EA202192975A1 - Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19 - Google Patents
Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19Info
- Publication number
- EA202192975A1 EA202192975A1 EA202192975A EA202192975A EA202192975A1 EA 202192975 A1 EA202192975 A1 EA 202192975A1 EA 202192975 A EA202192975 A EA 202192975A EA 202192975 A EA202192975 A EA 202192975A EA 202192975 A1 EA202192975 A1 EA 202192975A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- genetically engineered
- cell
- allogenic
- cells targeting
- malignancies
- Prior art date
Links
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 title abstract 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 230000036210 malignancy Effects 0.000 title abstract 2
- 238000002659 cell therapy Methods 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 101150076800 B2M gene Proteins 0.000 abstract 1
- 101710153660 Nuclear receptor corepressor 2 Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract
Популяция генетически сконструированных иммунных клеток (например, T-клеток), которые экспрессируют химерный антигенный рецептор (CAR), специфический в отношении CD19, и содержат нарушенный ген TRAC, нарушенный ген B2M или оба из них, для применения в лечении B-клеточного злокачественного новообразования.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962840913P | 2019-04-30 | 2019-04-30 | |
PCT/IB2020/054118 WO2020222176A1 (en) | 2019-04-30 | 2020-04-30 | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
Publications (1)
Publication Number | Publication Date |
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EA202192975A1 true EA202192975A1 (ru) | 2022-02-01 |
Family
ID=70614366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA202192975A EA202192975A1 (ru) | 2019-04-30 | 2020-04-30 | Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19 |
Country Status (14)
Country | Link |
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US (2) | US20220249558A1 (ru) |
EP (1) | EP3962535A1 (ru) |
JP (1) | JP2022531185A (ru) |
KR (1) | KR20220003586A (ru) |
CN (1) | CN113939319A (ru) |
AU (1) | AU2020267057A1 (ru) |
BR (1) | BR112021021542A2 (ru) |
CA (1) | CA3138633A1 (ru) |
EA (1) | EA202192975A1 (ru) |
IL (1) | IL287482A (ru) |
MA (1) | MA55797A (ru) |
MX (1) | MX2021013359A (ru) |
SG (1) | SG11202112032WA (ru) |
WO (1) | WO2020222176A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3195201A1 (en) * | 2020-10-20 | 2022-04-28 | Mark Benton | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
WO2022098756A1 (en) * | 2020-11-03 | 2022-05-12 | WUGEN, Inc. | Chimeric antigen receptor cell therapy |
CN117396607A (zh) | 2020-12-30 | 2024-01-12 | 阿劳诺斯治疗公司 | 包含多顺反子表达盒的重组载体及其使用方法 |
Family Cites Families (120)
Publication number | Priority date | Publication date | Assignee | Title |
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IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
EA004635B1 (ru) | 1999-08-17 | 2004-06-24 | Байоджен, Инк. | Рецептор baff (bcma), иммунорегуляторный агент |
EP1334188B1 (en) | 2000-11-07 | 2006-08-30 | City of Hope | Cd19-specific redirected immune cells |
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- 2020-04-30 KR KR1020217038948A patent/KR20220003586A/ko unknown
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KR20220003586A (ko) | 2022-01-10 |
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US20220249558A1 (en) | 2022-08-11 |
IL287482A (en) | 2021-12-01 |
JP2022531185A (ja) | 2022-07-06 |
CA3138633A1 (en) | 2020-11-05 |
BR112021021542A2 (pt) | 2022-04-19 |
SG11202112032WA (en) | 2021-11-29 |
MA55797A (fr) | 2022-03-09 |
CN113939319A (zh) | 2022-01-14 |
US11389481B2 (en) | 2022-07-19 |
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