328543T3 (xx) |
ES (1) | ES2330083T3 (xx) |
HK (1) | HK1153754A1 (xx) |
IL (5) | IL154853A0 (xx) |
MX (2) | MX357775B (xx) |
NZ (6) | NZ593617A (xx) |
SG (1) | SG165981A1 (xx) |
WO (1) | WO2002034771A2 (xx) |
ZA (1) | ZA200302739B (xx) |
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT909323E (pt) | 1996-01-04 | 2007-06-04 | Novartis Vaccines & Diagnostic | ''bacterioferritina de helicobacter pilori'' |
US7087235B2 (en) * | 1997-06-25 | 2006-08-08 | The United States Of America As Represented By The Secretary Of The Army | Fusion protein of streptococcal pyrogenic exotoxins |
US6890539B2 (en) | 1998-12-22 | 2005-05-10 | Microscience, Ltd. | Genes and proteins, and their use |
HUP0104825A3 (en) | 1998-12-22 | 2008-04-28 | Microscience Ltd | Genes and proteins, and their use |
US7491402B2 (en) * | 1998-12-24 | 2009-02-17 | Auckland Uniservices Limited | Superantigens SMEZ-2, SPE-G, SPE-H and SPE-J and uses thereof |
CA2397710A1 (en) * | 1999-12-23 | 2001-07-05 | Vmax Limited | Streptococcus pyogenes virulence genes and proteins and their use |
AU2001296864A1 (en) | 2000-08-31 | 2002-03-13 | Mayo Foundation For Medical Education And Research | Detection of varicella-zoster virus |
CA2881568C (en) * | 2000-10-27 | 2019-09-24 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from streptococcus groups a & b |
DE60134494D1 (de) | 2000-12-21 | 2008-07-31 | Id Biomedical Corp | Antigene aus streptococcus pyogenes und zugehörige dna-fragmente |
US7082569B2 (en) | 2001-01-17 | 2006-07-25 | Outlooksoft Corporation | Systems and methods providing dynamic spreadsheet functionality |
WO2002061390A2 (en) | 2001-01-31 | 2002-08-08 | Mayo Foundation For Medical Education And Research | Detection of herpes simplex virus |
US7691571B2 (en) | 2001-01-31 | 2010-04-06 | Mayo Foundation For Medical Education And Research | Detection of bordetella |
JP4281861B2 (ja) | 2001-02-21 | 2009-06-17 | アイディ・バイオメディカル・コーポレイション | Streptococcus pyogenesポリペプチドおよび対応するdnaフラグメント |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
WO2002083859A2 (en) | 2001-04-13 | 2002-10-24 | Wyeth | Surface proteins of streptococcus pyogenes |
AU2008207670B2 (en) * | 2001-04-13 | 2011-06-16 | Wyeth | Surface proteins of streptococcus pyogenes |
EP1390505A2 (en) * | 2001-05-02 | 2004-02-25 | Shire Biochem Inc. | Antigens of group b streptococcus and corresponding dna fragments |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
CA2453062C (en) | 2001-07-06 | 2013-04-02 | Shire Biochem Inc. | Group b streptococcus bvh-a5 antigens and corresponding dna fragments |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
EP2335724A1 (en) | 2001-12-12 | 2011-06-22 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation against chlamydia trachomatis |
GB0130228D0 (en) * | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
GB0210128D0 (en) * | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
AU2003228084A1 (en) * | 2002-05-28 | 2003-12-12 | Omrix Biopharmaceuticals Inc. | Method for obtaining anti-idiotype antibodies |
AU2003246495A1 (en) * | 2002-07-15 | 2004-02-02 | Id Biomedical Corporation | Polypeptide of streptococcus pyogenes |
WO2004011638A2 (en) * | 2002-07-31 | 2004-02-05 | Affinium Pharmaceuticals, Inc. | Deoxyuridine 5' triphosphate nucleotidohydrolase polypeptides and structures |
JP2005535350A (ja) * | 2002-08-12 | 2005-11-24 | アクゾ・ノベル・エヌ・ベー | ストレプトコッカス・ユベリス蛋白質、前記蛋白質をコードする核酸配列及び乳腺炎ワクチンにおけるその使用 |
DE10239629A1 (de) * | 2002-08-23 | 2004-04-08 | Idt Impfstoffwerk Dessau-Tornau Gmbh | Nicht-rekombinate Subunit-Vakzine gegen Streptococcus suis-Infektionen des Schweines |
AU2003260102A1 (en) * | 2002-08-26 | 2004-03-11 | Chiron Corporation | Conserved and specific streptococcal genomes |
CA2495295A1 (en) * | 2002-08-29 | 2004-03-11 | The Uab Research Foundation | Group b streptococcal phage lysin |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
CA2498847C (en) * | 2002-09-13 | 2014-10-28 | Chiron Corporation | Group b streptococcus vaccine |
US7074598B2 (en) | 2002-09-25 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of vancomycin-resistant enterococcus spp. |
US7365176B2 (en) | 2002-09-26 | 2008-04-29 | Mayo Foundation For Medical Education And Research | Detection of Epstein-Barr virus |
WO2004033709A2 (en) * | 2002-10-08 | 2004-04-22 | Emory University | Methods, probes, and kits for detecting group a streptococcus |
JP5116971B2 (ja) * | 2002-10-15 | 2013-01-09 | インターセル アーゲー | B群連鎖球菌の接着因子をコードする核酸、b群連鎖球菌の接着因子、およびその使用 |
US8409587B2 (en) | 2002-11-01 | 2013-04-02 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
WO2004046177A2 (en) | 2002-11-15 | 2004-06-03 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
DE10300335B4 (de) * | 2003-01-09 | 2008-06-26 | Iep Gmbh | Oxidoreduktase |
SI1601770T1 (sl) * | 2003-03-04 | 2010-01-29 | Intercell Ag | Streptococcus pyogenes antigeni |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
CA2522238A1 (en) | 2003-04-15 | 2004-10-28 | Intercell Ag | S. pneumoniae antigens |
CA2522986A1 (en) * | 2003-05-07 | 2004-11-18 | Intercell Ag | Streptococcus agalactiae antigens i + ii |
WO2004106367A2 (en) * | 2003-05-30 | 2004-12-09 | Intercell Ag | Enterococcus antigens |
CA2528007C (en) | 2003-06-02 | 2012-03-27 | Chiron Corporation | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
DE602004018141D1 (de) * | 2003-07-04 | 2009-01-15 | Affibody Ab | Polypeptide mit bindungsaffinität für her2 |
PT1648500E (pt) * | 2003-07-31 | 2014-10-10 | Novartis Vaccines & Diagnostic | Composições imunogénicas para estreptococos piogenes |
WO2005017093A2 (en) * | 2003-08-15 | 2005-02-24 | Id Biomedical Corporation | Polypeptides of streptococcus pyogenes |
US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
DE602004032550D1 (de) * | 2003-09-15 | 2011-06-16 | Novartis Vaccines & Diagnostic | Immunogene zusammensetzungen für streptococcus agalactiae |
WO2005028618A2 (en) * | 2003-09-15 | 2005-03-31 | Chiron Corporation | Immunogenic compositions for streptococcus agalactiae |
US7427475B2 (en) * | 2003-11-18 | 2008-09-23 | Mayo Foundation For Medical Education And Research | Detection of group B streptococcus |
GB0410866D0 (en) | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
WO2006002422A2 (en) | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
EP1766012B1 (en) * | 2004-07-02 | 2011-05-25 | AVI BioPharma, Inc. | Antisense antibacterial method and compound |
US20090317420A1 (en) * | 2004-07-29 | 2009-12-24 | Chiron Corporation | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
CN1989564A (zh) * | 2004-08-17 | 2007-06-27 | 松下电器产业株式会社 | 信息记录媒体、数据区别装置、以及数据再生装置 |
TWI377564B (en) * | 2004-08-17 | 2012-11-21 | Panasonic Corp | Information storage medium and multiplexing device |
GB0421465D0 (en) * | 2004-09-27 | 2004-10-27 | Chiron Srl | Group A streptococcus protein |
JP2008544949A (ja) * | 2004-10-08 | 2008-12-11 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 化膿性レンサ球菌のための免疫激性組成物および治療用組成物 |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
EP1809772B1 (en) | 2004-11-09 | 2013-06-05 | Gen-Probe Incorporated | Compositions and methods for detecting group a streptococci |
JP2008525033A (ja) * | 2004-12-22 | 2008-07-17 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | B群連鎖球菌 |
CA2593265A1 (en) | 2005-01-21 | 2006-07-27 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
GB0502096D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
ATE490342T1 (de) | 2005-02-07 | 2010-12-15 | Gen Probe Inc | Zusammensetzungen und verfahren zum nachweis von streptokokken der gruppe b |
