DOP2023000168A - Compuestos antivirales que contienen nitrilo - Google Patents
Compuestos antivirales que contienen nitriloInfo
- Publication number
- DOP2023000168A DOP2023000168A DO2023000168A DO2023000168A DOP2023000168A DO P2023000168 A DOP2023000168 A DO P2023000168A DO 2023000168 A DO2023000168 A DO 2023000168A DO 2023000168 A DO2023000168 A DO 2023000168A DO P2023000168 A DOP2023000168 A DO P2023000168A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- compounds containing
- antiviral compounds
- containing nitrile
- coronavirus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063073982P | 2020-09-03 | 2020-09-03 | |
| US202163143435P | 2021-01-29 | 2021-01-29 | |
| US202163170158P | 2021-04-02 | 2021-04-02 | |
| US202163194241P | 2021-05-28 | 2021-05-28 | |
| PCT/IB2021/057281 WO2021250648A1 (en) | 2020-09-03 | 2021-08-06 | Nitrile-containing antiviral compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2023000168A true DOP2023000168A (es) | 2023-10-15 |
Family
ID=77411985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2023000168A DOP2023000168A (es) | 2020-09-03 | 2023-08-25 | Compuestos antivirales que contienen nitrilo |
Country Status (38)
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| BR112022025037A2 (pt) | 2020-06-10 | 2023-02-14 | Aligos Therapeutics Inc | Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus |
| EP4178955A1 (en) | 2020-07-11 | 2023-05-17 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| EP4635972A3 (en) * | 2020-07-20 | 2025-12-24 | Enanta Pharmaceuticals, Inc. | Functionalized peptides as antiviral agents |
| CN116547294A (zh) * | 2020-08-13 | 2023-08-04 | 英安塔制药有限公司 | 作为抗病毒剂的功能化肽 |
| WO2022109360A1 (en) | 2020-11-23 | 2022-05-27 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| US12540141B2 (en) | 2020-11-23 | 2026-02-03 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US20240043417A1 (en) * | 2020-12-01 | 2024-02-08 | Purdue Research Foundation | Compounds for the treatment of sars |
| WO2022133588A1 (en) * | 2020-12-21 | 2022-06-30 | The Governors Of The University Of Alberta | Rna virus inhibitor compounds and uses thereof |
| LT4122926T (lt) | 2021-04-14 | 2025-07-25 | Shionogi & Co., Ltd. | Triazino dariniai, turintys virusų replikaciją slopinantį poveikį, ir juos apimanti farmacinė kompozicija |
| RS66213B1 (sr) * | 2021-04-16 | 2024-12-31 | Fujian Akeylink Biotechnology Co Ltd | Jedinjenje kratkog peptida prolina modifikovanog prstenom i upotreba istog |
| US11970502B2 (en) | 2021-05-04 | 2024-04-30 | Enanta Pharmaceuticals, Inc. | Macrocyclic antiviral agents |
| US11857617B2 (en) | 2021-05-10 | 2024-01-02 | Topelia Aust Limited (652 771 670) | Methods for treating, ameliorating or preventing infections using drug and vaccination combination treatment |
| US12398147B2 (en) | 2021-05-11 | 2025-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| WO2022251615A1 (en) | 2021-05-28 | 2022-12-01 | Arun K Ghosh | Compounds for the treatment of sars |
| JP2024522990A (ja) | 2021-06-02 | 2024-06-25 | エイシア セラピューティクス， インコーポレイテッド | 抗ウイルス薬としてのプロテアーゼ阻害剤 |
| WO2022266363A1 (en) * | 2021-06-16 | 2022-12-22 | The Scripps Research Institute | Protease inhibitors for the treatment of coronavirus infections |
| CN113444144A (zh) * | 2021-06-23 | 2021-09-28 | 周龙兴 | 一种蛋白酶抑制剂及其药物组合物和用途 |
| WO2023283256A1 (en) | 2021-07-09 | 2023-01-12 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US12643905B2 (en) | 2021-07-23 | 2026-06-02 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN114149415A (zh) * | 2021-07-26 | 2022-03-08 | 中国药科大学 | 一种拟肽类化合物及其衍生物、制备方法、药物组合物和应用 |
| US12479854B2 (en) | 2021-07-29 | 2025-11-25 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| EP4387980A1 (en) * | 2021-08-18 | 2024-06-26 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| US12186309B2 (en) | 2021-09-27 | 2025-01-07 | The Governors Of The University Of Alberta | RNA virus inhibitor compounds and uses thereof |
| AU2022353486A1 (en) | 2021-09-28 | 2024-05-02 | National University Corporation Hokkaido University | Pharmaceutical composition containing triazine derivative |
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| WO2023086400A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023088418A1 (en) * | 2021-11-20 | 2023-05-25 | Fochon Biosciences, Ltd. | Compounds as sars-cov-2 inhibitors |
| JP7253866B1 (ja) | 2021-11-24 | 2023-04-07 | 塩野義製薬株式会社 | トリアジン誘導体を含有する経口投与する製剤 |
| CN115490626B (zh) * | 2021-11-26 | 2024-08-23 | 杭州科巢生物科技有限公司 | 一种pf-07321332的关键手性化合物及其制备方法 |
