EA202092243A1 - Способы усиления персистенции адоптивно инфузированных т-клеток - Google Patents

Способы усиления персистенции адоптивно инфузированных т-клеток

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Publication number
EA202092243A1
EA202092243A1 EA202092243A EA202092243A EA202092243A1 EA 202092243 A1 EA202092243 A1 EA 202092243A1 EA 202092243 A EA202092243 A EA 202092243A EA 202092243 A EA202092243 A EA 202092243A EA 202092243 A1 EA202092243 A1 EA 202092243A1
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cells
methods
persistence
present
provides methods
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EA202092243A
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English (en)
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Амир Алперт
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Имматикс Юс, Инк.
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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Abstract

В настоящем изобретении предложены способы повышения эффективности Т-клеток. В одном аспекте в данном изобретении также предложены способы усиления персистенции Т-клеток для адоптивного клеточного переноса или терапии (АКТ). Анализы чувствительности к цитокинам (CSA) и связанные с ними методики, способные предсказать персистенцию адоптивно инфузированных Т-клеток, также предложены в настоящем изобретении. В данном изобретении также предложены способы лечения рака у субъекта, нуждающегося в этом, а также популяции Т-клеток, полученные способами, описанными в настоящем документе.
EA202092243A 2018-03-21 2019-03-20 Способы усиления персистенции адоптивно инфузированных т-клеток EA202092243A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862646180P 2018-03-21 2018-03-21
DE102018108612.1A DE102018108612A1 (de) 2018-03-21 2018-04-11 Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
PCT/US2019/023104 WO2019183181A1 (en) 2018-03-21 2019-03-20 Methods of enhancing persistence of adoptively infused t cells

Publications (1)

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EA202092243A1 true EA202092243A1 (ru) 2021-01-29

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US (2) US20190292520A1 (ru)
EP (1) EP3768330A4 (ru)
JP (1) JP7344898B2 (ru)
KR (1) KR20200133370A (ru)
CN (1) CN112512593A (ru)
AU (1) AU2019240039A1 (ru)
CA (1) CA3094344A1 (ru)
DE (1) DE102018108612A1 (ru)
EA (1) EA202092243A1 (ru)
MA (1) MA52138A (ru)
SG (1) SG11202009082YA (ru)
TW (1) TW202003050A (ru)
WO (1) WO2019183181A1 (ru)

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SG11202009082YA (en) 2020-10-29
TW202003050A (zh) 2020-01-16
US20190292520A1 (en) 2019-09-26
AU2019240039A1 (en) 2020-11-12
EP3768330A1 (en) 2021-01-27
US20210017493A1 (en) 2021-01-21
CN112512593A (zh) 2021-03-16
JP2021518121A (ja) 2021-08-02
US11905529B2 (en) 2024-02-20
JP7344898B2 (ja) 2023-09-14
EP3768330A4 (en) 2021-05-19
KR20200133370A (ko) 2020-11-27
CA3094344A1 (en) 2019-09-26
DE102018108612A1 (de) 2019-09-26
WO2019183181A1 (en) 2019-09-26
MA52138A (fr) 2021-01-27

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