HUE047657T2 - Kináz-moduláló hatású 1H-pirrolo[2,3-b]piridin származékok szintézise - Google Patents
Kináz-moduláló hatású 1H-pirrolo[2,3-b]piridin származékok szintéziseInfo
- Publication number
- HUE047657T2 HUE047657T2 HUE16723224A HUE16723224A HUE047657T2 HU E047657 T2 HUE047657 T2 HU E047657T2 HU E16723224 A HUE16723224 A HU E16723224A HU E16723224 A HUE16723224 A HU E16723224A HU E047657 T2 HUE047657 T2 HU E047657T2
- Authority
- HU
- Hungary
- Prior art keywords
- pyrrolo
- synthesis
- pyridin derivatives
- modulate kinases
- kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562157902P | 2015-05-06 | 2015-05-06 | |
| US201562241040P | 2015-10-13 | 2015-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE047657T2 true HUE047657T2 (hu) | 2020-05-28 |
Family
ID=56008879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16723224A HUE047657T2 (hu) | 2015-05-06 | 2016-05-05 | Kináz-moduláló hatású 1H-pirrolo[2,3-b]piridin származékok szintézise |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9745298B2 (hu) |
| EP (2) | EP3581573B1 (hu) |
| JP (3) | JP6530826B2 (hu) |
| KR (1) | KR102637844B1 (hu) |
| CN (2) | CN107531706A (hu) |
| BR (1) | BR112017023540B1 (hu) |
| CA (1) | CA2984899C (hu) |
| ES (2) | ES2774178T3 (hu) |
| HK (1) | HK1248675A1 (hu) |
| HU (1) | HUE047657T2 (hu) |
| IL (1) | IL255305B (hu) |
| TW (1) | TWI660956B (hu) |
| WO (1) | WO2016179412A1 (hu) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| JP6318156B2 (ja) | 2012-09-06 | 2018-04-25 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼをモジュレートするための化合物および方法、ならびにその指標 |
| PL2935248T3 (pl) | 2012-12-21 | 2018-07-31 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania dla nich |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| CA2903293C (en) | 2013-03-15 | 2020-10-13 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| CA2912568A1 (en) | 2013-05-30 | 2014-12-04 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2016179415A1 (en) | 2015-05-06 | 2016-11-10 | Plexxikon Inc. | Solid forms of a compound modulating kinases |
| CN107531706A (zh) | 2015-05-06 | 2018-01-02 | 普莱希科公司 | 调节激酶的1H‑吡咯并[2,3‑b]吡啶衍生物的合成 |
| HUE050936T2 (hu) | 2015-05-22 | 2021-01-28 | Plexxikon Inc | Heterociklusos vegyületek szintézise |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TWI732785B (zh) | 2015-09-21 | 2021-07-11 | 美商普雷辛肯公司 | 雜環化合物及其用途 |
| SG11201804711RA (en) | 2015-12-07 | 2018-07-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| WO2017161045A1 (en) | 2016-03-16 | 2017-09-21 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| WO2017215521A1 (zh) * | 2016-06-17 | 2017-12-21 | 苏州科睿思制药有限公司 | Plx3397的盐酸盐晶型及其制备方法和用途 |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| AU2017395023B2 (en) | 2016-12-23 | 2022-04-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| US10577366B2 (en) | 2017-03-20 | 2020-03-03 | Plexxikon Inc. | Crystalline forms of a compound that inhibits bromodomain |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| TWI805599B (zh) | 2017-07-25 | 2023-06-21 | 美商第一三共公司 | 激酶調節化合物之調配物 |
| CN111194318B (zh) | 2017-10-13 | 2023-06-09 | Opna生物公司 | 用于调节激酶的化合物固体形式 |
| JP7175309B2 (ja) | 2017-10-27 | 2022-11-18 | プレキシコン インコーポレーテッド | キナーゼを調節する化合物の製剤 |
| CN110156775A (zh) * | 2018-02-12 | 2019-08-23 | 新发药业有限公司 | 一种吡昔替尼的简便制备方法 |
| CN112119072A (zh) | 2018-03-20 | 2020-12-22 | 普莱希科公司 | 用于ido和tdo调节的化合物和方法，以及其适应症 |
| CN111349043B (zh) * | 2018-12-20 | 2022-09-27 | 上海医药工业研究院 | 用于制备派西尼布的中间体及其制备方法和应用 |
