ES2609612T3 - Una composición para detectar biofilms en tejidos viables - Google Patents

Una composición para detectar biofilms en tejidos viables Download PDF

Info

Publication number
ES2609612T3
ES2609612T3 ES11805905.4T ES11805905T ES2609612T3 ES 2609612 T3 ES2609612 T3 ES 2609612T3 ES 11805905 T ES11805905 T ES 11805905T ES 2609612 T3 ES2609612 T3 ES 2609612T3
Authority
ES
Spain
Prior art keywords
biofilm
composition
use according
biofilms
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11805905.4T
Other languages
English (en)
Inventor
Phillip Godfrey Bowler
Daniel Gary Metcalf
David Parsons
Emily Sonia Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Convatec Technologies Inc
Original Assignee
Convatec Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convatec Technologies Inc filed Critical Convatec Technologies Inc
Application granted granted Critical
Publication of ES2609612T3 publication Critical patent/ES2609612T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composición de tinte para uso en la producción de biofilm detectable en tejido viable, en donde la composición tiñe preferentemente el biofilm en lugar del tejido viable y comprende 0,1 a 2,0% en peso de EDTA, 0,1 a 1,0% en peso de un surfactante, y 0,0001% a 1% en peso, preferentemente 0,0025% a 0,025% en peso de un agente de tinción para teñir dicho biofilm y hacerlo detectable, caracterizada por que la composición es un líquido, el agente de tinción es Rosa Bengala y el surfactante se selecciona de cloruro de benzalconio o cloruro de bencetonio.

Description

5
10
15
20
25
30
35
40
45
50
55
60
65
DESCRIPCION
Una composicion para detectar biofilms en tejidos viables.
Esta invencion se refiere a una composicion que puede aplicarse a tejidos viables tales como heridas cronicas (v.g. ulceras de las piernas, ulceras de presion, ulceras de pie diabetico), heridas agudas (v.g. cortes, abrasiones, quemaduras), piel y hueso para la deteccion de biofilms microbianos como un indicador precoz de alarma para tejido en riesgo de infeccion. Mas particularmente, la invencion se refiere a una composicion capaz de producir biofilms en tejidos viables observables al mismo tiempo que se evitan la irritacion de la herida y la piel y el retardo de la curacion.
Los tejidos viables estan colonizados a menudo por una diversidad de microorganismos, algunos de los cuales pueden causar infeccion. Esta siendo cada vez mas aceptado que la curacion de heridas cronicas y agudas se ve dificultada por la presencia de microorganismos que colonizan la herida. Esta surgiendo una evidencia convincente de que estos microorganismos pueden existir en las heridas fundamentalmente en forma de biofilms. Durante la colonizacion, bacterias y otros microorganismos tales como levaduras y hongos, se fijan firmemente al tejido y forman biofilm por la secrecion de una matriz extracelular de sustancias polfmeras. Este modo de crecimiento imparte cierto grado de proteccion a los microorganismos dentro del biofilm en forma de proteccion ffsica contra los agentes antimicrobianos topicos y sistemicos debido a la matriz circundante. Se cree tambien que los microorganismos en el interior de los biofilms tienen fenotipos y genotipos alterados comparados con sus homologos planctonicos que nadan libremente. Es sabido que los microorganismos del biofilm son menos activos metabolicamente y, debido a ello, pueden proporcionar tambien cierto grado de resistencia a los metodos antimicrobianos tradicionales tales como los antibioticos, que se sabe actuan contra las bacterias metabolicamente activas. Adicionalmente, la presencia de biofilms en las heridas inhibe tambien el sistema inmune del hospedador en el aclaramiento de los microbios inflamatorios, y las fases de granulacion y re-epitelializacion, del proceso normal de curacion de las heridas.
Como consecuencia, existe necesidad de desarrollar metodos o dispositivos que detecten rapidamente la presencia de biofilm en los tejidos viables antes y despues de protocolos de tratamiento seleccionados. Esto podna ayudar a los investigadores a comprender si existen microorganismos vivos en el estado del biofilm en la piel y las heridas, y permitir a los mismos seguir la maduracion o aclaramiento de tales comunidades de biofilm. Un metodo o dispositivo de deteccion de biofilm podna permitir tambien que los investigadores desarrollen estrategias anti-biofilm eficaces y protocolos de cuidado eficaces para curacion de las heridas, y en la practica clmica, podna guiar la seleccion de vendajes apropiados de las heridas y ayudar a la monitorizacion de la eficacia de un protocolo de tratamiento dado por el profesional de cuidado de las heridas. Los biofilms estan constituidos tfpicamente por bacterias encerradas dentro de una sustancia (o matriz) exopolfmera que consiste en polisacaridos de cadena larga con p-enlaces complejos tales como enlaces hexosa unidos en 1,3 o 1,4 (ejemplos de algunos polisacaridos comunes de biofilm son acido teicoico, piruvato enlazados a cetal, N- acetil-glucosamina, y los acidos uronicos: acidos D-guluronico, D-galacturonico y manuronico), proterna (algunas de las cuales pueden jugar un papel estructural), DNA (extracelular, algunos de los cuales pueden tener un papel estructural), lfpidos, iones metalicos (Ca2+, Mg2+, Fe3+, etc.) y agua. Los biofilms pueden estar asociados tambien con tejidos desvitalizados del hospedador tales como escara y tejido necrotico.
A las sustancias polfmeras extracelulares (EPS) del biofilm se hace referencia tambien como matriz extracelular del biofilm o tejido derivado de bacterias. Mientras que el biofilm es principalmente agua en peso y las bacterias pueden constituir solo 10-20% del biofilm, el EPS constituye la mayor parte de la biomasa/peso seco del biofilm.
biofilms tales como los encontrados en los dientes en la forma de placa dental, son a menudo faciles de visualizar a simple vista debido a su grosor y su color y a la naturaleza del sustrato sobre el que se forman. La visualizacion del biofilm en, por ejemplo, una herida cronica o aguda no es simple debido a los colores presentes en la herida y los contenidos de la herida. Las heridas cronicas y agudas son usualmente complejas en el sentido de que contienen tejido muerto o desvitalizado (escara), exudado, pus, sangre, medicamentos, componentes del vendaje, ademas de bacterias y biofilm. Por ello, puede ser dificil detectar la presencia de un biofilm en una herida, dado que la visualizacion de los biofilms de la herida a simple vista es dificil. Por tanto, existe necesidad de un medio para ayudar a la deteccion del biofilm, por ejemplo por una composicion que sea capaz de tenir preferentemente los biofilms de heridas de tal modo que los mismos puedan ser visualizados. Una vez visualizado, el biofilm puede tratarse de modo adecuado. Sorprendentemente, se ha encontrado que es posible tenir preferentemente los biofilms por el uso de una composicion que comprende un tinte que permite la deteccion del biofilm.
Composiciones para tincion de biofilms se describen, por ejemplo, en la publicacion de patente internacional WO 2010/070292 A1; sin embargo, las composiciones descritas se encuentran predominantemente en forma de gel.
De acuerdo con ello, un primer aspecto de la invencion proporciona una composicion lfquida de tincion para uso en la produccion de biofilm en tejido viable detectable segun las reivindicaciones adjuntas, en donde la composicion tine preferentemente el biofilm. Con preferencia, el biofilm se hace detectable a simple vista o en asociacion con iluminacion y/o dispositivos opticos.
El agente de tincion es Rosa Bengala.
5
10
15
20
25
30
35
40
45
50
55
60
65
Por la expresion “tine preferentemente se entiende que el agente de tincion se fija selectivamente al biofilm en lugar de fijarse al tejido viable del hospedador. De esta manera, el agente de tincion puede utilizarse simplemente para detectar el biofilm por revelado de la presencia y localizacion del biofilm. El agente de tincion queda fijado o adsorbido a las moleculas de la matriz del biofilm extracelular ademas de fijarse o adsorberse a y/o ser capturado por las celulas bacterianas del biofilm en lugar de tejido de la herida. Preferiblemente, la tincion del biofilm por el agente de tincion revela la presencia de biofilm por hacerlo detectable a simple vista. Alternativamente, puede hacerse que el biofilm tenido emita fluorescencia, por ejemplo por iluminacion con una fuente luminosa. La fluorescencia puede hacer mas visible el biofilm tenido. La fuente luminosa se selecciona de modo que emita luz de una longitud de onda apropiada tal que el agente de tincion absorbe energfa luminosa en la forma de fotones que excitan el agente de tincion y causan que el mismo emita fluorescencia. La observacion de la fluorescencia puede mejorarse utilizando filtros opticos apropiados que excluyen las longitudes de onda no fluorescentes del agente de tincion, por ejemplo en la forma de lentes provistas de filtros opticos.
Las composiciones segun un primer aspecto de la invencion comprenden Rosa Bengala como el agente de tincion capaz de tenir preferentemente los biofilms.
El agente de tincion se incluye preferiblemente en la composicion a un nivel que oscila desde 0,0001% a 1% en peso, mas preferiblemente 0,0025% a 0,025% en peso, y aun mas preferiblemente 0,0025% a 0,01% en peso.
Las composiciones de la presente invencion pueden encontrarse en una forma que se adhiere ligeramente a los tejidos y pueden eliminarse facilmente por lavado despues de un breve periodo de tiempo para ayudar a la visualizacion del biofilm tenido. Por ejemplo, una solucion lfquida basada en agua o glicerol (en la forma de un aplicador, nebulizador u hoja), podna proporcionar contacto mtimo con un lecho de herida. En cualquier sistema de suministro de este tipo, la formulacion debena eliminarse preferiblemente con facilidad de los tejidos viables por lavado utilizando un irrigador estandar tal como solucion salina, durante unos cuantos segundos.
La composicion de la invencion puede comprender tambien un humectante tal como propilenglicol (PG), glicerol, polietilenglicol, polidextrosa, sorbitol, trietanolamina, ciclometicona, lactato de amonio o glicerol-ester. Preferiblemente, la composicion comprende desde 5% a 15% en peso de un humectante, y muy preferiblemente PG.
La composicion de la invencion comprende excipientes para optimizar la fijacion del tinte al biofilm, a saber, sal tetrasodica de acido etilenodiamina-tetraacetico (EDTA) a un nivel de 0,1 a 2,0% en peso, y un agente para ayudar a la penetracion del agente de tincion en el biofilm, a saber, el surfactante cloruro de benzalconio (BaCl) o cloruro de bencetonio (BeCl) a un nivel de 0,1 a 1,0% en peso. La adicion de un surfactante puede actuar tambien como agente espumante.
Preferiblemente, la composicion de la invencion tiene un pH comprendido en el intervalo de 5 a 7, y muy preferiblemente alrededor de 5,5. Con preferencia, la composicion de la invencion se encuentra la forma de una solucion aplicada a la herida desde una jeringuilla, bolsita, frasco de nebulizacion, frasco de aerosol, frasco dispensador sin propelente, pincel u hoja de gel, film u oblea que se disuelve.
La formulacion podna esterilizarse finalmente por tratamiento en autoclave o irradiacion gamma. Alternativamente, la formulacion podna ser una solucion preservada que contenga por ejemplo conservantes tales como DMDM-hidantoma o parabenes tales como metil-, etil- o propil-paraben.
La composicion de la presente invencion se utilizara fundamentalmente en tejidos viables que muestren signos de infeccion clmica (inflamacion, olor desagradable, exudado purulento, hipoxia, etc.), puedan encontrarse en riesgo de infeccion, parezcan encontrarse en presencia de escara (tejido derivado del hospedador) o biofilm (tejido derivado de bacterias), o sean reacios en general. La composicion podna utilizarse tambien en caso de cambio de vendaje, a fin de detectar biofilm, y tambien para monitorizar la eficacia del regimen de tratamiento y dirigir el tratamiento futuro por reduccion en el biofilm detectado.
En un ejemplo de uso tfpico, una composicion segun la invencion se aplica a toda la herida o a regiones deseadas a fin de conseguir una capa de composicion fina pero consistente, por ejemplo de 0,1 a 0,5 cm de grosor. La composicion se deja in situ durante 0,1 a 15 min, mas preferiblemente 0,5 a 2 min. Antes de cualquier iluminacion, la formulacion puede dejarse in situ, o mas preferiblemente el exceso de formulacion se elimina por lavado de la herida utilizando una solucion de irrigacion de heridas adecuada. La eliminacion del exceso de formulacion por lavado puede permitir que la tincion muestre donde se encuentra el biofilm en la herida, a fin de que estas areas puedan tratarse por ejemplo mediante raspado.
La herida se examina luego en cuanto a la presencia de biofilm tenido preferentemente. Esto puede hacerse a simple vista, o la herida puede iluminarse con una fuente luminosa a una distancia comprendida en el intervalo de 1 a 50 cm. Con preferencia, la fuente luminosa se encuentra a una distancia de 5 a 20 cm. La senal espectral de la fuente luminosa se selecciona de modo que corresponda al espectro de emision de fluorescencia del agente de tincion; a saber, para Rosa Bengala, que tiene un maximo de fluorescencia de 575 nm, una fuente luminosa adecuada podna emitir longitudes de onda de 550-600 nm. Esto causa que el agente contenido en el biofilm tenido emita fluorescencia. Preferiblemente, el
5
10
15
20
25
30
35
40
45
50
55
60
65
usuario lleva gafas para observar la herida u observa la herida a traves de una lente integrada en la fuente luminosa. Las gafas o la lente tienen un sistema de filtracion de luz que excluye las longitudes de onda de luz por debajo del intervalo de emision de fluorescencia del agente de tincion y permite que cualquier fluorescencia se observe de modo notablemente claro y espedfico y por tanto, la deteccion de cualquier biofilm presente.
Tfpicamente, el tratamiento debena tener lugar en los cambios de vendaje subsiguientes. La herida puede examinarse ulteriormente en cuanto a presencia y reduccion del biofilm - a simple vista o con la fuente luminosa y las gafas o la lente integrada. La herida puede vendarse luego con un vendaje primario y secundario apropiado.
Lo que sigue es una breve descripcion de las figuras y tablas:
Figura 1. Seleccion inicial de colorantes seleccionados como tintes de biofilm utilizando biofilms desarrollados en el CDFF (n = 6).
Figura 2a. Seleccion de colorantes seleccionados como tintes de biofilm utilizando biofilms desarrollados en el reactor de biofilm CDC (n = 9).
Datos de absorcion.
Figura 2b. Seleccion de colorantes seleccionados como tintes de biofilm utilizando biofilms desarrollados en el reactor CDC (n = 9).
Datos de concentracion.
Figura 3. Rosa bengala con muestras tenidas (A-C) con EDTA y BaCl (RBEB) y muestras de control (DE) de carne que contema biofilms mixtos de S. aureus y P. aeruginosa.
Figura 4. Edad de un biofilm de S. aureus frente a concentracion de colorante.
Figura 5. Edad de un biofilm de P. aeruginosa frente a concentracion de Rosa Bengala.
Los ejemplos siguientes son ilustrativos de la presente invencion.
Ejemplo 1
Evaluacion de las tinciones de biofilm utilizando el fermentador de biofilm de altura constante
Se utilizo un fermentador de biofilm de altura constante (CDFF) para cultivar biofilms mixtos de 4 dfas de Staphylococcus aureus y Pseudomonas aeruginosa. Resumidamente, se formaron biofilms en rebajos en 15 cubetas de PTFe alrededor del borde de una mesa rotativa de acero sobre la cual se dejaba gotear continuamente inoculo o medio de crecimiento esteril. Una barra rascadora distribrna el inoculo bacteriano o medio sobre las cubetas a medida que giraba la mesa rotativa, manteniendo los biofilms en una altura constante. Cada cubeta contema 5 muestras amovibles, de 4 mm de diametro, que estaban rebajadas hasta una altura de 300 pm. Los biofilms resultantes que credan en los rebajos de las muestras eran reproducibles en terminos de aspecto y composicion microbiana, y podfan retirarse del CDFF por una abertura de muestreo utilizando instrumentos esteriles. Por duplicado, se retiraron del CDFF cubetas que conteman el biofilm, se lavaron una sola vez por inmersion en solucion salina esteril durante 5 segundos, y se incubaron luego en volumenes de 10 mL de los tintes potenciales de biofilm siguientes a concentracion 100 pM en agua desionizada a no ser que se indique otra cosa, en la oscuridad durante 2 minutos: Eritrosina; Rosa Bengala; Verde Rapido; Rosa Bengala con 2% peso/volumen de EDTA y 1% peso/volumen de cloruro de benzalconio (BaCI) (RBEB); Rosa Bengala con 2% peso/volumen de EDTA tetrasodico y 1% peso/volumen de cloruro de benzalconio en 2% peso/volumen de hidroxietilcelulosa y 10% peso/volumen de gel de propilenglicol (Gel-RBEB). Despues de otro lavado en solucion salina, se incubaron durante una noche 6 muestras para cada tinte a 37°C en volumenes de 6 mL de dodecilsulfato de sodio (SDS) al 2% en agua para digestion. Las muestras se centrifugaron luego 13.000 rpm durante 10 min para separar el sobrenadante de los residuos celulares digeridos. Los espectros de absorcion de los sobrenadantes aspirados se midieron luego en un espectrofotometro y estos espectros se compararon con espectros de concentraciones conocidas (100 pM) de cada tinte en SDS al 2%.
La Figura 1 muestra que Verde Rapido pareda ser el tinte mas eficaz en los biofilms desarrollados en el CDFF, seguido de cerca por Rosa Bengala con EDTa y BaCl en forma lfquida. La adicion de los excipientes EDTA y BaCl pareda mejorar la captura de Rosa Bengala en los biofilms.
Ejemplo 2
Evaluacion de las tinciones de biofilm utilizando el reactor de biofilm CDC
Se utilizo un reactor de biofilm del Centro para Control de las Enfermedades (CDC) para cultivar biofilms mixtos de 48 horas de Staphylococcus aureus y Pseudomonas aeruginosa. Resumidamente, se formaron biofilms sobre probetas en bastoncillos de reactor que se mantuvieron dentro de la vasija del reactor que contema un cultivo mezclado continuamente de S. Aureus y P. aeruginosa a 35° C. Las probetas que conteman el biofilm se retiraron de los bastoncillos, se lavaron una sola vez por inmersion en solucion salina esteril durante 5 segundos, y se incubaron luego en volumenes de 10 mL de los tintes de biofilm siguientes a concentracion 100 pM en agua desionizada, en la oscuridad durante 2 min: Eritrosina; Rosa Bengala; Azul Alcian; Rodamina B; Rodamina 123; Rosa Bengala con 2% peso/volumen de EDTA y 1%
5
10
15
20
25
30
35
40
45
50
55
60
peso/volumen de BaCI (RBEB). Despues de otro lavado en solucion salina, se anadieron 9 probetas para cada tincion a volumenes de 2 mL de SDS al 2% para rechazo a ajuste 'alto' durante 1 minuto y se incubaron luego durante una noche en la oscuridad a 37°C, para digestion. Las muestras se centrifugaron luego 13.000 rpm durante 5 min para separar el sobrenadante de los residuos celulares digeridos. Los espectros de absorcion de los sobrenadantes aspirados se midieron luego en un espectrofotometro y estos espectros se compararon con espectros de concentraciones conocidas (100 jM) de cada tinte en SDS al 2%.
La figura 2a muestra como, en terminos de absorcion absoluta o 'brillo', RBEB era el tinte de biofilm mas eficiente, seguido por el tinte de carbohidrato, Azul Alcian. El EDTA y/o BaCl paredan mejorar la captura de Rosa Bengala mas de 60%. Cuando se expresaron los mismos datos como una ratio de absorcion medida: absorcion a 100 jM (es decir concentracion), Azul Alcian pareda ser el tinte de biofilm mas eficaz.
Ejemplo 3
Evaluacion de tintes de biofilm utilizando un modelo de biofilm de panza de cerdo
Se utilizo un modelo de biofilm de panza de cerdo para evaluar mas los tintes de biofilm. Se cortaron trozos de panza de cerdo utilizando un taladro de 20 mm y una barrena de 6 mm para crear indentaciones en el centro de las muestras. Las muestras se esterilizaron luego por irradiacion gamma. Las muestras se inocularon con volumenes de 10 jl de una suspension mixta de ~1 x 107 unidades formadoras de colonias/mililitro de S. aureus y P. aeruginosa y se incubaron luego a 35° C en placas de Petri selladas con Parafilm durante 72-96 horas. Las muestras que paredan tener biofilms visibles unicamente en el orificio central del taladro se tineron luego por inmersion de las muestras en volumenes de 10 mL de Rosa Bengala 100 jM con 2% peso/volumen de EDTA y 1% peso/volumen de BaCl (RBEB) durante 2 minutos con lavado en solucion salina antes y despues de la tincion. Las muestras de control no se tineron y por tanto se sumergieron unicamente en solucion salina durante 2 minutos. Las muestras se fotografiaron luego, ejemplos de las cuales se representan en Fig. 3. Las tres muestras (A a C) mostraban que estaban tenidas con RBEB, demostrando claramente la captura selectiva del tinte por los biofilms que estaban contenidos dentro de las indentaciones. Las tres muestras de control demuestran que sin esta tincion es dificil averiguar si y donde esta presente biofilm en las muestras
Ejemplo 4
Tincion con Rosa Bengala de biofilms desarrollados utilizando un modelo de biofilm en filtro de membrana
Se utilizo un modelo de biofilm en filtro de membrana para estudiar el efecto de la concentracion de Rosa Bengala sobre la eficacia de la tincion del biofilm. Resumidamente, se anadio un volumen de 5 jL de una suspension de 5 * 105 unidades formadoras de colonias/mililitro de S. aureus o P. aeruginosa al centro de discos de filtros de membrana esteriles (tamano de poro 0,2 jm; Anodisc, Whatman) que se pusieron en volumenes de 7 mL de Caldo Tnptico de Soja esteril en placas de 6 pocillos tapadas. Las muestras se incubaron durante 4 horas (biofilms inmaduros), y 24 y 48 horas (biofilms maduros), y el exceso de celulas planctonicas se retiro de los filtros por lavado. Los biofilms que se encontraban en los filtros se tineron por pipeteado de volumenes de 2 mL de Rosa Bengala (60 jM o 300 jM) o solucion salina (control negativo) durante 30 segundos, seguido por lavado. El Rosa Bengala se recupero de las muestras de biofilm por rechazo y digestion durante una noche en dodecilsulfato de sodio al 2%, centrifugacion, y medicion posterior de los espectros de absorcion en un espectrofotometro UV-vis. La captura de Rosa Bengala por muestra se determino por comparacion de los valores de absorcion con una curva estandar de Rosa Bengala en SDS al 2%.
Las Tablas 1 y 2 muestran que los biofilms de S. aureus y P. aeruginosa capturaban Rosa Bengala de una manera dependiente de la concentracion de colorante y la edad del biofilm. Unicamente a las concentraciones maximas de 300 jM paredan tenirse los biofilms inmaduros de 4 horas, aunque esto se debfa probablemente a cierta tincion de los filtros propiamente dichos. Las Figuras 4 y 5 muestran como los biofilms maduros de 48 horas de S. aureus y P. aeruginosa capturaban mas Rosa Bengala que los biofilms de 24 horas, y tambien que Rosa Bengala 300 jM daba como resultado una tincion significativamente mayor de los biofilms que Rosa Bengala 60 jM. Este metodo simple para cuantificar la captura de Rosa Bengala por los biofilms utiliza los espectros de absorcion del colorante. La utilizacion de los espectros de absorcion para cuantificar el colorante es similar a la deteccion de la fluorescencia utilizando una fuente luminosa con filtros opticos. La captura podna observarse alternativamente de modo cualitativo a simple vista o por observacion de la emision de fluorescencia del Rosa Bengala en conjuncion con una fuente luminosa y un filtro optico.
Tabla 1
Edad (h)
[RB] (uM) 1 2 3 Media S.D.
4
0 0 0 0 0 0
4
60 0 0 0 0 0
4
300 z,59 1,45 1,64 1,56 0,10
24
0 0 0 0 0 0
24
60 1,66 1,72 2 ,17 1,85 0,28
24
300 4,82 4,55 3,95 4,44 0,45
48
0 0 0 0 0 0
48
60 1,22 1,12 1,37 1,24 0,12
48
300 6,26 5,18 5,71 5,72 0,54
Tabla 2
Edad (h)
[RB] (uM) 1 2 3 Media S.D.
4
0 0 0 0 0 0
4
60 0 0 0 0 0
4
300 1,52 1,76 1,88 1,72 0,18
24
0 0 0 0 0 0
24
60 2,04 1,76 2,02 1,94 0,15
24
300 5,05 5,84 4,41 5,10 0,72
48
0 0 0 0 0 0
48
60 3,15 1,66 2,37 2,39 0,74
48
300 6,20 9,01 6,69 7,30 1,50

