CL2023000167A1 - Péptidos funcionalizados como agentes antivirales - Google Patents

Péptidos funcionalizados como agentes antivirales

Info

Publication number
CL2023000167A1
CL2023000167A1 CL2023000167A CL2023000167A CL2023000167A1 CL 2023000167 A1 CL2023000167 A1 CL 2023000167A1 CL 2023000167 A CL2023000167 A CL 2023000167A CL 2023000167 A CL2023000167 A CL 2023000167A CL 2023000167 A1 CL2023000167 A1 CL 2023000167A1
Authority
CL
Chile
Prior art keywords
formula
pharmaceutically acceptable
antiviral agents
functionalized peptides
subject
Prior art date
Application number
CL2023000167A
Other languages
English (en)
Inventor
Dexter Davis
Samuel Bartlett
Joseph D Panarese
Nathaniel Thomas Kenton
Sean Rafferty
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=79729492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2023000167(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CL2023000167A1 publication Critical patent/CL2023000167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención divulga compuestos de fórmula (I), y sales farmacéuticamente aceptables de los mismos, que inhiben la actividad de replicación del coronavirus. La invención se refiere además a composiciones farmacéuticas que comprenden un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo, y a métodos de tratamiento o prevención de una infección por coronavirus en un sujeto que lo necesita, que comprenden administrar al sujeto una cantidad terapéuticamente eficaz de un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo.
CL2023000167A 2020-07-20 2023-01-18 Péptidos funcionalizados como agentes antivirales CL2023000167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063054048P 2020-07-20 2020-07-20

Publications (1)

Publication Number Publication Date
CL2023000167A1 true CL2023000167A1 (es) 2023-09-08

Family

ID=79729492

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023000167A CL2023000167A1 (es) 2020-07-20 2023-01-18 Péptidos funcionalizados como agentes antivirales

Country Status (17)

Country Link
US (3) US20220033383A1 (es)
EP (1) EP4051265A4 (es)
JP (1) JP2023535701A (es)
KR (1) KR20230069090A (es)
CN (1) CN116348477A (es)
AU (1) AU2021313130A1 (es)
BR (1) BR112022026899A2 (es)
CA (1) CA3173964A1 (es)
CL (1) CL2023000167A1 (es)
CO (1) CO2023000199A2 (es)
DE (3) DE202021004113U1 (es)
ES (2) ES2922973T1 (es)
GB (2) GB2619610A (es)
HU (1) HUE21846991T1 (es)
IL (1) IL300027A (es)
MX (1) MX2023000798A (es)
WO (1) WO2022020242A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11124497B1 (en) * 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
WO2022109360A1 (en) 2020-11-23 2022-05-27 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
EP4209494B1 (en) * 2021-04-16 2024-10-09 Fujian Akeylink Biotechnology Co., Ltd. Ring-modified proline short peptide compound and use thereof
US11970502B2 (en) 2021-05-04 2024-04-30 Enanta Pharmaceuticals, Inc. Macrocyclic antiviral agents
US20230033285A1 (en) * 2021-06-16 2023-02-02 The Scripps Research Institute Protease Inhibitors for Treatment of Coronavirus Infections
EP4366831A1 (en) 2021-07-09 2024-05-15 Aligos Therapeutics, Inc. Anti-viral compounds
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds
US11858945B2 (en) 2021-11-12 2024-01-02 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
WO2023086400A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11912714B2 (en) 2021-11-12 2024-02-27 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023088418A1 (en) * 2021-11-20 2023-05-25 Fochon Biosciences, Ltd. Compounds as sars-cov-2 inhibitors
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
CN116888099A (zh) * 2021-12-22 2023-10-13 福建广生中霖生物科技有限公司 含β-胺基酮的短肽化合物及其应用
TW202334123A (zh) * 2021-12-31 2023-09-01 大陸商蘇州愛科百發生物醫藥技術有限公司 用於預防和治療冠狀病毒感染的化合物及其偶聯物和方法
US12006291B2 (en) 2022-01-11 2024-06-11 Enanta Pharmaceuticals, Inc. Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid
CN118451090A (zh) * 2022-01-13 2024-08-06 海南先声药业有限公司 一种酰胺类抗病毒化合物
US11760722B2 (en) 2022-01-18 2023-09-19 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
CN114230504B (zh) * 2022-02-24 2022-06-03 南京桦冠生物技术有限公司 一种吡咯烷酮中间体的合成方法
CN116768967A (zh) * 2022-03-07 2023-09-19 广州谷森制药有限公司 氘代内酰胺类化合物及其制备方法、组合物和用途
CN114957383A (zh) * 2022-04-01 2022-08-30 中国科学院上海药物研究所 一种拟肽类化合物及其制备方法、药物组合物和用途
WO2024059087A1 (en) * 2022-09-13 2024-03-21 Takeda Pharmaceutical Company Limited 3-(1h-indole-2-carbonyl)-6,6-dimethyl-n-((s)-1-oxo-3-((s)-2-oxopyrrolidin-3-yl)p ropan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide derivatives as mpro inhibitors for the treatment of coronavirus infections
WO2024107778A1 (en) * 2022-11-15 2024-05-23 Takeda Pharmaceutical Company Limited Novel protease inhibitors for treatment of coronavirus infections
WO2024112621A1 (en) * 2022-11-22 2024-05-30 Merck Sharp & Dohme Llc 2-amino-n-(4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)benzamide derivatives as protease inhibitors for treating or preventing coronavirus infection

