DK1159974T3 - Antiangiogene sammensætninger indeholdende taxol og en ikke-bionedbrydelig bærer og deres anvendelse - Google Patents

Antiangiogene sammensætninger indeholdende taxol og en ikke-bionedbrydelig bærer og deres anvendelse

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Publication number
DK1159974T3
DK1159974T3 DK01117873T DK01117873T DK1159974T3 DK 1159974 T3 DK1159974 T3 DK 1159974T3 DK 01117873 T DK01117873 T DK 01117873T DK 01117873 T DK01117873 T DK 01117873T DK 1159974 T3 DK1159974 T3 DK 1159974T3
Authority
DK
Denmark
Prior art keywords
compositions containing
biodegradable carrier
containing taxol
taxol
antiangiogenic compositions
Prior art date
Application number
DK01117873T
Other languages
Danish (da)
English (en)
Inventor
Lindsay S Machan
William L Hunter
Helen M Burt
A Larry Arsenault
Original Assignee
Angiotech Pharm Inc
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22245764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1159974(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angiotech Pharm Inc, Univ British Columbia filed Critical Angiotech Pharm Inc
Application granted granted Critical
Publication of DK1159974T3 publication Critical patent/DK1159974T3/da

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    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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DK01117873T 1993-07-19 1994-07-19 Antiangiogene sammensætninger indeholdende taxol og en ikke-bionedbrydelig bærer og deres anvendelse DK1159974T3 (da)

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Families Citing this family (440)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5994341A (en) * 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
NZ533467A (en) * 1993-07-19 2006-02-24 Angiotech Pharm Inc Anti-angiogenic compositions and methods of use
WO1995003795A1 (fr) 1993-07-29 1995-02-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Procede de traitement de l'atherosclerose ou de la restenose au moyen d'un agent de stabilisation des microtubules
US6025334A (en) * 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US6028118A (en) * 1996-08-08 2000-02-22 Les Laboratoires Aeterna Inc. Methods of using extracts of shark cartilage
US6380366B1 (en) 1994-04-28 2002-04-30 Les Laboratoires Aeterna Inc. Shark cartilage extract:process of making, methods of using and compositions thereof
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US20070203520A1 (en) * 1995-06-07 2007-08-30 Dennis Griffin Endovascular filter
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7867275B2 (en) * 1995-06-07 2011-01-11 Cook Incorporated Coated implantable medical device method
US7846202B2 (en) * 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
HUP9700322A3 (en) 1995-06-09 2001-03-28 Euro Celtique Sa Formulations and methods for providing prolonged local anesthesia
SI0932399T1 (sl) * 1996-03-12 2006-10-31 Pg Txl Co Lp Vodotopna paklitakselna predzdravila
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
NZ505584A (en) * 1996-05-24 2002-04-26 Univ British Columbia Delivery of a therapeutic agent to the smooth muscle cells of a body passageway via an adventia
AU775787B2 (en) * 1996-05-24 2004-08-12 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
WO1997049391A1 (fr) 1996-06-24 1997-12-31 Euro-Celtique, S.A. Methodes sures d'anesthesie locale
US7351421B2 (en) * 1996-11-05 2008-04-01 Hsing-Wen Sung Drug-eluting stent having collagen drug carrier chemically treated with genipin
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6204388B1 (en) * 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
DE69734362T2 (de) * 1996-12-03 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
US20050043376A1 (en) * 1996-12-03 2005-02-24 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO1998040088A1 (fr) 1997-03-11 1998-09-17 Les Laboratoires Aeterna Inc. Compositions pour traiter les tumeurs, contenant des extraits de cartilage de requin et des agents antineoplastiques
US6511477B2 (en) 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6306166B1 (en) 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
WO1999008729A1 (fr) * 1997-08-13 1999-02-25 Boston Scientific Limited Mise en charge et liberation de medicaments insolubles dans l'eau
DE69841984D1 (de) * 1997-09-05 2010-12-16 Maruho K K Zusammensetzung aus nanokapseln zur behandlung von intraarticulaeren erkrankungen
DE19744135C1 (de) * 1997-09-29 1999-03-25 Schering Ag Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
US6485514B1 (en) * 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
CA2318446C (fr) * 1998-03-04 2008-09-23 Takeda Chemical Industries, Ltd. Preparation a liberation prolongee d'un antagoniste de l'aii, sa production, et son utilisation
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
ATE219693T1 (de) * 1998-04-27 2002-07-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US6168807B1 (en) 1998-07-23 2001-01-02 Les Laboratoires Aeterna Inc. Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
AU771367B2 (en) * 1998-08-20 2004-03-18 Cook Medical Technologies Llc Coated implantable medical device
WO2000010552A2 (fr) * 1998-08-24 2000-03-02 Global Vascular Concepts, Inc. Utilisation d'agents anti-angiogeniques pour empecher la lesion des parois vasculaires
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
AU1821200A (en) * 1998-12-03 2000-06-19 Scimed Life Systems, Inc. Stent having drug crystals thereon
US6120847A (en) * 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
ATE297198T1 (de) * 1999-02-23 2005-06-15 Angiotech Int Ag Zusammensetzungen und verfahren zur verbesserung der integrität von angegriffenen körperpassagewegen und höhlen
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
AU3759100A (en) * 1999-03-24 2000-10-09 B.F. Goodrich Company, The Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
US6156373A (en) * 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6290673B1 (en) * 1999-05-20 2001-09-18 Conor Medsystems, Inc. Expandable medical device delivery system and method
US20040110722A1 (en) * 1999-05-27 2004-06-10 Ornberg Richard L. Modified hyaluronic acid polymers
ES2240101T3 (es) 1999-05-27 2005-10-16 Monsanto Company Biomateriales modificados con mimeticos de superoxido dismutasa.