| WO2023095860A1 (ja) * | 2021-11-26 | 2023-06-01 | 塩野義製薬株式会社 | ３ｃｌプロテアーゼ阻害剤及びｃｏｖｉｄ－１９治療用薬剤を組み合わせることを特徴とするｃｏｖｉｄ－１９治療用医薬 |
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| WO2023125825A1 (en) * | 2021-12-29 | 2023-07-06 | Shanghai Curegene Pharmaceutical Co., Ltd. | Anticoronviral compounds and compositions and uses thereof |
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| CN114605436B (zh) * | 2022-03-23 | 2023-07-21 | 浙江九洲药业股份有限公司 | 帕罗韦德或波普瑞韦的中间体、制备方法和应用 |
| CN114437044B (zh) * | 2022-03-24 | 2022-10-04 | 山东诚创蓝海医药科技有限公司 | 一种奈玛特韦的制备方法 |
| CN114702425B (zh) * | 2022-03-28 | 2024-04-19 | 苏州汉酶生物技术有限公司 | （s）-2-氨基-(s)-3-[吡咯烷酮-2’]丙氨酸衍生物及中间体的制备方法 |
| US11648300B1 (en) * | 2022-03-31 | 2023-05-16 | Asavi Llc | Pharmaceutical combination therapy and prevention with aprotinin + nirmatrelvir of SARS-CoV-2 and/or disease associated with this infection, including COVID-19 |
| CN115043900B (zh) * | 2022-03-31 | 2025-02-18 | 深圳博瑞医药科技有限公司 | 一种拟肽化合物及其制备2019-nCoV主蛋白酶抑制剂的用途 |
| CN114957383B (zh) * | 2022-04-01 | 2024-12-31 | 中国科学院上海药物研究所 | 一种拟肽类化合物及其制备方法、药物组合物和用途 |
| US12145942B2 (en) | 2022-04-05 | 2024-11-19 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN117203195A (zh) * | 2022-04-08 | 2023-12-08 | 盐野义制药株式会社 | 具有病毒增殖抑制活性的尿嘧啶衍生物及含有其的医药组合物 |
| AU2023249953A1 (en) * | 2022-04-08 | 2024-10-24 | Shionogi & Co., Ltd. | Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same |
| CN114957087A (zh) * | 2022-04-13 | 2022-08-30 | 湖南复瑞生物医药技术有限责任公司 | 一种帕罗韦德中间体制备方法 |
| WO2023200364A1 (ru) * | 2022-04-15 | 2023-10-19 | Общество С Ограниченной Ответственностью "Промомед Рус" | Способы получения (1r,2s,5s)-n-[(1s)-1-циано-2-[(3s)-2-оксопирролидин-3-ил]этил]-3-[(2s)-3,3-диметил-2-[(2,2,2-трифторацетил)амино]бутаноил]-6,6-диметил-3-азабицикло[3.1.0]гексан-2-карбоксамида |
| CN114702545A (zh) * | 2022-04-19 | 2022-07-05 | 海化生命(厦门)科技有限公司 | 一种抗新冠病毒药物尼玛瑞韦的制备方法 |
| CN117126229A (zh) | 2022-05-19 | 2023-11-28 | 浙江海正药业股份有限公司 | Hs378晶型及其制备方法 |
| CN114957053B (zh) * | 2022-05-20 | 2023-12-22 | 中国医学科学院医药生物技术研究所 | 一种氧代亚乙基类化合物或其药学上可接受的盐及其制备方法和应用、药物组合物及其应用 |
| CN114989045B (zh) * | 2022-06-14 | 2023-09-08 | 斯坦德药典标准物质研发(湖北)有限公司 | 合成奈玛特韦的中间体及其制法以及合成奈玛特韦的方法 |
| WO2023245166A2 (en) * | 2022-06-17 | 2023-12-21 | Trawsfynydd Therapeutics, Inc. | Compounds for treatment of a coronavirus infection |
| IL317872A (en) | 2022-06-30 | 2025-02-01 | Pfizer | Process and useful intermediates for the preparation of NIRMATRELVIR |
| AU2023303408A1 (en) | 2022-07-06 | 2024-12-19 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| CN116970028A (zh) * | 2022-07-08 | 2023-10-31 | 腾讯科技（深圳）有限公司 | 大环拟肽类蛋白酶抑制剂及其用途 |
| CN116621918B (zh) * | 2022-07-20 | 2023-10-31 | 深圳信立泰药业股份有限公司 | 一种螺环化合物及其制备方法与应用 |
| CN117466971A (zh) * | 2022-07-22 | 2024-01-30 | 苏州第四制药厂有限公司 | 一种奈玛特韦中间体溶剂化物及其制备方法与应用 |
| US11986479B2 (en) | 2022-07-22 | 2024-05-21 | PharSoln, Inc. | Combination drug products for treating patients suffering from one or more medical conditions caused by coronavirus infection, including by SARS-CoV-2, its alpha, beta, delta, or omicron variants and sub variants |
| CN117503776A (zh) * | 2022-08-05 | 2024-02-06 | 临港国家实验室 | 一种药物组合物及其用途 |
| IL320050A (en) | 2022-10-06 | 2025-06-01 | Enanta Pharm Inc | Crystalline forms of SARS-anti-COV-2 compound |
| WO2024078302A1 (zh) * | 2022-10-13 | 2024-04-18 | 广东众生睿创生物科技有限公司 | 一种酮酰胺衍生物的晶型以及其制备方法 |
| CN119894917A (zh) * | 2022-10-13 | 2025-04-25 | 广东众生睿创生物科技有限公司 | 酮酰胺衍生物的无定型及其制备方法 |
| JP7883062B2 (ja) * | 2022-10-14 | 2026-06-30 | 福建▲広▼生中霖生物科技有限公司 | シアノ置換含有ポリペプチド系化合物の結晶及びその製造方法 |
| CN118251404B (zh) * | 2022-10-18 | 2025-10-10 | 福建广生中霖生物科技有限公司 | 药物中间体及其制备方法 |
| CN120076804A (zh) * | 2022-10-19 | 2025-05-30 | 普罗莫梅德俄罗斯有限责任公司 | 治疗冠状病毒感染用药物组合物和药品 |
| WO2024086777A2 (en) * | 2022-10-21 | 2024-04-25 | The Trustees Of Indiana University | Compounds and methods for treating diseases caused by viruses and bacteria |
| WO2024091148A2 (ru) * | 2022-10-26 | 2024-05-02 | Общество С Ограниченной Ответственностью "Абицея Медикал Технолоджис" | Жидкий бальнеологический концентрат и ампула с мерной шкалой и устройством для удобного дозирования бальнеологического концентрата |
| WO2024089159A1 (en) | 2022-10-27 | 2024-05-02 | Ubiq Holding B.V. | Main protease inhibitors |
| WO2024094152A1 (zh) * | 2022-11-03 | 2024-05-10 | 中国科学院上海药物研究所 | 一类螺环化合物、其制备方法及用途 |
| WO2024135828A1 (ja) | 2022-12-23 | 2024-06-27 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | エバーメクチン誘導体 |