| WO2020210366A1 (en) | 2019-04-09 | 2020-10-15 | Plexxikon Inc. | Condensed azines for ep300 or cbp modulation and indications therefor |
| CN113444083A (zh) * | 2020-03-25 | 2021-09-28 | 上海天慈国际药业有限公司 | 一种小分子酪氨酸激酶抑制剂的制备方法 |
| CN116323588A (zh) | 2020-04-23 | 2023-06-23 | 奥普纳生物有限公司 | 用于cd73调节的化合物和方法及其适应症 |
| EP4199926A1 (en) | 2020-08-21 | 2023-06-28 | Plexxikon Inc. | Combinational drug anticancer therapies |
| EP4355732A1 (en) | 2021-06-15 | 2024-04-24 | Johnson Matthey Public Limited Company | Process for preparing pexidartinib |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| EP1648867B1 (en) | 2003-07-17 | 2013-09-04 | Plexxikon Inc. | Ppar active compounds |
| EP1696920B8 (en) | 2003-12-19 | 2015-05-06 | Plexxikon Inc. | Compounds and methods for development of ret modulators |
| US7517970B2 (en) | 2003-12-19 | 2009-04-14 | Plexxikon, Inc. | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same |
| US7585859B2 (en) | 2004-05-06 | 2009-09-08 | Plexxikon, Inc. | PDE4B inhibitors and uses therefor |
| EP1786813A2 (en) | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| KR20080027775A (ko) | 2005-05-17 | 2008-03-28 | 플렉시콘, 인코퍼레이티드 | 피롤(２,３-ｂ)피리딘 유도체 단백질 키나제 억제제 |
| CN102603581B (zh) | 2005-06-22 | 2015-06-24 | 普莱希科公司 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2009152087A1 (en) | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor |
| WO2009152083A1 (en) | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor |
| PE20120184A1 (es) | 2009-03-11 | 2012-03-28 | Plexxikon Inc | Derivados del pirrolo[2,3-b]piridina para la inhibicion de las proteinas quinasas raf |
| CR20170089A (es) | 2009-04-03 | 2017-07-17 | Plexxikon Inc | Composiciones del acido propano-1--sulfonico {3-[5-(4-cloro-fenil)-1h-pirrolo [2,3-b] piridina-3-carbonil] -2,4-difluoro-fenil}-amida y el uso de las mismas |
| NZ599866A (en) * | 2009-11-06 | 2014-09-26 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| ES2627911T3 (es) | 2009-11-18 | 2017-08-01 | Plexxikon, Inc. | Derivados de N-[2-fluoro-3-(4-amino-7H-pirrolo[2,3-d]pirimidin-5-carbonil)-fenil]-4-bencenosulfonamida como moduladores de la proteína quinasa Raf para el tratamiento del cáncer |
| CN102753549A (zh) | 2009-12-23 | 2012-10-24 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
| MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| RU2631487C2 (ru) | 2011-05-17 | 2017-09-22 | Плексксикон Инк. | Модуляция киназ и показания к её применению |
| US9358235B2 (en) * | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| WO2014017342A1 (ja) * | 2012-07-24 | 2014-01-30 | キッセイ薬品工業株式会社 | インドール誘導体、またはその薬理学的に許容される塩 |
| JP6318156B2 (ja) | 2012-09-06 | 2018-04-25 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼをモジュレートするための化合物および方法、ならびにその指標 |
| PL2935248T3 (pl) | 2012-12-21 | 2018-07-31 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania dla nich |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| CA2903293C (en) | 2013-03-15 | 2020-10-13 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| CA2912568A1 (en) | 2013-05-30 | 2014-12-04 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP6832846B2 (ja) | 2014-09-15 | 2021-02-24 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ヘテロ環化合物およびその用途 |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN107531706A (zh) | 2015-05-06 | 2018-01-02 | 普莱希科公司 | 调节激酶的1H‑吡咯并[2,3‑b]吡啶衍生物的合成 |