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
DE29911689U1 (de) * 1999-07-06 2000-04-06 Sterk, Peter, Dr., 88212 Ravensburg Mittel für den Gefässverschluß von organischem Gewebe
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
EP1235598A2 (fr) * 1999-11-12 2002-09-04 Angiotech Pharmaceuticals, Inc. Compositions et methodes destinees au traitement de maladies utilisant une therapie radioactive et des inhibiteurs du cycle cellulaire combines
AU2609401A (en) * 1999-12-29 2001-07-09 Nicholas Kipshidze Apparatus and method for delivering compounds to a living organism
WO2001064214A2 (fr) * 2000-02-28 2001-09-07 The University Of British Columbia Compositions et methodes de traitement de maladies inflammatoires
WO2001066016A1 (fr) * 2000-03-06 2001-09-13 Scimed Life Systems, Inc. Agents emboliques visibles par ultrasons
US20020077290A1 (en) 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
US20030099683A1 (en) * 2000-03-18 2003-05-29 Michael Grunze Polyphosphazene derivatives
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
ES2551164T3 (es) * 2000-03-24 2015-11-16 Biosphere Medical, Inc. Microesferas para embolización activa
WO2001072280A2 (fr) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Compositions et methodes pour therapie genique
JP2004500918A (ja) 2000-04-11 2004-01-15 ポリゼニックス　ゲーエムベーハー ポリ−トリ−フルオロ−エトキシポリホスファゼンカバーリングおよびフィルム
US20090004240A1 (en) * 2000-08-11 2009-01-01 Celonova Biosciences, Inc. Implants with a phosphazene-containing coating
EP1179353A1 (fr) * 2000-08-11 2002-02-13 B. Braun Melsungen Ag Implants antithrombotiques avec un revêtement de polyphosphazène et d'un agent actif
ATE547080T1 (de) 2000-08-30 2012-03-15 Univ Johns Hopkins Vorrichtungen zur intraokularen arzneimittelabgabe
US7402173B2 (en) * 2000-09-18 2008-07-22 Boston Scientific Scimed, Inc. Metal stent with surface layer of noble metal oxide and method of fabrication
US7101391B2 (en) * 2000-09-18 2006-09-05 Inflow Dynamics Inc. Primarily niobium stent
ATE343969T1 (de) † 2000-09-29 2006-11-15 Cordis Corp Beschichtete medizinische geräte
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
EP1498084B1 (fr) 2000-10-16 2014-06-18 Innovational Holdings, LLC Dispositif médicale extensible destiné à l'apport d'un agent benefique
US7803149B2 (en) * 2002-07-12 2010-09-28 Cook Incorporated Coated medical device
WO2002068000A2 (fr) * 2000-11-16 2002-09-06 Microspherix Llc Grain de brachytherapie imageable polymere
US7776310B2 (en) 2000-11-16 2010-08-17 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
US6746661B2 (en) * 2000-11-16 2004-06-08 Microspherix Llc Brachytherapy seed
US7425217B2 (en) 2000-11-16 2008-09-16 Maier Nathan C System and method for inhibiting cellular proliferation with tachykinins
AU2002218995A1 (en) 2000-11-21 2002-06-03 Schering A.G. Tubular vascular implants (stents) and methods for producing the same
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
GB0100761D0 (en) * 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
DE10100961B4 (de) * 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
GB0100760D0 (en) 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US20020176893A1 (en) * 2001-02-02 2002-11-28 Wironen John F. Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue
US6685626B2 (en) 2001-02-02 2004-02-03 Regeneration Technologies, Inc. Compositions, devices, methods, and kits for induction of adhesions
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040204756A1 (en) * 2004-02-11 2004-10-14 Diaz Stephen Hunter Absorbent article with improved liquid acquisition capacity
US6964680B2 (en) * 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
GB0104383D0 (en) 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
EP1418945A2 (fr) 2001-03-13 2004-05-19 Angiotech Pharmaceuticals, Inc. Vecteurs de delivrance de medicament micellaires, leurs precurseurs et leurs utilisations
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
DE60220519T2 (de) * 2001-04-20 2007-09-27 The University Of British Columbia, Vancouver Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
US20030157161A1 (en) * 2001-05-01 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents
US7651695B2 (en) * 2001-05-18 2010-01-26 Advanced Cardiovascular Systems, Inc. Medicated stents for the treatment of vascular disease
US20030032935A1 (en) * 2001-08-10 2003-02-13 Scimed Life Systems, Inc. Packages facilitating convenient mixing and delivery of liquids
ATE340551T1 (de) * 2001-08-17 2006-10-15 Polyzenix Gmbh Vorrichtung auf basis von nitinol mit polyphosphazenüberzug
US20040249443A1 (en) * 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US20040121981A1 (en) * 2001-11-21 2004-06-24 Glycogenesys, Inc. Method for controlling angiogenesis in animals
US7927368B2 (en) 2002-03-25 2011-04-19 Kieran Murphy Llc Device viewable under an imaging beam
US9375203B2 (en) 2002-03-25 2016-06-28 Kieran Murphy Llc Biopsy needle
US20030181810A1 (en) 2002-03-25 2003-09-25 Murphy Kieran P. Kit for image guided surgical procedures
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) * 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
CN100553677C (zh) * 2002-04-22 2009-10-28 财团法人乙卯研究所 用于血管性疾病治疗的药物
NZ536308A (en) * 2002-05-24 2009-01-31 Angiotech Int Ag Compositions and methods for coating medical implants
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
CZ294371B6 (cs) * 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
AU2003240000A1 (en) 2002-06-12 2003-12-31 Boston Scientific Limited Bulking agents
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
CN100346850C (zh) * 2003-05-28 2007-11-07 微创医疗器械(上海)有限公司 一种药物涂层支架
US20080138377A1 (en) * 2002-07-05 2008-06-12 Celonova Biosciences, Inc. Vasodilator Eluting Luminal Stent Devices With A Specific Polyphosphazene Coating and Methods for Their Manufacture and Use
US20080138433A1 (en) * 2002-07-05 2008-06-12 Celonova Biosciences, Inc. Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US20040076582A1 (en) * 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
ES2281692T3 (es) 2002-08-23 2007-10-01 Sloan-Kettering Institute For Cancer Research Sintesis de epotilones, sus intermediarios, sus analogos y sus usos.