ES2385045T3 (es) | 2005-02-18 | 2012-07-17 | Novartis Vaccines And Diagnostics, Inc. | Inmunógenos de Escherichia coli uropatogénica |
SG160329A1 (en) | 2005-02-18 | 2010-04-29 | Novartis Vaccines & Diagnostic | Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli |
EP1919934A2 (en) * | 2005-05-13 | 2008-05-14 | Novartis Vaccines and Diagnostics, Inc. | Serum resistance factors of gram positive bacteria |
FR2886312B1 (fr) * | 2005-05-26 | 2012-12-14 | Abag | Nouvelles proteines permettant la mise en evidence in vitro et la prevention des infections a streptococcus pyogenes |
EP3009146B1 (en) | 2005-06-27 | 2021-10-20 | Pfizer Ireland Pharmaceuticals | Immunogenic composition |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
WO2007016938A2 (en) * | 2005-07-27 | 2007-02-15 | Stichting Katholieke Universiteit | Methods for diagnosing colon cancer and streptococcus bovis proteins for use in the method |
EP1937304A2 (en) * | 2005-08-24 | 2008-07-02 | Novartis Vaccines and Diagnostics S.r.l. | Zwitterionization of capsular saccharides |
WO2007047749A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
EP1969001A2 (en) | 2005-11-22 | 2008-09-17 | Novartis Vaccines and Diagnostics, Inc. | Norovirus and sapovirus antigens |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
EP2368570A3 (en) | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
ATE514794T1 (de) | 2006-05-12 | 2011-07-15 | Gen Probe Inc | Zusammensetzungen und verfahren für den nachweis von enterokokken-nukleinsäuren |
EP2035035A2 (en) | 2006-06-09 | 2009-03-18 | Novartis AG | Immunogenic compositions for streptococcus agalactiae |
EP2292644A3 (en) * | 2006-07-07 | 2011-05-25 | Intercell AG | Small Streptococcus pyogenes antigens and their use |
JP2010500399A (ja) | 2006-08-16 | 2010-01-07 | ノバルティス アーゲー | 尿路病原性大腸菌由来の免疫原 |
JP2010508276A (ja) * | 2006-10-30 | 2010-03-18 | ノバルティス アーゲー | 化膿連鎖球菌のための免疫原性組成物および治療組成物 |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
EP2269626A3 (en) | 2007-01-12 | 2012-08-08 | Intercell AG | Protective proteins of S. agalactiae, combinations thereof and methods of using the same |
EP1953247A1 (en) * | 2007-01-31 | 2008-08-06 | GC Corporation | A method for measuring the number of oral streptococci, and a PCR primers-probe set used for the same |
EP2173902A4 (en) * | 2007-07-03 | 2013-01-09 | Mt Sinai Hospital | THERAPEUTIC AND DIAGNOSTIC AGENTS FOR STREPTOCOCCUS OF GROUP A |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
US20110250221A1 (en) * | 2007-08-24 | 2011-10-13 | University Of Wollongong | Group A Streptococcus Pharmaceutical Compositions and Methods Thereof |
MX2010002773A (es) | 2007-09-12 | 2010-03-31 | Novartis Ag | Antigenos mutantes de gas57 y anticuerpos de gas57. |
AU2013203022B2 (en) * | 2007-09-12 | 2015-09-03 | Glaxosmithkline Biologicals S.A. | GAS57 mutant antigens and GAS57 antibodies |
PL2234635T3 (pl) * | 2007-12-19 | 2017-08-31 | Rhovac Aps | Immunoterapia oparta na białkach rhoc |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
CA2709927C (en) | 2007-12-21 | 2017-05-16 | Novartis Ag | Mutant forms of streptolysin o |
AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
US8466167B2 (en) | 2008-03-03 | 2013-06-18 | Irm Llc | Compounds and compositions as TLR activity modulators |
US8247170B2 (en) * | 2008-05-16 | 2012-08-21 | Medical Diagnostic Laboratories, Llc | Detection of penicillin tolerance in Group B Streptococcus: single nucleotide polymorphisms in penicillin binding protein 4 |
US9545431B1 (en) * | 2008-05-23 | 2017-01-17 | The United States Of America, As Represented By The Secretary Of Agriculture | Isolated recombinant cDNA |
BRPI0914312A2 (pt) * | 2008-06-20 | 2017-05-30 | Wyeth Llc | composição e métodos de uso de orf 554 de cepas estreptocócicas beta hemolíticas |
CA2728308A1 (en) * | 2008-06-20 | 2009-12-23 | Wyeth Llc | Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains |
HUE029265T2 (en) | 2008-10-27 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Method of purifying carbohydrates from the group streptococci |
RU2478396C2 (ru) | 2008-11-05 | 2013-04-10 | ВАЙЕТ ЭлЭлСи | МНОГОКОМПОНЕНТНАЯ ИММУНОГЕННАЯ КОМПОЗИЦИЯ ДЛЯ ПРЕДУПРЕЖДЕНИЯ ЗАБОЛЕВАНИЯ, ВЫЗВАННОГО β-ГЕМОЛИТИЧЕСКИМИ СТРЕПТОКОККАМИ (БГС) |
NZ594029A (en) | 2009-01-12 | 2014-01-31 | Novartis Ag | Cna_b domain antigens in vaccines against gram positive bacteria |
ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
JP5867952B2 (ja) | 2009-06-10 | 2016-02-24 | ノバルティス アーゲー | ベンゾナフチリジン含有ワクチン |
ES2596653T3 (es) | 2009-06-16 | 2017-01-11 | Glaxosmithkline Biologicals Sa | Ensayos bactericidas de opsonización y dependientes de anticuerpo mediado por el complemento de alto rendimiento |
WO2011008548A1 (en) * | 2009-06-29 | 2011-01-20 | Genocea Biosciences, Inc. | Vaccines and compositions against streptococcus pneumoniae |
BR112012004275A2 (pt) | 2009-08-27 | 2016-11-16 | Novartis Ag | polipeptídios híbridos incluindo sequências meningocócicas de fhbp |
JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
ES2812523T3 (es) | 2009-09-30 | 2021-03-17 | Glaxosmithkline Biologicals Sa | Conjugación de polisacáridos capsulares de Staphylococcus aureus de tipo 5 y de tipo 8 |
MX2012004850A (es) | 2009-10-27 | 2012-05-22 | Novartis Ag | Polipeptidos fhbp meningococicos modificados. |
CN102971009A (zh) | 2009-10-30 | 2013-03-13 | 诺华有限公司 | 金黄色葡萄球菌5型和8型荚膜多糖的纯化 |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
AU2010339921B2 (en) | 2009-12-15 | 2016-08-11 | Glaxosmithkline Biologicals S.A. | Homogeneous suspension of immunopotentiating compounds and uses thereof |
US9173954B2 (en) | 2009-12-30 | 2015-11-03 | Glaxosmithkline Biologicals Sa | Polysaccharide immunogens conjugated to E. coli carrier proteins |
CA2792938C (en) | 2010-03-23 | 2018-07-31 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
JP2013532008A (ja) | 2010-05-28 | 2013-08-15 | テトリス オンライン インコーポレイテッド | 対話式ハイブリッド非同期コンピュータ・ゲーム・インフラストラクチャ |
JP2013530154A (ja) | 2010-05-28 | 2013-07-25 | サレプタ セラピューティクス, インコーポレイテッド | 修飾されたサブユニット間結合および/または末端基を有するオリゴヌクレオチドアナログ |
FI4005592T3 (fi) | 2010-07-06 | 2023-01-13 | Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille | |
HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
EP2590626B1 (en) | 2010-07-06 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Liposomes with lipids having an advantageous pka-value for rna delivery |
US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
WO2012006369A2 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation of large mammals with low doses of rna |
WO2012031046A2 (en) | 2010-08-31 | 2012-03-08 | Novartis Ag | Lipids suitable for liposomal delivery of protein-coding rna |
PL2611461T3 (pl) | 2010-08-31 | 2022-07-04 | Glaxosmithkline Biologicals Sa | Pegylowane liposomy do dostarczania rna kodującego immunogen |
WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
ES2759484T3 (es) | 2010-09-10 | 2020-05-11 | Glaxosmithkline Biologicals Sa | Meningococo que sobreexpresa NadA y/o NHBA y vesículas de la membrana externa derivadas del mismo |
GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
KR102266691B1 (ko) | 2010-10-11 | 2021-06-23 | 노파르티스 아게 | 항원 전달 플랫폼 |
CA2860331A1 (en) | 2010-12-24 | 2012-06-28 | Novartis Ag | Compounds |
WO2012097313A2 (en) | 2011-01-14 | 2012-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
EP2665490B1 (en) | 2011-01-20 | 2020-03-04 | Genocea Biosciences, Inc. | Vaccines and compositions against streptococcus pneumoniae |