| WO2016179415A1 (en) | 2015-05-06 | 2016-11-10 | Plexxikon Inc. | Solid forms of a compound modulating kinases |
| CA2986739C (en) | 2015-05-22 | 2023-03-14 | Plexxikon Inc. | Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases |
| HUE050936T2 (hu) | 2015-05-22 | 2021-01-28 | Plexxikon Inc | Heterociklusos vegyületek szintézise |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TWI732785B (zh) | 2015-09-21 | 2021-07-11 | 美商普雷辛肯公司 | 雜環化合物及其用途 |
| SG11201804711RA (en) | 2015-12-07 | 2018-07-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| WO2017161045A1 (en) | 2016-03-16 | 2017-09-21 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| AU2017395023B2 (en) | 2016-12-23 | 2022-04-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| US10577366B2 (en) | 2017-03-20 | 2020-03-03 | Plexxikon Inc. | Crystalline forms of a compound that inhibits bromodomain |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| TWI805599B (zh) | 2017-07-25 | 2023-06-21 | 美商第一三共公司 | 激酶調節化合物之調配物 |
| CN111194318B (zh) | 2017-10-13 | 2023-06-09 | Opna生物公司 | 用于调节激酶的化合物固体形式 |
| JP7175309B2 (ja) | 2017-10-27 | 2022-11-18 | プレキシコン インコーポレーテッド | キナーゼを調節する化合物の製剤 |
| CN112119072A (zh) | 2018-03-20 | 2020-12-22 | 普莱希科公司 | 用于ido和tdo调节的化合物和方法，以及其适应症 |
-
2016
- 2016-05-05 CN CN201680025474.9A patent/CN107531706A/zh active Pending
- 2016-05-05 WO PCT/US2016/031022 patent/WO2016179412A1/en active Application Filing
- 2016-05-05 JP JP2017557337A patent/JP6530826B2/ja active Active
- 2016-05-05 CN CN202011386092.3A patent/CN112574196A/zh active Pending
- 2016-05-05 TW TW105114056A patent/TWI660956B/zh active
- 2016-05-05 EP EP19189460.9A patent/EP3581573B1/en active Active
- 2016-05-05 BR BR112017023540-4A patent/BR112017023540B1/pt active IP Right Grant
- 2016-05-05 CA CA2984899A patent/CA2984899C/en active Active
- 2016-05-05 US US15/147,709 patent/US9745298B2/en active Active
- 2016-05-05 KR KR1020177034517A patent/KR102637844B1/ko active IP Right Grant
- 2016-05-05 ES ES16723224T patent/ES2774178T3/es active Active
- 2016-05-05 HU HUE16723224A patent/HUE047657T2/hu unknown
- 2016-05-05 EP EP16723224.8A patent/EP3292122B1/en active Active
- 2016-05-05 ES ES19189460T patent/ES2923943T3/es active Active
-
2017
- 2017-08-01 US US15/665,804 patent/US10040792B2/en active Active
- 2017-10-29 IL IL255305A patent/IL255305B/en active IP Right Grant
-
2018
- 2018-06-14 HK HK18107742.6A patent/HK1248675A1/zh unknown
- 2018-06-29 US US16/024,197 patent/US10399975B2/en active Active
-
2019
- 2019-05-17 JP JP2019093379A patent/JP6986045B2/ja active Active
- 2019-07-12 US US16/510,617 patent/US10730876B2/en active Active
-
2021
- 2021-08-12 JP JP2021131707A patent/JP2021185163A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1248675A1 (zh) | 調節激酶的1h 吡咯並[2，3-b]吡啶衍生物的合成 | |
| HK1244804A1 (zh) | 4h-吡咯並[3，2-c]吡啶-4-酮衍生物 | |
| SI3429591T1 (sl) | Substituirani tieno(2,3-d)pirimidinski derivati kot inhibitorji menin-MLL in postopki uporabe | |
| EP3367898A4 (en) | TRANSCRANIAL CONTROL OF RECONSOLIDATION OF PROCEDURAL MEMORY FOR ACQUIRING SKILLS | |
| IL286788B1 (en) | Methods for the preparation of cytotoxic benzodiazepine compounds | |
| HK1247923A1 (zh) | 可用作哺乳動物酪氨酸激酶ror1活性抑制劑的2-苯基-3h-咪唑並[4，5-b]吡啶衍生物 | |
| IL293192A (en) | Methods for the preparation of indolinobenzodiazepine derivatives | |
| IL252254A0 (en) | Anticancer drugs derived from 7-morpholinyl-2-n-piperazinyl-methyl thiano-[3,2-c]-pyridine | |
| GB201417646D0 (en) | Formulations of phosphate derivatives |