HK1248675A1 - 調節激酶的1h 吡咯並[2,3-b]吡啶衍生物的合成 - Google Patents

調節激酶的1h 吡咯並[2,3-b]吡啶衍生物的合成

Info

Publication number
HK1248675A1
HK1248675A1 HK18107742.6A HK18107742A HK1248675A1 HK 1248675 A1 HK1248675 A1 HK 1248675A1 HK 18107742 A HK18107742 A HK 18107742A HK 1248675 A1 HK1248675 A1 HK 1248675A1
Authority
HK
Hong Kong
Prior art keywords
pyrrolo
synthesis
pyridin derivatives
modulate kinases
kinases
Prior art date
Application number
HK18107742.6A
Other languages
English (en)
Inventor
Prabha N Ibrahim
Masayoshi Jin
Shinji Matsuura
Original Assignee
Plexxikon Inc
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc, Daiichi Sankyo Co Ltd filed Critical Plexxikon Inc
Publication of HK1248675A1 publication Critical patent/HK1248675A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
HK18107742.6A 2015-05-06 2018-06-14 調節激酶的1h 吡咯並[2,3-b]吡啶衍生物的合成 HK1248675A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562157902P 2015-05-06 2015-05-06
US201562241040P 2015-10-13 2015-10-13
PCT/US2016/031022 WO2016179412A1 (en) 2015-05-06 2016-05-05 Synthesis of 1 h-pyrrolo[2,3-b]pyridin derivatives that modulate kinases

Publications (1)

Publication Number Publication Date
HK1248675A1 true HK1248675A1 (zh) 2018-10-19

Family

ID=56008879

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107742.6A HK1248675A1 (zh) 2015-05-06 2018-06-14 調節激酶的1h 吡咯並[2,3-b]吡啶衍生物的合成

Country Status (13)

Country Link
US (4) US9745298B2 (zh)
EP (2) EP3581573B1 (zh)
JP (4) JP6530826B2 (zh)
KR (1) KR102637844B1 (zh)
CN (2) CN112574196A (zh)
BR (1) BR112017023540B1 (zh)
CA (1) CA2984899C (zh)
ES (2) ES2923943T3 (zh)
HK (1) HK1248675A1 (zh)
HU (1) HUE047657T2 (zh)
IL (1) IL255305B (zh)
TW (1) TWI660956B (zh)
WO (1) WO2016179412A1 (zh)

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JP7170030B2 (ja) 2017-07-25 2022-11-11 プレキシコン インコーポレーテッド キナーゼを調節する化合物の製剤
JP2020536917A (ja) 2017-10-13 2020-12-17 プレキシコン インコーポレーテッドPlexxikon Inc. キナーゼを調節するための化合物の固体形態
WO2019084462A1 (en) 2017-10-27 2019-05-02 Plexxikon Inc. FORMULATION OF A COMPOUND MODULATING KINASES
CN110156775A (zh) * 2018-02-12 2019-08-23 新发药业有限公司 一种吡昔替尼的简便制备方法
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CN111349043B (zh) * 2018-12-20 2022-09-27 上海医药工业研究院 用于制备派西尼布的中间体及其制备方法和应用
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EP3757104A1 (en) 2015-05-06 2020-12-30 Plexxikon Inc. Solid forms of a compound modulating kinases
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CA3129180A1 (en) 2015-09-21 2017-03-30 Plexxikon Inc. Heterocyclic compounds and uses thereof
AU2016367147B2 (en) 2015-12-07 2021-04-08 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
ES2904615T3 (es) 2016-03-16 2022-04-05 Plexxikon Inc Compuestos y métodos para la modulación de quinasas e indicaciones al respecto
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ido及tdo調節之化合物及方法以及其適應症
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JP2020511467A (ja) 2017-03-20 2020-04-16 プレキシコン インコーポレーテッドPlexxikon Inc. ブロモドメインを阻害する4−(1−(1,1−ジ(ピリジン−2−イル)エチル)−6−(3,5−ジメチルイソオキサゾール−4−イル)−1H−ピロロ[3,2−b]ピリジン−3−イル)安息香酸の結晶形
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
JP7170030B2 (ja) 2017-07-25 2022-11-11 プレキシコン インコーポレーテッド キナーゼを調節する化合物の製剤
JP2020536917A (ja) 2017-10-13 2020-12-17 プレキシコン インコーポレーテッドPlexxikon Inc. キナーゼを調節するための化合物の固体形態
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CA3094336A1 (en) 2018-03-20 2019-09-26 Plexxikon Inc. Compounds and methods for ido and tdo modulation, and indications therefor

Also Published As

Publication number Publication date
US9745298B2 (en) 2017-08-29
US10730876B2 (en) 2020-08-04
IL255305A0 (en) 2017-12-31
EP3292122B1 (en) 2020-01-15
CN112574196A (zh) 2021-03-30
TW201706271A (zh) 2017-02-16
US20180305358A1 (en) 2018-10-25
TWI660956B (zh) 2019-06-01
CN107531706A (zh) 2018-01-02
EP3292122A1 (en) 2018-03-14
US10040792B2 (en) 2018-08-07
US20190337943A1 (en) 2019-11-07
EP3581573A1 (en) 2019-12-18
WO2016179412A1 (en) 2016-11-10
JP6530826B2 (ja) 2019-06-12
ES2774178T3 (es) 2020-07-17
KR20180015142A (ko) 2018-02-12
US20170334909A1 (en) 2017-11-23
JP2018516880A (ja) 2018-06-28
IL255305B (en) 2020-05-31
BR112017023540A2 (pt) 2018-07-24
JP2021185163A (ja) 2021-12-09
BR112017023540B1 (pt) 2023-04-04
ES2923943T3 (es) 2022-10-03
JP2019147828A (ja) 2019-09-05
KR102637844B1 (ko) 2024-02-19
CA2984899C (en) 2021-06-15
EP3581573B1 (en) 2022-07-06
JP6986045B2 (ja) 2021-12-22
CA2984899A1 (en) 2016-11-10
JP2024056918A (ja) 2024-04-23
US20160326169A1 (en) 2016-11-10
HUE047657T2 (hu) 2020-05-28
US10399975B2 (en) 2019-09-03

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