Claims (12)

  1. 5
    10
    15
    20
    25
    30
    35
    40
    45
    50
    REIVINDICACIONES
    1. Una composicion de tinte para uso en la produccion de biofilm detectable en tejido viable, en donde la composicion tine preferentemente el biofilm en lugar del tejido viable y comprende 0,1 a 2,0% en peso de EDTA, 0,1 a 1,0% en peso de un surfactante, y 0,0001% a 1% en peso, preferentemente 0,0025% a 0,025% en peso de un agente de tincion para tenir dicho biofilm y hacerlo detectable, caracterizada por que la composicion es un lfquido, el agente de tincion es Rosa Bengala y el surfactante se selecciona de cloruro de benzalconio o cloruro de bencetonio.
  2. 2. Una composicion para uso segun la reivindicacion 1, caracterizada por que la composicion tine preferentemente el biofilm por fijacion selectiva al biofilm, siendo la composicion opcionalmente capaz de tenir preferentemente los biofilms por fluorescencia y deteccion visual a simple vista o utilizando una fuente luminosa y filtros opticos correspondientes a los espectros de emision de fluorescencia del agente de tincion.
  3. 3. Una composicion para uso segun la reivindicacion 1 o la reivindicacion 2, caracterizada por que la composicion permite la deteccion del biofilm por tincion y revelado preferentes del mismo, preferiblemente a simple vista.
  4. 4. Una composicion para uso segun la reivindicacion 1 o 2, caracterizada por que el agente de tincion absorbe luz de longitudes de onda que van desde 380 nm a 720 nm.
  5. 5. Una composicion para uso segun cualquiera de las reivindicaciones anteriores, caracterizada por que la composicion permite la deteccion del biofilm por tincion y revelado preferentes del mismo cuando se ilumina este con luz que incluye longitudes de onda que causan que el mismo emita fluorescencia.
  6. 6. Una composicion para uso segun cualquiera de las reivindicaciones anteriores, caracterizada por que la composicion es una solucion lfquida basada en agua o glicerol (en forma de un aplicador, nebulizador u hoja).
  7. 7. Una composicion para uso segun cualquiera de las reivindicaciones anteriores, caracterizada por que la composicion comprende ademas al menos un agente adicional seleccionado del grupo constituido por un humectante y un agente de rotura de biofilms.
  8. 8. Un kit de partes para uso en la deteccion de biofilms en tejido viable, comprendiendo el kit:
    una composicion segun la reivindicacion 1 y una fuente luminosa capaz de causar que el agente de tincion del biofilm emita fluorescencia.
  9. 9. Un kit para uso segun la reivindicacion 8, caracterizado por que la fuente luminosa emite luz para hacer que el agente de tincion emita fluorescencia.
  10. 10. Un kit para uso segun las reivindicaciones 8 o 9, caracterizado por que el mismo comprende gafas o lentes para uso en la deteccion del biofilm, en donde las gafas o lente actuan para excluir todas las longitudes de onda de luz excepto aquellas a los cuales el agente de tincion emite fluorescencia.
  11. 11. Un kit para uso segun las reivindicaciones 8, 9 o 10 que comprende adicionalmente una solucion de irrigacion de herida.
  12. 12. Uso de una composicion segun la reivindicacion 1 para deteccion de un biofilm en una herida, que comprende los pasos de:
    (a) aplicar dicha composicion;
    (b) examinar el tejido respecto a la presencia de biofilm tenido a simple vista o con una fuente luminosa que causa que el biofilm tenido emita fluorescencia;
    (c) detectar la fluorescencia emitida por el biofilm tenido.
ES11805905.4T 2010-11-30 2011-11-30 Una composición para detectar biofilms en tejidos viables Active ES2609612T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201020236 2010-11-30
GBGB1020236.4A GB201020236D0 (en) 2010-11-30 2010-11-30 A composition for detecting biofilms on viable tissues
PCT/GB2011/001665 WO2012072980A1 (en) 2010-11-30 2011-11-30 A composition for detecting biofilms on viable tissues

Publications (1)

Publication Number Publication Date
ES2609612T3 true ES2609612T3 (es) 2017-04-21

Family

ID=43500822

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11805905.4T Active ES2609612T3 (es) 2010-11-30 2011-11-30 Una composición para detectar biofilms en tejidos viables

Country Status (20)

Country Link
US (3) US20140161728A1 (es)
EP (1) EP2646566B1 (es)
JP (3) JP2014500495A (es)
CN (2) CN108330157A (es)
AU (2) AU2011334682B2 (es)
BR (1) BR112013013662A2 (es)
CA (1) CA2819303C (es)
DK (1) DK2646566T3 (es)
ES (1) ES2609612T3 (es)
GB (1) GB201020236D0 (es)
HK (1) HK1258842A1 (es)
HU (1) HUE032884T2 (es)
LT (1) LT2646566T (es)
MX (1) MX344623B (es)
NZ (1) NZ612573A (es)
PL (1) PL2646566T3 (es)
PT (1) PT2646566T (es)
RU (1) RU2650803C2 (es)
SI (1) SI2646566T1 (es)
WO (1) WO2012072980A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525504D0 (en) 2005-12-14 2006-01-25 Bristol Myers Squibb Co Antimicrobial composition
CA2684150C (en) 2007-05-14 2016-10-04 Research Foundation Of State University Of New York Decenoic acid dispersion inducers in the treatment of biofilms
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
SE536793C2 (sv) * 2012-07-02 2014-08-19 Richter Life Science Dev Ab Detektion av kolhydrater
CA2895896A1 (en) 2012-12-20 2014-06-26 Convatec Technologies Inc. Processing of chemically modified cellulosic fibres
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
CA2916337C (en) 2013-07-03 2022-03-22 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
RU2553431C2 (ru) * 2013-07-09 2015-06-10 Государственное бюджетное учреждение здравоохранения города Москвы Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения г. Москвы Тест-система для определения активности интерферона человека
US10465038B2 (en) * 2013-12-26 2019-11-05 Daicel Corporation Curable composition for lens, lens and optical device
CN103694732A (zh) * 2013-12-31 2014-04-02 江苏省原子医学研究所 一种苏木素染色液及其含苏木素染色液的he染色液
WO2015149177A1 (en) 2014-04-01 2015-10-08 Klox Technologies Inc. Tissue filler compositions and methods of use
ES2856841T3 (es) 2014-10-31 2021-09-28 Klox Tech Inc Fibras y medios de tela fotoactivables
KR101688212B1 (ko) * 2014-12-15 2016-12-20 한국화학연구원 형광 신호 증폭용 광결정 폴리머 기판의 제조 방법
US10416153B2 (en) 2015-04-24 2019-09-17 Nanyang Technological University Chemical fluorescent probes for detecting biofilms
KR20170099739A (ko) 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
CA2965904A1 (en) * 2016-05-02 2017-11-02 James M. Rynerson Methods and devices for detecting biofilms on the eyelid margin
DE102016113166B4 (de) * 2016-07-18 2022-02-24 Joanneum Research Forschungsgesellschaft Mbh Verfahren zum Nachweis eines Biofilms und Mittel zum Nachweis eines Biofilms
MX2019010358A (es) * 2017-03-03 2019-10-22 Procter & Gamble Sondas fluorescentes para calcio para evaluar la eficacia de las composiciones para el cuidado bucal en una biopelicula.
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11572578B2 (en) 2018-07-31 2023-02-07 Saraya Co., Ltd. Reagent kit for detecting biofilm and method for detecting biofilm
JP7511585B2 (ja) 2019-06-03 2024-07-05 コンバテック リミティド 病原体を破壊して封じ込めるための方法およびデバイス
RU2718910C1 (ru) * 2020-01-28 2020-04-15 Общество с ограниченной ответственностью «БФР лабораториз» Индикатор для выявления биологических плёнок бактерий на медицинских инструментах (варианты)
US20230078234A1 (en) * 2020-02-26 2023-03-16 Meiji Pharmaceutical University Method for evaluating biofilm formation, and invertebrate for use in evaluating biofilm formation
IT202200000689A1 (it) * 2022-01-18 2023-07-18 Marco Balato Impiego di coloranti nell’identificazione selettiva di siti infetti nelle infezioni biofilm correlate
WO2024024648A1 (ja) * 2022-07-29 2024-02-01 パナソニックＩｐマネジメント株式会社 有機色素組成物及びそれを含むスプレー剤