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP3887588B2 (ja) * 2002-08-30 2007-02-28 株式会社リガク Ｘ線回折による応力測定法
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
ES2428354T3 (es) * 2002-09-18 2013-11-07 Trustees Of The University Of Pennsylvania Rapamicina para usar en la inhibición o prevención de la neovascularización coroidea
US20040127976A1 (en) * 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
JP2006500121A (ja) * 2002-09-20 2006-01-05 コナー　メドシステムズ，　インコーポレイテッド 複数の有益な作用物質の送出用の開口を有する拡張式医療器具
MXPA05003183A (es) * 2002-09-26 2005-06-08 Angiotech Int Ag Evolturas perivasculares.
CA2501717C (fr) * 2002-10-15 2012-09-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Utilisation de derives d'epothilone pour le traitement de l'hyperparathyroidie
WO2004038752A2 (fr) * 2002-10-21 2004-05-06 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sources d'electronebulisation a capillaires contigus et dispositif analytique
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
WO2004043511A1 (fr) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Procede et appareil permettant de traiter une plaque arteriosclereuse vulnerable
US20040143321A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US20040142014A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US9770349B2 (en) 2002-11-13 2017-09-26 University Of Virginia Patent Foundation Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
EP1572032B1 (fr) 2002-11-13 2008-07-30 Setagon, Inc. Dispositifs medicaux comportant des couches poreuses et leurs procedes de fabrication
KR20200083657A (ko) 2002-12-09 2020-07-08 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
US7338557B1 (en) * 2002-12-17 2008-03-04 Advanced Cardiovascular Systems, Inc. Nozzle for use in coating a stent
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
JP2006525386A (ja) * 2003-03-26 2006-11-09 ポリゼニックス ゲーエムベーハー コーティングされた歯科用移植物
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
US20050002983A1 (en) * 2003-03-28 2005-01-06 Johnson Robert G. Devices, methods, and compositions to prevent restenosis
US20050010170A1 (en) * 2004-02-11 2005-01-13 Shanley John F Implantable medical device with beneficial agent concentration gradient
WO2004087214A1 (fr) 2003-03-28 2004-10-14 Conor Medsystems, Inc. Dispositif medical implantable a gradient de concentration d'agent utile
US7306580B2 (en) 2003-04-16 2007-12-11 Cook Incorporated Medical device with therapeutic agents
US20040220534A1 (en) * 2003-04-29 2004-11-04 Martens Paul W. Medical device with antimicrobial layer
JP4824549B2 (ja) * 2003-05-02 2011-11-30 サーモディクス，インコーポレイティド 制御放出型の生体活性物質デリバリー・デバイス
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US7169179B2 (en) * 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
CA2535345A1 (fr) * 2003-08-13 2005-03-03 Medtronic, Inc. Systemes de distribution d'agents actifs comprenant un melange de polymeres miscibles, dispositifs medicaux et procedes
WO2005018600A2 (fr) * 2003-08-22 2005-03-03 Cube Medical A/S Méthode de traitement d'un patient atteint d'une tumeur solide
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
CA2539324A1 (fr) * 2003-09-18 2005-03-31 Macusight, Inc. Administration transsclerale d'agents therapeutiques
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US7056337B2 (en) * 2003-10-21 2006-06-06 Cook Incorporated Natural tissue stent
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
FR2861993B1 (fr) * 2003-11-06 2006-01-21 Jean Claude Rigaud Complexe moleculaire anti restenose pour endoprothese intracoronaire
JP2007516740A (ja) * 2003-11-10 2007-06-28 アンジオテック インターナショナル アーゲー 医療移植片（ｉｍｐｌａｎｔｓ）および瘢痕化抑制剤
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
AU2004293463A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US20050209664A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Electrical devices and anti-scarring agents
CN1897930A (zh) * 2004-01-30 2007-01-17 血管技术国际股份公司 用于治疗挛缩的组合物和方法
US7349971B2 (en) * 2004-02-05 2008-03-25 Scenera Technologies, Llc System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information
US7294145B2 (en) * 2004-02-26 2007-11-13 Boston Scientific Scimed, Inc. Stent with differently coated inside and outside surfaces
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US8003122B2 (en) * 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
WO2005099786A1 (fr) * 2004-04-06 2005-10-27 Surmodics, Inc. Compositions de revetement pour agents bioactifs
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
ATE367132T1 (de) * 2004-05-25 2007-08-15 Cook William Europ Stent und stentbeseitigungsvorrichtung
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US20050287287A1 (en) * 2004-06-24 2005-12-29 Parker Theodore L Methods and systems for loading an implantable medical device with beneficial agent
