AR127247A1 - Inhibidores de cdk2 de ciclopentilpirazol - Google Patents

Inhibidores de cdk2 de ciclopentilpirazol

Info

Publication number
AR127247A1
AR127247A1 ARP220102682A ARP220102682A AR127247A1 AR 127247 A1 AR127247 A1 AR 127247A1 AR P220102682 A ARP220102682 A AR P220102682A AR P220102682 A ARP220102682 A AR P220102682A AR 127247 A1 AR127247 A1 AR 127247A1
Authority
AR
Argentina
Prior art keywords
pharmaceutically acceptable
subject
pharmaceutical composition
cdk2
acceptable salt
Prior art date
Application number
ARP220102682A
Other languages
English (en)
Inventor
Jessica Marie Grandner
Kevin M Johnson
Steven Magnuson
Jeremy Mark Murray
Brendan T Parr
Vishal A Verma
Yong Wang
Mingshuo Zeng
Melissa A Ashley
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR127247A1 publication Critical patent/AR127247A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En la presente se describen compuestos de fórmula (1) y sales farmacéuticamente aceptables de estos, composiciones farmacéuticas que los comprenden, y sus usos y preparación. Reivindicación 70: Una composición farmacéutica que comprende un compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 69, o una sal farmacéuticamente aceptable de este, y un excipiente farmacéuticamente aceptable. Reivindicación 71: Un método para tratar un trastorno mediado por CDK2 en un sujeto que lo necesita, en donde el método comprende administrar al sujeto una cantidad terapéuticamente eficaz de un compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 69, o una sal farmacéuticamente aceptable de este, o una composición farmacéutica de acuerdo con la reivindicación 70. Reivindicación 74: Un método para elaborar un medicamento para tratar un trastorno mediado por CDK2 en un sujeto que lo necesita, caracterizado porque se usa el compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 69, o una sal farmacéuticamente aceptable de este, o una composición farmacéutica de acuerdo con la reivindicación 70.
ARP220102682A 2021-10-05 2022-10-04 Inhibidores de cdk2 de ciclopentilpirazol AR127247A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163252394P 2021-10-05 2021-10-05

Publications (1)

Publication Number Publication Date
AR127247A1 true AR127247A1 (es) 2024-01-03

Family

ID=84245758

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220102682A AR127247A1 (es) 2021-10-05 2022-10-04 Inhibidores de cdk2 de ciclopentilpirazol

Country Status (7)

Country Link
KR (1) KR20240077491A (es)
CN (1) CN118019734A (es)
AR (1) AR127247A1 (es)
AU (1) AU2022360968A1 (es)
CA (1) CA3229067A1 (es)
TW (1) TW202330501A (es)
WO (1) WO2023060057A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023208143A1 (zh) * 2022-04-28 2023-11-02 正大天晴药业集团股份有限公司 一种吡唑取代环戊酯衍生物及其用途
WO2024104455A1 (zh) * 2022-11-17 2024-05-23 山东绿叶制药有限公司 Cdk2抑制剂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU20210065A7 (es) * 2019-01-31 2022-04-07 Pfizer Compuestos de 3-carbonilamino-5-ciclopentil-1h-pirazol que tienen actividad inhibitoria en cdk2
CN110536068B (zh) 2019-09-29 2021-09-28 Oppo广东移动通信有限公司 对焦方法和装置、电子设备、计算机可读存储介质
TW202246255A (zh) * 2021-02-12 2022-12-01 美商傳達治療有限公司 Cdk抑制劑及其使用方法

Also Published As

Publication number Publication date
WO2023060057A1 (en) 2023-04-13
KR20240077491A (ko) 2024-05-31
AU2022360968A1 (en) 2024-02-29
CN118019734A (zh) 2024-05-10
TW202330501A (zh) 2023-08-01
CA3229067A1 (en) 2023-04-13

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