EA201490364A1 - Костимулирующие рецепторы-переключатели - Google Patents
Костимулирующие рецепторы-переключателиInfo
- Publication number
- EA201490364A1 EA201490364A1 EA201490364A EA201490364A EA201490364A1 EA 201490364 A1 EA201490364 A1 EA 201490364A1 EA 201490364 A EA201490364 A EA 201490364A EA 201490364 A EA201490364 A EA 201490364A EA 201490364 A1 EA201490364 A1 EA 201490364A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- receptors
- costimulating
- switching
- negative
- positive
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/17—Hinge-spacer domain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Abstract
В общих чертах изобретение относится к слитому белку, который при его представлении на клетке может преобразовывать передаваемый клетке отрицательный сигнал в положительный сигнал. Слитый белок представляет собой химерный белок, т.е. белок, содержащий по меньшей мере два домена, где первым доменом является полипептид, который связан с отрицательным сигналом, а вторым доменом является полипептид, который связан с положительным сигналом. Так, например, изобретение охватывает рецепторы-переключатели, обладающие способностью преобразовывать отрицательные сигналы в положительные сигналы, и, тем самым, усиливать иммунный ответ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161513259P | 2011-07-29 | 2011-07-29 | |
PCT/US2012/048543 WO2013019615A2 (en) | 2011-07-29 | 2012-07-27 | Switch costimulatory receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201490364A1 true EA201490364A1 (ru) | 2014-08-29 |
Family
ID=47629855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490364A EA201490364A1 (ru) | 2011-07-29 | 2012-07-27 | Костимулирующие рецепторы-переключатели |
Country Status (21)
Country | Link |
---|---|
US (2) | US10981969B2 (ru) |
EP (3) | EP3549611B1 (ru) |
JP (4) | JP6334398B2 (ru) |
KR (1) | KR20140045533A (ru) |
CN (3) | CN107266584B (ru) |
AU (1) | AU2012290342A1 (ru) |
BR (1) | BR112014002006A2 (ru) |
CA (1) | CA2842368A1 (ru) |
CL (1) | CL2014000195A1 (ru) |
CO (1) | CO6862107A2 (ru) |
EA (1) | EA201490364A1 (ru) |
EC (1) | ECSP14013186A (ru) |
ES (2) | ES2888651T3 (ru) |
GT (1) | GT201400015A (ru) |
IL (1) | IL230496A0 (ru) |
MA (1) | MA35360B1 (ru) |
MX (1) | MX2014001222A (ru) |
PE (1) | PE20141520A1 (ru) |
TN (1) | TN2014000020A1 (ru) |
WO (1) | WO2013019615A2 (ru) |
ZA (1) | ZA201400477B (ru) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2888651T3 (es) * | 2011-07-29 | 2022-01-05 | Univ Pennsylvania | Receptores de conmutación coestimulantes |
US9688740B2 (en) | 2011-10-26 | 2017-06-27 | National Cancer Center | Mutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy |
WO2013147606A1 (en) | 2012-03-28 | 2013-10-03 | Umc Utrecht Holding B.V. | Combinatorial gamma 9 delta 2 t cell receptor chain exchange |
MX370265B (es) | 2012-05-25 | 2019-12-09 | Cellectis | Métodos para manipular por ingeniería genética célula t alogénica y resistente a inmunosupresores para inmunoterapia. |
EP3597215A1 (en) * | 2012-10-02 | 2020-01-22 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
EP2958942B1 (en) | 2013-02-20 | 2020-06-03 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
US9394368B2 (en) | 2013-02-20 | 2016-07-19 | Novartis Ag | Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor |
