ES2923894T3 - Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina - Google Patents

Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina Download PDF

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Publication number
ES2923894T3
ES2923894T3 ES16719611T ES16719611T ES2923894T3 ES 2923894 T3 ES2923894 T3 ES 2923894T3 ES 16719611 T ES16719611 T ES 16719611T ES 16719611 T ES16719611 T ES 16719611T ES 2923894 T3 ES2923894 T3 ES 2923894T3
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seq
cell
car
fluoro
cyclopropyl
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Inventor
Hans Bitter
Jennifer Mary Bordeaux
Barbara Brannetti
Jennifer Brogdon
Naveen Kumar Dakappagari
Saar Gill
Steven Highfill
Lu Huang
Carl H June
Ju Young Kim
Ming Lei
Na Li
Andreas Loew
Elena Orlando
Marco Ruella
Thai Tran
Jimin Zhang
Li Zhou
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K2317/622—Single chain antibody (scFv)
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ES16719611T 2015-04-08 2016-04-08 Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina Active ES2923894T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562144639P 2015-04-08 2015-04-08
US201562144615P 2015-04-08 2015-04-08
US201562144497P 2015-04-08 2015-04-08
US201562207255P 2015-08-19 2015-08-19
US201562263423P 2015-12-04 2015-12-04
PCT/US2016/026655 WO2016164731A2 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell

Publications (1)

Publication Number Publication Date
ES2923894T3 true ES2923894T3 (es) 2022-10-03

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Application Number Title Priority Date Filing Date
ES16719611T Active ES2923894T3 (es) 2015-04-08 2016-04-08 Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
ES22162298T Active ES3009008T3 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car)- expressing cell

Family Applications After (1)

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ES22162298T Active ES3009008T3 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car)- expressing cell

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US (4) US10253086B2 (OSRAM)
EP (3) EP3280729B1 (OSRAM)
JP (3) JP6961490B2 (OSRAM)
KR (1) KR20170134642A (OSRAM)
CN (3) CN119925616A (OSRAM)
AU (2) AU2016245958B2 (OSRAM)
BR (1) BR112017021500A2 (OSRAM)
CA (1) CA2981751A1 (OSRAM)
CO (1) CO2017010190A2 (OSRAM)
DK (1) DK3280729T3 (OSRAM)
ES (2) ES2923894T3 (OSRAM)
HR (1) HRP20220893T1 (OSRAM)
HU (1) HUE059218T2 (OSRAM)
IL (2) IL303972A (OSRAM)
LT (1) LT3280729T (OSRAM)
MX (2) MX2017012939A (OSRAM)
PL (1) PL3280729T3 (OSRAM)
PT (1) PT3280729T (OSRAM)
RU (2) RU2021121771A (OSRAM)
SG (2) SG11201708191XA (OSRAM)
SI (1) SI3280729T1 (OSRAM)
TW (1) TWI746437B (OSRAM)
WO (1) WO2016164731A2 (OSRAM)

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ES2760023T3 (es) 2013-02-20 2020-05-12 Univ Pennsylvania Tratamiento del cáncer utilizando receptor de antígeno quimérico anti-EGFRvIII humanizado
EP2958942B1 (en) 2013-02-20 2020-06-03 Novartis AG Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
RU2714902C2 (ru) 2013-12-19 2020-02-20 Новартис Аг Химерные рецепторы антигена против мезотелина человека и их применение
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
EP4303229A3 (en) 2014-01-21 2024-04-17 Novartis AG Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
WO2015117229A1 (en) 2014-02-07 2015-08-13 Mcmaster University Trifunctional t cell-antigen coupler and methods and uses thereof
KR102442436B1 (ko) * 2014-03-14 2022-09-15 노파르티스 아게 Lag-3에 대한 항체 분자 및 그의 용도
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RU2021121771A (ru) 2022-01-12

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