ES2612511T3 (es) | 2011-01-27 | 2017-05-17 | Glaxosmithkline Biologicals Sa | Nanoemulsiones de adyuvante con inhibidores de cristalización |
ES2785108T3 (es) | 2011-03-24 | 2020-10-05 | Glaxosmithkline Biologicals Sa | Nanoemulsiones adyuvantes con fosfolípidos |
CN103764121A (zh) | 2011-07-06 | 2014-04-30 | 诺华股份有限公司 | 用于递送rna分子的具有有用n:p比的脂质体 |
US11896636B2 (en) | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
US9149541B2 (en) | 2011-07-08 | 2015-10-06 | Novartis Ag | Tyrosine ligation process |
EP2557424A1 (en) * | 2011-08-11 | 2013-02-13 | InGen Biosciences | Method for diagnosing Streptococcus, Enterococcus and Pepstostreptococcus genera infections |
SG10201602456WA (en) | 2011-08-31 | 2016-04-28 | Novartis Ag | Pegylated liposomes for delivery of immunogen-encoding rna |
WO2013038375A2 (en) | 2011-09-14 | 2013-03-21 | Novartis Ag | Methods for making saccharide-protein glycoconjugates |
CN104080479B (zh) | 2011-11-07 | 2019-11-05 | 葛兰素史密丝克莱恩生物有限公司 | 包括spr0096和spr2021抗原的运载体分子 |
CN111808135A (zh) | 2011-11-18 | 2020-10-23 | 萨勒普塔医疗公司 | 功能改性的寡核苷酸及其亚单元 |
EP2788022B1 (en) | 2011-12-08 | 2018-10-31 | GlaxoSmithKline Biologicals SA | Clostridium difficile toxin-based vaccine |
GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
WO2013114363A2 (en) * | 2012-01-30 | 2013-08-08 | Yeda Research And Development Co.Ltd. | Antimicrobial agents |
US9120111B2 (en) | 2012-02-24 | 2015-09-01 | Rain Bird Corporation | Arc adjustable rotary sprinkler having full-circle operation and automatic matched precipitation |
EP2817320A1 (en) | 2012-02-24 | 2014-12-31 | Novartis AG | Pilus proteins and compositions |
JP6542662B2 (ja) | 2012-03-20 | 2019-07-10 | サレプタ セラピューティクス, インコーポレイテッド | オリゴヌクレオチドアナログのボロン酸結合体 |
GB201206366D0 (en) * | 2012-04-11 | 2012-05-23 | Absynth Biologics Ltd | Bacterial vaccine |
BR112014026812A8 (pt) | 2012-04-26 | 2022-10-04 | Novartis Ag | Antígenos e combinações de antígenos |
US10279026B2 (en) | 2012-04-26 | 2019-05-07 | Glaxosmithkline Biologicals Sa | Antigens and antigen combinations |
CN104736180A (zh) | 2012-05-22 | 2015-06-24 | 诺华股份有限公司 | 脑膜炎球菌血清组x偶联物 |
PE20190844A1 (es) | 2012-05-25 | 2019-06-17 | Emmanuelle Charpentier | Modulacion de transcripcion con arn de direccion a adn generico |
WO2013192278A1 (en) | 2012-06-19 | 2013-12-27 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses |
US9156043B2 (en) | 2012-07-13 | 2015-10-13 | Rain Bird Corporation | Arc adjustable rotary sprinkler with automatic matched precipitation |
EP4056198A3 (en) | 2012-09-18 | 2022-12-07 | GlaxoSmithKline Biologicals SA | Outer membrane vesicles |
MX2015004171A (es) | 2012-10-02 | 2015-10-22 | Glaxosmithkline Biolog Sa | Conjugados de sacaridos no lineales. |
JP6266631B2 (ja) | 2012-10-03 | 2018-01-24 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
KR102145760B1 (ko) | 2012-12-06 | 2020-08-19 | 시그마-알드리치 컴퍼니., 엘엘씨 | Crispr-기초된 유전체 변형과 조절 |
EP2950819B1 (en) | 2013-02-01 | 2018-03-28 | GlaxoSmithKline Biologicals SA | Intradermal delivery of immunological compositions comprising toll-like receptor agonists |
JP6352950B2 (ja) | 2013-03-08 | 2018-07-04 | ノバルティス アーゲー | 活性薬物の送達のための脂質と脂質組成物 |
DK3620534T3 (da) | 2013-03-14 | 2021-12-06 | Caribou Biosciences Inc | Crispr-cas sammensætninger af nucleinsyre-targeting nucleinsyrer |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
EP2970997A1 (en) * | 2013-03-15 | 2016-01-20 | Regents of the University of Minnesota | Engineering plant genomes using crispr/cas systems |
PL231394B1 (pl) * | 2013-06-28 | 2019-02-28 | Instytut Immunologii I Terapii Doświadczalnej Im Ludwika Hirszfelda Polskiej Akademii Nauk | Test diagnostyczny zakażeń Streptococcus agalactiae |
JP6586083B2 (ja) * | 2013-09-19 | 2019-10-02 | ゾエティス・サービシーズ・エルエルシー | 油性アジュバント |
WO2015070193A1 (en) * | 2013-11-11 | 2015-05-14 | Liu Oliver | Compositions and methods for targeted gene disruption in prokaryotes |
BR112016012306A2 (pt) | 2013-12-03 | 2017-09-26 | Swiss Tropical And Public Health Inst | peptídeos ricos em prolina para proteção contra s. pneumoniae |
US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
EP3083579B1 (en) | 2013-12-19 | 2022-01-26 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
WO2015095340A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
SG11201606478YA (en) | 2014-02-28 | 2016-09-29 | Glaxosmithkline Biolog Sa | Modified meningococcal fhbp polypeptides |
CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
GB201415602D0 (en) * | 2014-09-03 | 2014-10-15 | Moredun Res Inst | Streptococcal antigens |
JP6731912B2 (ja) | 2014-09-05 | 2020-07-29 | ノバルティス アーゲー | 活性物質の送達用の脂質および脂質組成物 |
US9951344B2 (en) * | 2014-10-10 | 2018-04-24 | Board Of Regents, The University Of Texas System | Exogenous terminators for controlling fungal gene expression |
US10420826B2 (en) * | 2014-11-11 | 2019-09-24 | Massachusetts Eye & Ear Infirmary | Conjunctivitis vaccines |
CN107532168A (zh) | 2015-02-23 | 2018-01-02 | 克里斯珀医疗股份公司 | 治疗血红蛋白病的材料和方法 |
EP3061826A1 (en) | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
WO2016196897A1 (en) | 2015-06-04 | 2016-12-08 | Sarepta Therapeutics, Inc. | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
EA039366B1 (ru) | 2015-06-24 | 2022-01-19 | Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер |
JP6914193B2 (ja) | 2015-06-24 | 2021-08-04 | Jcrファーマ株式会社 | Bdnfを含む融合蛋白質 |
US9872188B2 (en) * | 2015-07-28 | 2018-01-16 | Futurewei Technologies, Inc. | Adaptive filtering based network anomaly detection |
WO2017031189A1 (en) * | 2015-08-17 | 2017-02-23 | Zuchem, Inc. | Production of activated tdp-deoxysugars in recombinant microorganisms |
CN105112350B (zh) * | 2015-09-06 | 2019-02-01 | 西北农林科技大学 | 一种罗伊乳酸杆菌无抗性标记基因整合体系的建立方法及其应用 |
US20190225955A1 (en) | 2015-10-23 | 2019-07-25 | President And Fellows Of Harvard College | Evolved cas9 proteins for gene editing |
US10652910B2 (en) * | 2015-11-05 | 2020-05-12 | Intel IP Corporation | Long-term evolution (LTE) and wireless local area network (WLAN) aggregation (LWA) connection procedures |
WO2017100376A2 (en) | 2015-12-07 | 2017-06-15 | Zymergen, Inc. | Promoters from corynebacterium glutamicum |
US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
WO2017175082A1 (en) | 2016-04-05 | 2017-10-12 | Gsk Vaccines S.R.L. | Immunogenic compositions |
WO2018005793A1 (en) | 2016-06-30 | 2018-01-04 | Zymergen Inc. | Methods for generating a glucose permease library and uses thereof |
KR102345899B1 (ko) | 2016-06-30 | 2021-12-31 | 지머젠 인코포레이티드 | 박테리아 헤모글로빈 라이브러리를 생성하는 방법 및 이의 용도 |
KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
CN106169969B (zh) * | 2016-08-31 | 2020-01-10 | 华为技术有限公司 | 建立虚拟专用网标签交换路径方法、相关设备和系统 |
KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
US10759864B2 (en) | 2016-12-26 | 2020-09-01 | Jcr Pharmaceuticals Co., Ltd. | Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
EP3592777A1 (en) | 2017-03-10 | 2020-01-15 | President and Fellows of Harvard College | Cytosine to guanine base editor |
CN108624516B (zh) * | 2017-03-20 | 2022-08-26 | 华东理工大学 | 一种提高发酵细胞中的代谢产物量及制备idms标准品的方法 |
US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
AU2018256755A1 (en) | 2017-04-26 | 2019-12-05 | Auckland Uniservices Limited | Analytical and therapeutic methods and compositions, and uses thereof |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
PL239045B1 (pl) * | 2018-01-09 | 2021-11-02 | Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk | Epitop specyficzny dla zakaźnych Streptococcus agalactiae oraz sposób wykrywania zakażenia pacjenta szczepem Streptococcus agalactiae |