US20080280973A1 (en) * 2004-06-28 2008-11-13 Wender Paul A Laulimalide Analogues as Therapeutic Agents
WO2006017275A1 (fr) 2004-07-13 2006-02-16 The University Of Tennessee Research Foundation Composition adhésive pour le support d’agents thérapeutiques comme vecteur d’enduits appliqués sur des implants vasculaires
US8119153B2 (en) * 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
EP1799151A4 (fr) * 2004-09-15 2014-09-17 Conor Medsystems Inc Endoprothese vasculaire pour bifurcation, dotee d'une extremite pouvant etre ecrasee, et procede de placement d'une endoprothese vasculaire au niveau d'une bifurcation
US8940311B2 (en) 2004-10-21 2015-01-27 Tae-Hong Lim In situ controlled release drug delivery system
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20060093647A1 (en) * 2004-10-29 2006-05-04 Villafana Manuel A Multiple layer coating composition
EP1809279B1 (fr) * 2004-11-08 2013-05-29 Baxter International Inc. Compositions particulaires d'inhibiteurs de la tubuline
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
JP2008528204A (ja) * 2005-01-28 2008-07-31 テファ， インコーポレイテッド ポリ−４−ヒドロキシブチレート粒子を使用した塞栓形成
BRPI0606130A2 (pt) * 2005-02-03 2009-06-02 Cinv Ag materiais de administração de fármacos feitos através de tecnologia sol/gel
US9050393B2 (en) 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
DK1848431T3 (en) * 2005-02-09 2016-04-18 Santen Pharmaceutical Co Ltd LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
CA3054535A1 (fr) 2005-02-18 2006-08-24 Abraxis Bioscience, Llc Combinaisons et modes d'administration d'agents therapeutiques et de therapie combinee
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US20060224170A1 (en) * 2005-03-30 2006-10-05 Michael Duff Surgical marker clip and method for cholangiography
CA2604696C (fr) 2005-04-15 2015-03-24 Interface Biologics, Inc. Complexes polymeres a agent actif sur le plan biologique pour administration localisee dudit agent actif sur le plan biologique
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
JO3058B1 (ar) 2005-04-29 2017-03-15 Applied Molecular Evolution Inc الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها
EP1879554B2 (fr) 2005-05-09 2018-03-07 Biosphere Medical, S.A. Compositions et procedes d'utilisation de microspheres et agents de contraste non ioniques
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US20060286071A1 (en) * 2005-06-21 2006-12-21 Epstein Samuel J Therapeutic pastes for medical device coating
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8187159B2 (en) 2005-07-22 2012-05-29 Biocompatibles, UK Therapeutic member including a rail used in brachytherapy and other radiation therapy
US7736293B2 (en) 2005-07-22 2010-06-15 Biocompatibles Uk Limited Implants for use in brachytherapy and other radiation therapy that resist migration and rotation
CA2618404A1 (fr) * 2005-08-04 2007-02-15 Angiotech International Ag Compositions de copolymere sequence et utilisations de ces dernieres
KR101643416B1 (ko) * 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 증가된 안정성을 가진 수 난용성 약물의 조성물 및 제조방법
PL3311805T3 (pl) 2005-08-31 2020-07-27 Abraxis Bioscience, Llc Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
US8192483B2 (en) 2005-10-06 2012-06-05 Kaneka Corporation Stent to be placed in the living body
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
AU2007212271B2 (en) 2006-02-09 2012-11-01 Santen Pharmaceutical Co., Ltd. Stable formulations, and methods of their preparation and use
CN100464736C (zh) * 2006-03-17 2009-03-04 山东蓝金生物工程有限公司 同载抗代谢药物及其增效剂的抗癌缓释注射剂
BRPI0709016A2 (pt) 2006-03-23 2011-06-21 Macusight Inc formulações e métodos para doenças ou condições relacionadas com a permeabilidade vascular
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
EP2094268A2 (fr) * 2006-05-26 2009-09-02 Bayer HealthCare, LLC Associations de médicaments comportant des urées de diaryle substituées pour le traitement du cancer
US20070298069A1 (en) * 2006-06-26 2007-12-27 Boston Scientific Scimed, Inc. Medical devices for release of low solubility therapeutic agents
EP2035074A4 (fr) 2006-06-30 2012-11-07 Cvdevices Llc Accès intravasculaire percutané au tissu cardiaque
WO2008134245A1 (fr) * 2007-04-27 2008-11-06 Cvdevices, Llc Dispositifs, systèmes et méthodes pour favoriser la guérison d'un infarctus et le renforcement de la zone de limite
US8211084B2 (en) * 2006-06-30 2012-07-03 Cvdevices, Llc Devices, systems, and methods for accessing the epicardial surface of the heart
US9023075B2 (en) * 2006-06-30 2015-05-05 Cvdevices, Llc Devices, systems, and methods for lead delivery
US20080051702A1 (en) * 2006-08-24 2008-02-28 Herrmann Robert A Therapeutic agent delivery for the treatment of asthma via implantable and insertable medical devices
CN101541354B (zh) 2006-10-10 2012-11-21 西洛诺瓦生物科学公司 含聚磷氮烯的生物人工心瓣膜