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
US6083922A (en) 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
EP1628674A2 (en) 2003-05-06 2006-03-01 Cytovia, Inc. Protease inhibitors for coronaviruses and sars-cov and the use thereof
WO2004101781A1 (en) 2003-05-13 2004-11-25 Universität Zu Lübeck Crystal structure of human coronavirus 229e main proteinase, and uses thereof for developing sars inhibitors
US20060014821A1 (en) * 2003-08-27 2006-01-19 Agouron Pharmaceuticals, Inc. Inhibitors of SARS 3C like protease
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
WO2005113580A1 (en) * 2004-05-21 2005-12-01 Pfizer Inc. Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
WO2006061714A2 (en) 2004-12-09 2006-06-15 Pfizer Inc. Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
EP1783228A1 (en) 2005-11-08 2007-05-09 ETH Zürich Recombinant expression of multiprotein complexes using polygenes
WO2007081447A2 (en) 2005-11-22 2007-07-19 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
SG10201503055TA (en) 2006-07-05 2015-06-29 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
EP3150701B1 (en) 2009-06-05 2018-10-03 FUJIFILM Cellular Dynamics, Inc. Reprogramming t cells and hematopoietic cells
US9008723B2 (en) * 2010-01-08 2015-04-14 United States Foundation For Inspiration And Recognition Of Science And Technology Wireless adapter
AU2011267849B2 (en) 2010-06-15 2015-02-05 FUJIFILM Cellular Dynamics, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
EP2760827A4 (en) 2011-09-27 2015-06-24 Univ Kansas State ANTIVIRAL MEDIUM WITH A WIDE SPECTRUM AGAINST 3C OR 3C-SIMILAR PROTEASES FROM PICORNIVIRUS SUPERCLUSTS: PICORNIVERS, CALICIVIRES AND CORONA VIRUSES
CN104220461A (zh) 2011-12-29 2014-12-17 Atyr医药公司 天冬氨酰-tRNA合成酶-FC缀合物
US9828342B2 (en) 2012-02-24 2017-11-28 City Of Hope Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof
WO2013166319A1 (en) 2012-05-02 2013-11-07 Kansas State University Research Foundation Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses
US9791436B2 (en) 2012-09-12 2017-10-17 The University Of Queensland Protease-based biosensor
KR20150105979A (ko) 2013-01-11 2015-09-18 임파서블 푸즈 인크. 코아세르베이트를 포함하는 비-낙농 치즈 모조물
US20160068820A9 (en) 2013-02-08 2016-03-10 The United States Of America, As Represented By The Secretary Of Agriculture Novel Nylanderia Pubens Virus
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
JP6543626B2 (ja) 2013-07-29 2019-07-10 ブルーバード バイオ， インコーポレイテッド 多部分シグナル伝達タンパク質およびその使用
EP3044322A4 (en) 2013-09-12 2017-09-06 The University Of Queensland Bimolecular protease-based biosensor
GB201320351D0 (en) 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
US10774343B2 (en) 2014-04-25 2020-09-15 Bluebird Bio, Inc. MND promoter chimeric antigen receptors
US10023879B2 (en) 2014-06-04 2018-07-17 Fate Therapeutics, Inc. Minimal volume reprogramming of mononuclear cells
CA2951044C (en) 2014-06-06 2023-10-03 Bluebird Bio, Inc. Improved t cell compositions
US10017463B2 (en) 2014-07-21 2018-07-10 Brandeis University Inhibitors of deubiquitinating proteases
GB201413020D0 (en) 2014-07-23 2014-09-03 Pribright The Inst Coronavirus
US9328147B2 (en) 2014-09-05 2016-05-03 Chung Yuan Christian University Recombinant baculovirus vector and uses thereof
DK3628687T3 (da) 2014-12-12 2021-10-18 2Seventy Bio Inc Kimære bcma-antigenreceptorer