| CN115998836B (zh) * | 2023-02-08 | 2026-02-24 | 南通市海门品尚医药科技有限公司 | 一种含有奈玛特韦和利托那韦的液体制剂及其制备方法与应用 |
| CN118697729A (zh) * | 2023-03-27 | 2024-09-27 | 江苏天士力帝益药业有限公司 | 一种含有水飞蓟宾的组合物 |
| KR20250167038A (ko) * | 2023-05-04 | 2025-11-28 | 광둥 레이노벤트 바이오테크 컴퍼니 리미티드 | 항-sars-cov-2 약학 조성물 및 이의 제조 방법 |
| CN116283741B (zh) * | 2023-05-10 | 2023-09-05 | 江苏欣诺科催化剂股份有限公司 | 双亚胺配体及其制备方法与应用 |
| WO2024237816A1 (ru) * | 2023-05-12 | 2024-11-21 | Общество С Ограниченной Ответственностью "Промомед Рус" | Новые производные азабициклогексана |
| TW202515537A (zh) | 2023-06-09 | 2025-04-16 | 美商輝瑞大藥廠 | 製備伊布紮特韋(Ibuzatrelvir)之方法及中間體 |
| CN121311467A (zh) | 2023-06-09 | 2026-01-09 | 辉瑞大药厂 | N-(甲氧羰基)-3-甲基-l-缬氨酰基-(4r)-n-{(1s)-1-氰基-2-[(3s)-2-氧代吡咯烷-3-基]乙基}-4-(三氟甲基)-l-脯氨酰胺及其溶剂化物的固体形式 |
| EP4501942A1 (en) | 2023-08-02 | 2025-02-05 | Consejo Superior De Investigaciones Científicas (CSIC) | Peptidomimetics with antiviral activity |
| WO2025037206A1 (en) | 2023-08-11 | 2025-02-20 | Pfizer Inc. | Deuterated antiviral compounds |
| CN116763898A (zh) * | 2023-08-21 | 2023-09-19 | 北京科翔中升医药科技有限公司 | 一种蛋白酶抑制剂化合物在制备猫冠状病毒感染药物中的用途 |
| WO2025005306A1 (ja) * | 2023-10-05 | 2025-01-02 | 塩野義製薬株式会社 | ウラシル誘導体を含有する医薬組成物 |
| CN122270280A (zh) * | 2023-10-05 | 2026-06-23 | 盐野义制药株式会社 | 含有尿嘧啶衍生物的制剂 |
| US20250163026A1 (en) * | 2023-11-21 | 2025-05-22 | Daljit Singh Dhanoa | Deuterium-Enriched Nirmatrelvir as SARS-CoV-2 Mpro Inhibitor for the Treatment of COVID-19 |
| CN119139307B (zh) * | 2023-12-29 | 2025-09-23 | 上海柯君医药科技有限公司 | 螺环类化合物在制备3CLpro蛋白酶抑制剂或药物中的用途 |
| EP4686470A1 (en) | 2024-08-01 | 2026-02-04 | Ospedale San Raffaele S.r.l. | Macrocyclic peptidomimetics as antiviral agents |
| WO2025125695A2 (en) | 2024-12-17 | 2025-06-19 | Medchemica Consultancy Ltd | Chemical compoundsid50000167790940 p. doc 2025-05-07 filing no.:19 |
Family Cites Families (227)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583238A (en) | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
| DE69334250D1 (de) | 1992-12-29 | 2009-01-29 | Abbott Lab | Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern |
| US5543417A (en) | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| CA2246256A1 (en) | 1996-02-13 | 1997-08-21 | Akzo Nobel Nv | Serine protease inhibitors |
| IL120310A (en) | 1996-03-01 | 2002-02-10 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
| WO1997037997A1 (en) | 1996-04-04 | 1997-10-16 | Brystol-Myers Squibb Company | Cephalosporin derivatives |
| DE19748470A1 (de) | 1997-11-03 | 1999-05-06 | Hoechst Schering Agrevo Gmbh | Carbamoylphenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| US20050267148A1 (en) | 1998-07-15 | 2005-12-01 | Teijin Limited | Benzimidazole derivative |
| CN1187337C (zh) | 1998-07-15 | 2005-02-02 | 帝人株式会社 | 硫代苯并咪唑衍生物 |
| JP2003506457A (ja) | 1999-08-04 | 2003-02-18 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | 抗ピコルナウィルス化合物及び組成物、その医薬的使用、並びにその合成のための物質 |
| PA8507801A1 (es) | 1999-12-03 | 2002-08-26 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| US7012066B2 (en) | 2000-07-21 | 2006-03-14 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| AR037938A1 (es) | 2001-12-21 | 2004-12-22 | Syngenta Participations Ag | Derivados de avermectina b1 que tienen un substituyente de aminosulfoniloxilo en la posicion 4'' |
| MXPA04007163A (es) | 2002-01-23 | 2004-10-29 | Schering Corp | Compuestos de prolina como inhibidores de la proteasa serina ns3 para utilizarse en el tratamiento de la infeccion por el virus de la hepatitis c. |
| GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| DE60322857D1 (de) | 2002-03-25 | 2008-09-25 | Nippon Kayaku Kk | Neues alpha-amino-n-(diaminophosphinyl)lactamderivat |
| MY133587A (en) | 2002-05-29 | 2007-11-30 | Glaxo Group Ltd | Aromatic sulfones and their medical use |
| TW200406386A (en) | 2002-06-07 | 2004-05-01 | Novartis Ag | Organic compounds |
| UA84404C2 (ru) | 2002-06-12 | 2008-10-27 | Байоджен Айдек Ма Инк. | Способ лечения ишемического реперфузионного повреждения с помощью антагонистов рецептора аденозина |
| GB0220187D0 (en) | 2002-08-30 | 2002-10-09 | Novartis Ag | Organic compounds |
| WO2004058717A1 (en) | 2002-12-20 | 2004-07-15 | X-Ceptor Therapeutics, Inc. | Isoquinolinone derivatives and their use as therapeutic agents |
| US7078419B2 (en) | 2003-03-10 | 2006-07-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
| WO2004093860A1 (en) | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Inhibitors of sars related coronavirus proteinase |