Family Cites Families (748)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2396514A (en) 1943-03-20 1946-03-12 Ludwig Jekels Sterilizing materials and methods for making the same
GB735462A (en) 1951-12-20 1955-08-24 Dow Chemical Co Improvements in or relating to iodine-containing ethylenediaminetetraacetic acid compounds and methods of making same
US2785106A (en) 1952-08-16 1957-03-12 Ions Exchange And Chemical Cor Process for making antiseptic article
US3092552A (en) 1958-05-19 1963-06-04 Albert C Nolte Oligodynamic silver compositions and uses
US3061469A (en) 1959-11-05 1962-10-30 Givaudan Corp Antibacterial textile fabrics
US3246624A (en) 1965-02-05 1966-04-19 Novo Ind Corp Pressure indicating device
JPS5738564B2 (es) * 1974-09-27 1982-08-16
US4258056A (en) 1978-12-18 1981-03-24 Economics Laboratory, Inc. Control of mastitis and compositions therefor
JPS6015641B2 (ja) 1981-03-18 1985-04-20 花王株式会社 繊維状カルボキシメチルセルロ−スの製造方法
EP0124536A4 (en) 1982-11-05 1985-06-06 Baxter Travenol Lab ANTIMICROBIAL COMPOSITIONS.
US4655758A (en) 1982-12-16 1987-04-07 Johnson & Johnson Products, Inc. Microbial polysaccharide articles and methods of production
US4889654A (en) 1984-07-31 1989-12-26 Rio Linda Chemical Company, Inc. Aqueous foam disinfectant containing chlorine dixoide and preparation and use thereof
US4612337A (en) 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
US4728323A (en) 1986-07-24 1988-03-01 Minnesota Mining And Manufacturing Company Antimicrobial wound dressings
FR2604900B1 (fr) 1986-10-08 1989-01-13 Blomet Marie Claude Solution physiologique pour le lavage des parties du corps humain ayant ete mises en contact avec un acide fluorhydrique et concentre pour sa preparation
GB8709498D0 (en) 1987-04-22 1987-05-28 Bay M Wound dressing
US4829129A (en) 1987-05-29 1989-05-09 International Dioxcide, Inc. Reaction product of polymer with chlorine dioxide
GB2220881B (en) 1988-04-28 1992-07-08 Toyo Boseki Improvements in or relating to superabsorbent materials
US4906100A (en) 1988-05-13 1990-03-06 University Of Cincinnati Method of detecting adriamycin (doxorubicin) or daunomycin in the environment
RU2092180C1 (ru) 1988-06-22 1997-10-10 Эпплаид Микробиолоджи Инк. Антимикробная композиция
US4973848A (en) 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
US5340924A (en) 1990-01-18 1994-08-23 Morinaga Milk Industry Co., Ltd. Method for heat treatment of lactoferrin without losing physiological activities thereof
US6066469A (en) 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
JPH04282311A (ja) 1991-03-08 1992-10-07 Koike Kagaku Kk エアゾール型発泡性傷口消毒剤
WO1992018098A1 (en) 1991-04-10 1992-10-29 Capelli Christopher C Antimicrobial compositions useful for medical applications
US5662913A (en) 1991-04-10 1997-09-02 Capelli; Christopher C. Antimicrobial compositions useful for medical applications
GB9126193D0 (en) 1991-12-10 1992-02-12 Courtaulds Plc Cellulosic fibres
US5407656A (en) 1992-03-04 1995-04-18 Arco Research Co., Inc. Method and compositions for the production of chlorine dioxide
DE69311706T2 (de) 1992-03-20 1997-12-18 Unilever Nv Verbesserung in oder in bezug auf reinigungsmittel
US5762620A (en) 1992-04-02 1998-06-09 Ndm Acquisition Corp. Wound dressing containing a partially dehydrated hydrogel
HUT70688A (en) 1992-07-22 1995-10-30 Unilever Nv Process for combating of surface bound micro-organisms
EP0665733B1 (en) 1992-10-21 2003-05-07 Gynetech Laboratories, Inc. Vaginal sponge delivery system
GB9301258D0 (en) 1993-01-22 1993-03-17 Courtaulds Plc Use of absorbent fibre
WO1994016746A1 (en) 1993-01-22 1994-08-04 Courtaulds Plc Wound dressings
US5848995A (en) 1993-04-09 1998-12-15 Walder; Anthony J. Anti-infective medical article and method for its preparation
US5567495A (en) 1993-08-06 1996-10-22 The Trustees Of Columbia University In The City Of New York Infection resistant medical devices
US5744155A (en) 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
JP2746527B2 (ja) * 1993-09-14 1998-05-06 鐘紡株式会社 徐染性染毛剤組成物及びその製造方法
US5670169A (en) * 1993-12-20 1997-09-23 E.R. Squibb & Sons, Inc. Wound hydrating gel with novel preservative system and low cytotoxicity
JP3121503B2 (ja) 1994-10-18 2001-01-09 レンゴー株式会社 抗菌剤
JP3297969B2 (ja) 1994-12-26 2002-07-02 ライオン株式会社 点眼剤
US5616347A (en) 1995-02-14 1997-04-01 Alliger; Howard Chlorine dioxide skin medicating compositions for preventing irritation
SE506869C2 (sv) 1995-06-30 1998-02-23 Inst Polymerutveckling Ab Metod för laminering genom fotoympning, laminat framställt enligt metoden samt dess användning
CA2225808C (en) 1995-06-30 2002-12-17 Christopher C. Capelli Silver-based pharmaceutical compositions
DE19609143C1 (de) 1996-03-08 1997-11-13 Rhodia Ag Rhone Poulenc Melt-blown-Vlies, Verfahren zu dessen Herstellung und dessen Verwendungen
US5820918A (en) 1996-07-11 1998-10-13 Hercules Incorporated Medical devices containing in-situ generated medical compounds
EP0920252A4 (en) 1996-08-16 2004-08-18 Christopher C Capelli ANTIMICROBIAL COMPOSITIONS BASED ON SILVER
US20030104018A1 (en) 1996-12-31 2003-06-05 Griscom Bettle Skin product having micro-spheres, and processes for the production thereof
EP0925396B1 (en) 1997-04-11 2003-05-02 Bristol-Myers Squibb Company Knitted wound dressings
KR20010013377A (ko) 1997-06-04 2001-02-26 데이비드 엠 모이어 마일드한 잔류성 항균 조성물
US5993864A (en) 1997-07-11 1999-11-30 Kross; Robert D. Chlorine dioxide chelate compositions and method of use
US5860947A (en) 1997-08-20 1999-01-19 Stamler; Keith D. Wound irrigation device and method
US6605751B1 (en) 1997-11-14 2003-08-12 Acrymed Silver-containing compositions, devices and methods for making
US6753063B1 (en) 1997-11-19 2004-06-22 The Procter & Gamble Company Personal cleansing wipe articles having superior softness
IL123437A0 (en) 1998-02-24 1998-09-24 Shalev Pinchas Apparatus and method for photothermal destruction of oral bacteria
JP2002519153A (ja) 1998-07-01 2002-07-02 アコーディス スペシャリティー ファイバーズ リミティド 傷手当用品及びその製造並びにその使用に適切な材料の製造
US6413556B1 (en) 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
DE19909214A1 (de) 1999-03-03 2000-09-07 Basf Ag Wasserabsorbierende, schaumförmige, vernetzte Polymerisate mit verbesserter Verteilungswirkung, Verfahren zu ihrer Herstellung und ihre Verwendung
GB9905663D0 (en) 1999-03-12 1999-05-05 Bristol Myers Squibb Co Iodine preparation composition
ES2270824T3 (es) 1999-04-02 2007-04-16 Kci Licensing, Inc. Sistema de cierre asistido por vacio con provision de calentamiento y enfriamiento.
US6172040B1 (en) 1999-05-28 2001-01-09 A. Satyanarayan Naidu Immobilized lactoferrin antimicrobial agents and the use thereof
EP1216319B1 (en) 1999-09-27 2004-04-07 BHK Holding Ltd. Absorptive fabric
EP1216065B1 (en) 1999-10-01 2008-10-29 Acrymed Silver-containing compositions, devices and methods for making
US6592890B1 (en) 1999-10-20 2003-07-15 Oxibio, Inc. Conveyance of anti-infective activity to wound dressings
US6555508B1 (en) * 2000-02-17 2003-04-29 Leonard Paul Liquid foaming soap compositions
AU2001239835A1 (en) 2000-02-26 2001-09-03 Advanced Photodynamic Technologies, Inc. Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant
GB0011202D0 (en) 2000-05-09 2000-06-28 Kci Licensing Inc Abdominal wound dressing
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
CA2386985A1 (en) 2000-08-11 2002-02-21 The Lawson Health Research Institute Compositions and methods for inhibiting islet dysfunction and autoimmune disorders
US20020091074A1 (en) 2000-09-20 2002-07-11 Wooley Richard E. Medical compositions, dressings and methods for treating microbial infections of skin lesions
US20070003508A1 (en) 2005-07-01 2007-01-04 Wooley Richard E Methods and compositions for promoting wound healing
GB2370226A (en) 2000-09-21 2002-06-26 Acordis Speciality Fibres Ltd Wound dressing
BRPI0115730B8 (pt) 2000-11-29 2021-07-27 Bristol Myers Squibb Co método de preparação de um material compreendendo um polímero hidrofílico, anfótero ou aniônico que possui atividade antimicrobiana
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US20020172709A1 (en) 2001-03-30 2002-11-21 Brian Nielsen Medical dressing comprising an antimicrobial silver compound and a method for enhancing wound healing
JP4517101B2 (ja) * 2001-08-21 2010-08-04 学校法人日本大学 歯垢染色用組成物
AU2002334063B2 (en) 2001-09-12 2008-08-14 Acordis Speciality Fibres Limited Antibacterial wound dressing
GB2382527A (en) 2001-12-03 2003-06-04 Acordis Speciality Fibres Ltd Wound dressings
US8541472B2 (en) 2001-12-05 2013-09-24 Aseptica, Inc. Antiseptic compositions, methods and systems
JP4165754B2 (ja) 2001-12-05 2008-10-15 タイコ・ヘルスケアー・グループ・エルピー 抗菌性システムおよび方法
CZ14554U1 (cs) 2002-02-11 2004-07-26 Unimed Pharma Spol. S R. O. Oční kapky na bázi jodidového anionu
US6468965B1 (en) 2002-04-22 2002-10-22 Paul Cutler Pharmaceutical composition for oral administration of a mixture of chelating agents
US20040033916A1 (en) 2002-06-28 2004-02-19 Kuzmin Vladimir Semenovich Disinfecting composition
GB0215023D0 (en) 2002-06-28 2002-08-07 Bristol Myers Squibb Co Wound dressing
GB2393120A (en) 2002-09-18 2004-03-24 Johnson & Johnson Medical Ltd Compositions for wound treatment
CN1688322B (zh) 2002-09-25 2012-08-15 埃德温·奥德尔·迈纳 含有与聚果胶酸酯和edta螯合的银的抗菌溶液
DE10393374D2 (de) 2002-10-14 2005-09-01 Arconia Gmbh Malans Zusammensetzung
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
WO2004056346A1 (en) 2002-12-19 2004-07-08 University Of Georgia Research Foundation, Inc. Methods and compositions for wound management
CN1771061B (zh) 2003-01-09 2010-05-12 聚合物器官股份有限公司 生物医用泡沫
US7629000B2 (en) 2003-05-13 2009-12-08 E.I. Du Pont De Nemours And Company Method for making antimicrobial polyester-containing articles with improved wash durability and articles made thereby
JP2007501683A (ja) * 2003-05-22 2007-02-01 エラン ファーマ インターナショナル リミテッド γ線照射によるナノ粒子活性物質分散体の滅菌法
CN102743785A (zh) 2003-08-14 2012-10-24 美利肯公司 含银创伤护理装置、其组合物及制造方法
US20050202066A1 (en) 2003-08-28 2005-09-15 Arata Andrew B. Silver dihydrogen citrate compositions comprising a second antimicrobial agent
US20050059731A1 (en) 2003-09-16 2005-03-17 Ceramoptec Industries, Inc. Erythrosin-based antimicrobial photodynamic therapy compound and its use
GB0325129D0 (en) 2003-10-28 2003-12-03 Smith & Nephew Apparatus in situ
FI117056B (fi) * 2003-11-06 2006-05-31 Kemira Oyj Menetelmä biofilmiä muodostavien mikro-organismien esiintymisen monitoroimiseksi paperiteollisuudessa
US7033511B2 (en) 2004-01-20 2006-04-25 A-Dec, Inc. Sustained water treatment in dental equipment
JP2005210997A (ja) * 2004-01-30 2005-08-11 Nichirei Corp バイオフィルム染色剤
WO2005079582A1 (en) 2004-02-24 2005-09-01 Campina B.V. Antimicrobial lactoferrin compositions for surfaces, cavities, and foodstuff
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US20070254349A1 (en) 2004-04-16 2007-11-01 Helbo Photodynamic Systems Gmbh & Co.Kg Preparation for the Photodynamic Control of Micro-Organisms and Use Thereof
US10413644B2 (en) 2004-04-27 2019-09-17 Smith & Nephew Plc Wound treatment apparatus and method
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
RU2007101243A (ru) 2004-06-12 2008-07-20 Сигнум Байосайенсиз Композиции и способы для местного применения для состояний, связанных с эпителием
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
ATE410535T1 (de) 2004-07-09 2008-10-15 Johnson & Johnson Gmbh Kosmetischer und/oder dermatologischer absorbierender körperpflegeartikel mit mindestens einer absorbierenden schicht
CA2573744A1 (en) 2004-07-22 2006-03-02 Ondine International Ltd. Sonophotodynamic therapy for dental applications
EP1781098B1 (en) 2004-07-30 2015-10-07 Avent, Inc. Antimicrobial devices and compositions
US20060115440A1 (en) 2004-09-07 2006-06-01 Arata Andrew B Silver dihydrogen citrate compositions
US20060051430A1 (en) 2004-09-07 2006-03-09 Arata Andrew B Silver dihydrogen citrate compositions
US9028852B2 (en) 2004-09-07 2015-05-12 3M Innovative Properties Company Cationic antiseptic compositions and methods of use
GB0424833D0 (en) 2004-11-10 2004-12-15 Photocure Asa Method
CA2593482A1 (en) 2005-01-14 2006-07-20 Neurogen Corporation Heteroaryl substituted quinolin-4-ylamine analogues
US20060234959A1 (en) 2005-04-14 2006-10-19 Advanced Photodynamic Technologies, Inc. Photodynamic therapy utilizing multiple duty cycle light modulation
FR2884422B1 (fr) 2005-04-18 2008-04-11 Roquette Freres Composition anti-inflammatoire de l'intestin comprenant des maltodextrines branchees
US9162005B2 (en) 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
US20060254988A1 (en) 2005-05-10 2006-11-16 Confirm Monitoring Systems, Inc. Methods and compositions for the treatment of water
EP2351828B1 (en) * 2005-05-24 2017-10-18 NewSouth Innovations Pty Limited Methods and compositions for regulating biofilm development
GB0513552D0 (en) 2005-07-01 2005-08-10 Bristol Myers Squibb Co Bandage
DK1922044T3 (da) 2005-09-07 2015-05-26 Smith & Nephew Inc Lukket sårforbindingsapparat
AU2006287460A1 (en) 2005-09-07 2007-03-15 Tyco Healthcare Group Lp Wound dressing with vacuum reservoir
GB0525504D0 (en) 2005-12-14 2006-01-25 Bristol Myers Squibb Co Antimicrobial composition
JP2007167266A (ja) * 2005-12-21 2007-07-05 Lion Corp 歯垢検出システムおよび歯垢検出方法
US20070166399A1 (en) 2006-01-13 2007-07-19 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
BRPI0706847A2 (pt) 2006-01-23 2011-04-12 Kci Licensing Inc sistema de tratamento de ferida, sistema de tratamento de ferida para limpar cirurgicamente e curar um sìtio de ferida, sistema de tratamento ultra-sÈnico de ferida para tratar um sìtio de ferida, método para o tratamento de uma ferida, bandagem de ferida de múltiplos propósitos e bandagem de limpeza de ferida de múltiplos propósitos
BRPI0706893B8 (pt) 2006-02-06 2021-06-22 Kci Licensing Inc adaptador de pressão reduzida rotativo para conectar uma fonte de pressão reduzida a uma almofada porosa.
CA2646195C (en) 2006-04-11 2014-07-08 Tyco Healthcare Group Lp Wound dressings with anti-microbial and chelating agents
US7779625B2 (en) 2006-05-11 2010-08-24 Kalypto Medical, Inc. Device and method for wound therapy
GB2439928A (en) 2006-07-13 2008-01-16 Ethicon Inc Hydrogel wound dressings exhibiting reduced fiber losses
JP4826382B2 (ja) 2006-08-08 2011-11-30 アルケア株式会社 抗菌性セルロース繊維及び皮膚接触用繊維製品
US7858106B2 (en) 2006-09-21 2010-12-28 Alcare Co., Ltd. Antimicrobial fiber and its production method, and antimicrobial fiber product comprising the antimicrobial fiber, its production method and regeneration method
CA2776011C (en) 2006-10-13 2017-01-10 Kci Licensing, Inc. Reduced pressure delivery system having a manually-activated pump for providing treatment to low-severity wounds
JP4806330B2 (ja) * 2006-10-30 2011-11-02 シスメックス株式会社 網状赤血球及び血小板測定用試薬、網状赤血球及び血小板測定用試薬キット並びに網状赤血球及び血小板測定方法
US9034352B2 (en) 2006-11-14 2015-05-19 Rohm And Haas Company Microbicide combinations containing silver
US20080226724A1 (en) * 2007-01-19 2008-09-18 Genentech, Inc. Prevention of hydrogel viscosity loss
FR2916356B1 (fr) 2007-05-25 2009-08-28 Urgo Soc Par Actions Simplifie Nouvel agent permettant le relargage d'actifs dans des pansements contenant au moins un corps gras
GB0710846D0 (en) 2007-06-06 2007-07-18 Bristol Myers Squibb Co A wound dressing
WO2009020612A1 (en) 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
GB2452720A (en) 2007-09-11 2009-03-18 Ethicon Inc Wound dressing with an antimicrobial absorbent layer and an apertured cover sheet
JP5511670B2 (ja) 2007-10-11 2014-06-04 スピレイカー・インコーポレイテッド 縫合された切開の陰圧創傷治療装置および使用方法
US8808259B2 (en) 2007-11-21 2014-08-19 T.J. Smith & Nephew Limited Suction device and dressing
EP3360519B1 (en) 2007-11-21 2020-11-18 Smith & Nephew plc Wound dressing
EP2231734B1 (en) 2007-12-12 2013-11-06 3M Innovative Properties Company Methods of making an article and articles
US8152785B2 (en) 2008-03-13 2012-04-10 Tyco Healthcare Group Lp Vacuum port for vacuum wound therapy
US20090234306A1 (en) 2008-03-13 2009-09-17 Tyco Healthcare Group Lp Vacuum wound therapy wound dressing with variable performance zones
KR100868574B1 (ko) * 2008-03-17 2008-11-13 한국광해관리공단 토양 입자 표면에 형성된 바이오필름의 함량 측정 방법
GB0805162D0 (en) 2008-03-19 2008-04-23 Bristol Myers Squibb Co Antibacterial wound dressing
US20110112492A1 (en) 2008-04-04 2011-05-12 Vivek Bharti Wound dressing with micropump
US20100015245A1 (en) 2008-04-24 2010-01-21 Joe Harrison Combination of Copper Cations with Peroxides or Quaternary Ammonium Compounds for the Treatment of Biofilms
GB0808376D0 (en) 2008-05-08 2008-06-18 Bristol Myers Squibb Co Wound dressing
ES2715633T3 (es) 2008-05-20 2019-06-05 Univ Health Network Dispositivo y método para formación de imágenes y supervisión por fluorescencia
