EA201591331A1 - Антагонисты il-33 и их применение - Google Patents
Антагонисты il-33 и их применениеInfo
- Publication number
- EA201591331A1 EA201591331A1 EA201591331A EA201591331A EA201591331A1 EA 201591331 A1 EA201591331 A1 EA 201591331A1 EA 201591331 A EA201591331 A EA 201591331A EA 201591331 A EA201591331 A EA 201591331A EA 201591331 A1 EA201591331 A1 EA 201591331A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- antagonists
- present
- protein
- applications
- Prior art date
Links
- 102000017761 Interleukin-33 Human genes 0.000 title abstract 9
- 108010067003 Interleukin-33 Proteins 0.000 title abstract 9
- 239000005557 antagonist Substances 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 102100039880 Interleukin-1 receptor accessory protein Human genes 0.000 abstract 1
- 101710180389 Interleukin-1 receptor accessory protein Proteins 0.000 abstract 1
- 102100036706 Interleukin-1 receptor-like 1 Human genes 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
Abstract
В настоящем изобретении предлагаются антагонисты интерлейкина-33 (IL-33), включающие один или несколько IL-33-связывающих доменов и один или более мультимеризующих доменов, и способы их применения. Согласно некоторым вариантам реализации изобретения IL-33-связывающие домены могут содержать IL-33-связывающий участок белка ST2 и/или внеклеточный участок белка IL-1RAcP. Антагонисты IL-33 по данному изобретению могут применяться для лечения заболеваний и патологий, связанных с передачей сигнала IL-33 и/или клеточной экспрессией IL-33, таких как инфекционные заболевания, воспалительные заболевания, аллергические заболевания и фиброзные заболевания.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361787121P | 2013-03-15 | 2013-03-15 | |
US201361819029P | 2013-05-03 | 2013-05-03 | |
US201361913417P | 2013-12-09 | 2013-12-09 | |
PCT/US2014/027058 WO2014152195A1 (en) | 2013-03-15 | 2014-03-14 | Il-33 antagonists and uses thereof |
Publications (2)
Publication Number | Publication Date |
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EA201591331A1 true EA201591331A1 (ru) | 2016-01-29 |
EA034834B1 EA034834B1 (ru) | 2020-03-26 |
Family
ID=50513479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591331A EA034834B1 (ru) | 2013-03-15 | 2014-03-14 | Антагонисты il-33 и их применение |
Country Status (12)
Country | Link |
---|---|
US (3) | US9637535B2 (ru) |
EP (1) | EP2968454B1 (ru) |
JP (1) | JP6404314B2 (ru) |
KR (1) | KR20150127591A (ru) |
CN (1) | CN105007929B (ru) |
AU (1) | AU2014240101B2 (ru) |
CA (1) | CA2904377C (ru) |
EA (1) | EA034834B1 (ru) |
HK (1) | HK1220373A1 (ru) |
IL (1) | IL240393B (ru) |
MX (1) | MX364591B (ru) |
WO (1) | WO2014152195A1 (ru) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11492398B2 (en) | 2017-08-31 | 2022-11-08 | Mitsubishi Tanabe Pharma Corporation | IL-33 antagonist-containing therapeutic agent for endometriosis |
US11725049B2 (en) | 2013-12-26 | 2023-08-15 | Mitsubishi Tanabe Pharma Corporation | Human anti-IL-33 neutralizing monoclonal antibody |
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JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
US9637535B2 (en) | 2013-03-15 | 2017-05-02 | Regeneron Pharmaceuticals, Inc. | IL-33 antagonists and uses thereof |
CN112552401B (zh) * | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
MX2016009047A (es) | 2014-01-10 | 2017-04-13 | Anaptysbio Inc | Anticuerpos dirigidos contra interleucina-33 (il-33). |
WO2015164354A1 (en) | 2014-04-21 | 2015-10-29 | The Childen's Hospital Of Philadelphia | Compositions and methods for treating cytokine-related disorders |
US10544225B2 (en) | 2014-07-03 | 2020-01-28 | Beigene, Ltd. | Anti-PD-L1 antibodies and their use as therapeutics and diagnostics |
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JP7231326B2 (ja) | 2014-11-10 | 2023-03-01 | ジェネンテック, インコーポレイテッド | Il-33媒介性障害のための治療及び診断方法 |
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- 2014-03-14 EA EA201591331A patent/EA034834B1/ru not_active IP Right Cessation
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11725049B2 (en) | 2013-12-26 | 2023-08-15 | Mitsubishi Tanabe Pharma Corporation | Human anti-IL-33 neutralizing monoclonal antibody |
US11492398B2 (en) | 2017-08-31 | 2022-11-08 | Mitsubishi Tanabe Pharma Corporation | IL-33 antagonist-containing therapeutic agent for endometriosis |
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CN105007929A (zh) | 2015-10-28 |
AU2014240101B2 (en) | 2018-05-17 |
NZ712651A (en) | 2021-04-30 |
IL240393A0 (en) | 2015-09-24 |
US10774128B2 (en) | 2020-09-15 |
WO2014152195A1 (en) | 2014-09-25 |
HK1220373A1 (zh) | 2017-05-05 |
EP2968454B1 (en) | 2019-02-13 |
JP2016515130A (ja) | 2016-05-26 |
IL240393B (en) | 2019-03-31 |
JP6404314B2 (ja) | 2018-10-10 |
MX2015011408A (es) | 2016-04-27 |
CN105007929B (zh) | 2019-05-10 |
CA2904377A1 (en) | 2014-09-25 |
US20170204158A1 (en) | 2017-07-20 |
US20140271642A1 (en) | 2014-09-18 |
AU2014240101A1 (en) | 2015-10-15 |
US10011647B2 (en) | 2018-07-03 |
EA034834B1 (ru) | 2020-03-26 |
CA2904377C (en) | 2021-07-13 |
US20180265567A1 (en) | 2018-09-20 |
US9637535B2 (en) | 2017-05-02 |
KR20150127591A (ko) | 2015-11-17 |
MX364591B (es) | 2019-05-02 |
EP2968454A1 (en) | 2016-01-20 |
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