| US20040235952A1 (en) | 2003-05-05 | 2004-11-25 | Agouron Pharmaceuticals, Inc. | Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase |
| SE0301320D0 (sv) | 2003-05-06 | 2003-05-06 | Astrazeneca Ab | Positive modulators of nicotinic acetylcholine receptors |
| US7754188B2 (en) | 2003-06-30 | 2010-07-13 | Merck Sharp & Dohme Corp. | Radiolabeled cannabinoid-1 receptor modulators |
| MXPA06002250A (es) | 2003-08-26 | 2006-05-17 | Schering Corp | Inhibidores peptidomimeticos novedosos de la serina proteasa ns3 del virus de la hepatitis c. |
| US20060014821A1 (en) | 2003-08-27 | 2006-01-19 | Agouron Pharmaceuticals, Inc. | Inhibitors of SARS 3C like protease |
| AU2004270251B2 (en) | 2003-09-05 | 2011-03-31 | The General Hospital Corporation | Polyacetal drug conjugates as release system |
| KR20060118532A (ko) | 2003-12-11 | 2006-11-23 | 쉐링 코포레이션 | Ｃ형 간염 바이러스 ｎｓ３／ｎｓ４ａ 세린 프로테아제의억제제 |
| AU2004312547A1 (en) | 2003-12-31 | 2005-07-21 | Taigen Biotechnology | Protease inhibitors |
| US7462594B2 (en) | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
| JP2007522135A (ja) | 2004-01-30 | 2007-08-09 | ザ ジョンズ ホプキンス ユニバーシティ | ニトロキシル前駆化合物および使用方法 |
| RU2006134002A (ru) | 2004-02-27 | 2008-04-10 | Шеринг Корпорейшн (US) | Новые соединения, действующие как ингибиторы сериновой протеазы ns3 вируса гепатита с |
| US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
| CN1950393A (zh) | 2004-02-27 | 2007-04-18 | 先灵公司 | 丙型肝炎病毒ns3蛋白酶的抑制剂 |
| US7173057B2 (en) | 2004-02-27 | 2007-02-06 | Schering Corporation | Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus |
| RU2428428C9 (ru) | 2004-02-27 | 2012-03-10 | Шеринг Корпорейшн | Серусодержащие соединения, действующие как ингибиторы сериновой протеазы ns3 вируса гепатита с |
| WO2005113580A1 (en) | 2004-05-21 | 2005-12-01 | Pfizer Inc. | Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| CA2570694A1 (en) | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| ATE459605T1 (de) | 2004-09-03 | 2010-03-15 | Syngenta Ltd | Isoxazolinderivate und deren verwendung als herbizide |
| ATE520672T1 (de) | 2004-09-30 | 2011-09-15 | Tibotec Pharm Ltd | Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine |
| US8575342B2 (en) | 2004-09-30 | 2013-11-05 | Tibotech Pharmaceuticals Ltd. | HIV inhibiting 5-heterocyclyl pyrimidines |
| CN100363346C (zh) * | 2004-10-22 | 2008-01-23 | 清华大学 | 冠状病毒主蛋白酶的小分子抑制剂、制备方法及其应用 |
| BRPI0517272A (pt) | 2004-10-29 | 2008-10-07 | Tibotec Pharm Ltd | derivados de pirimidina bicìclicos de inibição de hiv |
| WO2006061714A2 (en) | 2004-12-09 | 2006-06-15 | Pfizer Inc. | Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| GB2422829A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| JP2008533181A (ja) | 2005-04-14 | 2008-08-21 | エフ．ホフマン−ラ ロシュ アーゲー | 三環式アゾール誘導体、それらの製造及び医薬品としての使用 |
| CA2603204A1 (en) | 2005-04-14 | 2006-10-19 | F. Hoffmann-La Roche Ag | Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents |
| US20060281689A1 (en) | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
| WO2006130552A2 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| KR20080031281A (ko) | 2005-06-16 | 2008-04-08 | 노파르티스 아게 | 락탐을 함유하는 ｈｃｖ 억제제 |
| JP2009510157A (ja) | 2005-10-03 | 2009-03-12 | ファイザー・プロダクツ・インク | Ｈｉｖインテグラーゼ酵素の阻害剤 |
| WO2007058832A2 (en) | 2005-11-12 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Pyrrolo (2, 3-b) pyridine derivatives useful as tec kinase inhibitors |
| DE102005055354A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| WO2007068465A1 (en) | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents |
| DE102006012251A1 (de) | 2006-03-15 | 2007-11-08 | Grünenthal GmbH | Substituierte 4-Amino-chinazolin-Derivate und ihre Verwendung zur Herstellung von Arzneimitteln |
| CA2652307A1 (en) | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| TW200815351A (en) | 2006-05-02 | 2008-04-01 | Astrazeneca Ab | Novel compounds |
| WO2008037266A1 (en) | 2006-09-25 | 2008-04-03 | Universite Libre De Bruxelles | Inhibitors of conventional protein kinase c isozymes and use thereof for treating inflammatory diseases |
| US20100093738A1 (en) | 2006-10-06 | 2010-04-15 | Basf Se | Fungicidal Compounds and Fungicidal Compositions |
| US20090137549A1 (en) | 2006-11-09 | 2009-05-28 | Paul John Edward | Novel compounds useful for the treatment of degenerative & inflamatory diseases |
| AU2007338410B2 (en) | 2006-12-27 | 2012-08-16 | Sanofi-Aventis | Cycloalkylamine substituted isoquinoline derivatives |
| CN101595094B (zh) | 2006-12-27 | 2013-02-20 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹诺酮衍生物 |