US20110130712A1 (en) 2008-05-21 2011-06-02 Moris Topaz Wound healing device
ITAR20080022A1 (it) 2008-05-26 2009-11-27 Daniele Guidi Dispositivo per drenaggio, in particolare per aspirazione in caso di terapie in aspirazione, fistole, deiscenze di ferite chirurgiche, piaghe da decubito, traumi e lesioni similari.
EP2666488B1 (en) 2008-05-30 2015-10-07 KCI Licensing, Inc. Anisotropic drapes
US20200113741A1 (en) 2008-05-30 2020-04-16 Kci Licensing, Inc. Dressing with tissue viewing capability
KR101170266B1 (ko) 2008-05-30 2012-08-01 케이씨아이 라이센싱 인코포레이티드 감압으로 선형적인 상처를 폐쇄하는 볼스터 및 시스템
US8460698B2 (en) 2008-08-01 2013-06-11 Milliken & Company Composite article suitable for use as a wound dressing
EP2309961B1 (en) 2008-08-08 2017-12-06 Smith & Nephew, Inc. Wound dressing of continuous fibers
GB2463523B (en) 2008-09-17 2013-05-01 Medtrade Products Ltd Wound care device
GB0904582D0 (en) 2008-09-24 2009-04-29 Lumina Adhesives Switchable adhesives
GB0817796D0 (en) 2008-09-29 2008-11-05 Convatec Inc wound dressing
AU2009299453B2 (en) 2008-10-02 2014-10-02 L.R.R.& D. Ltd. Interface layer wound dressing
RU2011114000A (ru) 2008-11-07 2012-12-20 КейСиАй ЛАЙСЕНЗИНГ, ИНК. Повязки и системы терапии раны пониженным давлением
JP5778035B2 (ja) 2008-11-14 2015-09-16 ケーシーアイ ライセンシング インコーポレイテッド 組織部位からの流体を溜めるための流体嚢、システム、及び方法
JP5620917B2 (ja) 2008-11-18 2014-11-05 ケーシーアイライセンシング インコーポレイテッド 減圧用複合型マニホルド
EP2821095B1 (en) 2008-11-25 2017-08-09 KCI Licensing, Inc. Device for delivery of reduced pressure to body surfaces
US9221963B2 (en) 2008-11-27 2015-12-29 Speciality Fibres And Materials Ltd. Absorbent material
JP5513776B2 (ja) 2008-12-01 2014-06-04 花王株式会社 バイオフィルム除去剤組成物
GB0823265D0 (en) * 2008-12-20 2009-01-28 Convatec Technologies Inc Antimicrobial Composition
WO2010080907A1 (en) 2009-01-07 2010-07-15 Spiracur Inc. Reduced pressure therapy of the sacral region
US8162907B2 (en) 2009-01-20 2012-04-24 Tyco Healthcare Group Lp Method and apparatus for bridging from a dressing in negative pressure wound therapy
GB0902368D0 (en) 2009-02-13 2009-04-01 Smith & Nephew Wound packing
US20190298578A1 (en) 2009-03-26 2019-10-03 Stephen Shulman Vented emergency wound dressings with anti-thrombogenic layers
US10792404B2 (en) 2009-04-10 2020-10-06 Kci Licensing, Inc. Methods and devices for applying closed incision negative pressure wound therapy
GB2470040A (en) 2009-05-06 2010-11-10 Systagenix Wound Man Ip Co Bv Wound dressing material comprising N-acetyl cysteine
US20100310845A1 (en) 2009-06-03 2010-12-09 Eric Bryan Bond Fluid permeable structured fibrous web
AU2010262058B2 (en) 2009-06-16 2013-08-29 Baxter Healthcare S.A. Hemostatic sponge
CN104095709B (zh) 2009-06-16 2017-06-13 3M创新有限公司 具有自支承基底的适形医用敷料
US20100324516A1 (en) 2009-06-18 2010-12-23 Tyco Healthcare Group Lp Apparatus for Vacuum Bridging and/or Exudate Collection
US8469936B2 (en) 2009-07-15 2013-06-25 Kci Licensing, Inc. Reduced-pressure dressings, systems, and methods employing desolidifying barrier layers
US20110066123A1 (en) 2009-09-15 2011-03-17 Aidan Marcus Tout Medical dressings, systems, and methods employing sealants
GB2474694B (en) 2009-10-23 2011-11-02 Innovia Films Ltd Biodegradable composites
CN102686249B (zh) 2009-11-09 2014-06-25 3M创新有限公司 医疗制品以及使用不能混溶的材料进行制备的方法
WO2011057175A1 (en) 2009-11-09 2011-05-12 3M Innovative Properties Company Medical articles and methods of making using miscible composition
GB0919659D0 (en) 2009-11-10 2009-12-23 Convatec Technologies Inc A component for a wound dressing
CN102770165B (zh) 2009-12-22 2016-07-06 史密夫和内修有限公司 用于负压伤口治疗的设备
EP2525955B1 (en) 2010-01-20 2019-06-12 KCI Licensing, Inc. Foam wound inserts with regions of higher and lower densities, wound dressings, and methods
US8791315B2 (en) 2010-02-26 2014-07-29 Smith & Nephew, Inc. Systems and methods for using negative pressure wound therapy to manage open abdominal wounds
US10709883B2 (en) 2010-03-04 2020-07-14 Donald Spector Bandage with microneedles for antimicrobial delivery and fluid absorption from a wound
US8721606B2 (en) 2010-03-11 2014-05-13 Kci Licensing, Inc. Dressings, systems, and methods for treating a tissue site
US8469935B2 (en) 2010-03-11 2013-06-25 Kci Licensing, Inc. Abdominal treatment systems, delivery devices, and methods
US8430867B2 (en) 2010-03-12 2013-04-30 Kci Licensing, Inc. Reduced-pressure dressing connection pads, systems, and methods
US8814842B2 (en) 2010-03-16 2014-08-26 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US9358158B2 (en) 2010-03-16 2016-06-07 Kci Licensing, Inc. Patterned neo-epithelialization dressings, systems, and methods
US20110237994A1 (en) 2010-03-25 2011-09-29 Combat Medical Systems, Llc Void-filling wound dressing
WO2011121394A1 (en) 2010-03-31 2011-10-06 Pharmaplast Sae A wound care dressing, a method and a production line for manufacturing the wound care dressing
US8632512B2 (en) 2010-04-09 2014-01-21 Kci Licensing, Inc. Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
WO2011130246A2 (en) 2010-04-13 2011-10-20 Kci Licensing, Inc. Compositions with reactive ingredients, and wound dressings, apparatuses, and methods
US20190381222A9 (en) 2010-04-16 2019-12-19 Kci Licensing, Inc. Reduced-Pressure Sources, Systems, And Methods Employing A Polymeric, Porous, Hydrophobic Material
US8604265B2 (en) 2010-04-16 2013-12-10 Kci Licensing, Inc. Dressings and methods for treating a tissue site on a patient
GB201006986D0 (en) 2010-04-27 2010-06-09 Smith & Nephew Wound dressing
GB201008347D0 (en) 2010-05-19 2010-07-07 Smith & Nephew Wound protection
USRE48117E1 (en) 2010-05-07 2020-07-28 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US10639404B2 (en) 2010-06-03 2020-05-05 Wound Healing Technologies, Llc Wound dressing
EP2582404B1 (en) 2010-06-17 2020-08-19 Covalon Technologies Inc. Antimicrobial silicone-based wound dressings
US8795257B2 (en) 2010-07-19 2014-08-05 Kci Licensing, Inc. Systems and methods for electrically detecting the presence of exudate in dressings
US8795246B2 (en) 2010-08-10 2014-08-05 Spiracur Inc. Alarm system
GB201015656D0 (en) 2010-09-20 2010-10-27 Smith & Nephew Pressure control apparatus
EP2635696B1 (en) 2010-11-01 2017-11-29 Becton Dickinson and Company Gardnerella vaginalis assay
WO2012069794A1 (en) 2010-11-25 2012-05-31 Smith & Nephew Plc Composition i-ii and products and uses thereof
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
US8613733B2 (en) 2010-12-15 2013-12-24 Kci Licensing, Inc. Foam dressing with integral porous film
GB2488749A (en) 2011-01-31 2012-09-12 Systagenix Wound Man Ip Co Bv Laminated silicone coated wound dressing
EP3932327A1 (en) 2011-02-04 2022-01-05 University Of Massachusetts Negative pressure wound closure device
US9107990B2 (en) 2011-02-14 2015-08-18 Kci Licensing, Inc. Reduced-pressure dressings, systems, and methods for use with linear wounds
GB201105829D0 (en) 2011-04-06 2011-05-18 Convatec Technologies Inc Antimicrobial compositions
WO2012142002A1 (en) 2011-04-12 2012-10-18 Kci Licensing, Inc. Evaporative fluid pouch and systems for use with body fluids
GB201106491D0 (en) 2011-04-15 2011-06-01 Systagenix Wound Man Ip Co Bv Patterened silicone coating
US9382290B2 (en) 2011-04-29 2016-07-05 Kci Licensing, Inc. Aptamer-modified polymeric materials for the binding of factors in a wound environment
GB201108229D0 (en) 2011-05-17 2011-06-29 Smith & Nephew Tissue healing
US8708981B2 (en) 2011-05-26 2014-04-29 Kci Licensing, Inc. Systems and methods of stimulation and activation of fluids for use with instillation therapy
US9681993B2 (en) 2011-06-07 2017-06-20 Kci Licensing, Inc. Solutions for bridging and pressure concentration reduction at wound sites
EP3159020B1 (en) 2011-06-07 2019-11-06 Smith & Nephew plc Wound contacting members
WO2013016240A1 (en) 2011-07-26 2013-01-31 Kci Licensing, Inc. Systems and methods for treating a tissue site with reduced pressure involving a reduced-pressure interface having a cutting element
EP3622976B1 (en) 2011-07-26 2023-11-01 Smith & Nephew plc Systems and methods for controlling operation of a reduced pressure therapy system
GB201113515D0 (en) 2011-08-04 2011-09-21 Convatec Technologies Inc A dressing
EP2750723B1 (en) 2011-08-30 2020-06-24 Avery Dennison Corporation Silicone absorbent adhesive layer
DE102011081818A1 (de) 2011-08-30 2013-02-28 Beiersdorf Ag Wirkstoffhaltige Hautauflagen
CA2844924C (en) 2011-08-31 2019-12-03 Kci Licensing, Inc. Inline storage pouches for use with body fluids
DE202011108806U1 (de) 2011-09-02 2012-09-03 BLüCHER GMBH Wundauflage mit luftdurchlässiger Lage
PL2567682T5 (pl) 2011-09-09 2018-06-29 Paul Hartmann Ag Opatrunek na rany jamy brzusznej z narzędziem do aplikacji
CN104023741B (zh) 2011-09-12 2017-11-17 普罗蒂吉生物医药有限责任公司 用于伤口处理的组合物和敷料
DK2572737T3 (en) 2011-09-26 2016-06-27 Bsn Medical Gmbh improved wound dressing
WO2013064831A1 (en) 2011-11-01 2013-05-10 Brightwake Limited Wound dressings, and yarn useful therein
US9393354B2 (en) 2011-11-01 2016-07-19 J&M Shuler Medical, Inc. Mechanical wound therapy for sub-atmospheric wound care system
CN103889378B (zh) 2011-11-15 2016-08-17 凯希特许有限公司 具有热增强的蒸汽传输的医用敷件、系统、以及方法
US9132040B2 (en) 2011-11-17 2015-09-15 Ethicon, Inc. Dressing device
CA2855972C (en) 2011-11-18 2019-08-27 Kci Licensing, Inc. Tissue treatment systems and methods having a porous substrate with a compressed region and an expanded region
CN103917254B (zh) 2011-11-21 2016-08-24 凯希特许有限公司 用于识别伤口填充物遗留在组织部位处的部分的系统、装置以及方法
US10940047B2 (en) 2011-12-16 2021-03-09 Kci Licensing, Inc. Sealing systems and methods employing a hybrid switchable drape
AU2013208271B2 (en) 2012-01-10 2017-04-13 Kci Licensing, Inc. Systems and methods for delivering fluid to a wound therapy dressing
EP2806908B1 (en) 2012-01-25 2020-03-18 The University of Akron Fluorinated polymerizable hydrogels for wound dressings and methods of making same
GB201201751D0 (en) 2012-02-01 2012-03-14 Haemostatix Ltd Haemostatic wound dressing
AU2013215067A1 (en) 2012-02-02 2014-06-12 Kci Licensing, Inc. Foam structure wound inserts for directional granulation
CA3019704C (en) 2012-02-21 2020-06-16 Kci Licensing, Inc. A multi-orientation canister for use with a reduced pressure treatment system
US10470936B2 (en) 2012-02-29 2019-11-12 Hollister Incorporated Buffered adhesive compositions for skin-adhering medical products
AU2013226154B2 (en) 2012-02-29 2015-07-09 Hollister Incorporated Buffered adhesive compositions for skin-adhering products and methods of making same
EP2636417B1 (de) 2012-03-05 2017-04-26 Lohmann & Rauscher GmbH Wundversorgungsanordnung und Abdeckeinrichtung dafür
AU2013234034B2 (en) 2012-03-12 2017-03-30 Smith & Nephew Plc Reduced pressure apparatus and methods
US10576037B2 (en) 2012-03-14 2020-03-03 MAM Holdings of West Florida, L.L.C. Compositions comprising placental collagen for use in wound healing
US9427505B2 (en) 2012-05-15 2016-08-30 Smith & Nephew Plc Negative pressure wound therapy apparatus
EP2852419B1 (en) 2012-05-22 2019-11-20 Smith & Nephew plc Wound closure device
HUE047600T2 (hu) 2012-05-23 2020-04-28 Smith & Nephew Berendezések negatív nyomású sebgyógyításhoz
GB201209745D0 (en) 2012-05-31 2012-07-18 Convatec Technologies Inc Wound dressing
JP6230166B2 (ja) 2012-06-03 2017-11-15 ダニエル・エデュアード・クレイナー 管腔内陰圧治療デバイス
CA2868854A1 (en) 2012-06-28 2014-01-03 Kci Licensing, Inc. Wound connection pad with rfid and integrated strain gauge pressure sensor
MX357725B (es) 2012-07-16 2018-07-19 Univ Massachusetts Dispositivo de cierre de herida de presión negativa.
US10434210B2 (en) 2012-07-19 2019-10-08 Innovotech, Inc. Antimicrobial silver iodate
WO2014022400A1 (en) 2012-07-30 2014-02-06 Kci Licensing, Inc. Reduced-pressure absorbent dressing, system for treating a tissue site, and method of manufacturing the dressing
WO2014020440A1 (en) 2012-08-01 2014-02-06 Smith & Nephew Plc Wound dressing
WO2014028212A2 (en) 2012-08-13 2014-02-20 Kci Licensing, Inc. Intelligent therapy system with evaporation management
AU2013309002B2 (en) 2012-08-28 2016-05-26 3M Innovative Properties Company Chlorhexidine gluconate compositions, resin systems and articles
EP2890412B1 (en) 2012-08-31 2020-10-07 Stryker European Holdings I, LLC Hemostatic foam
US20150202354A1 (en) 2012-09-04 2015-07-23 Integrated Healing Technolgies, LLC Wound Dressing
EP3260144B1 (en) 2012-09-12 2020-01-29 KCI Licensing, Inc. Systems for collecting exudates in reduced-pressure therapy
EP3693035B1 (de) 2012-09-20 2024-02-07 Lohmann & Rauscher GmbH Unterdruckbehandlungsanordnung
GB201216928D0 (en) 2012-09-21 2012-11-07 I2R Medical Ltd Portable medical device system
US9877875B2 (en) 2012-10-09 2018-01-30 Parasol Medical LLC Antimicrobial hydrogel formulation
US9572968B2 (en) 2012-10-11 2017-02-21 Hanuman Pelican, Inc. Compressive oxygen diffusive wound dressings
JP6183831B2 (ja) 2012-10-23 2017-08-23 義之 小山 ハイドロゲル形成材
EP2912087A1 (en) 2012-10-24 2015-09-02 KCI Licensing, Inc. Amine-functionalized polymeric compositions for medical devices
EP3611205A1 (en) 2012-10-24 2020-02-19 KCI Licensing, Inc. Sulfhydryl-functionalized polymeric compositions for medical devices
CA2895896A1 (en) 2012-12-20 2014-06-26 Convatec Technologies Inc. Processing of chemically modified cellulosic fibres
CN104884009A (zh) 2012-12-21 2015-09-02 3M创新有限公司 包括翼片的医用敷料
JP6474731B2 (ja) 2013-01-03 2019-02-27 ケーシーアイ ライセンシング インコーポレイテッド 吸湿性シール
GB201309369D0 (en) 2013-05-24 2013-07-10 Smith & Nephew Moisture indicating system
EP3607977A1 (en) 2013-01-16 2020-02-12 KCI Licensing, Inc. Ion exchange enhanced absorbent systems
US20140256925A1 (en) 2013-03-05 2014-09-11 The Penn State Research Foundation Composite materials
WO2014163733A2 (en) 2013-03-13 2014-10-09 Kci Licensing, Inc. Expandable fluid collection canister
WO2014158529A1 (en) 2013-03-14 2014-10-02 Kci Licensing, Inc. A fluid collection canister with integrated moisture trap
EP2968704B1 (en) 2013-03-14 2020-07-15 KCI Licensing, Inc. Negative pressure therapy with dynamic profile capability
EP2968703B1 (en) 2013-03-14 2019-04-10 KCI Licensing, Inc. Micro-porous conduit
EP3804742A1 (en) 2013-03-15 2021-04-14 3M Innovative Properties Company Wound healing compositions
US11452698B2 (en) 2013-03-15 2022-09-27 Smith & Nephew, Inc. Dissolvable gel-forming film for delivery of active agents
US10492956B2 (en) 2013-03-15 2019-12-03 Kci Licensing, Inc. Topical vacuum-press surgical incisional dressings, surgical adjuncts, hybrids and composites
CA2907220A1 (en) 2013-03-15 2014-10-16 Euromed Inc. Adhesive composition comprising silica
CA2902392C (en) 2013-03-15 2023-08-01 Smith & Nephew Plc Wound dressing for negative pressure wound therapy
US20160038347A1 (en) 2013-03-15 2016-02-11 Stb, Ltd. Compositions having cylindrical volume, methods, and applicators for sealing injuries
US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
GB2512841B (en) 2013-04-08 2020-07-15 Brightwake Ltd Absorbent wound dressings
HUE048583T2 (hu) 2013-04-08 2020-09-28 Univ Yeditepe Polimer alapú hidrogél
WO2014169250A1 (en) 2013-04-11 2014-10-16 President And Fellows Of Harvard College Prefabricated alginate-drug bandages
US10687983B2 (en) 2013-04-17 2020-06-23 Mölnlycke Health Care Ab Wound pad
US10016380B2 (en) 2013-05-01 2018-07-10 Lanny Leo Johnson Antimicrobials and methods of use thereof
US9884087B1 (en) 2013-05-03 2018-02-06 Chan Soon-Shiong Nanthealth Foundation Compositions and methods of improved wound healing
AU2014266943B2 (en) 2013-05-10 2018-03-01 Smith & Nephew Plc Fluidic connector for irrigation and aspiration of wounds
GB201308770D0 (en) 2013-05-15 2013-06-26 Convatec Technologies Inc Wound Dressing Comprising an Antimicrobial Composition
WO2014190038A2 (en) 2013-05-22 2014-11-27 The Penn State Research Foundation Wound dressings and applications thereof
US10772767B2 (en) 2013-06-28 2020-09-15 3M Innovative Properties Company Fibrin-coated wound dressing
US9993577B2 (en) 2013-07-01 2018-06-12 Trustees Of Boston University Dissolvable hydrogel compositions for wound management and methods of use
US10765774B2 (en) 2013-07-09 2020-09-08 Ethicon, Inc. Hemostatic pad assembly kit and method
KR20160040242A (ko) 2013-08-05 2016-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 완충 요소가 수용된 지지 장치
BR112016002822B1 (pt) 2013-08-12 2022-07-12 Bsn Medical Gmbh Artigo para o tratamento de feridas plano e seu uso
US20160193244A1 (en) 2013-08-13 2016-07-07 Seikagaku Corporation Drug containing cationized chitosan
EP3578209B1 (en) 2013-08-26 2023-12-20 3M Innovative Properties Company Dressing interface with moisture controlling feature and sealing function
GB2518199A (en) 2013-09-13 2015-03-18 Xiros Ltd Method of producing a swellable polymer fibre