EP3749767A1 (en) | 2018-02-05 | 2020-12-16 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
MA51788A (fr) | 2018-02-05 | 2020-12-16 | Vertex Pharma | Substances et méthodes pour traiter des hémoglobinopathies |
AU2019218978A1 (en) | 2018-02-12 | 2020-09-03 | Inimmune Corporation | Toll-like receptor ligands |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
CN109064036B (zh) * | 2018-08-08 | 2021-07-06 | 武汉大学 | 面向管理领域的生态系统服务供需指数变化检测方法 |
EP3607967A1 (en) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
CA3130488A1 (en) | 2019-03-19 | 2020-09-24 | David R. Liu | Methods and compositions for editing nucleotide sequences |
US20220211859A1 (en) | 2019-05-10 | 2022-07-07 | Glaxosmithkline Biologicals Sa | Conjugate production |
CN110489587B (zh) * | 2019-07-31 | 2023-04-28 | 西安邮电大学 | 局部梯度方向三值模式的轮胎痕迹图像特征提取方法 |
US10948568B1 (en) * | 2019-09-12 | 2021-03-16 | Cypress Semiconductor Corporation | Radar detection in a wireless LAN |
CN111048833B (zh) * | 2019-10-30 | 2022-04-26 | 深圳市卓能新能源股份有限公司 | 一种高电压电解液及高电压锂离子动力电池 |
GB2614813A (en) | 2020-05-08 | 2023-07-19 | Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
CN111518857A (zh) * | 2020-06-11 | 2020-08-11 | 江苏海飞生物科技有限公司 | 酶法生产氨基葡萄糖盐及其提纯方法 |
US11820989B2 (en) | 2020-11-04 | 2023-11-21 | Eligo Bioscience | Phage-derived particles for in situ delivery of DNA payload into C. acnes population |
WO2022256310A1 (en) * | 2021-06-01 | 2022-12-08 | The Regents Of The University Of California | Protective vaccine antigen against streptococcal infection |
WO2023021421A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Low-dose lyophilized rna vaccines and methods for preparing and using the same |
WO2023021427A1 (en) | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof |
GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (312)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2386796A (en) | 1942-08-05 | 1945-10-16 | Bond Crown & Cork Co | Extruding device |
US3676548A (en) * | 1970-09-18 | 1972-07-11 | Lilly Co Eli | Method of vaccinating swine against jowl abscess disease |
DE2855719A1 (de) | 1978-12-22 | 1980-07-10 | Siemens Ag | Zahnaerztliche handstueckanordnung |
US4336336A (en) | 1979-01-12 | 1982-06-22 | President And Fellows Of Harvard College | Fused gene and method of making and using same |
AU545912B2 (en) | 1980-03-10 | 1985-08-08 | Cetus Corporation | Cloned heterologous jive products in bacillies |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
NO821391L (no) | 1981-04-29 | 1982-11-01 | Biogen Nv | Kloningsvektorer, rekombinante dna-molekyler samt bakterieverter transformert med disse |
US4551433A (en) | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
US4425330A (en) * | 1981-05-20 | 1984-01-10 | Cornell Research Foundation, Inc. | Bovine mastitis vaccine and method for detecting efficacy thereof |
US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
US4454121A (en) | 1982-07-27 | 1984-06-12 | The University Of Tennessee Research Corporation | Synthetic peptides corresponding to antigenic determinants of the M protein of Streptococcus pyogenes |
DE3485094D1 (de) * | 1983-01-25 | 1991-10-31 | Ciba Geigy Ag | Neue peptidderivate. |
US4659561A (en) * | 1983-02-18 | 1987-04-21 | The University Of Vermont And State Agricultural College | Process for treating the oral cavity |
US4876197A (en) | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
JPS59166086A (ja) | 1983-03-09 | 1984-09-19 | Teruhiko Beppu | 新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法 |
US4546083A (en) | 1983-04-22 | 1985-10-08 | Stolle Research & Development Corporation | Method and device for cell culture growth |
US4588684A (en) | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
JPS59205983A (ja) | 1983-04-28 | 1984-11-21 | ジエネツクス・コ−ポレイシヨン | 異種遺伝子を原核微生物で発現させる方法 |
US4663280A (en) | 1983-05-19 | 1987-05-05 | Public Health Research Institute Of The City Of New York | Expression and secretion vectors and method of constructing vectors |
DE3485810T2 (de) | 1983-05-27 | 1992-12-10 | Texas A & M Univ Sys | Verfahren zur herstellung eines rekombinanten baculovirus-expressionsvektors. |
US4689406A (en) | 1983-08-10 | 1987-08-25 | Amgen | Enhancement of microbial expression of polypeptides |
US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
JPS6054685A (ja) | 1983-09-02 | 1985-03-29 | Suntory Ltd | 改良発現ベクタ−およびその利用 |
EP0136907A3 (en) | 1983-10-03 | 1986-12-30 | Genentech, Inc. | A xenogeneic expression control system, a method of using it, expression vectors containing it, cells transformed thereby and heterologous proteins produced therefrom |
DK518384A (da) | 1984-01-31 | 1985-07-01 | Idaho Res Found | Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse |
DK219084D0 (da) * | 1984-05-02 | 1984-05-02 | Frederik Carl Peter Lindberg | Antigen |
EP0164556B1 (en) | 1984-05-11 | 1994-03-02 | Chiron Corporation | Enhanced yeast transcription employing hybrid promoter region constructs |
US4880734A (en) | 1984-05-11 | 1989-11-14 | Chiron Corporation | Eukaryotic regulatable transcription |
CA1282721C (en) | 1984-06-04 | 1991-04-09 | Bernard Roizman | Herpes simplex virus as a vector |
US5288641A (en) | 1984-06-04 | 1994-02-22 | Arch Development Corporation | Herpes Simplex virus as a vector |
US4738921A (en) | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
US4745056A (en) | 1984-10-23 | 1988-05-17 | Biotechnica International, Inc. | Streptomyces secretion vector |
US4837148A (en) | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
EP0196056B1 (en) | 1985-03-28 | 1991-05-22 | Chiron Corporation | Improved expression using fused genes providing for protein product |
US6103243A (en) * | 1985-05-15 | 2000-08-15 | Biotechnology Australia Pty, Ltd | Oral vaccines |
US4865974A (en) | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
JPS6296086A (ja) | 1985-10-21 | 1987-05-02 | Agency Of Ind Science & Technol | 複合プラスミド |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
ATE110111T1 (de) | 1986-05-02 | 1994-09-15 | Gist Brocades Nv | Sekretionssignal-selektionsvektoren für extrazelluläre proteinsynthese in bazillen. |
GB8618443D0 (en) * | 1986-07-29 | 1986-09-03 | Univ London | Monoclonal antibodies |
WO1988002406A2 (en) | 1986-10-02 | 1988-04-07 | Massachusetts Institute Of Technology | Methods of regulating metabolic stability of proteins |
AU8108587A (en) * | 1986-10-08 | 1988-05-06 | David Bernstein | Method for exposing group a streptococcal antigens and an improved diagnostic test for the identification of group a streptococci |
JPS63123383A (ja) | 1986-11-11 | 1988-05-27 | Mitsubishi Kasei Corp | ハイブリツドプロモ−タ−、発現調節dna配列および発現ベクタ− |
GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
DE3888561T2 (de) | 1987-03-23 | 1994-09-01 | Zymogenetics Inc | Hohe Proteinsyntheserate in Hefe. |
US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
US4929555A (en) | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
DE318216T1 (de) | 1987-11-18 | 1990-06-13 | Chiron Corp., Emeryville, Calif., Us | Nanbv-diagnostika und vakzine. |
SE456639B (sv) | 1987-11-27 | 1988-10-24 | Golf Comback Ab C O Wiklund | Golftraeningsanordning innefattande ett hus med lintrumma |
WO1989005349A1 (en) | 1987-12-09 | 1989-06-15 | The Australian National University | Method of combating viral infections |
CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
