EA201591240A1 - Композиции {3-[5-(4-хлорфенил)-1h-пирроло[2,3-b]пиридин-3-карбонил]-2,4-дифторфенил}амида пропан-1-сульфоновой кислоты и их применение - Google Patents
Композиции {3-[5-(4-хлорфенил)-1h-пирроло[2,3-b]пиридин-3-карбонил]-2,4-дифторфенил}амида пропан-1-сульфоновой кислоты и их применениеInfo
- Publication number
- EA201591240A1 EA201591240A1 EA201591240A EA201591240A EA201591240A1 EA 201591240 A1 EA201591240 A1 EA 201591240A1 EA 201591240 A EA201591240 A EA 201591240A EA 201591240 A EA201591240 A EA 201591240A EA 201591240 A1 EA201591240 A1 EA 201591240A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- chlorophenyl
- carbonyl
- diftorfenyl
- pirrolo
- amida
- Prior art date
Links
- 241000670727 Amida Species 0.000 title 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 title 1
- PKOMKQDGPYWKIK-UHFFFAOYSA-N CCC(c1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F)S(N)(=O)=O Chemical compound CCC(c1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F)S(N)(=O)=O PKOMKQDGPYWKIK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000007962 solid dispersion Substances 0.000 abstract 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
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Abstract
Предложены твердые дисперсии, твердые молекулярные комплексы, соли и кристаллические полиморфные формы, включающие {3-[5-(4-хлорфенил)-1Н-пирроло[2,3-b]пиридин-3-карбонил]-2,4-дифторфенил}амид пропан-1-сульфоновой кислоты (формула I)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US16667709P | 2009-04-03 | 2009-04-03 | |
US17605109P | 2009-05-06 | 2009-05-06 | |
EP09175665 | 2009-11-11 |
Publications (2)
Publication Number | Publication Date |
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EA201591240A1 true EA201591240A1 (ru) | 2016-05-31 |
EA031116B1 EA031116B1 (ru) | 2018-11-30 |
Family
ID=42352265
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EA201591240A EA031116B1 (ru) | 2009-04-03 | 2010-03-31 | КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ |
EA201190098A EA022924B1 (ru) | 2009-04-03 | 2010-03-31 | ТВЁРДАЯ ФОРМА {3-[5-(4-ХЛОРФЕНИЛ)-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ И ЕЁ ПРИМЕНЕНИЕ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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EA201190098A EA022924B1 (ru) | 2009-04-03 | 2010-03-31 | ТВЁРДАЯ ФОРМА {3-[5-(4-ХЛОРФЕНИЛ)-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ И ЕЁ ПРИМЕНЕНИЕ |
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EP (3) | EP2414356B1 (ru) |
JP (2) | JP5511942B2 (ru) |
KR (3) | KR20170058465A (ru) |
CN (4) | CN102361870B (ru) |
AR (2) | AR078033A1 (ru) |
AU (3) | AU2010232670B2 (ru) |
BR (2) | BRPI1008709B8 (ru) |
CA (2) | CA2738573C (ru) |
CO (1) | CO6410296A2 (ru) |
CR (2) | CR20170089A (ru) |
DK (1) | DK2414356T3 (ru) |
DO (1) | DOP2011000291A (ru) |
EA (2) | EA031116B1 (ru) |
EC (1) | ECSP11011282A (ru) |
ES (1) | ES2552386T3 (ru) |
HU (1) | HUE027598T2 (ru) |
IL (2) | IL214328A (ru) |
MA (1) | MA33028B1 (ru) |
MX (3) | MX2011008303A (ru) |
MY (2) | MY172424A (ru) |
NZ (1) | NZ594398A (ru) |
PE (1) | PE20120876A1 (ru) |
PL (1) | PL2414356T3 (ru) |
PT (1) | PT2414356E (ru) |
RU (1) | RU2012123958A (ru) |
SG (1) | SG173178A1 (ru) |
SI (1) | SI2414356T1 (ru) |
SM (1) | SMT201500302B (ru) |
SV (1) | SV2011004004A (ru) |
TN (1) | TN2011000436A1 (ru) |
TW (1) | TWI404719B (ru) |
UY (1) | UY32540A (ru) |
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EP2414356B1 (en) * | 2009-04-03 | 2015-09-02 | F.Hoffmann-La Roche Ag | Propane-i-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
MX2012005827A (es) | 2009-11-18 | 2012-06-19 | Plexxikon Inc | Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello. |
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TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
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CA2879252C (en) * | 2012-08-17 | 2017-10-10 | F. Hoffmann-La Roche Ag | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
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