US20080095816A1 (en) * 2006-10-10 2008-04-24 Celonova Biosciences, Inc. Compositions and Devices Comprising Silicone and Specific Polyphosphazenes
US20080167592A1 (en) * 2006-10-26 2008-07-10 Greer Steven E Preventing or treating wounds with a collodion barrier incorporating active agents
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
EP2409687B1 (fr) 2006-11-09 2014-06-11 Alcon Research, Ltd. Matrice polymère insoluble dans l'eau pour l'administration de médicaments
CA2669642A1 (fr) * 2006-11-09 2008-05-22 Alcon Research, Ltd. Bouchon meatique comprenant une matrice polymere insoluble dans l'eau
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080175887A1 (en) * 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080171068A1 (en) * 2007-01-17 2008-07-17 Etcetera Llc Antimicrobial, infection-control and odor-control film and film composite
DE102007003184A1 (de) 2007-01-22 2008-07-24 Orlowski, Michael, Dr. Verfahren zur Beladung von strukturierten Oberflächen
WO2008097511A2 (fr) 2007-02-07 2008-08-14 Cook Incorporated Revêtements de dispositifs médicaux servant à libérer un agent thérapeutique à différentes vitesses
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
AU2008223387B2 (en) * 2007-03-06 2014-03-06 Covidien Lp Wound closure material
US9888924B2 (en) * 2007-03-06 2018-02-13 Covidien Lp Wound closure material
US20100076489A1 (en) * 2007-03-06 2010-03-25 Joshua Stopek Wound closure material
US9375164B2 (en) 2007-03-08 2016-06-28 Sync-Rx, Ltd. Co-use of endoluminal data and extraluminal imaging
US9968256B2 (en) 2007-03-08 2018-05-15 Sync-Rx Ltd. Automatic identification of a tool
US9305334B2 (en) 2007-03-08 2016-04-05 Sync-Rx, Ltd. Luminal background cleaning
US9629571B2 (en) 2007-03-08 2017-04-25 Sync-Rx, Ltd. Co-use of endoluminal data and extraluminal imaging
JP5639764B2 (ja) 2007-03-08 2014-12-10 シンク−アールエックス，リミティド 運動する器官と共に使用するイメージング及びツール
US11197651B2 (en) 2007-03-08 2021-12-14 Sync-Rx, Ltd. Identification and presentation of device-to-vessel relative motion
US11064964B2 (en) 2007-03-08 2021-07-20 Sync-Rx, Ltd Determining a characteristic of a lumen by measuring velocity of a contrast agent
US10716528B2 (en) 2007-03-08 2020-07-21 Sync-Rx, Ltd. Automatic display of previously-acquired endoluminal images
US8781193B2 (en) 2007-03-08 2014-07-15 Sync-Rx, Ltd. Automatic quantitative vessel analysis
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
US9050064B2 (en) * 2007-04-27 2015-06-09 Cvdevices, Llc Systems for engaging a bodily tissue and methods of using the same
US8540674B2 (en) 2007-04-27 2013-09-24 Cvdevices, Llc Devices, systems, and methods for transeptal atrial puncture using an engagement catheter platform
JP5174891B2 (ja) 2007-04-27 2013-04-03 シーヴィ デヴァイシズ，エルエルシー 心臓の心外膜表面にアクセスするための装置、システム、および方法
GB2463181B (en) 2007-05-14 2013-03-27 Univ New York State Res Found Induction of a physiological dispersion response in bacterial cells in a biofilm
US8147769B1 (en) 2007-05-16 2012-04-03 Abbott Cardiovascular Systems Inc. Stent and delivery system with reduced chemical degradation
JP2008305262A (ja) * 2007-06-08 2008-12-18 Konica Minolta Business Technologies Inc サーバ及びシンクライアント環境でのプリンタ紹介方法
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8003621B2 (en) * 2007-09-14 2011-08-23 Nitto Denko Corporation Drug carriers
EP2050441A1 (fr) * 2007-10-19 2009-04-22 Université Victor Segalen Bordeaux 2 Utilisation de bêtabloquants pour la fabrication d'un médicament pour le traitement d'hémangiomes
FR2922452B1 (fr) * 2007-10-19 2010-01-22 Coatex Sas Formulations de composes organoplatiniques en presence de polymeres associatifs, produits obtenus et leurs utilisations
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
CA2713341C (fr) * 2008-02-05 2016-09-27 Cvdevices, Llc Dispositifs de catheter a engagement de guidage, systemes et procedes
DE102008008263A1 (de) 2008-02-08 2009-08-13 Thomas Kuczera Restenoseprophylaxe
US8365432B2 (en) * 2008-03-19 2013-02-05 Morimoto-Pharma Co., Ltd. Freeze-drying method and freeze-drying apparatus
WO2009126705A2 (fr) 2008-04-10 2009-10-15 Virginia Commonwealth University Induction d'une hypoxie tumorale pour une thérapie du cancer
DE202008006190U1 (de) 2008-05-06 2008-07-17 Sellin, Lothar Restenoseprophylaxe
DE202008007347U1 (de) 2008-05-31 2008-10-16 Orlowski, Benjamin Daniel Kupfer Stent
WO2009152374A2 (fr) 2008-06-12 2009-12-17 Medtronic Xomed, Inc. Procédé de traitement de plaies chroniques
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
US20090319031A1 (en) * 2008-06-19 2009-12-24 Yunbing Wang Bioabsorbable Polymeric Stent With Improved Structural And Molecular Weight Integrity
ES2770273T3 (es) 2008-06-27 2020-07-01 Tepha Inc Administración inyectable de micropartículas y composiciones para ello