RU2680010C2 (ru) | 2013-02-26 | 2019-02-14 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы иммунотерапии |
EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
NZ712693A (en) * | 2013-03-15 | 2021-07-30 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
TWI654206B (zh) * | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
EP3470423B1 (en) * | 2013-04-17 | 2021-10-06 | Baylor College of Medicine | Immunosuppressive tgf-beta signal converter |
US11077144B2 (en) | 2013-05-13 | 2021-08-03 | Cellectis | CD19 specific chimeric antigen receptor and uses thereof |
EP2997141B1 (en) * | 2013-05-13 | 2022-10-12 | Cellectis | Cd19 specific chimeric antigen receptor and uses thereof |
CA2927543C (en) | 2013-10-15 | 2021-07-20 | The California Institute For Biomedical Research | Peptidic chimeric antigen receptor t cell switches and uses thereof |
TWI672379B (zh) * | 2013-12-19 | 2019-09-21 | 瑞士商諾華公司 | 人類間皮素嵌合性抗原受體及其用途 |
JP6793902B2 (ja) | 2013-12-20 | 2020-12-02 | ノバルティス アーゲー | 調節可能キメラ抗原受容体 |
ES2963718T3 (es) * | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
ES2876263T3 (es) | 2014-04-07 | 2021-11-12 | Novartis Ag | Tratamiento del cáncer usando receptor de antígeno quimérico anti-cd19 |
AU2015292811B2 (en) | 2014-07-21 | 2019-12-19 | Novartis Ag | Treatment of cancer using a CLL-1 chimeric antigen receptor |
SG11201700416TA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
CN106687483B (zh) * | 2014-07-21 | 2020-12-04 | 诺华股份有限公司 | 使用人源化抗-bcma嵌合抗原受体治疗癌症 |
EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
EP3660042B1 (en) | 2014-07-31 | 2023-01-11 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
EP3712171A1 (en) | 2014-08-19 | 2020-09-23 | Novartis AG | Treatment of cancer using a cd123 chimeric antigen receptor |
DK3194443T3 (da) | 2014-09-17 | 2021-09-27 | Novartis Ag | Målretning af cytotoksiske celler med kimære receptorer i forbindelse med adoptiv immunterapi |
CN106973568B (zh) | 2014-10-08 | 2021-07-23 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
CN107106670A (zh) * | 2014-10-31 | 2017-08-29 | 宾夕法尼亚大学董事会 | 用于修饰的t细胞的方法和组合物 |
CN114836385A (zh) | 2014-10-31 | 2022-08-02 | 宾夕法尼亚大学董事会 | 改变cart细胞中的基因表达及其用途 |
CN107109369B (zh) * | 2014-11-20 | 2021-07-09 | Umc乌德勒支控股有限公司 | 用于富集具有外源性免疫受体的工程化t细胞的抗体的用途和用于清除工程化t细胞的抗体 |
CA3197849A1 (en) | 2014-12-29 | 2016-07-07 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
WO2016122738A1 (en) * | 2015-01-31 | 2016-08-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for t cell delivery of therapeutic molecules |
WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
BR112017018770A2 (pt) * | 2015-03-02 | 2018-04-17 | Innovative Cellular Therapeutics CO., LTD. | redução da tolerância imunológica induzida por pd-l1 |
RU2755227C2 (ru) | 2015-03-05 | 2021-09-14 | Фред Хатчинсон Кансэр Рисёч Сентер | Иммуномодулирующие слитые белки и пути их применения |
US10800828B2 (en) | 2015-03-26 | 2020-10-13 | The Scripps Research Institute | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer |
EP3404410B1 (en) * | 2015-03-31 | 2021-07-14 | Fundamental Solutions Corporation | Biosensor system for the rapid detection of analytes |