US4973551A (en) | 1988-01-15 | 1990-11-27 | Merck & Co., Inc. | Vector for the expression of fusion proteins and protein immunogens |
US5098827A (en) | 1988-02-26 | 1992-03-24 | The University Of Florida | Novel bacterial markers for pathogenic group B streptococci |
US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
CH684094A5 (de) | 1988-03-21 | 1994-07-15 | Viagene Inc | Rekombinante Retroviren. |
US5591624A (en) | 1988-03-21 | 1997-01-07 | Chiron Viagene, Inc. | Retroviral packaging cell lines |
US5206152A (en) | 1988-04-08 | 1993-04-27 | Arch Development Corporation | Cloning and expression of early growth regulatory protein genes |
US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
WO1990002806A1 (en) | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
US5354846A (en) | 1988-11-18 | 1994-10-11 | Michael Kehoe | Streptolysin O antigen derivatives, its production and uses |
GB8827038D0 (en) | 1988-11-18 | 1988-12-21 | Kehoe M | Streptolysin o antigens & uses |
DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
DE68929323T2 (de) | 1988-12-16 | 2002-04-18 | Nederlanden Staat | Pneumolysin-mutanten und pneumokokken-impfstoffe daraus |
GB2233977B (en) | 1989-01-04 | 1993-03-31 | Michael Kehoe | Cytolytic streptolysin o mutants and uses |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
EP0448650A4 (en) | 1989-02-01 | 1992-05-13 | The General Hospital Corporation | Herpes simplex virus type i expression vector |
JP3140757B2 (ja) | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
WO1990011361A1 (en) | 1989-03-17 | 1990-10-04 | E.I. Du Pont De Nemours And Company | External regulation of gene expression |
CA2489769A1 (en) | 1989-03-21 | 1990-10-04 | Philip L. Felgner | Expression of exogenous polynucleotide sequences in a vertebrate |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
EP0486573B1 (en) | 1989-08-15 | 1995-10-11 | Pasminco Australia Limited | Absorption of zinc vapour in molten lead |
EP0487587A1 (en) | 1989-08-18 | 1992-06-03 | Chiron Corporation | Recombinant retroviruses delivering vector constructs to target cells |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
US5648241A (en) * | 1989-09-15 | 1997-07-15 | The General Hospital Corporation | Conjugate vaccine against group B streptococcus |
IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
AU7007491A (en) | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
ZA911974B (en) | 1990-03-21 | 1994-08-22 | Res Dev Foundation | Heterovesicular liposomes |
CA2039921A1 (en) | 1990-04-16 | 1991-10-17 | Xandra O. Breakefield | Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
US5821088A (en) | 1990-05-11 | 1998-10-13 | Siga Pharmaceuticals, Inc. | Use of gram-positive bacteria to express recombinant proteins |
US6737521B1 (en) | 1990-05-11 | 2004-05-18 | The Rockefeller University | Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria |
WO1991018088A1 (en) | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
US5149655A (en) | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
EP0471177B1 (en) | 1990-08-13 | 1995-10-04 | American Cyanamid Company | Filamentous hemagglutinin of bordetella pertussis as a carrier molecule for conjugate vaccines |
EP1285967A3 (en) | 1990-09-21 | 2005-03-02 | Chiron Corporation | Human retroviral packaging cell line |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
WO1992007945A1 (en) | 1990-10-30 | 1992-05-14 | Dana Farber Cancer Institute | Cell type specific alteration of levels of gene products in neural cells |
SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
CA2098849C (en) | 1990-12-20 | 2007-07-10 | Ralph R. Weichselbaum | Control of gene expression by ionizing radiation |
DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
US5391712A (en) | 1991-08-30 | 1995-02-21 | Beckman Instruments, Inc. | Non-hemolytic streptolysin O variants |
US5378620A (en) | 1991-08-30 | 1995-01-03 | Beckman Instruments, Inc. | Streptolysin O derivatives |
FR2681786A1 (fr) | 1991-09-27 | 1993-04-02 | Centre Nat Rech Scient | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
IL103059A0 (en) | 1991-09-30 | 1993-02-21 | Boehringer Ingelheim Int | Conjugates for introducing nucleic acid into higher eucaryotic cells |
NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
WO1993014778A1 (en) | 1992-01-23 | 1993-08-05 | Vical, Inc. | Ex vivo gene transfer |
IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
WO1993025234A1 (en) | 1992-06-08 | 1993-12-23 | The Regents Of The University Of California | Methods and compositions for targeting specific tissue |
EP0644946A4 (en) | 1992-06-10 | 1997-03-12 | Us Health | VECTOR PARTICLES RESISTANT TO HUMAN SERUM INACTIVATION. |
ES2143716T3 (es) | 1992-06-25 | 2000-05-16 | Smithkline Beecham Biolog | Composicion de vacuna que contiene adyuvantes. |
GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
JPH08501686A (ja) | 1992-09-25 | 1996-02-27 | ローン−プーラン・ロレ・ソシエテ・アノニム | 中枢神経系、特に脳における細胞への外来遺伝子の転移のためのアデノウィルスベクター |
EP0957172B1 (en) | 1992-11-18 | 2005-10-19 | Arch Development Corporation | Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle |
DE4240056A1 (de) | 1992-11-28 | 1994-06-01 | Boehringer Mannheim Gmbh | Streptolysin O Peptidantigene und Verfahren zur Bestimmung von Streptolysin-Antikörper |
EP1024198A3 (en) | 1992-12-03 | 2002-05-29 | Genzyme Corporation | Pseudo-adenoviral vectors for the gene therapy of haemophiliae |
US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
FI93733C (fi) * | 1993-01-29 | 1995-05-26 | Kaarina Tikkanen | Streptococcus suis-bakteerin adhesiiniproteiini ja menetelmä sen valmistamiseksi |
EP0613947B1 (en) | 1993-02-01 | 2004-03-03 | Beckman-Coulter, Inc. | Mitogenic factor, gene thereof and method of microdetection therefor |
US5348358A (en) | 1993-02-22 | 1994-09-20 | Selick David A | Contact lens insertion tool |
US6015889A (en) * | 1993-03-19 | 2000-01-18 | Gunnar Lindahl | Protein rib, a cell surface protein that confers immunity to many strains of the group B streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition |
EP0689454B2 (en) | 1993-03-23 | 2005-02-23 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine compositions containing 3-o deacylated monophosphoryl lipid a |
DE4311651A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Ingelheim Int | Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen |
US5759573A (en) | 1993-04-22 | 1998-06-02 | Depotech Corporation | Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use |
ATE183241T1 (de) * | 1993-05-17 | 1999-08-15 | Akzo Nobel Nv | Impstoff gegen streptococcus suis-infektion |
CA2162271A1 (en) | 1993-05-26 | 1994-12-08 | Robert Kotin | Fusion proteins containing adeno-associated virus rep protein and bacterial protein |
FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
WO1995000650A1 (en) | 1993-06-23 | 1995-01-05 | Beckman Instruments, Inc. | Recombinant dnase b derived from streptococcus pyogenes |
DE69434486T2 (de) | 1993-06-24 | 2006-07-06 | Advec Inc. | Adenovirus vektoren für gentherapie |
KR100356615B1 (ko) | 1993-07-13 | 2003-04-03 | 아방티 파르마 소시에테 아노님 | 결함아데노바이러스벡터및유전자치료에서그의사용 |
CA2167706A1 (en) | 1993-07-27 | 1995-02-09 | Nigel Fraser | Modified dna virus vectors and uses therefor |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US5362865A (en) | 1993-09-02 | 1994-11-08 | Monsanto Company | Enhanced expression in plants using non-translated leader sequences |
EP0716148B1 (en) | 1993-09-15 | 2004-01-02 | Chiron Corporation | Recombinant alphavirus vectors |