US10342891B2 (en) 2013-09-19 2019-07-09 Medline Industries, Inc. Wound dressing containing saccharide and collagen
WO2015051018A2 (en) 2013-10-02 2015-04-09 Kci Licensing, Inc. Disposable reduced-pressure therapy system with mechanical feedback
CA2926370C (en) 2013-10-10 2018-06-26 F. Hoffmann-La Roche Ag Carrier system for an object worn on the body and method of production
SG11201603058UA (en) 2013-10-18 2016-05-30 Agency Science Tech & Res Nanoparticle-containing hydrogels
CN106170275B (zh) 2013-10-21 2021-05-07 史密夫和内修有限公司 负压伤口闭合装置
GB201318842D0 (en) 2013-10-24 2013-12-11 First Water Ltd Flexible hydrogel wound dressings
WO2015065742A1 (en) 2013-10-28 2015-05-07 Kci Licensing, Inc. Hybrid sealing tape
EP3656362A1 (en) 2013-10-30 2020-05-27 KCI Licensing, Inc. Condensate absorbing and dissipating system related application
MX351120B (es) 2013-11-07 2017-10-03 Bsn Medical Gmbh Apósito médico.
GB2522178B (en) 2013-11-12 2018-07-18 First Water Ltd Multilayer composition
WO2015075406A1 (en) 2013-11-19 2015-05-28 Lipopeptide Ab New treatment of chronic ulcers
SG10201811454WA (en) 2013-12-12 2019-01-30 Innovation Technologies Inc Materials and methods for controlling infections
CN105873549B (zh) 2013-12-31 2017-10-27 3M创新有限公司 适形的消毒盖布覆盖敷料
WO2015112810A1 (en) 2014-01-24 2015-07-30 Avent, Inc. Traumatic wound dressing system with conformal cover
EP3939554A1 (en) 2014-02-11 2022-01-19 3M Innovative Properties Company Devices for applying closed incision negative pressure wound therapy
DE102014202578A1 (de) 2014-02-12 2015-08-13 Aesculap Ag Medizinisches Produkt und Verfahren zu seiner Herstellung
AU2015218302B2 (en) 2014-02-14 2019-11-07 Atomic Medical Innovations, Inc. Systems and methods for tissue healing
US10610623B2 (en) 2014-02-14 2020-04-07 Kci Licensing, Inc. Systems and methods for increasing absorbent capacity of a dressing
WO2015130471A1 (en) 2014-02-28 2015-09-03 Kci Licensing, Inc. Hybrid drape having a gel-coated perforated mesh
GB201404021D0 (en) 2014-03-05 2014-04-23 Lumina Adhesives Ab Low cytotoxity switchable adhesive compositions, medical dressings and skin coverings, and methods of treatment using same
US20150367019A1 (en) 2014-03-12 2015-12-24 Stb, Ltd. Hemostatic compositions and methods
CA2939277C (en) 2014-03-21 2022-07-26 Bridget DONAVAN Wound management system and methods of using
IN2014DE00838A (es) 2014-03-24 2015-10-02 Datt Mediproducts Ltd
GB2524510B (en) 2014-03-25 2020-02-19 Brightwake Ltd Wound dressing impregnated with honey
AU2014393037B2 (en) 2014-04-30 2019-02-28 Matoke Holdings Limited Antimicrobial compositions
US10406266B2 (en) 2014-05-02 2019-09-10 Kci Licensing, Inc. Fluid storage devices, systems, and methods
WO2015172111A1 (en) 2014-05-09 2015-11-12 Kci Licensing, Inc. Disruptive dressing for use with negative pressure and fluid instillation
CN111134959B (zh) 2014-05-09 2022-08-16 3M创新知识产权公司 具有用于线性组织部位的收缩层的敷件
US10398610B2 (en) 2014-05-13 2019-09-03 The Procter & Gamble Company Absorbent article with dual core
GB2526267B (en) 2014-05-14 2020-10-28 Brightwake Ltd Dressing for surgical drain
CN106535842B (zh) 2014-06-05 2020-07-17 凯希特许有限公司 具有流体获取和分配特征的敷料
KR101743274B1 (ko) 2014-06-12 2017-06-02 주식회사 엘지화학 고흡수성 수지
JP6586431B2 (ja) 2014-06-18 2019-10-02 スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ 創傷包帯および治療方法
ES2790800T3 (es) 2014-06-18 2020-10-29 Toray Industries Laminado y procedimiento de fabricación del mismo
WO2016006457A1 (ja) 2014-07-07 2016-01-14 株式会社村田製作所 陰圧閉鎖治療装置
WO2016007692A1 (en) 2014-07-09 2016-01-14 Lubrizol Advanced Materials, Inc. Hydrogel compositions
CA2954467A1 (en) 2014-07-10 2016-01-28 Smith & Nephew Plc Improvements in and relating to devices
CN107075165A (zh) 2014-07-24 2017-08-18 亚瑟罗凯尔公司 弹性多糖泡沫及其用途
US20200289723A1 (en) 2014-07-31 2020-09-17 Smith & Nephew, Inc. Reduced pressure therapy apparatus construction and control
EP3659638A1 (en) 2014-07-31 2020-06-03 Smith & Nephew, Inc. Systems and methods for applying reduced pressure therapy
US20170209615A1 (en) 2014-08-04 2017-07-27 Hospital Sant Joan De Deu System for the immediate release of active agents
US9770369B2 (en) 2014-08-08 2017-09-26 Neogenix, Llc Wound care devices, apparatus, and treatment methods
US10583042B2 (en) 2014-08-08 2020-03-10 Neogenix, Llc Wound care devices, apparatus, and treatment methods
CA2955060A1 (en) 2014-08-11 2016-02-18 Kci Licensing, Inc. Protease modulating wound interface layer for use with negative pressure wound therapy
WO2016040489A1 (en) 2014-09-09 2016-03-17 Shaoyi Jiang Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methds for their use
EP2995287A1 (en) 2014-09-11 2016-03-16 Mölnlycke Health Care AB Medical dressing
EP2995324A1 (en) 2014-09-11 2016-03-16 Mölnlycke Health Care AB Medical dressing
JP6793117B2 (ja) 2014-10-01 2020-12-02 スリーエム イノベイティブ プロパティズ カンパニー デブリードマンのための多孔質デバイス、キット、及び方法
EP3446665B1 (en) 2014-10-06 2021-12-15 3M Innovative Properties Company Ion exchange absorbent systems, apparatuses
EP3204057B1 (en) 2014-10-06 2019-12-04 GATT Technologies B.V. Tissue-adhesive porous haemostatic product
US9855364B2 (en) 2014-10-15 2018-01-02 Allison Coomber Wound dressing materials incorporating anthocyanins derived from fruit or vegetable sources
EP3011978B1 (de) 2014-10-24 2017-05-10 Sefar AG Wundauflagematerial und Verfahren zu seiner Herstellung
US10485893B2 (en) 2014-11-13 2019-11-26 Sarasota Medical Products, Inc. Antimicrobial hydrocolloid dressing containing sequestered peroxide and preparation thereof
EP3023083A1 (en) 2014-11-20 2016-05-25 Mölnlycke Health Care AB Wound dressings
WO2016086088A2 (en) 2014-11-25 2016-06-02 Northwestern University Wound healing through sirt1 overexpression
JP2017536402A (ja) 2014-12-04 2017-12-07 スリーエム イノベイティブ プロパティズ カンパニー バイオガラスを含む抗菌性組成物
CN107206119B (zh) 2014-12-09 2021-01-29 实体科学公司 具有生物相容性层的医疗设备涂层
TW201622668A (zh) 2014-12-16 2016-07-01 準訊生醫股份有限公司 長效型貼片敷料結構
WO2016100098A1 (en) 2014-12-17 2016-06-23 Kci Licensing, Inc. Dressing with offloading capability
CN107107598B (zh) 2014-12-18 2019-11-22 3M创新有限公司 处理粘合层合物贴剂的方法
EP3234052B1 (en) 2014-12-19 2020-09-16 3M Innovative Properties Company Adhesive article comprising a poly(meth)acrylate-based primer layer and methods of making same
AU2015370586B2 (en) 2014-12-22 2020-07-16 Smith & Nephew Plc Negative pressure wound therapy apparatus and methods
US10828403B2 (en) 2014-12-29 2020-11-10 Smith & Nephew Plc Negative pressure wound therapy apparatus and methods for operating the apparatus
US10549016B2 (en) 2014-12-30 2020-02-04 Smith & Nephew, Inc. Blockage detection in reduced pressure therapy
WO2016109418A1 (en) 2014-12-30 2016-07-07 3M Innovative Properties Company Wound dressing with multiple adhesive layers
US10660851B2 (en) 2015-01-02 2020-05-26 Rxos Medical Polyfunctional radical scavenger hydrogel formulation
KR101949455B1 (ko) 2015-01-07 2019-02-18 주식회사 엘지화학 내고화성이 향상된 고흡수성 수지 및 그 제조 방법
GB201500430D0 (en) 2015-01-12 2015-02-25 Univ Birmingham Dressing
US10806819B2 (en) 2015-01-15 2020-10-20 Marshall University Research Corporation Wound coverings comprising vitamin d and related methods
GB201501334D0 (en) 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
GB201501330D0 (en) 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
GB201501333D0 (en) 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
US10500235B2 (en) 2015-01-29 2019-12-10 San Melix Laboratories, Inc. Wound healing compositions comprising buckwheat honey and methylglyoxal and methods of use
US20200093756A1 (en) 2015-01-29 2020-03-26 Sanmelix Laboratories, Inc. Buckwheat honey and povidone-iodine wound-healing dressing
KR101841469B1 (ko) 2015-01-30 2018-03-23 (주)메디팁 바이오폴리머를 이용한 창상 피복재의 제조방법 및 이를 이용하여 제조된 바이오폴리머를 이용한 창상 피복재
WO2016126444A1 (en) 2015-02-02 2016-08-11 Kci Licensing, Inc. Customizable closed tissue site dressing for improved postoperative removal
US11207458B2 (en) 2015-02-02 2021-12-28 Kci Licensing, Inc. Pressure-operated switch
US10512707B2 (en) 2015-02-02 2019-12-24 University Of Southern California System for sutureless closure of scleral perforations and other ocular tissue discontinuities
CA2975197A1 (en) 2015-02-03 2016-08-11 Matoke Holdings Limited Antimicrobial fibers and compositions
GB201501965D0 (en) 2015-02-05 2015-03-25 Lumina Adhesives Ab Polyurethane based switchable adhesives
US10485892B2 (en) 2015-03-10 2019-11-26 Covalon Technologies Inc. Method for local reduction of microbial skin flora
EP3265137B1 (en) 2015-03-10 2020-06-17 Covalon Technologies Inc. Method for local reduction of microbial skin flora
WO2016145237A1 (en) 2015-03-11 2016-09-15 Yu Fu-Shin X Composition and methods to promote wound healing
GB201506236D0 (en) 2015-04-13 2015-05-27 Jellagen Pty Ltd Modified collagen, methods of manufacture thereof
EP3085344B1 (en) 2015-04-21 2019-12-04 Mölnlycke Health Care AB A wound pad and a self-adhesive member comprising a wound pad
CN107847633B (zh) 2015-04-23 2021-06-29 佛罗里达大学研究基金会公司 用于增强愈合的双层设备
ES2769811T3 (es) 2015-04-27 2020-06-29 Smith & Nephew Aparatos de presión reducida
WO2016179575A1 (en) 2015-05-07 2016-11-10 Kci Liensing, Inc. A controlled release iodine structure for use with wound care
US10507259B2 (en) 2015-05-08 2019-12-17 First Quality Retail Services, Llc Flexible absorbent pad
US20190298580A1 (en) 2015-05-08 2019-10-03 Kci Licensing, Inc. Low-acuity dressing with integral pump
US11246975B2 (en) 2015-05-08 2022-02-15 Kci Licensing, Inc. Low acuity dressing with integral pump
EP3294158B1 (en) 2015-05-08 2020-05-06 KCI Licensing, Inc. Wound debridement by irrigation with ultrasonically activated microbubbles
EP3093031A1 (de) 2015-05-11 2016-11-16 3M Innovative Properties Company Wundversorgungssystem
EP3092987A1 (de) 2015-05-11 2016-11-16 3M Innovative Properties Company System zur wundbehandlung mit serum
WO2016184918A1 (en) 2015-05-18 2016-11-24 Smith & Nephew Plc Heat-assisted pumping systems for use in negative pressure wound therapy
US10076594B2 (en) 2015-05-18 2018-09-18 Smith & Nephew Plc Fluidic connector for negative pressure wound therapy
WO2016187666A1 (en) 2015-05-26 2016-12-01 Monash University Antibacterial bismuth complexes
KR101889677B1 (ko) 2015-06-12 2018-08-17 제이에프이미네라르 가부시키가이샤 피부 창상 또는 피부 거침 치료제
US11559421B2 (en) 2015-06-25 2023-01-24 Hill-Rom Services, Inc. Protective dressing with reusable phase-change material cooling insert
EP3313469B1 (en) 2015-06-29 2019-01-02 KCI Licensing, Inc. Apparatus for negative-pressure therapy and irrigation
WO2017011204A1 (en) 2015-07-14 2017-01-19 Kci Licensing, Inc. Medical dressing interface devices, systems, and methods
EP3117806B1 (de) 2015-07-16 2020-06-10 Lohmann & Rauscher GmbH Wundversorgungsanordnung
EP3708193B1 (en) 2015-07-24 2023-02-22 Mölnlycke Health Care AB Absorbent antimicrobial wound dressings
US10583228B2 (en) 2015-07-28 2020-03-10 J&M Shuler Medical, Inc. Sub-atmospheric wound therapy systems and methods
US10682257B2 (en) 2015-07-29 2020-06-16 Evophancie Biotech Ltd Biological fiber composite dressing
WO2017023623A1 (en) 2015-07-31 2017-02-09 Wu, Karl Composition for use in promoting wound healing
EP3334449B1 (en) 2015-08-10 2021-09-29 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Methods and pharmaceutical compositions for improving wound healing using cd24
KR101787192B1 (ko) 2015-08-12 2017-10-18 주식회사 제네웰 항균 드레싱재 및 그 제조방법
EP3135304A1 (en) 2015-08-26 2017-03-01 Mölnlycke Health Care AB Foamed silicone in wound care
JP6875378B2 (ja) 2015-08-31 2021-05-26 スリーエム イノベイティブ プロパティズ カンパニー 湿潤表面に対する接着力が高められた（メタ）アクリレート感圧接着剤を含む陰圧閉鎖創傷療法被覆材
US10617608B2 (en) 2015-09-25 2020-04-14 Lotte Fine Chemical Co., Ltd. Composition for hydrogel sheet, hydrogel sheet manufactured therefrom, and method for manufacturing same
CN108137841B (zh) 2015-09-30 2021-07-06 3M创新有限公司 粘结到聚合物基材的水凝胶组合物
GB2543307B (en) 2015-10-14 2020-12-09 Selentus Science Ltd Haemostatic device
AU2016344202B2 (en) 2015-10-30 2020-10-29 Advanced Dressings, LLC Tissue treatment device and method
EP3373984B1 (en) 2015-11-13 2020-12-23 3M Innovative Properties Company Anti-microbial articles and methods of using same
GB2544342B (en) 2015-11-13 2020-06-03 First Water Ltd Compositions for application to wounds
WO2017087173A1 (en) 2015-11-18 2017-05-26 Kci Licensing, Inc. Medical drapes and methods for reducing trauma on removal
WO2017087163A1 (en) 2015-11-20 2017-05-26 Kci Licensing, Inc. Medical system with flexible fluid storage bridge
GB201520990D0 (en) 2015-11-27 2016-01-13 Edixomed Ltd Dressing system
FR3044893B1 (fr) 2015-12-09 2018-05-18 Emile Droche Pansement pour soins de la peau en milieu humide
US10575991B2 (en) 2015-12-15 2020-03-03 University Of Massachusetts Negative pressure wound closure devices and methods
EP3397219B1 (en) 2015-12-30 2020-10-21 Smith & Nephew plc Absorbent negative pressure wound therapy dressing
EP3187204B1 (en) 2015-12-30 2020-07-15 Paul Hartmann AG Methods and devices for controlling negative pressure wound therapy
CA3009878A1 (en) 2015-12-30 2017-07-06 Smith & Nephew Plc Negative pressure wound therapy apparatus
WO2017119996A1 (en) 2016-01-06 2017-07-13 Kci Liecensing, Inc. System and methods for the treatment of wounds with dressing having closed cells
US10426809B2 (en) 2016-01-12 2019-10-01 Council Of Scientific & Industrial Research Nanobiocomposite formulation for wound healing and a process for the preparation thereof
DE102016000569B3 (de) 2016-01-20 2017-06-22 Lohmann & Rauscher Gmbh Verfahren zum Herstellen eines Folienschlauchs
US10918770B2 (en) 2016-02-12 2021-02-16 Corning Incorporated Vacuum assisted wound closure assembly and methods of irradiating a wound using the same
FR3047901B1 (fr) 2016-02-22 2018-02-23 Universite Pierre Et Marie Curie (Paris 6) Biomateriaux composites a liberation controlee de principe actif
US20190060127A1 (en) 2016-03-01 2019-02-28 Kci Licensing, Inc. Drape For Use With Medical Therapy Systems
KR101958014B1 (ko) 2016-03-14 2019-03-13 주식회사 엘지화학 고흡수성 수지의 제조 방법
FR3048885A1 (fr) 2016-03-17 2017-09-22 Bluestar Silicones France Gel silicone adhesif a la peau
EP3429643A1 (en) 2016-03-18 2019-01-23 KCI USA, Inc. Antimicrobial wound dressing
KR101959547B1 (ko) 2016-03-25 2019-03-18 주식회사 엘지화학 고흡수성 수지의 제조 방법
US20200023102A1 (en) 2016-04-05 2020-01-23 Patrick Kenneth Powell Wound therapy system
GB201608099D0 (en) 2016-05-09 2016-06-22 Convatec Technologies Inc Negative pressure wound dressing
EP3246050A1 (de) 2016-05-17 2017-11-22 BSN medical GmbH Wund- oder hautauflage
EP4194017A1 (en) 2016-05-31 2023-06-14 Octapharma AG Plasma-based films and methods for making and using the same
US20200282100A1 (en) 2016-06-01 2020-09-10 3-D Matrix, Ltd. Hemostatic Dressings with Self-Assembling Peptide Hydrogels
KR20190028467A (ko) 2016-07-08 2019-03-18 컨바텍 테크놀러지스 인크 체액 수집 장치
TWI673056B (zh) 2016-07-22 2019-10-01 大江生醫股份有限公司 包含細菌的水凝膠及其製備方法
US10076552B2 (en) 2016-08-09 2018-09-18 DATT MEDIPRODUCTS LIMITED and DATT LIFE SCIENCE PVT. LTD. Multifunctional formulation comprised of natural ingredients and method of preparation/manufacturing thereof
WO2018031761A1 (en) 2016-08-10 2018-02-15 Argentum Medical, Llc Antimicrobial hydrogel dressings
DE102016114819A1 (de) 2016-08-10 2018-02-15 Paul Hartmann Ag Saugkörper zur endoluminalen Unterdrucktherapie
ES2833899T3 (es) 2016-08-10 2021-06-16 Adv Med Solutions Ltd Apósito para heridas
US20180056087A1 (en) 2016-08-26 2018-03-01 Adolfo Ribeiro Wearable Micro-LED Healing Bandage
US11111362B2 (en) 2016-09-26 2021-09-07 Becton, Dickinson And Company Breathable films with microbial barrier properties
US10590184B2 (en) 2016-09-26 2020-03-17 National Yang-Ming University Process for a preparation of the modified porcine plasma fibronectin for enhance wound healing
IT201600096247A1 (it) 2016-09-26 2018-03-26 Emodial S R L Bendaggio a base di poliuretano e idrogel comprendente clorexidina
US10293080B2 (en) 2016-10-05 2019-05-21 The Arizona Board Of Regents On Behalf Of Northern Arizona University Ionic liquids that sterilize and prevent biofilm formation in skin wound healing devices
EP3522941A4 (en) 2016-10-05 2020-06-17 3M Innovative Properties Company FIBRINOGEN COMPOSITION, METHOD AND ARTICLES FOR WOUNDS
GB2555584B (en) 2016-10-28 2020-05-27 Smith & Nephew Multi-layered wound dressing and method of manufacture
US20190298249A1 (en) 2016-11-02 2019-10-03 Conopco, Inc., D/B/A Unilever Malodour sampling method
CA3042673A1 (en) 2016-11-02 2018-05-11 Smith & Nephew Inc. Wound closure devices
WO2018089563A1 (en) 2016-11-11 2018-05-17 3M Innovative Properties Company Trimmable conformable wound dressing
US11590255B2 (en) 2016-11-11 2023-02-28 Avery Dennison Corporation Rubber-based soft gel skin adhesives