| WO2008104994A2 (en) | 2007-02-28 | 2008-09-04 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| JP2008260716A (ja) | 2007-04-12 | 2008-10-30 | Sumitomo Chemical Co Ltd | ヒドラジド化合物及びそれを含有する有害節足動物防除剤 |
| JP2008280339A (ja) | 2007-04-12 | 2008-11-20 | Sumitomo Chemical Co Ltd | ヒドラジド化合物及びそれを含有する有害節足動物防除剤 |
| KR20100031578A (ko) | 2007-05-24 | 2010-03-23 | 메모리 파마슈티칼스 코포레이션 | 5-ｈｔ6 수용체 친화성을 갖는 4'-치환된 화합물 |
| MX2010005033A (es) | 2007-11-06 | 2010-05-27 | Du Pont | Aminas heterociclicas fungicidas. |
| US9446995B2 (en) | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| US10189803B2 (en) | 2008-02-22 | 2019-01-29 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| GB0808953D0 (en) | 2008-05-16 | 2008-06-25 | Shire Llc | substituted quinazolines |
| GB0808951D0 (en) | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808952D0 (en) | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808967D0 (en) | 2008-05-16 | 2008-06-25 | Shire Llc | Substitute quinazolines |
| GB0808950D0 (en) | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808947D0 (en) | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| ES2533788T3 (es) | 2008-05-30 | 2015-04-14 | Genentech, Inc. | Compuestos inhibidores de PI3K de tipo purina y métodos de uso |
| US8440827B2 (en) | 2008-07-31 | 2013-05-14 | Duke University | Photolabile caged transition metal complexes and methods of using the same |
| WO2010039982A1 (en) | 2008-10-01 | 2010-04-08 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| US8497269B2 (en) | 2008-10-10 | 2013-07-30 | Amgen Inc. | Phthalazine compounds as p38 map kinase modulators and methods of use thereof |
| US8772481B2 (en) | 2008-10-10 | 2014-07-08 | Amgen Inc. | Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof |
| JP5819730B2 (ja) | 2008-12-22 | 2015-11-24 | ケモセントリックス，インコーポレイティド | Ｃ５ａＲアンタゴニスト |
| JP2012521429A (ja) | 2009-03-23 | 2012-09-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛治療用のｐ２ｘ３受容体アンタゴニスト |
| WO2010138685A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
| WO2010138659A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating brain tumors |
| WO2010138695A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating neurofibromatosis |
| WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
| WO2010138706A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating breast cancer |
| US9221765B2 (en) | 2009-06-10 | 2015-12-29 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives |
| WO2011003932A2 (de) | 2009-07-10 | 2011-01-13 | Basf Se | Verfahren zur direktaminierung von kohlenwasserstoffen zu aminokohlenwasserstoffen mit elektrochemischer abtrennung von wasserstoff |
| KR20120051022A (ko) | 2009-07-21 | 2012-05-21 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리데 바이러스의억제제 |
| JP2013501003A (ja) | 2009-07-31 | 2013-01-10 | バイオクライスト ファーマシューティカルズ， インコーポレイテッド | ヤヌスキナーゼ阻害剤としてのピロロ［１，２−ｂ］ピリダジン誘導体 |
| JP2011057661A (ja) | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
| TW201124078A (en) | 2009-12-22 | 2011-07-16 | Du Pont | Fungicidal 2-(bicyclic aryloxy) carboxamides |
| TWI491609B (zh) | 2010-01-15 | 2015-07-11 | Gilead Sciences Inc | 黃熱病毒科（Ｆｌａｖｉｖｉｒｉｄａｅ）病毒之抑制劑類 |
| EA201290575A1 (ru) | 2010-01-15 | 2013-01-30 | Джилид Сайэнс, Инк. | Ингибиторы вирусов flaviviridae |
| US20120329704A1 (en) | 2010-02-25 | 2012-12-27 | Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patieentenzorg | Process for the preparation of substituted prolyl peptides and similar peptidomimetics |
| WO2011132048A1 (en) | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceutical S.A. | Heteroaryl compounds as pde10a inhibitors |
| WO2011133659A2 (en) | 2010-04-20 | 2011-10-27 | Emory University | Inhibitors of hif and angiogenesis |
| WO2011146748A1 (en) | 2010-05-21 | 2011-11-24 | New York University | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase |
| WO2012022045A1 (en) | 2010-08-20 | 2012-02-23 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
| BR112013005223A2 (pt) | 2010-09-03 | 2016-05-03 | Bayer Ip Gmbh | "pirimidinonas e dihidropirimidinonas fusionadas substituídas." |
| AU2011320651A1 (en) | 2010-10-29 | 2013-05-02 | Merck Canada Inc. | HIV integrase inhibitors |
| WO2012058531A2 (en) | 2010-10-29 | 2012-05-03 | North Carolina State University | Modulation of response regulators by imidazole derivatives |
| WO2012087372A1 (en) | 2010-12-22 | 2012-06-28 | E. I. Du Pont De Nemours And Company | Fungicidal 2-(bicyclic aryloxy)carboxamides |