WO2016138421A1 (en) 2015-02-27 2016-09-01 Iowa State University Research Foundation, Inc. Porcine epidemic diarrhea virus strains and immunogenic compositions therefrom
WO2017034175A1 (en) 2015-08-21 2017-03-02 Lg Electronics Inc. Method for transmitting information for lte-wlan aggregation system and a device therefor
US11058779B2 (en) 2015-09-08 2021-07-13 Sirnaomics, Inc. Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
US9975885B2 (en) 2016-04-28 2018-05-22 Purdue Research Foundation Broad-spectrum non-covalent coronavirus protease inhibitors
WO2017197377A1 (en) 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection
WO2017222935A1 (en) 2016-06-20 2017-12-28 Kansas State University Research Foundation Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses
US11033600B2 (en) 2016-07-28 2021-06-15 Kansas State University Research Foundation Protease transition state inhibitor prodrugs
TW201817714A (zh) * 2016-08-30 2018-05-16 英商葛蘭素史密斯克藍智慧財產權有限公司 抑制3c及3cl蛋白酶之化合物及其使用方法
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
US20210147818A1 (en) 2017-05-25 2021-05-20 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
MX2021014742A (es) 2019-06-05 2022-02-11 Univ Emory Peptidomimeticos para el tratamiento de infecciones por coronavirus y picornavirus.
US11045546B1 (en) 2020-03-30 2021-06-29 Cytodyn Inc. Methods of treating coronavirus infection
WO2021205296A1 (en) 2020-04-05 2021-10-14 Pfizer Inc. Method of treating covid-19
US20230148179A1 (en) 2020-04-08 2023-05-11 Arizona Board Of Regents On Behalf Of The University Of Arizona SMALL MOLECULE INHIBITORS OF SARS-CoV-2 VIRAL REPLICATION AND USES THEREOF
US20230131564A1 (en) 2020-04-10 2023-04-27 Cocrystal Phaema, Inc. Inhibitors of norovirus and coronavirus replication
KR20230008079A (ko) 2020-04-10 2023-01-13 코크리스탈 파마, 아이엔씨. 노로바이러스 및 코로나바이러스 복제 억제제
US11124497B1 (en) 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
EP4146267A1 (en) * 2020-05-08 2023-03-15 The Board of Trustees of the Leland Stanford Junior University Protease inhibitors for treatment or prevention of coronavirus disease
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
AU2021286560A1 (en) * 2020-06-09 2023-02-02 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
IL298324A (en) 2020-06-10 2023-01-01 Aligos Therapeutics Inc Antiviral compounds for the treatment of coronavirus, picornavirus and novovirus infections
WO2022013684A1 (en) * 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US10959969B1 (en) 2020-07-24 2021-03-30 Lanny L Johnson Methods of treating SARS Cov-2 virus with protocatechuic acid
WO2022020711A1 (en) 2020-07-24 2022-01-27 The Texas A&M University System Sars-cov-2 main protease inhibitors
CN115960088B (zh) * 2020-07-31 2024-07-26 四川大学 一种新型冠状病毒主蛋白酶的抑制剂及其制备方法和用途
US11351149B2 (en) * 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
EP4209494B1 (en) * 2021-04-16 2024-10-09 Fujian Akeylink Biotechnology Co., Ltd. Ring-modified proline short peptide compound and use thereof
WO2022251615A1 (en) * 2021-05-28 2022-12-01 Arun K Ghosh Compounds for the treatment of sars
EP4347034A1 (en) * 2021-06-02 2024-04-10 ACEA Therapeutics, Inc. Protease inhibitors as antivirals
EP4159211A1 (en) * 2021-07-15 2023-04-05 National Center for Global Health and Medicine Compound exhibiting physiological activity such as antiviral activity