JP6961490B2 (ja) | 2015-04-08 | 2021-11-05 | ノバルティス アーゲー | Cd20療法、cd22療法、およびcd19キメラ抗原受容体(car)発現細胞との併用療法 |
EP3283113A4 (en) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
EP4234685A3 (en) | 2015-04-17 | 2023-09-06 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
CN115925971A (zh) * | 2015-06-19 | 2023-04-07 | 塞巴斯蒂安·科博尔德 | Pd-1-cd28融合蛋白及其在医学中的用途 |
EP3313883B1 (en) * | 2015-06-23 | 2023-12-06 | Memorial Sloan Kettering Cancer Center | Novel pd-1 immune modulating agents |
CN108137707A (zh) * | 2015-06-29 | 2018-06-08 | 约翰霍普金斯大学 | 免疫检查点嵌合受体疗法 |
WO2017004252A1 (en) * | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
TW201708538A (zh) | 2015-07-21 | 2017-03-01 | 諾華公司 | 改良免疫細胞之功效及擴展之方法 |
GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
WO2017040930A2 (en) | 2015-09-03 | 2017-03-09 | The Trustees Of The University Of Pennsylvania | Biomarkers predictive of cytokine release syndrome |
US11242375B2 (en) | 2015-09-04 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
CN106554414B (zh) * | 2015-09-18 | 2019-04-23 | 上海科济制药有限公司 | 抗cd19全人抗体以及靶向cd19的免疫效应细胞 |
KR20180051651A (ko) | 2015-10-01 | 2018-05-16 | 히트 바이오로직스, 인코퍼레이티드 | 비상동성 키메라 단백질로서의 i형 및 ii형 세포외 도메인을 인접시키기 위한 조성물 및 방법 |
CN105331585A (zh) | 2015-11-13 | 2016-02-17 | 科济生物医药(上海)有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
CA3007980A1 (en) | 2015-12-09 | 2017-06-15 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of using same |
JP7082055B2 (ja) | 2015-12-22 | 2022-06-07 | ノバルティス アーゲー | 抗癌治療における組み合わせ使用のためのメソテリンキメラ抗原受容体(car)およびpd-l1阻害剤に対する抗体 |
US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
EP3433269B1 (en) | 2016-03-23 | 2023-09-27 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
KR102489954B1 (ko) | 2016-06-10 | 2023-01-19 | 가데타 비.브이. | 인간 백혈구 항원 제한된 감마 델타 t 세포 수용체 및 이의 사용 방법 |
CN107586342A (zh) * | 2016-07-08 | 2018-01-16 | 生命序有限公司 | 重组免疫检查点受体及其应用 |
WO2018012895A1 (ko) * | 2016-07-14 | 2018-01-18 | 주식회사 큐로셀 | 면역관문을 극복한 면역세포 및 상기 면역세포를 포함한 약제학적 조성물 |
CN110461315A (zh) | 2016-07-15 | 2019-11-15 | 诺华股份有限公司 | 使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征 |
KR20230167769A (ko) * | 2016-08-26 | 2023-12-11 | 베이롤 칼리지 오브 메드신 | 세포 치료요법을 위한 항상성 활성 사이토킨 수용체 |
CA3034691A1 (en) | 2016-08-30 | 2018-03-08 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
CA3037086A1 (en) | 2016-10-03 | 2018-04-12 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
AU2017341047A1 (en) | 2016-10-07 | 2019-05-02 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
KR102613430B1 (ko) | 2016-10-19 | 2023-12-18 | 더 스크립스 리서치 인스티튜트 | 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도 |
CN107988164B (zh) * | 2016-10-26 | 2020-07-07 | 阿思科力(苏州)生物科技有限公司 | 一种pd-1 car nk-92细胞及其制备方法与应用 |
CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
KR20190096969A (ko) * | 2016-12-22 | 2019-08-20 | 윈드밀 테라퓨틱스, 인크. | 면역계를 조절하기 위한 조성물 및 방법 |
US10613083B2 (en) | 2016-12-22 | 2020-04-07 | Fundamental Solutions Corporation | Universal biosensor system for analyte detection |
EP4043485A1 (en) | 2017-01-26 | 2022-08-17 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
CN110290798B (zh) | 2017-02-27 | 2024-04-05 | 沙塔克实验室有限公司 | 基于vsig8的嵌合蛋白 |
WO2018157164A1 (en) | 2017-02-27 | 2018-08-30 | Shattuck Labs, Inc. | Csf1r-based chimeric proteins |