| WO2012125668A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| CA2833887A1 (en) | 2011-05-04 | 2012-11-08 | Merck Sharp & Dohme Corp. | Drug substances, pharmaceutical compositions and methods for preparing the same |
| CA2833507A1 (en) | 2011-06-07 | 2012-12-13 | Dainippon Sumitomo Pharma Co., Ltd. | Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102838523A (zh) | 2011-06-23 | 2012-12-26 | 南开大学 | 抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途 |
| JP6121658B2 (ja) | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | 治療用化合物、及び関連する使用の方法 |
| EP2731953A1 (en) | 2011-07-15 | 2014-05-21 | Abbvie Inc. | Tricyclic inhibitors of kinases useful for the treatment of proliferative diseases |
| CN103732567A (zh) | 2011-08-22 | 2014-04-16 | 先正达参股股份有限公司 | 作为杀虫化合物的二氢呋喃衍生物 |
| CA2850003C (en) | 2011-09-27 | 2020-01-07 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
| CN103130710B (zh) | 2011-11-29 | 2015-12-16 | 南开大学 | 抗肠病毒71(ev71)己内酰胺醛类化合物及其制备方法和用途 |
| CN103145608B (zh) | 2011-12-07 | 2015-09-02 | 南开大学 | 抗肠病毒71(ev71)己内酰胺类化合物及其制备方法和用途 |
| US9643974B2 (en) | 2011-12-12 | 2017-05-09 | Bayer Intellectual Property Gmbh | Amino-substituted imidazopyridazines |
| US9453014B2 (en) | 2011-12-22 | 2016-09-27 | Connexios Life Sciences Pvt. Ltd. | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof |
| SG11201402765TA (en) | 2011-12-30 | 2014-06-27 | Hanmi Pharm Ind Co Ltd | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES |
| US20150080381A1 (en) | 2012-04-12 | 2015-03-19 | Ironwood Pharmaceuticals, Inc. | Methods of treating alopecia and acne |
| CN104350039B (zh) | 2012-04-20 | 2017-10-03 | 组合化学工业株式会社 | 烷基苯基硫醚衍生物及有害生物防除剂 |
| CA2872147A1 (en) | 2012-05-02 | 2013-11-07 | Kansas State University Research Foundation | Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses |
| WO2013181135A1 (en) | 2012-05-31 | 2013-12-05 | Emory University | Quinazoline derivatives, compositions, and uses related thereto |
| US10314816B2 (en) | 2012-06-08 | 2019-06-11 | Wisconsin Alumni Research Foundation | Antimicrobial compounds, compositions and methods of use thereof |
| KR20150028999A (ko) | 2012-06-27 | 2015-03-17 | 에프. 호프만-라 로슈 아게 | 5-아자인다졸 화합물 및 이의 사용 방법 |
| EP2733143A1 (en) | 2012-11-14 | 2014-05-21 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands |
| WO2014078214A1 (en) | 2012-11-15 | 2014-05-22 | Merck Sharp & Dohme Corp. | Azetidine benzimidazoles as pde10 inhibitors |
| JP2014133739A (ja) | 2012-12-12 | 2014-07-24 | Dainippon Sumitomo Pharma Co Ltd | インダゾール誘導体またはピロロピリジン誘導体からなる医薬 |
| ES2684776T3 (es) | 2013-01-18 | 2018-10-04 | Bristol-Myers Squibb Company | Ftalazinonas e isoquinolinonas como inhibidores de ROCK |
| WO2014172871A1 (en) | 2013-04-25 | 2014-10-30 | Syngenta Participations Ag | Dihydrobenzofuran derivatives as insecticidal compounds |
| TWI646092B (zh) | 2013-08-26 | 2019-01-01 | 拜耳作物科學股份有限公司 | 具有殺蟲活性之化合物 |
| WO2015036059A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
| CA2923101A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
| AU2014331111B2 (en) | 2013-10-04 | 2018-05-31 | Bayer Cropscience Aktiencesellschaft | Use of substituted dihydro-oxindolyl sulfonamides, or the salts thereof, for increasing the stress tolerance of plants |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| JP5542237B1 (ja) | 2013-11-28 | 2014-07-09 | 新日鉄住金エンジニアリング株式会社 | 高炉ガス乾式集塵設備のガス温度調節方法および高炉ガス乾式集塵設備 |
| WO2015104254A1 (en) | 2014-01-09 | 2015-07-16 | Bayer Pharma Aktiengesellschaft | Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders |
| EP3096751B1 (en) | 2014-01-22 | 2021-01-06 | Nabriva Therapeutics GmbH | 12-epi-pleuromutilins |
| NO2699580T3 (enExample) | 2014-01-24 | 2018-02-24 | ||
| JP6295702B2 (ja) | 2014-02-14 | 2018-03-20 | 東洋インキＳｃホールディングス株式会社 | 反応性単量体、およびそれを用いた重合性組成物 |
| WO2015143653A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| JP6577958B2 (ja) | 2014-04-11 | 2019-09-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | スピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン誘導体およびＭＤＭ２−ｐ５３阻害剤としてのそれらの使用 |
| CN105037367A (zh) | 2014-04-18 | 2015-11-11 | 四川海思科制药有限公司 | 氨基六元环类衍生物及其在医药上的应用 |
| US9884876B2 (en) | 2014-05-09 | 2018-02-06 | Kineta, Inc. | Anti-viral compounds, pharmaceutical compositions, and methods of use thereof |
| DK3154957T3 (da) | 2014-06-16 | 2020-02-17 | Fundacion Para La Investig Medica Aplicada | Hidtil ukendte forbindelser som dobbelte inhibitorer af histonmethyltransferaser og dna-methyltransferaser |
