DK3280729T3 - Cd20-behandlinger, cd22-behandlinger og kombinationsbehandlinger med en cd19-kimær antigenreceptor (car)-udtrykkende celle - Google Patents

Cd20-behandlinger, cd22-behandlinger og kombinationsbehandlinger med en cd19-kimær antigenreceptor (car)-udtrykkende celle Download PDF

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Publication number
DK3280729T3
DK3280729T3 DK16719611.2T DK16719611T DK3280729T3 DK 3280729 T3 DK3280729 T3 DK 3280729T3 DK 16719611 T DK16719611 T DK 16719611T DK 3280729 T3 DK3280729 T3 DK 3280729T3
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treatments
car
antigen receptor
chimeric antigen
expressing cell
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DK16719611.2T
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Danish (da)
English (en)
Inventor
Hans Bitter
Jennifer Mary Bordeaux
Barbara Brannetti
Jennifer Brogdon
Naveen Kumar Dakappagari
Saar Gill
Steven Highfill
Lu Huang
Carl H June
Ming Lei
Na Li
Elena Orlando
Marco Ruella
Thai Tran
Jimin Zhang
Li Zhou
Andreas Loew
Ju Young Kim
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Novartis Ag
Univ Pennsylvania
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/36—Immune checkpoint inhibitors
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    • A61K40/41—Vertebrate antigens
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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DK16719611.2T 2015-04-08 2016-04-08 Cd20-behandlinger, cd22-behandlinger og kombinationsbehandlinger med en cd19-kimær antigenreceptor (car)-udtrykkende celle DK3280729T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562144639P 2015-04-08 2015-04-08
US201562144615P 2015-04-08 2015-04-08
US201562144497P 2015-04-08 2015-04-08
US201562207255P 2015-08-19 2015-08-19
US201562263423P 2015-12-04 2015-12-04
PCT/US2016/026655 WO2016164731A2 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell

Publications (1)

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DK3280729T3 true DK3280729T3 (da) 2022-07-25

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DK16719611.2T DK3280729T3 (da) 2015-04-08 2016-04-08 Cd20-behandlinger, cd22-behandlinger og kombinationsbehandlinger med en cd19-kimær antigenreceptor (car)-udtrykkende celle

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US (4) US10253086B2 (OSRAM)
EP (3) EP3280729B1 (OSRAM)
JP (3) JP6961490B2 (OSRAM)
KR (1) KR20170134642A (OSRAM)
CN (3) CN119925616A (OSRAM)
AU (2) AU2016245958B2 (OSRAM)
BR (1) BR112017021500A2 (OSRAM)
CA (1) CA2981751A1 (OSRAM)
CO (1) CO2017010190A2 (OSRAM)
DK (1) DK3280729T3 (OSRAM)
ES (2) ES2923894T3 (OSRAM)
HR (1) HRP20220893T1 (OSRAM)
HU (1) HUE059218T2 (OSRAM)
IL (2) IL303972A (OSRAM)
LT (1) LT3280729T (OSRAM)
MX (2) MX2017012939A (OSRAM)
PL (1) PL3280729T3 (OSRAM)
PT (1) PT3280729T (OSRAM)
RU (2) RU2021121771A (OSRAM)
SG (2) SG11201708191XA (OSRAM)
SI (1) SI3280729T1 (OSRAM)
TW (1) TWI746437B (OSRAM)
WO (1) WO2016164731A2 (OSRAM)

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ES2760023T3 (es) 2013-02-20 2020-05-12 Univ Pennsylvania Tratamiento del cáncer utilizando receptor de antígeno quimérico anti-EGFRvIII humanizado
EP2958942B1 (en) 2013-02-20 2020-06-03 Novartis AG Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
RU2714902C2 (ru) 2013-12-19 2020-02-20 Новартис Аг Химерные рецепторы антигена против мезотелина человека и их применение
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
EP4303229A3 (en) 2014-01-21 2024-04-17 Novartis AG Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
WO2015117229A1 (en) 2014-02-07 2015-08-13 Mcmaster University Trifunctional t cell-antigen coupler and methods and uses thereof
KR102442436B1 (ko) * 2014-03-14 2022-09-15 노파르티스 아게 Lag-3에 대한 항체 분자 및 그의 용도
ES2876263T3 (es) 2014-04-07 2021-11-12 Novartis Ag Tratamiento del cáncer usando receptor de antígeno quimérico anti-cd19
PT3132247T (pt) 2014-04-16 2021-11-03 Juno Therapeutics Gmbh Métodos, kits e aparelho para ampliar uma população de células
RU2763795C2 (ru) 2014-04-23 2022-01-11 Джуно Терапьютикс, Инк. Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
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