CN110234345A (zh) | 2017-02-27 | 2019-09-13 | 沙塔克实验室有限公司 | 制备和使用基于细胞外结构域的嵌合蛋白的方法 |
EP3589295A4 (en) | 2017-02-28 | 2020-11-04 | Endocyte, Inc. | COMPOSITIONS AND METHODS OF T CAR LYMPHOCYTE THERAPY |
AU2018236461A1 (en) | 2017-03-17 | 2019-09-19 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
CN110832075A (zh) | 2017-03-22 | 2020-02-21 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
CN108977453A (zh) * | 2017-06-02 | 2018-12-11 | 阿思科力(苏州)生物科技有限公司 | 一种以robo1为靶点的嵌合抗原受体细胞及其制备和应用 |
MX2020002901A (es) | 2017-09-19 | 2020-07-22 | Massachusetts Inst Technology | Composiciones para la terapia con celulas t con receptores de antigeno quimerico y usos de las mismas. |
US11559549B2 (en) * | 2017-09-26 | 2023-01-24 | Longwood University | PD1-specific chimeric antigen receptor as an immunotherapy |
SG11202002728VA (en) | 2017-10-03 | 2020-04-29 | Juno Therapeutics Inc | Hpv-specific binding molecules |
US11866731B2 (en) | 2017-11-10 | 2024-01-09 | Chineo Medical Technology Co., Ltd | Modified immune cells and uses thereof |
CN108085340B (zh) * | 2017-12-07 | 2020-07-07 | 北京市肿瘤防治研究所 | 一种同时表达靶向cd19和cd20的car与pd1-cd28嵌合受体的慢病毒载体 |
WO2019118508A1 (en) * | 2017-12-12 | 2019-06-20 | The Trustees Of The University Of Pennsylvania | Genetically modified immune cells targeting ny-eso-1 and methods of use thereof |
AU2018388413A1 (en) | 2017-12-22 | 2020-06-11 | Fate Therapeutics, Inc. | Enhanced immune effector cells and use thereof |
EP3737765B1 (en) * | 2018-01-12 | 2021-12-22 | Curocell Inc. | Enhanced immune cells using dual shrna and composition including the same |
TW201940182A (zh) | 2018-01-22 | 2019-10-16 | 美商安德賽特公司 | Car t 細胞之使用方法 |
CN111954715A (zh) | 2018-03-29 | 2020-11-17 | 菲特治疗公司 | 工程改造的免疫效应细胞和其用途 |
KR20210029707A (ko) | 2018-04-05 | 2021-03-16 | 주노 쎄러퓨티크스 인코퍼레이티드 | 재조합 수용체를 발현하는 세포의 생산 방법 및 관련 조성물 |
CN112566698A (zh) | 2018-04-05 | 2021-03-26 | 朱诺治疗学股份有限公司 | T细胞受体和表达该t细胞受体的工程化细胞 |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
WO2019237035A1 (en) | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
TW202016139A (zh) | 2018-06-13 | 2020-05-01 | 瑞士商諾華公司 | Bcma 嵌合抗原受體及其用途 |
CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
CN110257338B (zh) * | 2018-06-21 | 2022-08-26 | 上海斯丹赛生物技术有限公司 | 嵌合细胞因子受体 |
US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
US20200102370A1 (en) | 2018-09-28 | 2020-04-02 | Massachusetts Institute Of Technology | Collagen-localized immunomodulatory molecules and methods thereof |
EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
WO2020069405A1 (en) | 2018-09-28 | 2020-04-02 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
GB201902277D0 (en) | 2019-02-19 | 2019-04-03 | King S College London | Therapeutic agents |
KR20210136042A (ko) * | 2019-03-01 | 2021-11-16 | 알로젠 테라퓨틱스 인코포레이티드 | Pd-1 엑토도메인을 보유하는 키메라 사이토카인 수용체 |
JP2022538974A (ja) | 2019-06-26 | 2022-09-07 | マサチューセッツ インスチテュート オブ テクノロジー | 免疫調節融合タンパク質-金属水酸化物錯体およびその方法 |
WO2021009701A1 (en) * | 2019-07-17 | 2021-01-21 | Curocell Inc. | Enhanced immune cells using dual shrna and composition including the same |
WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
CN114761037A (zh) | 2019-11-26 | 2022-07-15 | 诺华股份有限公司 | 结合bcma和cd19的嵌合抗原受体及其用途 |
EP4117716A2 (en) | 2020-03-10 | 2023-01-18 | Massachusetts Institute of Technology | Methods for generating engineered memory-like nk cells and compositions thereof |