| EP2957561A1 (en) | 2014-06-18 | 2015-12-23 | Université Paris 6 Pierre et Marie Curie UPMC | Novel fluoroquinolones and use thereof to treat bacterial infections |
| US9873680B2 (en) | 2014-08-29 | 2018-01-23 | Gilead Sciences, Inc. | Therapeutic compounds |
| WO2016050921A1 (en) | 2014-10-02 | 2016-04-07 | F. Hoffmann-La Roche Ag | Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk) |
| CN105566321B (zh) | 2014-10-29 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| JP6695875B2 (ja) | 2014-11-20 | 2020-05-20 | カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ | 抗がん剤としての新規な１，３，５−トリアジン系ｐｉ３ｋ阻害剤及びその製造方法 |
| JP6858712B2 (ja) | 2015-01-30 | 2021-04-14 | リーバー インスティテュート フォー ブレイン ディベロップメントＬｉｅｂｅｒ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｒａｉｎ Ｄｅｖｅｌｏｐｍｅｎｔ | Ｃｏｍｔ阻害方法及び組成物 |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502045D0 (en) | 2015-02-06 | 2015-03-25 | Ocado Innovation Ltd | Device and method for purchasing goods and services |
| US9409872B1 (en) | 2015-02-16 | 2016-08-09 | Mark Quang Nguyen | Fumarate compounds, pharmaceutical compositions thereof, and methods of use |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| EP3308562B1 (en) | 2015-06-15 | 2020-12-09 | ARRIS Enterprises LLC | Operator formed network consortiums |
| GB2548542A (en) | 2015-06-16 | 2017-09-27 | Redx Pharma Plc | Compounds |
| FR3037955B1 (fr) | 2015-06-25 | 2017-08-18 | Univ Nantes | Ligands polydentates et complexes metalliques |
| HK1246781A1 (zh) | 2015-07-30 | 2018-09-14 | 美迪维尔公司 | 呼吸道合胞病毒抑制剂 |
| HUE054985T2 (hu) | 2015-10-09 | 2021-11-29 | Boehringer Ingelheim Int | Spiro[3H-indol-3,2'-pirrolidin]-2(1H)-on vegyületek és számrazékok, mint MDM2-P53 inhibitorok |
| CN110072864B (zh) | 2015-12-24 | 2022-05-27 | 基因泰克公司 | Tdo2抑制剂 |
| CN106928206B (zh) | 2015-12-31 | 2022-02-18 | 中国科学院上海药物研究所 | 醛基类化合物及其制法和用途 |
| JP6806413B2 (ja) | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | 多環性ピリドン誘導体およびそのプロドラッグ |
| WO2017155816A1 (en) | 2016-03-09 | 2017-09-14 | Merck Sharp & Dohme Corp. | Quinazoline compounds useful as m1 receptor positive allosteric modulators |
| WO2017165311A1 (en) | 2016-03-21 | 2017-09-28 | Perlstein Lab Pbc | Fused heterocyclic organic compounds and uses thereof |
| US9975885B2 (en) | 2016-04-28 | 2018-05-22 | Purdue Research Foundation | Broad-spectrum non-covalent coronavirus protease inhibitors |
| TW201808888A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| TW201808903A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| TWI920577B (zh) | 2016-05-05 | 2026-04-01 | 美商嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| US11021513B2 (en) | 2016-05-13 | 2021-06-01 | Emory University | Peptidomimetics for the treatment of norovirus infection |
| CN107459511B (zh) | 2016-06-02 | 2020-05-29 | 南开大学 | 抗肠病毒71(ev71)4-亚氨基恶唑烷-2-酮类化合物及其制备方法和用途 |
| US20170355708A1 (en) | 2016-06-09 | 2017-12-14 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| US11013779B2 (en) | 2016-06-20 | 2021-05-25 | Kansas State University Research Foundation | Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses |
| DK3481826T3 (da) | 2016-07-08 | 2022-01-10 | Rigel Pharmaceuticals Inc | Tyrosinkinaseinhibitorer |
| WO2018015818A2 (en) | 2016-07-15 | 2018-01-25 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| WO2018023054A1 (en) | 2016-07-28 | 2018-02-01 | Kansas State University Research Foundation | Protease transition state inhibitor prodrugs |
| UY37381A (es) | 2016-08-30 | 2018-03-23 | Glaxosmithkline Ip No 2 Ltd | Compuestos que inhiben proteasas 3c y 3cl y métodos de uso de los mismos |
| CN108069984B (zh) | 2016-11-18 | 2021-02-05 | 沈阳中化农药化工研发有限公司 | 含嘧啶并环的取代五元杂环类化合物及其制备方法和用途 |
| WO2018108627A1 (de) | 2016-12-12 | 2018-06-21 | Bayer Cropscience Aktiengesellschaft | Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
| EP3342779A1 (en) | 2016-12-27 | 2018-07-04 | Zedira GmbH | Inhibitors of transglutaminases |
| US20180289676A1 (en) | 2017-03-30 | 2018-10-11 | Saint Louis University | Compounds and methods targeting gper in cancer |
| CN108690043B (zh) | 2017-04-11 | 2019-10-18 | 东莞东阳光科研发有限公司 | 喹啉类衍生物及其制备方法和用途 |
| KR102638253B1 (ko) | 2017-05-31 | 2024-02-16 | 케모센트릭스, 인크. | C5a 억제제로서의 6-5 융합 고리 |
| EP3642187A1 (en) | 2017-06-19 | 2020-04-29 | Basf Se | 2-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]aryloxy](thio)acetamides for combating phytopathogenic fungi |
| JP2020152641A (ja) | 2017-07-07 | 2020-09-24 | 国立研究開発法人理化学研究所 | リジン特異的脱メチル化酵素１阻害活性を有する新規化合物、その製造方法及びその用途 |
