MX2023003846A - Compuesto de bifenilo como inmunomodulador, metodo de preparacion del mismo y aplicacion del mismo. - Google Patents
Compuesto de bifenilo como inmunomodulador, metodo de preparacion del mismo y aplicacion del mismo.Info
- Publication number
- MX2023003846A MX2023003846A MX2023003846A MX2023003846A MX2023003846A MX 2023003846 A MX2023003846 A MX 2023003846A MX 2023003846 A MX2023003846 A MX 2023003846A MX 2023003846 A MX2023003846 A MX 2023003846A MX 2023003846 A MX2023003846 A MX 2023003846A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- application
- method therefor
- immunomodulator
- biphenyl compound
- Prior art date
Links
- -1 Biphenyl compound Chemical class 0.000 title abstract 2
- 235000010290 biphenyl Nutrition 0.000 title abstract 2
- 239000004305 biphenyl Substances 0.000 title abstract 2
- 239000002955 immunomodulating agent Substances 0.000 title abstract 2
- 229940121354 immunomodulator Drugs 0.000 title abstract 2
- 230000002584 immunomodulator Effects 0.000 title abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de bifenilo representado por la fórmula (I), un método de preparación del mismo, y una aplicación del mismo. La presente invención también se refiere a una composición farmacéutica que comprende el compuesto como un ingrediente activo. El compuesto es un novedoso inmunomodulador de molécula pequeña que tiene excelentes atributos de absorción oral y se puede utilizar para el tratamiento y/o la prevención de diversas enfermedades relacionadas con la inmunidad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011178102 | 2020-10-29 | ||
| PCT/CN2021/126917 WO2022089511A1 (zh) | 2020-10-29 | 2021-10-28 | 作为免疫调节剂的联苯类化合物及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003846A true MX2023003846A (es) | 2023-06-23 |
Family
ID=81381542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023003846A MX2023003846A (es) | 2020-10-29 | 2021-10-28 | Compuesto de bifenilo como inmunomodulador, metodo de preparacion del mismo y aplicacion del mismo. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11866452B2 (es) |
| EP (1) | EP4190782A4 (es) |
| JP (1) | JP2024504224A (es) |
| KR (1) | KR20230096985A (es) |
| CN (2) | CN115433212A (es) |
| AU (1) | AU2021369898A1 (es) |
| BR (1) | BR112023006312A2 (es) |
| CA (1) | CA3197685A1 (es) |
| MX (1) | MX2023003846A (es) |
| TW (1) | TW202227436A (es) |
| WO (1) | WO2022089511A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230096985A (ko) | 2020-10-29 | 2023-06-30 | 쉔젠 칩스크린 바이오사이언스 씨오., 엘티디. | 면역조절제로서의 비페닐 화합물, 이의 제조방법 및 이의 적용 |
| WO2023207933A1 (zh) * | 2022-04-26 | 2023-11-02 | 深圳微芯生物科技股份有限公司 | 一种作为免疫调节剂的联苯类化合物的晶型及其制备方法 |
| TW202346308A (zh) * | 2022-04-26 | 2023-12-01 | 大陸商深圳微芯生物科技股份有限公司 | 作為免疫調節劑的聯苯類化合物的鹽型、晶型及其製備方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102641030B1 (ko) * | 2016-12-22 | 2024-02-29 | 인사이트 코포레이션 | Pd-l1 내재화 유도제로서의 테트라하이드로 이미다조[4,5-c]피리딘 유도체 |
| CN112752756A (zh) * | 2018-05-11 | 2021-05-04 | 因赛特公司 | 作为PD-L1免疫调节剂的四氢-咪唑并[4,5-c]吡啶衍生物 |
| CN111039942B (zh) | 2018-10-12 | 2023-04-14 | 上海长森药业有限公司 | 含氮杂环类化合物，及其制备方法、药物组合物和应用 |
| KR20230096985A (ko) | 2020-10-29 | 2023-06-30 | 쉔젠 칩스크린 바이오사이언스 씨오., 엘티디. | 면역조절제로서의 비페닐 화합물, 이의 제조방법 및 이의 적용 |
| KR20230141812A (ko) * | 2021-02-01 | 2023-10-10 | 쉔젠 칩스크린 바이오사이언스 씨오., 엘티디. | 면역 조절제로서의 바이페닐 화합물, 이의 제조방법 및 용도 |
-
2021
- 2021-10-28 KR KR1020237011531A patent/KR20230096985A/ko unknown
- 2021-10-28 MX MX2023003846A patent/MX2023003846A/es unknown
- 2021-10-28 CA CA3197685A patent/CA3197685A1/en active Pending
- 2021-10-28 CN CN202211181776.9A patent/CN115433212A/zh active Pending
- 2021-10-28 EP EP21885238.2A patent/EP4190782A4/en active Pending
- 2021-10-28 US US18/029,869 patent/US11866452B2/en active Active
- 2021-10-28 WO PCT/CN2021/126917 patent/WO2022089511A1/zh active Application Filing
- 2021-10-28 TW TW110140123A patent/TW202227436A/zh unknown
- 2021-10-28 JP JP2023521026A patent/JP2024504224A/ja active Pending
- 2021-10-28 CN CN202180004723.7A patent/CN114698376B/zh active Active
- 2021-10-28 AU AU2021369898A patent/AU2021369898A1/en active Pending
- 2021-10-28 BR BR112023006312A patent/BR112023006312A2/pt unknown
-
2023
- 2023-11-15 US US18/510,546 patent/US20240109919A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022089511A1 (zh) | 2022-05-05 |
| EP4190782A1 (en) | 2023-06-07 |
| US20230365590A1 (en) | 2023-11-16 |
| CA3197685A1 (en) | 2022-05-05 |
| EP4190782A4 (en) | 2024-01-03 |
| JP2024504224A (ja) | 2024-01-31 |
| CN114698376B (zh) | 2022-10-18 |
| CN115433212A (zh) | 2022-12-06 |
| US20240109919A1 (en) | 2024-04-04 |
| CN114698376A (zh) | 2022-07-01 |
| BR112023006312A2 (pt) | 2023-05-09 |
| US11866452B2 (en) | 2024-01-09 |
| KR20230096985A (ko) | 2023-06-30 |
| AU2021369898A1 (en) | 2023-05-18 |
| TW202227436A (zh) | 2022-07-16 |
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