AU2021232853A1 (en) | 2020-03-10 | 2022-09-22 | Massachusetts Institute Of Technology | Compositions and methods for immunotherapy of NPM1c-positive cancer |
WO2021221783A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
WO2021221782A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Chimeric antigen receptor-targeting ligands and uses thereof |
CA3201499A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
EP4355340A1 (en) | 2021-06-16 | 2024-04-24 | Instil Bio, Inc. | Receptors providing targeted costimulation for adoptive cell therapy |
WO2023288278A1 (en) | 2021-07-16 | 2023-01-19 | Instil Bio (Uk) Limited | Chimeric molecules providing targeted costimulation for adoptive cell therapy |
WO2023081715A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
WO2023222829A1 (en) * | 2022-05-17 | 2023-11-23 | Centre Hospitalier Universitaire Vaudois | Designed biosensors for enhanced t cell therapy |
CN116925236A (zh) * | 2023-05-12 | 2023-10-24 | 上海恩凯细胞技术有限公司 | 嵌合转换受体及其应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
US5712149A (en) * | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
WO2001014557A1 (en) * | 1999-08-23 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
ATE360031T1 (de) * | 2000-01-03 | 2007-05-15 | Tr Associates L L C | Chimäre proteine und anwendungen |
WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
GB0225279D0 (en) * | 2002-10-30 | 2002-12-11 | Celltech R&D Ltd | Biological products |
US20050113564A1 (en) * | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
US7285522B2 (en) | 2004-08-25 | 2007-10-23 | The Clorox Company | Bleaching with improved whitening |
US20070054360A1 (en) * | 2005-05-12 | 2007-03-08 | Zeren Gao | Compositions and methods for modulating immune responses |
NZ564243A (en) * | 2005-06-08 | 2011-03-31 | Dana Farber Cancer Inst Inc | Methods and compositions for the treatment of persistent infections by inhibiting the programmed cell death 1 (PD-1) pathway |
JP2006345852A (ja) * | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
ES2961498T3 (es) | 2008-08-26 | 2024-03-12 | Hope City | Método y composiciones para el funcionamiento mejorado del efecto antitumoral de las células T |
JP5794917B2 (ja) | 2008-09-12 | 2015-10-14 | アイシス・イノベーション・リミテッドIsis Innovationlimited | Pd−1特異抗体およびその使用 |
CN103124743A (zh) | 2009-12-29 | 2013-05-29 | 新兴产品开发西雅图有限公司 | Ron结合构建物及其使用方法 |
ES2888651T3 (es) | 2011-07-29 | 2022-01-05 | Univ Pennsylvania | Receptores de conmutación coestimulantes |
-
2012
- 2012-07-27 ES ES19162250T patent/ES2888651T3/es active Active
- 2012-07-27 BR BR112014002006A patent/BR112014002006A2/pt not_active IP Right Cessation
- 2012-07-27 PE PE2014000116A patent/PE20141520A1/es not_active Application Discontinuation
- 2012-07-27 WO PCT/US2012/048543 patent/WO2013019615A2/en active Application Filing
- 2012-07-27 AU AU2012290342A patent/AU2012290342A1/en not_active Abandoned
- 2012-07-27 EP EP19162250.5A patent/EP3549611B1/en not_active Revoked
- 2012-07-27 ES ES12820516T patent/ES2723181T3/es active Active
- 2012-07-27 CN CN201710520988.8A patent/CN107266584B/zh active Active
- 2012-07-27 CA CA2842368A patent/CA2842368A1/en not_active Abandoned