| AU2018344883B2 (en) | 2017-10-02 | 2024-03-07 | Scientist Of Fortune S.A. | Cellular transport system for transferring a sulfonic acid construct carrying a cargo into the cytoplasm of a cell |
| US10807951B2 (en) | 2017-10-13 | 2020-10-20 | The Regents Of The University Of California | mTORC1 modulators |
| WO2019086474A1 (en) | 2017-10-31 | 2019-05-09 | Syngenta Participations Ag | Pesticidally active mesoionics heterocyclic compounds |
| US12275729B2 (en) | 2017-11-01 | 2025-04-15 | Merck Sharp & Dohme Llc | Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors |
| WO2019104070A1 (en) | 2017-11-21 | 2019-05-31 | Nanostring Technologies, Inc. | O-nitrobenzyl photocleavable bifunctional linker |
| US20200305429A1 (en) | 2017-11-23 | 2020-10-01 | Basf Se | Herbicidal phenylethers |
| CN111902386A (zh) | 2017-12-28 | 2020-11-06 | 瑞璞鑫(苏州)生物科技有限公司 | 作为fto抑制剂的苯基甲酮衍生物 |
| CN109988109B (zh) | 2017-12-29 | 2020-12-29 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其用途 |
| GB201801355D0 (en) | 2018-01-26 | 2018-03-14 | Enterprise Therapeutics Ltd | Compounds |
| US11884645B2 (en) | 2018-03-02 | 2024-01-30 | Inflazome Limited | Sulfonyl acetamides as NLRP3 inhibitors |
| US20190282703A1 (en) | 2018-03-13 | 2019-09-19 | Mavupharma, Inc. | Ectonucleotide pyrophosphatase-phosphodiesterase (enpp) conjugates and uses thereof |
| WO2019191504A1 (en) | 2018-03-30 | 2019-10-03 | Mavupharma, Inc. | Ectonucleotide pyrophosphate-phosphodiesterase (enpp) conjugates and uses thereof |
| WO2019201432A1 (en) | 2018-04-17 | 2019-10-24 | Zedira Gmbh | Inhibitors of blood coagulation factor xiii |
| EP3781567B1 (en) | 2018-04-20 | 2022-08-24 | Virginia Tech Intellectual Properties, Inc. | Imidazopyridines useful as mitochondrial uncouplers |
| CN110054596B (zh) | 2018-05-29 | 2023-03-31 | 沈阳化工大学 | 一种取代噁二唑类化合物及其应用 |
| WO2019232245A1 (en) | 2018-06-01 | 2019-12-05 | The Regents Of The University Of California | A method for fluorinated ring-opening of a substrate |
| EP3820500A4 (en) | 2018-07-13 | 2022-04-13 | Teqla Therapeutics, Inc. | USE OF BCL6 INHIBITORS TO TREAT AUTOIMMUNE DISEASES |
| RU2761824C2 (ru) | 2018-08-03 | 2021-12-13 | Закрытое Акционерное Общество "Биокад" | Ингибиторы CDK8/19 |
| CN110818691A (zh) | 2018-08-09 | 2020-02-21 | 中国科学院上海药物研究所 | 酮酰胺类化合物及其制备方法、药物组合物和用途 |
| US11884685B2 (en) | 2018-08-16 | 2024-01-30 | Cornell University | Rhenium complexes and methods of use for treating cancer |
| EP3843846A4 (en) | 2018-08-27 | 2022-09-07 | Spinogenix, Inc. | FASCIN-BINDING COMPOUNDS FOR SPINOGENESIS |
| SG11202105256QA (en) | 2018-11-21 | 2021-06-29 | Accutar Biotechnology Inc | Novel compounds having estrogen receptor alpha degradation activity and uses thereof |
| EP3656762A1 (en) | 2018-11-26 | 2020-05-27 | Instituto Biomar S.A. | Compounds for the treatment of nf-kb-related diseases or disorders |
| SG11202105685TA (en) | 2019-01-03 | 2021-06-29 | Univ Pittsburgh Commonwealth Sys Higher Education | Methods and materials for increasing transcription factor eb polypeptide levels |
| TWI756636B (zh) | 2019-02-18 | 2022-03-01 | 美商建南德克公司 | 嘧啶并嘧啶化合物及使用方法 |
| WO2020169682A1 (en) | 2019-02-19 | 2020-08-27 | Yncrea Hauts De France | Hydrazide derivatives and their specific use as antibacterial agents by controlling acinetobacter baumannii bacterium |
| CN110105348A (zh) | 2019-03-08 | 2019-08-09 | 南开大学 | 新型迈克尔受体类肠病毒71型抑制剂的制备及用途 |
| KR20210145773A (ko) | 2019-03-28 | 2021-12-02 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 티에노헤테로고리형 유도체, 이의 제조 방법 및 이의 의약적 용도 |
| AU2020289560A1 (en) | 2019-06-05 | 2021-12-23 | Emory University | Peptidomimetics for the treatment of coronavirus and picornavirus infections |
| KR20220151038A (ko) * | 2020-03-31 | 2022-11-11 | 피닉스 바이오테크놀러지 인코포레이티드. | 코로나바이러스 감염 예방를 위한 조성물 |
| MX2021013934A (es) * | 2020-04-05 | 2021-12-15 | Pfizer | Compuestos y metodos para el tratamiento de covid-19. |
| IL297069A (en) * | 2020-04-10 | 2022-12-01 | Cocrystal Pharma Inc | Replication inhibitors of norovirus and corona virus |
| US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| GB2595975B (en) | 2020-06-09 | 2022-12-07 | Pardes Biosciences Inc | Inhibitors of cysteine proteases and methods of use thereof |
| BR112022025037A2 (pt) | 2020-06-10 | 2023-02-14 | Aligos Therapeutics Inc | Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus |
| EP4635972A3 (en) | 2020-07-20 | 2025-12-24 | Enanta Pharmaceuticals, Inc. | Functionalized peptides as antiviral agents |
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