FR2710536B1 (fr) | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
JPH09505561A (ja) | 1993-10-01 | 1997-06-03 | アメリカ合衆国 | 神経系の遺伝子治療 |
ES2256842T4 (es) | 1993-10-25 | 2007-02-01 | Canji, Inc. | Vector de adenovirus recombinante y metodos de uso. |
BR9408072A (pt) | 1993-11-16 | 1997-08-12 | Depotech Corp | Vesículas com liberação controlada de ativos |
US5693506A (en) | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
FR2712603B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
US5585098A (en) | 1993-11-23 | 1996-12-17 | Ovimmune, Inc. | Oral administration of chicken yolk immunoglobulins to lower somatic cell count in the milk of lactating ruminants |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
JPH07241786A (ja) | 1994-03-08 | 1995-09-19 | Fanuc Ltd | 産業用ロボットの制御装置 |
US6780406B1 (en) | 1994-03-21 | 2004-08-24 | The Regents Of The University Of Michigan | Inhibition of vascular smooth muscle cell proliferation administering a thymidine kinase gene |
US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
WO1995029993A1 (en) | 1994-04-28 | 1995-11-09 | The University Of Michigan | Gene delivery vector using plasmid dna packaged into an adenovirus and a packaging cell line |
AU2585395A (en) | 1994-05-09 | 1995-11-29 | Chiron Corporation | Retroviral vectors having a reduced recombination rate |
EP1548118A2 (en) | 1994-06-10 | 2005-06-29 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
DE69535905D1 (de) | 1994-07-15 | 2009-02-26 | Coley Pharm Group Inc | Immunomodulatorische Oligonukleotide |
FR2723588B1 (fr) | 1994-08-12 | 1996-09-20 | Rhone Poulenc Rorer Sa | Adenovirus comprenant un gene codant pour la glutathion peroxydase |
ATE294868T1 (de) * | 1994-09-14 | 2005-05-15 | Baylor College Medicine | Impfstoff gegen streptokokkeninfektionen der gruppe a |
WO1996011263A1 (en) | 1994-10-07 | 1996-04-18 | Rockefeller University | Enzyme for cleavage of the anchor region of surface proteins from gram positive bacteria |
AUPM885194A0 (en) | 1994-10-14 | 1994-11-10 | Council Of The Queensland Institute Of Medical Research, The | Synthetic peptides and vaccines comprising same |
IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
WO1996037626A1 (en) | 1995-05-22 | 1996-11-28 | Chiron Corporation | Position-specific integration of vector constructs into eukaryotic genomes mediated by a chimeric integrase protein |
US6284884B1 (en) | 1995-06-07 | 2001-09-04 | North American Vaccine, Inc. | Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof |
US6936259B2 (en) | 1995-06-08 | 2005-08-30 | University Of Saskatchewan | CAMP factor of Streptococcus uberis |
GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
US6355255B1 (en) * | 1998-12-07 | 2002-03-12 | Regents Of The University Of Minnesota | Streptococcal C5a peptidase vaccine |
US5846547A (en) | 1996-01-22 | 1998-12-08 | Regents Of The University Of Minnesota | Streptococcal C5a peptidase vaccine |
US5753235A (en) | 1996-02-15 | 1998-05-19 | Heska Corporation | Recombinant canine herpesviruses |
US6346392B1 (en) | 1996-11-27 | 2002-02-12 | Smithkline Beecham Corporation | Polynucleotides encoding a novel glutamine transport ATP-binding protein |
IES960488A2 (en) * | 1996-07-03 | 1997-11-19 | Trinity College Dublin | Subunit Vaccine for Streptococcus Equi |
US5945278A (en) * | 1996-07-08 | 1999-08-31 | The Finnish National Public Health Institute | Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria |
EP0821070A1 (en) | 1996-07-22 | 1998-01-28 | Carelli, Claude Marcel Henri | Pit-1 gene polymorphism and trait selection in animals |
DE19630390A1 (de) | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
US6251433B1 (en) | 1996-08-13 | 2001-06-26 | Chiron Corporation | Polycationic polymers |
ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
WO1998018931A2 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
EP1007069A1 (en) | 1996-11-01 | 2000-06-14 | Smithkline Beecham Corporation | Novel coding sequences |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US7033765B1 (en) | 1997-02-20 | 2006-04-25 | Toronto Research Chemicals, Inc. | Site-specific drug delivery |
CA2281493A1 (en) * | 1997-02-20 | 1998-08-27 | David S. Dime | Site-specific drug delivery |
EP1039935A4 (en) | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | USE OF NUCLEIC ACIDS CONTAINING NON-METHYLATED CpG DINUCLEOTIDES IN THE TREATMENT OF LIPOPOLYSACCHARIDE-ASSOCIATED ILLNESSES |
WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
US6426074B1 (en) | 1997-03-19 | 2002-07-30 | The Brigham And Women's Hospital Inc. | Group B Streptococcus vaccine |
KR20010012223A (ko) | 1997-05-06 | 2001-02-15 | 벤슨 로버트 에이치. | 엔테로코커스 패칼리스 폴리뉴클레오타이드 및 폴리펩타이드 |
AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
ES2326848T3 (es) | 1997-06-06 | 2009-10-20 | The Regents Of The University Of California | Inhibidores de la actividad de secuencias inmunoestimulatorias de adn. |
US6635623B1 (en) | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
ES2201551T3 (es) | 1997-09-05 | 2004-03-16 | Glaxosmithkline Biologicals S.A. | Emulsiones de aceite en agua que contienen saponinas. |
US6716433B1 (en) * | 1997-09-12 | 2004-04-06 | University Of Tennessee Research Foundation | Group a streptococcal vaccines |
EP1003875B1 (en) | 1997-09-12 | 2006-12-27 | University of Tennessee Research Foundation | Group a streptococcal vaccines |
US6406883B1 (en) | 1997-09-26 | 2002-06-18 | Luetticken Rudolf | Lmb gene of Streptococcus agalactiae |
AU9507698A (en) | 1997-09-26 | 1999-04-23 | Med Immune, Inc. | (lmb) gene of (streptococcus agalactiae) |
ES2273439T3 (es) | 1997-10-17 | 2007-05-01 | Societe Des Produits Nestle S.A. | Nueva especie de bacteria lactica. |
CN1263854C (zh) | 1997-11-06 | 2006-07-12 | 启龙股份公司 | 奈瑟球菌抗原 |
AU748950B2 (en) | 1997-11-21 | 2002-06-13 | New Zealand Pastoral Agriculture Research Institute Limited | Zoocin A immunity factor |
CA2307846A1 (en) | 1997-11-21 | 1999-06-03 | Genset S.A. | Chlamydia pneumoniae genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
WO1999028475A2 (en) | 1997-11-28 | 1999-06-10 | Genset | Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
EP1042480A1 (en) | 1997-12-31 | 2000-10-11 | Stressgen Biotechnologies Corporation | Streptococcal heat shock proteins of the hsp60 family |
WO1999036544A2 (en) | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Neisseria meningitidis antigens |
US7041814B1 (en) | 1998-02-18 | 2006-05-09 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Enterobacter cloacae for diagnostics and therapeutics |
OA11686A (en) | 1998-02-20 | 2005-01-12 | Iaf Biochem Int | Group B streptococcus antigens. |
US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
WO1999052549A1 (en) | 1998-04-09 | 1999-10-21 | Smithkline Beecham Biologicals S.A. | Adjuvant compositions |
GB9808327D0 (en) | 1998-04-20 | 1998-06-17 | Chiron Spa | Antidiotypic compounds |
EP1645631B1 (en) | 1998-05-01 | 2007-10-24 | Novartis Vaccines and Diagnostics, Inc. | Neisseria antigens and compositions |
DK1075512T3 (da) * | 1998-05-07 | 2010-06-07 | Univ Bruxelles | Cytotoxinbaseret biologisk indkapsling |
US6660520B2 (en) | 1998-06-05 | 2003-12-09 | Smithkline Beecham Corporation | Nrde |
AU5070999A (en) * | 1998-07-22 | 2000-02-14 | Id-Lelystad | (streptococcus suis) vaccines and diagnostic tests |
US6936252B2 (en) | 1998-07-27 | 2005-08-30 | Microbial Technics Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
US7098182B2 (en) | 1998-07-27 | 2006-08-29 | Microbial Technics Limited | Nucleic acids and proteins from group B streptococcus |