WO2018094061A1 (en) 2016-11-18 2018-05-24 Kci Licensing, Inc. Medical system and dressing for use under compression
US10426874B2 (en) 2016-12-02 2019-10-01 Apex Medical Corp. Wound management assembly and negative pressure wound therapy system
WO2018102322A1 (en) 2016-12-02 2018-06-07 3M Innovative Properties Company Muscle or joint support article with bump
US11446185B2 (en) 2016-12-02 2022-09-20 3M Innovative Properties Company Muscle or joint support article
US10500104B2 (en) 2016-12-06 2019-12-10 Novomer, Inc. Biodegradable sanitary articles with higher biobased content
EP3551195A4 (en) 2016-12-06 2020-07-15 Sami Shamoon College Of Engineering (R.A) TOPICAL ANTIMICROBIAL FORMULATIONS WITH MONOVALENT COPPERIONS AND SYSTEMS FOR PRODUCING MONOVALENT COPPERIONS
WO2018107130A1 (en) 2016-12-09 2018-06-14 Sanvio,Inc. Composition for treating wounds and other dermatological conditions
US11806217B2 (en) 2016-12-12 2023-11-07 Smith & Nephew Plc Wound dressing
DK3335696T3 (da) 2016-12-15 2020-03-16 Upm Kymmene Corp Fremgangsmåde til tørring af cellefrit vævsekstrakt i en hydrogel omfattende nanofibrillær cellulose og en tørret hydrogel omfattende nanofibrillær cellulose og cellefrit vævsekstrakt
EP3335740B1 (en) 2016-12-15 2024-07-24 UPM-Kymmene Corporation Medical hydrogel
DK3335695T3 (da) 2016-12-15 2020-04-20 Upm Kymmene Corp Fremgangsmåde til frysetørring af hydrogel omfattende nanofibrillær cellulose, frysetørret medicinsk hydrogel omfattende nanofibrillær cellulose og hydrogel omfattende nanofibrillær cellulose
EP3338813B1 (en) 2016-12-20 2020-01-29 BSN Medical GmbH Multi-layer wound care product with perforated release layer
CA3048014A1 (en) 2016-12-22 2018-06-28 Applied Tissue Technologies Llc Devices and methods for wound treatment
EP3401354B1 (en) 2016-12-22 2020-04-08 LG Chem, Ltd. Super absorbent polymer manufacturing method and super absorbent polymer
CN110099653A (zh) 2016-12-23 2019-08-06 卡尔冈碳素公司 活性炭复合伤口敷料
DE102016125579A1 (de) 2016-12-23 2018-06-28 Paul Hartmann Ag Wasserhaltige Hydrogelzusammensetzung, umfassend elementare Silberpartikel
US20200114040A1 (en) 2016-12-28 2020-04-16 Kci Usa, Inc. Antimicrobial wound dressings
WO2018124303A1 (ja) 2016-12-29 2018-07-05 アルケア株式会社 発泡体及び発泡体用組成物
CN110267630B (zh) 2017-01-09 2021-12-28 3M创新知识产权公司 用于改善流体移除的伤口敷料层
TWI621453B (zh) 2017-01-13 2018-04-21 廈門聖慈醫療器材有限公司 吸盤
KR102039701B1 (ko) 2017-01-19 2019-11-26 주식회사 리포바이오메드 아토피성 질환을 포함하는 혈장 단백질의 삼출성 피부질환의 완화 및 치료용 패드
EP3570798A1 (de) 2017-01-23 2019-11-27 Medela Holding AG Poröse wundeinlage zur verwendung bei der unterdrucktherapie
US20190365948A1 (en) 2017-01-27 2019-12-05 Aziyo Biologics, Inc. Lyophilized placental composite sheet and uses thereof
CN110248631B (zh) 2017-02-06 2021-12-10 巴斯夫欧洲公司 流体吸收制品
WO2018150267A2 (en) 2017-02-15 2018-08-23 Smith & Nephew Pte. Limited Negative pressure wound therapy apparatuses and methods for using the same
WO2018149835A1 (de) 2017-02-16 2018-08-23 Covestro Deutschland Ag Verfahren zur herstellung eines klebstofffreien wundkontaktverbundmaterials
WO2018156730A1 (en) 2017-02-22 2018-08-30 Cornell University Mechanical vacuum dressing for mechanically managing, protecting and suctioning small incisional wounds
WO2018158250A1 (en) 2017-02-28 2018-09-07 T.J.Smith And Nephew,Limited Multiple dressing negative pressure wound therapy system
WO2018161036A1 (en) 2017-03-03 2018-09-07 Loma Linda University Health Compositions and methods for promoting hemostasis
CA3055664A1 (en) 2017-03-08 2018-09-13 Smith & Nephew Plc Negative pressure wound therapy device control in presence of fault condition
EP3592212B1 (en) 2017-03-09 2024-08-07 Smith & Nephew plc Wound dressing
WO2018163093A1 (en) 2017-03-09 2018-09-13 Secretary, Department Of Biotechnology A wound dressing for combined negative pressure and fluid delivery system
EP3378450A1 (en) 2017-03-22 2018-09-26 Mölnlycke Health Care AB Method for manufacturing a wound dressing and a wound dressing
JP7150744B2 (ja) 2017-03-29 2022-10-11 スリーエム イノベイティブ プロパティズ カンパニー ポリマー基材に結合されたヒドロゲル組成物
US11452809B2 (en) 2017-04-04 2022-09-27 Kcl Licensing, Inc. Apparatuses, systems, and methods for the treatment of a tissue site with negative pressure and oxygen
BR112019020766B1 (pt) 2017-04-04 2022-11-29 Anti-Plasmin Technologies, Llc Composição para aperfeiçoar um tratamento médico não cirúrgico
KR101852718B1 (ko) 2017-04-04 2018-05-18 주식회사 제네웰 외과수술 후 절개부위 통증 감소를 위한 키트
GB201800057D0 (en) 2018-01-03 2018-02-14 Smith & Nephew Inc Component Positioning And stress Relief For Sensor Enabled Wound Dressings
CN108721677B (zh) 2017-04-17 2021-11-19 广西美丽肤医疗器械有限公司 复合性材料
WO2018195101A1 (en) 2017-04-19 2018-10-25 Smith & Nephew, Inc. Negative pressure wound therapy canisters
DE102017003826A1 (de) 2017-04-20 2018-10-25 Lohmann & Rauscher Gmbh Wundversorgungsanordnung für die Unterdrucktherapie
US20200085625A1 (en) 2017-05-04 2020-03-19 Klox Technologies Inc. Absorbent biophotonic devices and systems for wound healing
MY198078A (en) 2017-05-10 2023-07-31 Toray Industries Medical device
JP7069219B2 (ja) 2017-05-10 2022-05-17 メンリッケ・ヘルス・ケア・アーベー 創傷治療における複合フォーム
CN110870021A (zh) 2017-05-15 2020-03-06 史密夫及内修公开有限公司 使用欧拉视频放大的负压伤口治疗系统
US11850126B2 (en) 2017-05-16 2023-12-26 3M Innovative Properties Company Absorbent negative-pressure dressing system for use with post-surgical breast wounds
EP3634506A4 (en) 2017-05-17 2021-03-10 UVIC Industry Partnerships Inc. DRESSING FOR WOUND SURVEILLANCE AND THERAPEUTIC AGENT ADMINISTRATION
WO2018213534A1 (en) 2017-05-19 2018-11-22 Kci Usa, Inc. Dressings for filtering wound fluids
EP3630029A1 (en) 2017-05-22 2020-04-08 KCI USA, Inc. Extensible dressings
WO2018217621A1 (en) 2017-05-22 2018-11-29 Kci Usa, Inc. Elastically deformable wound dressings
US20200197227A1 (en) 2017-05-22 2020-06-25 Kci Usa, Inc. Post-operative surgical wound dressing
EP3409248B1 (en) 2017-06-01 2019-11-06 Absorbest AB Wound dressing
CA3065521A1 (en) 2017-06-07 2018-12-13 Kci Licensing, Inc. Multi-layer wound filler for extended wear time
BR112019025041A2 (pt) 2017-06-07 2020-06-16 Kci Licensing, Inc Penso para uso com tratamento de pressão negativa, kit de penso para uso com tratamento de pressão negativa e método para tratar um sítio de tecido com pressão negativa
WO2018226624A1 (en) 2017-06-07 2018-12-13 Kci Licensing, Inc. Composite dressings for improved granulation and reduced maceration with negative-pressure treatment
CA3065529A1 (en) 2017-06-07 2018-12-13 Kci Licensing, Inc. Composite dressings for improved granulation reduced maceration with negative-pressure treatment
RU2019142320A (ru) 2017-06-07 2021-07-09 Кейсиай ЛАЙСЕНСИНГ, ИНК. Отслаиваемый и размещаемый на месте перевязочный материал для терапии при отрицательном давлении
CA3065379A1 (en) 2017-06-07 2018-12-13 Kci Licensing, Inc. Systems, apparatuses, and methods for negative-pressure treatment with reduced tissue in-growth
EP3634337B1 (en) 2017-06-07 2023-05-24 3M Innovative Properties Company Methods for manufacturing and assembling dual material tissue interface for negative-pressure therapy
WO2018226592A1 (en) 2017-06-07 2018-12-13 Kci Usa, Inc. Wound dressing with odor absorption and increased moisture vapor transmission
WO2018226705A1 (en) 2017-06-07 2018-12-13 Kci Licensing, Inc. Composite dressings for improved granulation and reduced maceration with negative-pressure treatment
US20200085629A1 (en) 2017-06-07 2020-03-19 Kci Licensing, Inc. Composite dressings with even expansion profiles for treatment of wounds using negative-pressure treatment
CN110944607A (zh) 2017-06-07 2020-03-31 凯希特许有限公司 制造和组装用于负压疗法的双材料组织接口的方法
US11471584B2 (en) 2017-06-07 2022-10-18 Kci Licensing, Inc. Composite dressings for improved granulation and reduced maceration with negative-pressure treatment
KR20200016931A (ko) 2017-06-07 2020-02-17 케이씨아이 라이센싱 인코포레이티드 끈적끈적한 삼출물 및 점적주입을 위해 떼었다 붙였다 할 수 있는 드레싱재
EP3634521A1 (en) 2017-06-08 2020-04-15 KCI Licensing, Inc. Negative-pressure therapy with oxygen
EP3412319A1 (en) 2017-06-09 2018-12-12 Mölnlycke Health Care AB Foam in wound treatment
EP3634327B1 (en) 2017-06-09 2023-08-30 3M Innovative Properties Company Granulating dressing for low exuding chronic wounds
WO2018231825A1 (en) 2017-06-12 2018-12-20 Kci Licensing, Inc. Foamed and textured sintered polymer wound filler
JP7179022B2 (ja) 2017-06-13 2022-11-28 スミス アンド ネフュー ピーエルシー 創傷閉鎖装置および使用方法
EP3638167B1 (en) 2017-06-14 2023-11-01 T.J. Smith and Nephew, Limited Negative pressure wound therapy apparatus
WO2018231874A1 (en) 2017-06-14 2018-12-20 Smith & Nephew, Inc. Control of wound closure and fluid removal management in wound therapy
CA3063859A1 (en) 2017-06-14 2018-12-20 Smith & Nephew, Inc. Fluid removal management and control of wound closure in wound therapy
EP3641714A1 (en) 2017-06-19 2020-04-29 KCI USA, Inc. Wound dressing with saturation indicator
JP7189159B2 (ja) 2017-06-23 2022-12-13 スミス アンド ネフュー ピーエルシー センサを有効化した創傷モニタリングまたは治療のためのセンサの配置
US20200214898A1 (en) 2017-06-26 2020-07-09 Kci Usa, Inc. Absorbent wound dressing that incorporates a novel wound fluid indicating system
US10751212B2 (en) 2017-06-26 2020-08-25 Maryam Raza Multilayer dressing device and method for preventing and treating pressure ulcers and chronic wounds
DE102017006025A1 (de) 2017-06-27 2018-12-27 Carl Freudenberg Kg Hydrogel-bildende Mehrkomponentenfaser
US11554051B2 (en) 2017-06-30 2023-01-17 T.J. Smith And Nephew, Limited Negative pressure wound therapy apparatus
US20200121510A1 (en) 2017-07-07 2020-04-23 Smith & Nephew Plc Wound therapy system and dressing for delivering oxygen to a wound
FR3068975B1 (fr) 2017-07-12 2020-07-17 Urgo Recherche Innovation Et Developpement Composition pour pansement interface
FR3068974B1 (fr) 2017-07-12 2019-08-02 Urgo Recherche Innovation Et Developpement Pansement permettant la liberation controlee et prolongee d'actif
GB201711181D0 (en) 2017-07-12 2017-08-23 Smith & Nephew Polymer foam material, device and use
GB201711179D0 (en) 2017-07-12 2017-08-23 Smith & Nephew Wound care materials, devices and uses
GB201711183D0 (en) 2017-07-12 2017-08-23 Smith & Nephew Antimicrobial or wound care materials, devices and uses
CN110621354B (zh) 2017-07-21 2023-03-10 矿物快速护理有限公司 新颖止血用伤口敷料
GB201804502D0 (en) 2018-03-21 2018-05-02 Smith & Nephew Biocompatible encapsulation and component stress relief for sensor enabled negative pressure wound therapy dressings
CN110997019A (zh) 2017-07-26 2020-04-10 优瑞株式会社 包含透明质酸-钙和聚赖氨酸的创伤覆料及其制造方法
GB201712165D0 (en) 2017-07-28 2017-09-13 Smith & Nephew Wound dressing and method of manufacture
US10780201B2 (en) 2017-07-29 2020-09-22 Edward D. Lin Control apparatus and related methods for wound therapy delivery
US10729826B2 (en) 2017-07-29 2020-08-04 Edward D. Lin Wound cover apparatus and related methods of use
WO2019027933A1 (en) 2017-07-31 2019-02-07 Kci Usa, Inc. BIOREABORBABLE DRESSING WITH STRUCTURAL SUPPORT
JP2020529246A (ja) 2017-08-02 2020-10-08 ケーシーアイ ライセンシング インコーポレイテッド 創傷創面切除のためのシステム及び方法
WO2019027731A1 (en) 2017-08-02 2019-02-07 Kci Licensing, Inc. MULTILAYER COMPARTMENT DRESSING AND NEGATIVE PRESSURE PROCESSING METHOD
EP3664756B1 (en) 2017-08-07 2024-01-24 Smith & Nephew plc Wound closure device with protective layer
DE102017117828A1 (de) 2017-08-07 2019-02-07 Ivf Hartmann Ag Binde, insbesondere Kompressionsbinde
EP3666300B1 (en) 2017-08-09 2023-02-15 Toray Industries, Inc. Medical device and method for manufacturing same
WO2019030384A2 (en) 2017-08-10 2019-02-14 Smith & Nephew Plc SENSOR POSITIONING FOR MONITORING OR TREATING SENSOR ACTIVATED WOUNDS
US20200197580A1 (en) 2017-08-22 2020-06-25 Kci Licensing, Inc. In-line wound fluid sampling systems and methods for use with negative pressure wound therapy
GB201713511D0 (en) 2017-08-23 2017-10-04 Scapa Uk Ltd Wound dressing
WO2019040656A1 (en) 2017-08-23 2019-02-28 Cor Medical Ventures LLC POSTOPERATIVE SURGICAL SITE WOUND TREATMENT AND DEVICE REMOVAL METHOD
US11246756B2 (en) 2017-08-24 2022-02-15 The United States Of America, As Represented By The Secretary Of Agriculture Healthcare textiles
GB2565823A (en) 2017-08-24 2019-02-27 Xiros Ltd Psyllium based moisture absorbent material
EP3672655B1 (en) 2017-08-24 2022-01-19 KCI USA, Inc. Biomaterial and methods of making and using said biomaterial
WO2019050855A1 (en) 2017-09-05 2019-03-14 Kci Licensing, Inc. SYSTEMS AND METHODS FOR MITIGATING LIGHT-DE-ACTIVATED DEACTIVATION OF ADHESIVE OPERATIVE FIELDS DEACTIVATED BY LIGHT
JP2020532378A (ja) 2017-09-05 2020-11-12 ケーシーアイ ライセンシング インコーポレイテッド フィルタリング層を使用して光不活性化接着ドレープの早期の光不活性化を軽減するシステム及び方法
CN111093477B (zh) 2017-09-10 2023-09-12 史密夫及内修公开有限公司 用于检查装配有传感器的伤口敷料中的封装和部件的系统和方法
AU2018331954B2 (en) 2017-09-13 2024-07-04 Smith & Nephew Plc Negative pressure wound treatment apparatuses and methods with integrated electronics
GB201718070D0 (en) 2017-11-01 2017-12-13 Smith & Nephew Negative pressure wound treatment apparatuses and methods with integrated electronics
WO2019055176A1 (en) 2017-09-14 2019-03-21 Kci Licensing, Inc. OXYGEN THERAPY WITH FLUID REMOVAL
EP3681545A4 (en) 2017-09-15 2020-11-11 Bard Access Systems, Inc. ANTIMICROBIAL DRESSING WITH LINER FOR MEDICAL DEVICE
US12004926B2 (en) 2017-09-18 2024-06-11 Kci Licensing, Inc. Wound dressings and systems with remote oxygen generation for topical wound therapy and related methods
US11547611B2 (en) 2017-09-22 2023-01-10 Kci Licensing, Inc. Wound dressings and systems with high-flow therapeutic gas sources for topical wound therapy and related methods
IL254636A0 (en) 2017-09-24 2017-11-30 Reddress Ltd System and method for preparing a wound dressing
IL254644B (en) 2017-09-24 2021-06-30 Reddress Ltd Device for dressing a wound, system and method
GB2566951A (en) 2017-09-27 2019-04-03 Brightwake Ltd Compositions for wound treatment
EP3687467B1 (en) 2017-09-29 2022-02-23 3M Innovative Properties Company Dressing exhibiting low tissue ingrowth and negative-pressure treatment method
US20210393203A1 (en) 2017-10-09 2021-12-23 3M Innovative Properties Company Securement dressing with conformal border
GB201716986D0 (en) 2017-10-16 2017-11-29 Matoke Holdings Ltd Antimicrobial compositions
ES2911647T3 (es) 2017-10-20 2022-05-20 Safeguard Medical Tech Limited Composición
CA3082020A1 (en) 2017-10-23 2019-05-02 Kci Licensing, Inc. Low profile distribution components for wound therapy
WO2019083607A1 (en) 2017-10-23 2019-05-02 Kci Licensing, Inc. HIGH DENSITY EVAPORATIVE BRIDGE DRESSING
AU2018355151B2 (en) 2017-10-23 2024-09-19 Solventum Intellectual Properties Company Area management of tissue sites on articulating joints
WO2019083726A1 (en) 2017-10-23 2019-05-02 Kci Licensing, Inc. WOUND DRESSING FOR USE IN ANTIBACTERIAL TREATMENT
US11432967B2 (en) 2017-10-23 2022-09-06 Kci Licensing, Inc. Fluid bridge for simultaneous application of negative pressure to multiple tissue sites
CN111447901A (zh) 2017-10-24 2020-07-24 凯希特许有限公司 清创伤口敷料和使用清创伤口敷料的系统
CN111278942A (zh) 2017-10-26 2020-06-12 3M创新有限公司 包含有机硅基粘合剂和纤维素纳米晶体的组合物以及方法和制品
US11969317B2 (en) 2017-10-26 2024-04-30 3M Innovative Properties Company Wound dressing with welded elastic structure
EP3700597B8 (en) 2017-10-26 2023-11-15 3M Innovative Properties Company Manifolding apparatus
CA3078733C (en) 2017-10-27 2023-02-21 Kci Licensing, Inc. Contoured foam dressing shaped for providing negative pressure to incisions in the breast
KR102566942B1 (ko) 2017-10-27 2023-08-14 주식회사 엘지화학 고흡수성 수지의 제조 방법
WO2019089118A1 (en) 2017-10-30 2019-05-09 Kci Licensing, Inc. Systems, apparatuses, and methods for negative-pressure treatment with pressure delivery indication
WO2019089856A1 (en) 2017-10-31 2019-05-09 InMEDBio, LLC Absorbent, breathable and pathogen blocking/killing wound care dressing and fabrication thereof
GB201718014D0 (en) 2017-11-01 2017-12-13 Smith & Nephew Dressing for negative pressure wound therapy with filter
WO2019086332A1 (en) 2017-11-01 2019-05-09 Smith & Nephew Plc Negative pressure wound treatment apparatuses and methods with integrated electronics
GB201718054D0 (en) 2017-11-01 2017-12-13 Smith & Nephew Sterilization of integrated negative pressure wound treatment apparatuses and sterilization methods
IL255404B (en) 2017-11-02 2018-10-31 Technion Res & Dev Foundation A zwitterionic hydrogel in the configuration of an internal multiphase emulsion
WO2019089522A1 (en) 2017-11-02 2019-05-09 Systagenix Wound Management, Limited Wound dressing with humidity colorimeter sensor
US11771599B2 (en) 2017-11-03 2023-10-03 Kci Licensing, Inc. Extended wear-time dressing
EP3703636A1 (en) 2017-11-03 2020-09-09 Systagenix Wound Management, Limited Nutrient-enriched dressing