CA2729646C (fr) 2008-07-03 2016-10-18 Vesseltek Biomedical, Llc Liberation controlee et localisee de retinoides pour ameliorer l'hyperplasie neointimale
WO2010024898A2 (fr) 2008-08-29 2010-03-04 Lutonix, Inc. Procédés et appareils pour poser un revêtement sur des cathéters à ballonnet
US8257722B2 (en) 2008-09-15 2012-09-04 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8128951B2 (en) 2008-09-15 2012-03-06 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8114429B2 (en) 2008-09-15 2012-02-14 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US20100070013A1 (en) * 2008-09-18 2010-03-18 Medtronic Vascular, Inc. Medical Device With Microsphere Drug Delivery System
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9101286B2 (en) 2008-11-18 2015-08-11 Sync-Rx, Ltd. Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points
US8855744B2 (en) 2008-11-18 2014-10-07 Sync-Rx, Ltd. Displaying a device within an endoluminal image stack
US9095313B2 (en) 2008-11-18 2015-08-04 Sync-Rx, Ltd. Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe
US11064903B2 (en) 2008-11-18 2021-07-20 Sync-Rx, Ltd Apparatus and methods for mapping a sequence of images to a roadmap image
US9144394B2 (en) 2008-11-18 2015-09-29 Sync-Rx, Ltd. Apparatus and methods for determining a plurality of local calibration factors for an image
US10362962B2 (en) 2008-11-18 2019-07-30 Synx-Rx, Ltd. Accounting for skipped imaging locations during movement of an endoluminal imaging probe
US9974509B2 (en) 2008-11-18 2018-05-22 Sync-Rx Ltd. Image super enhancement
DE102009059070A1 (de) 2008-12-19 2010-07-01 Lothar Sellin Medizinische Einrichtung und Verfahren zu ihrer Herstellung
EP2210584A1 (fr) * 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Composition polymère stable comprenant un copolymère séquencé d'épothilone et amphiphile
WO2010093945A2 (fr) 2009-02-13 2010-08-19 Glaukos Corporation Implant médicamenteux uvéoscléral et ses procédés d'implantation
JP4782850B2 (ja) * 2009-02-24 2011-09-28 シャープ株式会社 画像データ処理装置
US7828996B1 (en) * 2009-03-27 2010-11-09 Abbott Cardiovascular Systems Inc. Method for the manufacture of stable, nano-sized particles
WO2010114770A1 (fr) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Conjugués polymère-agent, particules, compositions et procédés d'utilisation apparentés
WO2010114768A1 (fr) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Conjugués polymère-épothilone, particules, compositions et procédés d'utilisation apparentés
AU2010234916A1 (en) * 2009-03-30 2011-10-13 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
EP2243501A1 (fr) 2009-04-24 2010-10-27 Eurocor Gmbh Ballons de cathéter recouverts de gomme laque et de paclitaxel
SG175373A1 (en) 2009-04-28 2011-11-28 Surmodics Inc Devices and methods for delivery of bioactive agents
US20100285085A1 (en) * 2009-05-07 2010-11-11 Abbott Cardiovascular Systems Inc. Balloon coating with drug transfer control via coating thickness
DE202009006632U1 (de) 2009-05-07 2009-07-16 Sellin, Lothar Beschichtung von medizinischen Oberflächen
WO2012071476A2 (fr) 2010-11-24 2012-05-31 David Haffner Implant oculaire à élution de médicament
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
WO2010135433A1 (fr) * 2009-05-20 2010-11-25 Arsenal Medical, Inc. Implant médical
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
EP3064230B1 (fr) 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Utilisation de nanocristaux pour un ballonnet de distribution de médicament
JP5933434B2 (ja) 2009-07-17 2016-06-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 薬剤送達バルーンの製造方法
US8372133B2 (en) * 2009-10-05 2013-02-12 480 Biomedical, Inc. Polymeric implant delivery system
CA2777682C (fr) 2009-10-13 2015-02-24 The Regents Of The University Of Michigan Compositions de dendrimeres et procedes de synthese
DE202009014776U1 (de) 2009-11-02 2010-03-11 Sellin, Lothar Beschichtung
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
CN107033368A (zh) 2009-11-09 2017-08-11 聚光灯技术合伙有限责任公司 碎裂水凝胶
CA3037168A1 (fr) 2009-12-18 2011-06-23 Interface Biologics, Inc. Administration locale de medicaments a partir de revetements auto-assembles
DE202009017490U1 (de) 2009-12-22 2010-04-08 Sellin, Lothar Weihrauch- und/oder Boswelliasäuren Beschichtung
US20110218606A1 (en) * 2010-03-02 2011-09-08 Medtronic Vascular, Inc. Methods for Stabilizing Femoral Vessels
US20110224720A1 (en) * 2010-03-11 2011-09-15 Cvdevices, Llc Devices, systems, and methods for closing a hole in cardiac tissue
WO2011119536A1 (fr) 2010-03-22 2011-09-29 Abbott Cardiovascular Systems Inc. Système de pose d'endoprothèse pourvu d'une matrice fibreuse ayant une capacité de rétention améliorée de l'endoprothèse
MX2012011155A (es) 2010-03-29 2012-12-05 Abraxis Bioscience Llc Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos.