Also Published As

Publication number Publication date
GB2607514A (en) 2022-12-07
KR20230069090A (ko) 2023-05-18
DE21846991T1 (de) 2022-07-21
EP4051265A4 (en) 2022-12-28
CA3173964A1 (en) 2022-01-27
ES2936277R1 (es) 2023-04-18
IL300027A (en) 2023-03-01
DE112021000413B4 (de) 2023-02-23
EP4051265A1 (en) 2022-09-07
DE202021004113U1 (de) 2022-08-29
GB2607514B (en) 2023-06-21
GB202211934D0 (en) 2022-09-28
CO2023000199A2 (es) 2023-04-17
ES2922973T1 (es) 2022-09-22
US20220033383A1 (en) 2022-02-03
HUE21846991T1 (hu) 2022-09-28
US20220041652A1 (en) 2022-02-10
CN116348477A (zh) 2023-06-27
JP2023535701A (ja) 2023-08-21
GB202306834D0 (en) 2023-06-21
WO2022020242A1 (en) 2022-01-27
DE112021000413T5 (de) 2022-12-01
ES2936277A2 (es) 2023-03-15
US20220073499A1 (en) 2022-03-10
US11358953B2 (en) 2022-06-14
GB2619610A (en) 2023-12-13
MX2023000798A (es) 2023-02-27
AU2021313130A1 (en) 2023-02-09
BR112022026899A2 (pt) 2023-01-24

Similar Documents

Publication Publication Date Title
CL2023000167A1 (es) Péptidos funcionalizados como agentes antivirales
UY39529A (es) Nuevos agentes antivirales derivados de espiropirrolidina
CO2023002852A2 (es) Péptidos funcionalizados como agentes antivirales
MY196455A (en) Nitrile-Containing Compounds Useful as Antiviral Agents for The Treatment of a Coronavirus Infection
MX2023005983A (es) Nuevos agentes antivirales derivados de la espiropirrolidina.
CR20230616A (es) Análogos de triazolo pirimidina para el tratamiento de enfermedades relacionadas con la inhibición de la helicasa recq del síndrome de werner (wrn)
CO2021008055A2 (es) Heterociclos funcionalizados como agentes antivirales
UY37998A (es) Agentes antivirales contra la hepatitis b
EA200702445A1 (ru) Соединения тиазола и способы их применения
RU2013121788A (ru) Ингибиторы репликации вич
DOP2005000039A (es) Hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)- piperidin-1-il]-(4-bomo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos
UY39032A (es) Compuestos heterocíclicos como agentes antivirales
AR127247A1 (es) Inhibidores de cdk2 de ciclopentilpirazol
DOP2023000060A (es) Inhibidores de la línea-1 para tratar enfermedades antecedentes de la invención
AR128931A1 (es) Inhibidores del factor b del complemento y usos de los mismos
CL2023000418A1 (es) Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos
UY38614A (es) Derivados de benzodiazepinas como inhibidores del rsv
AR126501A1 (es) Nuevos agentes antivirales derivados de espiropirrolidina
AR126482A1 (es) Agentes antivirales derivados de espiropirrolidina
MX2024001377A (es) Nuevos agentes antivirales derivados de la espiropirrolidina.
CL2022001935A1 (es) Compuestos antivirales que contienen nitrilo
PE20240881A1 (es) Uso de un inhibidor de la ezh2 en la preparacion de farmacos para el tratamiento del linfoma de linfocitos t
CL2021001093A1 (es) Compuestos, composiciones, y métodos para modular la actividad cdk9
UY39738A (es) Compuestos antivirales que contienen nitrilo
AR124136A1 (es) Nuevos compuestos orgánicos