- 2012-07-27 KR KR1020147003058A patent/KR20140045533A/ko not_active Application Discontinuation
- 2012-07-27 EP EP21182535.1A patent/EP3915588A1/en active Pending
- 2012-07-27 CN CN202210444649.7A patent/CN114835823A/zh active Pending
- 2012-07-27 EA EA201490364A patent/EA201490364A1/ru unknown
- 2012-07-27 EP EP12820516.8A patent/EP2736540B1/en active Active
- 2012-07-27 MX MX2014001222A patent/MX2014001222A/es unknown
- 2012-07-27 CN CN201280041432.6A patent/CN104114233B/zh active Active
- 2012-07-27 JP JP2014523064A patent/JP6334398B2/ja active Active
- 2012-07-27 US US14/232,557 patent/US10981969B2/en active Active
-
2014
- 2014-01-15 TN TNP2014000020A patent/TN2014000020A1/en unknown
- 2014-01-16 IL IL230496A patent/IL230496A0/en unknown
- 2014-01-21 ZA ZA2014/00477A patent/ZA201400477B/en unknown
- 2014-01-22 CO CO14012252A patent/CO6862107A2/es unknown
- 2014-01-24 GT GT201400015A patent/GT201400015A/es unknown
- 2014-01-27 CL CL2014000195A patent/CL2014000195A1/es unknown
- 2014-01-30 EC ECSP14013186 patent/ECSP14013186A/es unknown
- 2014-02-24 MA MA36778A patent/MA35360B1/fr unknown
-
2018
- 2018-04-26 JP JP2018084610A patent/JP7000242B2/ja active Active
-
2019
- 2019-05-10 US US16/408,923 patent/US20190345219A1/en active Pending
-
2021
- 2021-08-26 JP JP2021137916A patent/JP7394093B2/ja active Active
-
2023
- 2023-11-27 JP JP2023199617A patent/JP2024020529A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201490364A1 (ru) | Костимулирующие рецепторы-переключатели | |
PH12019500781A1 (en) | IL15/IL15Ra HETERODIMERIC FC-FUSION PROTEINS | |
NZ630854A (en) | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus | |
AU2018260863A1 (en) | Human IgG1 Fc region variants and uses thereof | |
MX2018013738A (es) | Anticuerpos que comprenden dominios constantes quimericos. | |
WO2014144960A3 (en) | Fc variants | |
CA2929984C (en) | A t cell or natural killer (nk) cell which co-expresses two chimeric antigen receptors (cars) | |
MX371384B (es) | Receptor antigenico quimerico. | |
EA201790934A1 (ru) | ВАРИАНТЫ ИНТЕРФЕРОНА α2b | |
EA201491186A1 (ru) | Полипептиды химерного фактора viii и их применение | |
BR112015009924A2 (pt) | formulações de proteína imunoglobulina de domínio variável duplo estáveis | |
EA201390923A1 (ru) | Модифицированное антитело с улучшенным полупериодом существования | |
EA201591331A1 (ru) | Антагонисты il-33 и их применение | |
EA201391298A1 (ru) | Неводные концентрированные суспензионные композиции с пониженной вязкостью на основе антител | |
WO2014140904A3 (en) | Antibodies to mica and micb proteins | |
WO2012142515A3 (en) | Fc fusion proteins comprising novel linkers or arrangements | |
MX2013014961A (es) | Variantes anticuerpos y usos de las mismas. | |
WO2012158818A3 (en) | Multi-specific fab fusion proteins and methods of use | |
AR083454A1 (es) | Antigeno de citomegalovirus | |
EA201390666A1 (ru) | Cxcr2-связывающие полипептиды | |
UA108778C2 (xx) | Протираковий злитий протеїн | |
WO2014150748A3 (en) | Stabilized single human cd4 domains and fusion proteins | |
WO2013025846A3 (en) | Transferrin-tumstatin fusion protein and methods for producing and using the same | |
GB201103453D0 (en) | Kinase substrate sensor | |
GB201207155D0 (en) | Antibodies |