EP2552415B1 (fr) 2010-03-29 2016-09-07 Abraxis BioScience, LLC Méthodes de traitement du cancer
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
WO2011133183A1 (fr) * 2010-04-20 2011-10-27 University Of Utah Research Foundation Échafaudage pulvérisé à séparation de phase
CA2798084A1 (fr) 2010-05-17 2011-11-24 Aerie Pharmaceuticals, Inc. Dispositifs d'administration de medicament pour administration d'agents therapeutiques oculaires
US8858577B2 (en) 2010-05-19 2014-10-14 University Of Utah Research Foundation Tissue stabilization system
US8945156B2 (en) 2010-05-19 2015-02-03 University Of Utah Research Foundation Tissue fixation
NZ604029A (en) * 2010-06-02 2015-07-31 Abraxis Bioscience Llc Methods of treating bladder cancer
NZ706745A (en) 2010-06-04 2017-01-27 Abraxis Bioscience Llc Methods of treatment of pancreatic cancer
WO2012031236A1 (fr) 2010-09-02 2012-03-08 Boston Scientific Scimed, Inc. Procédé d'enrobage de ballonnets d'administration de médicaments utilisant une mémoire d'enveloppe induite par la chaleur
US8884027B2 (en) 2010-10-22 2014-11-11 University Of Rochester Melampomagnolide B derivatives as antileukemic and cytotoxic agents
KR20140009278A (ko) 2010-12-02 2014-01-22 마루젠세이야쿠 가부시키가이샤 Ｔｉｅ２ 활성화제, 혈관내피증식인자(ＶＥＧＦ) 억제제, 혈관신생 억제제, 혈관 성숙화제, 혈관 정상화제, 혈관 안정화제 및 약제학적 조성물
CN103458903B (zh) * 2011-01-28 2017-07-04 Abk生物医学公司 不透射线的栓塞颗粒
US8852214B2 (en) 2011-02-04 2014-10-07 University Of Utah Research Foundation System for tissue fixation to bone
DE202011002713U1 (de) 2011-02-14 2011-04-14 Sellin, Lothar Biologisch abbaubare medizinische Beschichtung und deren Verwendung
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
US9757497B2 (en) 2011-05-20 2017-09-12 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
RU2467705C1 (ru) * 2011-06-30 2012-11-27 ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ И СОЦИАЛЬНОГО РАЗВИТИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГУ "РНЦРХТ" Минздравсоцразвития России) Способ лечения облитерирующего атеросклероза сосудов нижних конечностей
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
EP2574918B1 (fr) 2011-09-28 2014-12-10 Mems Ag Procédé et capteur microthermiques pour la détermination de propriétés de gaz physiques
DE202011106744U1 (de) 2011-10-15 2011-11-11 Lothar Sellin Bessere Bioverfügbarkeit von Shellac/Paclitaxel Beschichtungen
US20130197657A1 (en) * 2011-12-08 2013-08-01 Diana Anca Central airway stent
US20130245759A1 (en) * 2012-03-09 2013-09-19 The Florida International University Board Of Trustees Medical devices incorporating silicone nanoparticles, and uses thereof
CA2899735A1 (fr) * 2012-05-21 2013-11-28 Sync-Rx, Ltd. Co-utilisation de donnees endoluminales et d'imagerie extraluminale
US20130317622A1 (en) * 2012-05-25 2013-11-28 Antonio Sambusseti Surgical method for grafting an artificial implant in a bladder and/or in a urethral or ureteral segment
EP2855030B1 (fr) 2012-06-01 2019-08-21 SurModics, Inc. Appareil et méthode de revêtement de cathéters à ballonnet
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
EP2863802B1 (fr) 2012-06-26 2020-11-04 Sync-RX, Ltd. Traitement d'image lié au flux dans les organes luminaux
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
WO2014008875A1 (fr) 2012-07-12 2014-01-16 Cardionovum Gmbh Ballonnet de cathéter, procédé de fabrication d'un ballonnet de cathéter revêtu, et utilisation de la substance active pharmacologique
US11957334B2 (en) 2012-07-30 2024-04-16 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9629632B2 (en) 2012-07-30 2017-04-25 Conextions, Inc. Soft tissue repair devices, systems, and methods
US11253252B2 (en) 2012-07-30 2022-02-22 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10390935B2 (en) 2012-07-30 2019-08-27 Conextions, Inc. Soft tissue to bone repair devices, systems, and methods
US9427309B2 (en) 2012-07-30 2016-08-30 Conextions, Inc. Soft tissue repair devices, systems, and methods
US10219804B2 (en) 2012-07-30 2019-03-05 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10835241B2 (en) 2012-07-30 2020-11-17 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11944531B2 (en) 2012-07-30 2024-04-02 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
CN107043561B (zh) 2012-10-29 2019-10-11 阿里斯特医疗有限责任公司 聚合物涂料组合物和涂覆的产品
JP6438406B2 (ja) 2012-11-05 2018-12-12 サーモディクス，インコーポレイテッド 疎水性生理活性物質を送達するための組成物および方法
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
RU2528249C2 (ru) * 2012-11-23 2014-09-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ подавления ангиогенеза с помощью рекомбинантных форм урокиназы
US20140212355A1 (en) * 2013-01-28 2014-07-31 Abbott Cardiovascular Systems Inc. Trans-arterial drug delivery
JP6350833B2 (ja) * 2013-03-15 2018-07-04 マイクロテック メディカル テクノロジーズ リミテッド 植込固定具
DE202013002567U1 (de) 2013-03-18 2013-05-07 Lothar Sellin NABP - Beschichtung