GB2568101B (en) 2017-11-06 2022-09-07 Brightwake Ltd Antimicrobial dressing
EP3706689A4 (en) 2017-11-08 2021-12-01 University Of Massachusetts POST-OPERATIVE HYBRID DRESSING TO OPTIMIZE SKIN TRANSPLANT PROCEDURES IN RECONSTRUCTIVE SURGERY
US20210177661A1 (en) 2017-11-09 2021-06-17 Kci Licensing, Inc. Multi-module dressing and therapy methods
WO2019094923A1 (en) 2017-11-13 2019-05-16 Kci Licensing, Inc. Light-responsive pressure sensitive adhesives for wound dressings
CN107899061A (zh) 2017-11-13 2018-04-13 广东泰宝医疗科技股份有限公司 一种藻酸盐创面修复敷料及其制备方法
US11559438B2 (en) 2017-11-15 2023-01-24 Smith & Nephew Plc Integrated sensor enabled wound monitoring and/or therapy dressings and systems
US20200289727A1 (en) 2017-12-06 2020-09-17 Kci Licensing, Inc. Wound dressing with negative pressure retaining valve
US11839527B2 (en) 2017-12-06 2023-12-12 Cornell University Manually-operated negative pressure wound therapy (NPWT) bandage with improved pump efficiency, automatic pressure indicator and automatic pressure limiter
AU2018384069B2 (en) 2017-12-11 2022-12-08 Animal Ethics Pty Ltd Wound dressing
EP3498242A1 (en) 2017-12-15 2019-06-19 Mölnlycke Health Care AB Medical dressing
IL256405A (en) 2017-12-19 2018-01-31 Omrix Biopharmaceuticals Ltd Wound bandage and method for its production
WO2019125962A1 (en) 2017-12-20 2019-06-27 Kci Licensing, Inc. Wound dressing for the harvesting of superficial epidermal grafts
US20200337904A1 (en) 2017-12-20 2020-10-29 Systagenix Wound Management, Limited Dressing including dehydrated placental tissue for wound healing
DE102017130893A1 (de) 2017-12-21 2019-06-27 Paul Hartmann Ag pH regulierende Wundauflage
WO2019134169A1 (zh) 2018-01-08 2019-07-11 万绵水 用于护创敷料的连接装置以及护创敷料
US11877912B2 (en) 2018-01-09 2024-01-23 3M Innovative Properties Company Systems and methods for coupling a wearable therapy system to a dressing
CN112040915B (zh) 2018-03-26 2022-04-01 帝皇工业有限公司 用于负压伤口治疗系统的多内腔桥
US20190298882A1 (en) 2018-03-27 2019-10-03 Kevin M. Nelson Hydrogel bandage
US20210077671A1 (en) 2018-03-29 2021-03-18 Kci Licensing, Inc. Wound therapy system with wound volume estimation
EP3773383A1 (en) 2018-03-30 2021-02-17 3M Innovative Properties Company An absorbent dressing incorporating ph wound condition indication
GB201805584D0 (en) 2018-04-05 2018-05-23 Smith & Nephew Negative pressure wound treatment apparatuses and methods with integrated electronics
GB2572642B (en) 2018-04-06 2021-03-31 Pellis Care Ltd Treatment of diabetic foot ulcers
US11040127B2 (en) 2018-04-09 2021-06-22 Kci Licensing, Inc. Abdominal dressing with mechanism for fascial closure
US20210379273A1 (en) 2018-04-10 2021-12-09 Kci Licensing, Inc. Bridge dressing with fluid management
BR102018007306A2 (pt) 2018-04-11 2019-10-29 Maria Cristina De Paula Mesquita processo para fabricação de fita /placa/ curativo cicatrizante de silicone aderente com formatos específicos
WO2019199596A1 (en) 2018-04-12 2019-10-17 Kci Licensing, Inc. Cutting template for a negative pressure wound therapy drape
WO2019199849A1 (en) 2018-04-13 2019-10-17 Kci Licensing, Inc. Dressing bolster with area pressure indicator
WO2019200035A1 (en) 2018-04-13 2019-10-17 Kci Licensing, Inc. Npwt system with selectively controllable airflow
WO2019199798A1 (en) 2018-04-13 2019-10-17 Kci Licensing, Inc. Compression strain and negative pressure delivery indicator for a wound dressing
JP7346443B2 (ja) 2018-04-13 2023-09-19 ケーシーアイ ライセンシング インコーポレイテッド 陰圧閉鎖された切開部ドレッシングにおける付加及び患者の四肢運動を動的に測定する方法
EP3787705B1 (en) 2018-05-03 2023-07-19 KCI Licensing, Inc. Negative pressure wound therapy system with detection of full absorbant dressing
JP2021522967A (ja) 2018-05-04 2021-09-02 ドライ シー エルエルシー 液体検出物品及びその作製方法
KR20210008351A (ko) 2018-05-08 2021-01-21 피디아 파마슈티치 에스.피.에이. 손상된 피부를 치료하기 위한 상처 드레싱
EP3569261B1 (en) 2018-05-14 2024-04-03 Paul Hartmann AG Functional wound dressing
EP3569210B1 (en) 2018-05-15 2022-04-27 The Procter & Gamble Company Disposable absorbent articles
US10898606B2 (en) 2018-05-15 2021-01-26 Legacy Research and Development Group, LLC Self-fusing low density silicone
US11253400B2 (en) 2018-05-16 2022-02-22 Midwest Training and Development Services, LLC Negative pressure wound apposition dressing system
US20190351095A1 (en) 2018-05-21 2019-11-21 Milliken & Company Wound care device having fluid transfer and adhesive properties
US20190351094A1 (en) 2018-05-21 2019-11-21 Milliken & Company Wound care device having fluid transfer and adhesive properties
FR3082123B1 (fr) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement Pansement cellularise et son procede de fabrication
NL2021186B1 (en) 2018-06-26 2020-01-06 Icap Holding B V Intelligent cap for skin tissue treatment
TWI693929B (zh) 2018-06-27 2020-05-21 南六企業股份有限公司 抗菌創傷敷料
WO2020005536A1 (en) 2018-06-27 2020-01-02 Kci Licensing, Inc. Wound dressing for wound volume estimation
US11701264B2 (en) 2018-06-27 2023-07-18 Kci Licensing, Inc. Wound therapy system with wound volume estimation using geometric approximation
US11896462B2 (en) 2018-06-28 2024-02-13 3M Innovative Properties Company Highly conformable wound dressing
WO2020005577A1 (en) 2018-06-28 2020-01-02 Kci Licensing, Inc. Distributed negative pressure wound therapy system incorporating an absorbent dressing and piezo-electric pump
WO2020003067A2 (en) 2018-06-28 2020-01-02 Systagenix Wound Management, Limited Multilayer absorbent dressing construction
US20200000643A1 (en) 2018-06-28 2020-01-02 Kci Licensing, Inc. Long-Duration, Deep Wound Filler With Means To Prevent Granulation In-Growth
WO2020005344A1 (en) 2018-06-28 2020-01-02 Kci Licensing, Inc. Release liner with edge protection
US20200000640A1 (en) 2018-06-29 2020-01-02 Milliken & Company Multi-Layer Wound Care Device Having Absorption and Fluid Transfer Properties
US20210178012A1 (en) 2018-07-04 2021-06-17 Coloplast A/S Foam wound dressing comprising an antiseptic
EP3820417A1 (en) 2018-07-12 2021-05-19 KCI Licensing, Inc. Abdominal dressing with user selection of fascial closure force profile
GB201811449D0 (en) 2018-07-12 2018-08-29 Smith & Nephew Apparatuses and methods for negative pressure wound therapy
WO2020014310A1 (en) 2018-07-13 2020-01-16 Kci Licensing, Inc. Advanced wound dressing with compression and increased total fluid handling
WO2020018300A1 (en) 2018-07-16 2020-01-23 Kci Licensing, Inc. Fluid instillation apparatus for use with negative-pressure system incorporating wireless therapy monitoring
US11383019B2 (en) 2018-07-18 2022-07-12 Kci Licensing, Inc. Wound view dressing and customization kit
WO2020026061A1 (en) 2018-07-30 2020-02-06 3M Innovative Properties Company Antimicrobial foam articles and method of making the same
US11534343B2 (en) 2018-07-31 2022-12-27 Kci Licensing, Inc. Devices and methods for preventing localized pressure points in distribution components for tissue therapy
US20200038252A1 (en) 2018-07-31 2020-02-06 Joseph Spiro Tri-layered wound dressing and method therefor
JP2021531899A (ja) 2018-08-01 2021-11-25 ケーシーアイ ライセンシング インコーポレイテッド 陰圧を使用する軟組織処置
WO2020026144A1 (en) 2018-08-01 2020-02-06 Systagenix Wound Management, Limited Dressing packaging with controlled hydration of fluid-activated dressing
US20200038251A1 (en) 2018-08-03 2020-02-06 Kci Licensing, Inc. Flexible and conformable wound dressing with enhanced fluid absorption capability
US11253401B2 (en) 2018-08-03 2022-02-22 Kci Licensing, Inc. Wound therapy system with wound volume estimation
US20210161725A1 (en) 2018-08-10 2021-06-03 Kci Licensing, Inc. Wound dressing system for management of fluids in a wound and methods for manufacturing same
US20200046876A1 (en) 2018-08-13 2020-02-13 Chuang Sheng Medicine Equipment Co. Ltd. Hydrogel surgical dressing product having a multi-dimensional flexible hydrophilic structure-linkage composite
WO2020036785A1 (en) 2018-08-13 2020-02-20 Kci Licensing, Inc. Disruptive dressing for use with negative pressure and fluid instillation
WO2020035811A1 (en) 2018-08-17 2020-02-20 3M Innovative Properties Company Wound dressing system
US11938236B2 (en) 2018-08-17 2024-03-26 Seoul Viosys Co., Ltd. Medical dressing
WO2020040917A1 (en) 2018-08-21 2020-02-27 Kci Licensing, Inc. Dressing and system with improved total fluid handling
EP3840794B1 (en) 2018-08-21 2023-10-11 3M Innovative Properties Company System for utilizing pressure decay to determine available fluid capacity in a negative pressure dressing
US11395918B2 (en) 2018-08-24 2022-07-26 United States Government As Represented By The Department Of Veterans Affairs Devices, and systems for remotely monitoring and treating wounds or wound infections
US11278454B2 (en) 2018-08-24 2022-03-22 Kci Licensing, Inc. Methods of managing moisture when using a low profile wound connection conduit
WO2020043665A1 (en) 2018-08-27 2020-03-05 Claudia Eder Antiseptic gel
AU2019331721B2 (en) 2018-08-27 2022-04-21 Advamedica Inc. Composite dressings, manufacturing methods and applications thereof
US11752039B2 (en) 2018-08-28 2023-09-12 Systagenix Wound Management, Limited Dressings for reduced tissue ingrowth
US11007083B2 (en) 2018-08-28 2021-05-18 Aatru Medical, LLC Dressing
WO2020046589A1 (en) 2018-08-30 2020-03-05 Kci Licensing, Inc. Electro-mechanical pump for negative-pressure treatment
WO2020047255A1 (en) 2018-08-31 2020-03-05 Kci Licensing, Inc. Cooling dressing for improved comfort
CN112584802B (zh) 2018-09-04 2023-03-17 凯希特许有限公司 伤口治疗装置和套件
CN113164286B (zh) 2018-09-04 2023-08-22 罗曼-劳氏股份有限公司 伤口清洁装置
US11471335B2 (en) 2018-09-05 2022-10-18 University Of South Carolina Gel-within-gel wound dressing
WO2020051273A1 (en) 2018-09-05 2020-03-12 Kci Licensing, Inc. Systems and methods for scheduling and controlling wound therapy
US20220111138A1 (en) 2018-09-12 2022-04-14 Kci Licensing, Inc. Systems, apparatuses, and methods for negative-pressure treatment with reduced tissue in-growth
CN112912117A (zh) 2018-09-12 2021-06-04 凯希特许有限公司 采用滴注治疗和动态压力控制的伤口治疗系统
WO2020055945A1 (en) 2018-09-12 2020-03-19 Kci Licensing, Inc. Negative pressure wound therapy systems and methods to indicate total fluid handling
CN112912042A (zh) 2018-09-14 2021-06-04 凯希特许有限公司 差异塌缩伤口敷料
EP3852828B1 (en) 2018-09-17 2024-04-10 Solventum Intellectual Properties Company Fluid ingress protection for npwt device
WO2020060918A1 (en) 2018-09-17 2020-03-26 Kci Licensing, Inc. Absorbent negative pressure dressing
US11305050B2 (en) 2018-09-19 2022-04-19 Deroyal Industries, Inc. Connector with valve for negative pressure wound therapy system
EP3852705A1 (en) 2018-09-20 2021-07-28 KCI Licensing, Inc. Super-absorbent, low trauma, advanced wound dressing
US20220047771A1 (en) 2018-09-25 2022-02-17 Systagenix Wound Management, Limited Wound dressing compositions and uses thereof
DE102018007692A1 (de) 2018-09-30 2020-04-02 Alexander Folwarzny Wundauflage
US11432965B2 (en) 2018-10-05 2022-09-06 Deborah Kantor Medical bandage for the head, a limb or a stump
EP3632476A1 (en) 2018-10-05 2020-04-08 John J. Ryan (Sealing Products) Limited Wound contact surface and method of manufacture
US11266538B2 (en) 2018-10-07 2022-03-08 Michael David Francis Adhesive wound dressing
EP3636233B1 (de) 2018-10-12 2023-06-07 IVF Hartmann AG Feuchte wundauflage mit kleberand
EP3866871A1 (en) 2018-10-15 2021-08-25 KCI Licensing, Inc. Micro balloon-on-tube wound filler
FR3087126A1 (fr) 2018-10-16 2020-04-17 Jean Francois Van Cleef Dispositif composite de protection moulant une plaie
US20200121509A1 (en) 2018-10-17 2020-04-23 Kci Licensing, Inc. Peel and place dressing having a closed-cell contact layer
EP3866741A1 (en) 2018-10-17 2021-08-25 KCI Licensing, Inc. Systems, apparatuses, and methods for negative-pressure treatment with reduce tissue in-growth
GB2611267B (en) 2018-10-18 2023-06-28 Smith & Nephew Tissue treatment device
GB201817052D0 (en) 2018-10-19 2018-12-05 Smith & Nephew Tissue treatment device
US11839528B2 (en) 2018-10-22 2023-12-12 Medline Industries, Lp Drypad with rapid absorption and liquid removal
US20200129339A1 (en) 2018-10-24 2020-04-30 Hydrofera, Llc Sterilization of medical devices with enhanced antimicrobial properties
EP3643330A1 (en) 2018-10-24 2020-04-29 Paul Hartmann AG Ph-triggered buffered wound dressing
EP3643331A1 (en) 2018-10-24 2020-04-29 Paul Hartmann AG Ph-triggered therapeutic wound dressing
EP3643328A1 (en) 2018-10-24 2020-04-29 Paul Hartmann AG Ph-triggered diagnostic wound dressing
WO2020092598A1 (en) 2018-10-30 2020-05-07 Kci Licensing, Inc. Ease of use dressing with integrated pouch and release liner
MX2021005161A (es) 2018-11-02 2021-10-13 Covalon Tech Inc Composiciones de espuma, matrices de espuma y metodos.
JP2022506830A (ja) 2018-11-08 2022-01-17 ケーシーアイ ライセンシング インコーポレイテッド 創傷床マクロ変形の洗浄を可能にする突出層を有するドレッシング
WO2020097529A1 (en) 2018-11-08 2020-05-14 Kci Licensing, Inc. Wound dressing with semi-rigid support to increase disruption using perforated dressing and negative pressure wound therapy
US20200146899A1 (en) 2018-11-09 2020-05-14 Kci Licensing, Inc. Hybrid adhesive tissue cover
CN113507907B (zh) 2018-11-13 2023-04-21 3M创新知识产权公司 用于伤口治疗的薄型分配部件
GB2579211A (en) 2018-11-23 2020-06-17 Brightwake Ltd Medical tube
GB2579368B (en) 2018-11-29 2022-11-09 Nexa Medical Ltd Wound-dressing conditioning device
US20200179300A1 (en) 2018-12-10 2020-06-11 Joseph Urban Topical Formulation Cures and Heals a Variety of Skin Conditions Including Ulcers, Decubitus Ulcers, Cancer, Abrasions and other Conditions and also accelerates the curing and healing of those Conditions
GB2579800B (en) 2018-12-13 2021-11-03 Adv Med Solutions Ltd Resilient wound dressing
GB2579790B (en) 2018-12-13 2022-10-05 Adv Med Solutions Ltd Ribbon wound dressing
WO2020124038A1 (en) 2018-12-13 2020-06-18 University Of Massachusetts Negative pressure wound closure devices and methods
HUE064633T2 (hu) 2018-12-21 2024-04-28 Hartmann Paul Ag Szuperabszorbens sebkötés sebbel érintkezõ szilikon réteggel
EP3669838A1 (en) 2018-12-21 2020-06-24 Paul Hartmann S.A. Array of absorbent dressings for the treatment of wounds
EP3669844B1 (en) 2018-12-21 2024-07-03 Paul Hartmann AG Superabsorbent wound dressing with silicone wound contact layer
EP3902882A1 (en) 2018-12-27 2021-11-03 3M Innovative Properties Company Hot melt processable (meth)acrylate-based medical adhesives
GB201900015D0 (en) 2019-01-02 2019-02-13 Smith & Nephew Negative pressure wound therapy apparatus
WO2020142284A1 (en) 2019-01-03 2020-07-09 Kci Licensing, Inc. Superabsorbent laminate dressing
GB201900407D0 (en) 2019-01-11 2019-02-27 Smith & Nephew Method of manufacturing a component for a wound dressing
CN109481731B (zh) 2019-01-23 2020-03-27 中南大学 一种纳米氧化物/高岭土复合止血抗菌材料、止血促愈合敷料及其制备方法
WO2020154175A1 (en) 2019-01-24 2020-07-30 Kci Licensing, Inc. Variable density dressing
JP2022517867A (ja) 2019-01-28 2022-03-10 ハイプロテック・インコーポレイテッド 凝血促進性、免疫調節性、および組織再生性を有する抗菌組成物
JP7367034B2 (ja) 2019-01-28 2023-10-23 ケーシーアイ ライセンシング インコーポレイテッド 引き裂き可能なドレッシング構造
WO2020159823A1 (en) 2019-01-29 2020-08-06 Kci Licensing, Inc. Removable and replaceable dressing interface for a negative-pressure therapy system
EP3917472A1 (en) 2019-01-29 2021-12-08 KCI Licensing, Inc. Absorbent dressing with indicator and mechanical decoupling of expansion forces
WO2020159752A1 (en) 2019-02-01 2020-08-06 Kci Licensing, Inc. Drape strip having selectable adhesive
CN113365588B (zh) 2019-02-01 2022-08-30 凯希特许有限公司 部分透明的伤口敷料
EP3917476A1 (en) 2019-02-01 2021-12-08 KCI Licensing, Inc. Abdominal negative pressure therapy dressing with remote wound sensing capability
TWM578166U (zh) 2019-02-01 2019-05-21 嬌朋生技股份有限公司 負壓傷口敷材
CN113168315A (zh) 2019-02-01 2021-07-23 惠普发展公司，有限责任合伙企业 基于来自多个源的分析的升级
WO2020161086A1 (en) 2019-02-04 2020-08-13 T.J.Smith And Nephew,Limited Wound contact layer and dressing for iodine delivery
WO2020162953A1 (en) 2019-02-06 2020-08-13 Kci Licensing, Inc. Wound therapy system with internal alternating orifice
CN113382700A (zh) 2019-02-07 2021-09-10 凯希特许有限公司 被成型用于为肩部中的切口提供负压的成轮廓的泡沫敷料
IT201900002767A1 (it) 2019-02-26 2020-08-26 Univ Bologna Alma Mater Studiorum Presidio medico per la cura di patologie cutanee e relativo metodo di realizzazione
US11529504B2 (en) 2019-02-27 2022-12-20 Jeffrey Wayne Hegg Dynamic gas-flow wound dressing assembly and method for enhancing the effect of generated gas flow across a wound
CN113507909A (zh) 2019-02-27 2021-10-15 希丝塔杰尼斯创伤护理有限公司 抗微生物敷料、敷料部件和方法
EP3930770A1 (de) 2019-02-28 2022-01-05 Speed Care Mineral GmbH Paste für die markierung von textilen gebilden und/oder anderweitigen röntgenkontrastunfähigen erzeugnissen
US20220145036A1 (en) 2019-02-28 2022-05-12 Covestro Intellectual Property Gmbh & Co. Kg Thermoplastic foam prepared from two special polyurethane dispersions