EP2053126A1 (en) * | 1998-07-27 | 2009-04-29 | Sanofi Pasteur Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
WO2000006736A2 (en) * | 1998-07-27 | 2000-02-10 | Microbial Technics Limited | Nucleic acids and proteins from group b streptococcus |
GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
JP2004511201A (ja) | 1998-10-09 | 2004-04-15 | カイロン コーポレイション | ナイセリアゲノム配列およびそれらの使用方法 |
SI1126876T1 (sl) | 1998-10-16 | 2007-08-31 | Glaxosmithkline Biolog Sa | Adjuvantni sistemi in vakcine |
US6175001B1 (en) | 1998-10-16 | 2001-01-16 | The Scripps Research Institute | Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same |
CA2350775A1 (en) | 1998-11-12 | 2000-05-18 | The Regents Of The University Of California | Chlamydia pneumoniae genome sequence |
GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
US7063850B1 (en) * | 1998-12-22 | 2006-06-20 | University Of Tennessee Research Foundation | Protective antigen of group A Streptococci |
US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
GB9828880D0 (en) * | 1998-12-31 | 1999-02-17 | Actinova Ltd | Protein |
HUP0200664A2 (en) | 1999-03-19 | 2002-06-29 | Smithkline Beecham Biolog | Streptococcus vaccine |
JP2002541808A (ja) | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | ポリサッカリド結合体ワクチンのための組換えトキシンaタンパク質キャリア |
US6790950B2 (en) | 1999-04-09 | 2004-09-14 | Pharmacia & Upjohn Company | Anti-bacterial vaccine compositions |
EP1233780A4 (en) | 1999-04-15 | 2004-09-22 | Univ California | IDENTIFICATION OF THE SORTASEGEN |
US7101692B2 (en) | 1999-04-15 | 2006-09-05 | The Regents Of The University Of California | Identification of sortase gene |
PL203951B1 (pl) | 1999-04-19 | 2009-11-30 | Smithkline Beecham Biolog | Kompozycja adiuwantowa, kompozycja szczepionki oraz sposób jej wytwarzania, szczepionka oraz zastosowanie |
WO2000078787A1 (en) | 1999-06-21 | 2000-12-28 | University Of Utah Research Foundation | ISOLATED GENES FROM VIRULENT GROUP B $i(STREPTOCOCCUS AGALACTIAE) |
US6833356B1 (en) | 1999-08-25 | 2004-12-21 | Medimmune, Inc. | Pneumococcal protein homologs and fragments for vaccines |
GB9921125D0 (en) * | 1999-09-07 | 1999-11-10 | Microbial Technics Limited | Proteins |
BR0014285A (pt) | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Adjuvantes compreendendo um éster ou éter de alquila de polioxietileno e pelo menos um tensoativo não-iÈnico |
PL355163A1 (en) | 1999-09-24 | 2004-04-05 | Smithkline Beecham Biologicals S.A. | Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
EP1265582A2 (en) | 1999-09-29 | 2002-12-18 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
MXPA02006962A (es) | 2000-01-17 | 2002-12-13 | Chiron Spa | Vacuna de vesicula de membrana exterior que comprende proteinas de membrana exterior de neisseria meningitidis serogrupo b. |
US6777547B1 (en) | 2000-01-31 | 2004-08-17 | Andreas Podbielski | Collagen-binding proteins from streptococcus pyogenes |
KR20020097200A (ko) | 2000-03-21 | 2002-12-31 | 엘리트라 파마슈티컬즈, 인코포레이티드 | 원핵세포에서의 필수유전자의 동정 |
AUPQ801700A0 (en) | 2000-06-07 | 2000-06-29 | Peplin Research Pty Ltd | Enzyme and viral activation |
CA2413576C (en) | 2000-07-06 | 2012-11-13 | Shire Biochem Inc. | Streptococcus pyogenes antigens |
US6620585B1 (en) * | 2000-08-02 | 2003-09-16 | Elitra Pharmaceuticals, Inc. | Use of ectoenzymes and secreted enzymes to monitor cellular proliferation |
ES2286133T3 (es) | 2000-08-08 | 2007-12-01 | St. Jude Children's Research Hospital | Acidos nucleicos de polipeptidos de estreptococos del grupo b y composiciones terapeuticas y vacunas de los mismos. |
FR2814754B1 (fr) * | 2000-10-04 | 2005-09-09 | Pasteur Institut | Listeria innocua, genome et applications |
US7160547B2 (en) | 2000-10-10 | 2007-01-09 | University Of Tennessee Research Corporation | Streptococcal streptolysin S vaccines |
WO2002057315A2 (en) | 2000-10-10 | 2002-07-25 | University Of Tennessee Research Corporation | Streptococcal streptolysin s vaccines |
CA2881568C (en) * | 2000-10-27 | 2019-09-24 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from streptococcus groups a & b |
AU2002306849A1 (en) | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
WO2002083859A2 (en) | 2001-04-13 | 2002-10-24 | Wyeth | Surface proteins of streptococcus pyogenes |
US20070128229A1 (en) | 2002-04-12 | 2007-06-07 | Wyeth | Surface proteins of Streptococcus pyogenes |
FR2824074A1 (fr) * | 2001-04-26 | 2002-10-31 | Pasteur Institut | Sequence du genome streptococcus agalactiae, application au developpement de vaccins, d'outils de diagnostic, et a l'identification de cibles therapeutiques |
CA2447599C (en) | 2001-05-18 | 2015-04-28 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention, Technology Transfer Office | Peptide vaccines against group a streptococci |
CA2453062C (en) * | 2001-07-06 | 2013-04-02 | Shire Biochem Inc. | Group b streptococcus bvh-a5 antigens and corresponding dna fragments |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
DE10136578B4 (de) * | 2001-07-27 | 2005-05-04 | Micronas Gmbh | Verfahren zum Prüfen eines Chips mit einem Gehäuse und zum Bestücken einer Platine mit dem Gehäuse sowie Chip mit einem Gehäuse |
US20060073530A1 (en) | 2001-08-15 | 2006-04-06 | Olaf Schneewind | Methods and compositions involving sortase B |
US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
WO2003060143A2 (en) * | 2001-10-26 | 2003-07-24 | Id Biomedical Corporation Of Washington | Efficient protein expression system |
AU2002360628A1 (en) * | 2001-12-21 | 2003-07-30 | Children's Hospital & Regional Medical Center | Use of a novel cell surface protease from Group B Streptococcus |
CN1281274C (zh) * | 2001-12-27 | 2006-10-25 | 大正制药株式会社 | 6-氟双环[3.1.0]己烷衍生物 |
ATE543906T1 (de) | 2002-02-11 | 2012-02-15 | Id Biomedical Corp | Antigen von streptococcus aus der b-gruppe |
GB2385274B (en) | 2002-02-13 | 2004-04-14 | Ming-Jeng Shue | Vaginal suppository delivery device |
US6593093B1 (en) * | 2002-02-20 | 2003-07-15 | Mayo Foundation For Medical Education And Research | Detection of group a Streptococcus |
US20050181388A1 (en) | 2002-04-02 | 2005-08-18 | Affinium Pharmaceuticals, Inc. | Novel purified polypeptides from bacteria |
AU2003213949A1 (en) | 2002-04-08 | 2003-10-27 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in membrane biogenesis |
GB0210128D0 (en) | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
AU2003260102A1 (en) | 2002-08-26 | 2004-03-11 | Chiron Corporation | Conserved and specific streptococcal genomes |
CA2498847C (en) | 2002-09-13 | 2014-10-28 | Chiron Corporation | Group b streptococcus vaccine |
TW566366U (en) | 2002-09-27 | 2003-12-11 | Wus Tech Co Ltd | Labor-saving portable battery equipment for power-driven walking assisted scooter |
JP5116971B2 (ja) * | 2002-10-15 | 2013-01-09 | インターセル アーゲー | B群連鎖球菌の接着因子をコードする核酸、b群連鎖球菌の接着因子、およびその使用 |
SI1601770T1 (sl) | 2003-03-04 | 2010-01-29 | Intercell Ag | Streptococcus pyogenes antigeni |
US20060134640A1 (en) * | 2003-04-22 | 2006-06-22 | Institut Pasteur | Inhibiting the growth of bacterial biofilms |
CA2522986A1 (en) | 2003-05-07 | 2004-11-18 | Intercell Ag | Streptococcus agalactiae antigens i + ii |
US20050016201A1 (en) | 2003-07-22 | 2005-01-27 | Ivanov Igor C. | Multi-staged heating system for fabricating microelectronic devices |
PT1648500E (pt) * | 2003-07-31 | 2014-10-10 | Novartis Vaccines & Diagnostic | Composições imunogénicas para estreptococos piogenes |