Also Published As

Publication number Publication date
CA2819303A1 (en) 2012-06-07
AU2017201084A1 (en) 2017-03-09
HUE032884T2 (hu) 2017-11-28
CN108330157A (zh) 2018-07-27
BR112013013662A2 (pt) 2016-09-06
PL2646566T3 (pl) 2017-06-30
WO2012072980A1 (en) 2012-06-07
EP2646566B1 (en) 2016-10-19
PT2646566T (pt) 2017-01-26
MX344623B (es) 2017-01-03
CA2819303C (en) 2022-04-19
RU2650803C2 (ru) 2018-04-17
AU2011334682B2 (en) 2016-11-17
LT2646566T (lt) 2017-01-25
JP2014500495A (ja) 2014-01-09
AU2017201084B2 (en) 2019-04-18
HK1258842A1 (zh) 2019-11-22
DK2646566T3 (en) 2017-01-23
JP2017062238A (ja) 2017-03-30
EP2646566A1 (en) 2013-10-09
AU2011334682A1 (en) 2013-07-18
US20210369874A1 (en) 2021-12-02
CN103328651A (zh) 2013-09-25
SI2646566T1 (sl) 2017-02-28
RU2013129866A (ru) 2015-01-10
GB201020236D0 (en) 2011-01-12
MX2013006090A (es) 2013-07-15
NZ612573A (en) 2015-05-29
JP2018189655A (ja) 2018-11-29
US11135315B2 (en) 2021-10-05
US20140161728A1 (en) 2014-06-12
US20190216953A1 (en) 2019-07-18

Similar Documents

Publication Publication Date Title
ES2609612T3 (es) Una composición para detectar biofilms en tejidos viables
JP6263465B2 (ja) 皮膚および創傷における使用のための組成物
CN102300587B (zh) 用于伤口愈合的氧化剂和光活化剂的组合物
CN102056629B (zh) 一种光敏组成物及其应用
EP1819360A1 (en) Method of treating microorganisms in the oral cavity via photodynamic therapy employing a non-coherent light source
TWI580445B (zh) 使用指示劑定量ｕｖ消毒劑量之方法
US20060093561A1 (en) Method of treating microorganisms in the oral cavity
Jurič et al. Antimicrobial efficacy of photodynamic therapy, Nd: YAG laser and QMiX solution against Enterococcus faecalis biofilm
da Rosa et al. Effectiveness of photodynamic therapy associated with irrigants over two biofilm models
Gupta et al. Pluronic and Chitosan based in situ gel system for periodontal application
Zeng et al. ROS-Responsive Sequential Release Systems with Excellent Biofilm Permeability for Enhanced Antibacterial and Regeneration-promoting Therapy in Periodontitis
Martu et al. PHOTODYNAMIC THERAPY IN THE TREATMENT OF PERIODONTAL DISEASE.
Suliman THE ANTIMICROBIAL EFFICIENCY OF 0.75% CHLORHEXIDINE GLUCONATE AS ENDODONTIC IRRIGANT