AU2003904237A0 (en) | 2003-08-08 | 2003-08-21 | Garvan Institute Of Medical Research | Novel translocation assay |
US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
WO2005028618A2 (en) | 2003-09-15 | 2005-03-31 | Chiron Corporation | Immunogenic compositions for streptococcus agalactiae |
JP2007520718A (ja) | 2004-02-06 | 2007-07-26 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 治療可能性のあるアドヘシンおよびアドヘシン様タンパク質を同定するためのコンピュータを利用した方法 |
US20060041961A1 (en) | 2004-03-25 | 2006-02-23 | Abad Mark S | Genes and uses for pant improvement |
WO2005108419A1 (en) | 2004-05-07 | 2005-11-17 | Lea-Ann Kirkham | Mutant cholesterol-binding cytolysin proteins |
US20090317420A1 (en) | 2004-07-29 | 2009-12-24 | Chiron Corporation | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
CN101056877B (zh) * | 2004-09-14 | 2010-06-09 | 诺华疫苗和诊断公司 | 咪唑并喹啉化合物 |
GB0421465D0 (en) | 2004-09-27 | 2004-10-27 | Chiron Srl | Group A streptococcus protein |
AU2005335216A1 (en) | 2004-10-05 | 2007-02-15 | Wyeth | Probe arrays for detecting multiple strains of different species |
JP2008544949A (ja) * | 2004-10-08 | 2008-12-11 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 化膿性レンサ球菌のための免疫激性組成物および治療用組成物 |
JP2008525033A (ja) | 2004-12-22 | 2008-07-17 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | B群連鎖球菌 |
GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
GB0502096D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
SG160329A1 (en) * | 2005-02-18 | 2010-04-29 | Novartis Vaccines & Diagnostic | Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli |
EP1919934A2 (en) | 2005-05-13 | 2008-05-14 | Novartis Vaccines and Diagnostics, Inc. | Serum resistance factors of gram positive bacteria |
EP1937304A2 (en) * | 2005-08-24 | 2008-07-02 | Novartis Vaccines and Diagnostics S.r.l. | Zwitterionization of capsular saccharides |
EP1770171A1 (en) | 2005-09-29 | 2007-04-04 | Universität Zu Köln | DNA microarray for rapid identification of Candida albicans in blood cultures. |
GB0522303D0 (en) | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
EP1969001A2 (en) * | 2005-11-22 | 2008-09-17 | Novartis Vaccines and Diagnostics, Inc. | Norovirus and sapovirus antigens |
DK176565B1 (da) | 2006-02-03 | 2008-09-08 | Quilts Of Denmark As | Möbelben med lys |
GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
EP2035035A2 (en) | 2006-06-09 | 2009-03-18 | Novartis AG | Immunogenic compositions for streptococcus agalactiae |
EP2292644A3 (en) | 2006-07-07 | 2011-05-25 | Intercell AG | Small Streptococcus pyogenes antigens and their use |
EP2063911A2 (en) * | 2006-07-26 | 2009-06-03 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
JP2010508276A (ja) | 2006-10-30 | 2010-03-18 | ノバルティス アーゲー | 化膿連鎖球菌のための免疫原性組成物および治療組成物 |
MX2010002773A (es) * | 2007-09-12 | 2010-03-31 | Novartis Ag | Antigenos mutantes de gas57 y anticuerpos de gas57. |
CA2709927C (en) * | 2007-12-21 | 2017-05-16 | Novartis Ag | Mutant forms of streptolysin o |
-
2001
- 2001-10-29 CA CA2881568A patent/CA2881568C/en not_active Expired - Lifetime
- 2001-10-29 IL IL15485301A patent/IL154853A0/xx unknown
- 2001-10-29 MX MX2015001810A patent/MX357775B/es unknown
- 2001-10-29 CA CA002425303A patent/CA2425303A1/en not_active Abandoned
- 2001-10-29 SG SG200504052-2A patent/SG165981A1/en unknown
- 2001-10-29 US US10/415,182 patent/US7939087B2/en not_active Expired - Fee Related
- 2001-10-29 EP EP10179740A patent/EP2284183A1/en not_active Withdrawn
- 2001-10-29 EP EP01982584A patent/EP1328543B1/en not_active Expired - Lifetime
- 2001-10-29 EP EP15154238.8A patent/EP2896629A1/en not_active Withdrawn
- 2001-10-29 NZ NZ593617A patent/NZ593617A/en not_active IP Right Cessation
- 2001-10-29 ES ES01982584T patent/ES2330083T3/es not_active Expired - Lifetime
- 2001-10-29 DK DK01982584T patent/DK1328543T3/da active
- 2001-10-29 DE DE60139563T patent/DE60139563D1/de not_active Expired - Lifetime
- 2001-10-29 MX MXPA03003690A patent/MXPA03003690A/es active IP Right Grant
- 2001-10-29 EP EP20100179744 patent/EP2277896A1/en not_active Ceased
- 2001-10-29 EP EP10179728A patent/EP2284182A1/en not_active Withdrawn
- 2001-10-29 AT AT01982584T patent/ATE439372T1/de active
- 2001-10-29 AU AU2002214127A patent/AU2002214127B2/en not_active Ceased
- 2001-10-29 AU AU1412702A patent/AU1412702A/xx active Pending
- 2001-10-29 EP EP10179732A patent/EP2277894A1/en not_active Withdrawn
- 2001-10-29 EP EP10179737.1A patent/EP2277895B1/en not_active Expired - Lifetime
- 2001-10-29 EP EP09004551A patent/EP2189473A3/en not_active Ceased
- 2001-10-29 NZ NZ524888A patent/NZ524888A/xx not_active IP Right Cessation
- 2001-10-29 EP EP10179723A patent/EP2284181A1/en not_active Withdrawn
- 2001-10-29 WO PCT/GB2001/004789 patent/WO2002034771A2/en active Application Filing
- 2001-10-29 JP JP2004571012A patent/JP4254931B1/ja not_active Expired - Fee Related
- 2001-10-29 NZ NZ583028A patent/NZ583028A/en not_active IP Right Cessation
- 2001-10-29 NZ NZ540544A patent/NZ540544A/xx not_active IP Right Cessation
- 2001-10-29 NZ NZ594877A patent/NZ594877A/en not_active IP Right Cessation
- 2001-10-29 NZ NZ560966A patent/NZ560966A/en not_active IP Right Cessation
- 2001-10-29 EP EP06075446A patent/EP1671981A3/en not_active Ceased
-
2003
- 2003-03-11 IL IL154853A patent/IL154853A/en not_active IP Right Cessation
- 2003-04-08 ZA ZA2003/02739A patent/ZA200302739B/en unknown
-
2006
- 2006-05-16 US US11/434,199 patent/US8137673B2/en not_active Expired - Fee Related
- 2006-05-16 US US11/434,184 patent/US8025890B2/en not_active Expired - Fee Related
- 2006-05-16 US US11/434,127 patent/US7955604B2/en not_active Expired - Fee Related
- 2006-05-16 US US11/434,203 patent/US8431139B2/en not_active Expired - Fee Related
- 2006-05-16 US US11/434,137 patent/US20060210579A1/en not_active Abandoned
-
2008
- 2008-12-12 JP JP2008317741A patent/JP4874323B2/ja not_active Expired - Fee Related
-
2009
- 2009-11-12 CY CY20091101182T patent/CY1110698T1/el unknown
- 2009-11-22 IL IL202254A patent/IL202254A/en not_active IP Right Cessation
-
2011
- 2011-06-23 JP JP2011139927A patent/JP2011239783A/ja active Pending
- 2011-07-26 HK HK11107796.8A patent/HK1153754A1/xx not_active IP Right Cessation
-
2012
- 2012-08-30 US US13/598,657 patent/US20130129740A1/en not_active Abandoned
-
2013
- 2013-03-06 JP JP2013043775A patent/JP2013165714A/ja not_active Withdrawn
-
2015
- 2015-04-16 IL IL238319A patent/IL238319B/en active IP Right Grant
- 2015-06-26 US US14/751,790 patent/US9840538B2/en not_active Expired - Lifetime
- 2015-09-14 JP JP2015180283A patent/JP2016026494A/ja active Pending
-
2016
- 2016-05-26 US US15/166,010 patent/US9738693B2/en not_active Expired - Lifetime
-
2017
- 2017-11-07 US US15/805,453 patent/US10428121B2/en not_active Expired - Fee Related
-
2019
- 2019-02-20 IL IL264925A patent/IL264925A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1153754A1 (en) | Nucleic acids and proteins from streptococcus groups a & b | |
WO2002094868A3 (en) | Staphylococcus aureus proteins and nucleic acids | |
WO2003093306A3 (en) | Nucleic acids and proteins from streptococcus groups a & b | |
EP2278008A3 (en) | Streptococcus pneumoniae proteins and nucleic acids | |
WO1999036544A3 (en) | Neisseria meningitidis antigens | |
AU2002302921A1 (en) | Gonococcal proteins and nucleic acids | |
WO1999057280A3 (en) | Neisseria meningitidis antigens and compositions | |
WO1999024578A3 (en) | Neisserial antigens | |
NO20020348D0 (no) | Peptid acceptor ligeringsmetoder |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20171029 |