US9504653B2 (en) 2013-04-01 2016-11-29 Allergan, Inc. Microsphere drug delivery system for sustained intraocular release
EP3060143B1 (fr) * 2013-10-25 2021-01-06 Mercator Medsystems, Inc. Conservation de perméabilité bronchique par administration locale d'agent cytotoxique, cytostatique ou anti-néoplasique
US10842969B2 (en) 2013-10-25 2020-11-24 Mercator Medsystems, Inc. Systems and methods of treating malacia by local delivery of hydrogel to augment tissue
US10525171B2 (en) 2014-01-24 2020-01-07 The Spectranetics Corporation Coatings for medical devices
US11583384B2 (en) 2014-03-12 2023-02-21 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
EP3119448B1 (fr) 2014-03-21 2020-04-22 University of Pittsburgh- Of the Commonwealth System of Higher Education Procédés pour la préparation d'un hydrogel stérilisé de manière terminale dérivé d'une matrice extracellulaire
CN106471074A (zh) 2014-04-22 2017-03-01 阿里斯特医疗公司 用于施加药物递送聚合物涂料的方法和工艺
WO2015184173A1 (fr) 2014-05-29 2015-12-03 Dose Medical Corporation Implants à caractéristiques de libération contrôlée de médicament et leurs procédés d'utilisation
RU2555378C1 (ru) * 2014-07-10 2015-07-10 Вадим Викторович Евдокимов Способ эндоскопической остановки и профилактики язвенных кровотечений из дефектов стенки 12-перстной кишки
KR20170054429A (ko) 2014-09-03 2017-05-17 제네세규스 인코포레이티드 치료용 나노입자 및 관련 조성물, 방법, 및 시스템
EP3223867B1 (fr) 2014-11-26 2021-04-07 ABK Biomedical Incorporated Particules de radio-embolisation
WO2016093412A1 (fr) * 2014-12-10 2016-06-16 주식회사 에이치제이메디칼 Éponge de gélatine contenant une solution de tampon de phosphate (pbs) ou un tampon de phosphate et appliquée à une chimio-embolisation artérielle transcathéter, et son procédé de préparation
DE202015002048U1 (de) 2015-03-16 2015-09-24 Han Bock-Sun Implantat
KR101620090B1 (ko) 2015-04-20 2016-05-12 주식회사 티젤바이오 약물전달 키트, 약물전달체 제조용 기구, 및 약물전달체 제조방법
BR112017026746B1 (pt) * 2015-06-18 2023-11-28 Acuitybio Corporation Composições de liberação de fármacos implantáveis e uso de uma mistura compreendendo copolímero de plga, peg 8000 e paclitaxel
KR101748120B1 (ko) * 2015-07-13 2017-06-16 서울대학교산학협력단 나노입자-유리체 기반 단백질 복합체를 유효성분으로 포함하는 혈관신생억제용 조성물 및 이의 용도
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
CA2998483C (fr) 2015-09-16 2022-09-06 Dfb Soria, Llc Administration de nanoparticules medicamenteuses et leurs methodes d'utilisation
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017066121A1 (fr) * 2015-10-12 2017-04-20 Toth, Landy Traitement contrôlé et précis de tissus cardiaques
EP3402876B1 (fr) 2016-01-13 2021-10-13 University of Pittsburgh- Of the Commonwealth System of Higher Education Hydrogel de matrice extracellulaire vasculaire
CN109937025B (zh) 2016-04-20 2022-07-29 多斯医学公司 生物可吸收眼部药物的递送装置
US11696822B2 (en) 2016-09-28 2023-07-11 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
WO2018170196A1 (fr) 2017-03-15 2018-09-20 Dfb Soria, Llc Thérapie topique pour le traitement de malignités cutanées au moyen de nanoparticules de taxanes
US11634400B2 (en) 2017-08-19 2023-04-25 University Of Rochester Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents
US11547397B2 (en) 2017-12-20 2023-01-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US12102317B2 (en) 2017-12-20 2024-10-01 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10973509B2 (en) 2017-12-20 2021-04-13 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US20190247638A1 (en) 2018-02-13 2019-08-15 Kieran P. Murphy Delivery system for delivering a drug depot to a target site under image guidance and methods and uses of same
CN112165949A (zh) 2018-03-16 2021-01-01 Dfb索里亚有限责任公司 使用紫杉烷纳米颗粒治疗宫颈上皮内瘤变(cin)和宫颈癌的局部疗法
CN112638436A (zh) 2018-05-22 2021-04-09 界面生物公司 用于将药物递送至血管壁的组合物和方法
CN109224119B (zh) * 2018-10-30 2021-02-23 北京大学深圳医院 一种π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂
WO2020112816A1 (fr) 2018-11-29 2020-06-04 Surmodics, Inc. Appareil et méthodes de revêtement de dispositifs médicaux
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
CN111388757B (zh) * 2020-03-21 2022-07-15 哈尔滨工程大学 一种采用螺旋镁丝制备的可降解镁基复合材料
EP4262675A1 (fr) 2020-12-17 2023-10-25 Mobius Therapeutics, LLC Dispositif d'injection et son procédé d'utilisation

Family Cites Families (249)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016308A (en) 1957-08-06 1962-01-09 Moore Business Forms Inc Recording paper coated with microscopic capsules of coloring material, capsules and method of making
US3029188A (en) 1958-02-20 1962-04-10 Olin Mathieson Gelatin adhesive pharmaceutical preparations
US3991527A (en) 1975-07-10 1976-11-16 Bates Abrasive Products, Inc. Coated abrasive disc
USRE30239E (en) 1975-11-10 1980-03-25 Cell proliferation and tissue invasion inhibitor
US4042457A (en) 1975-11-10 1977-08-16 Rush-Presbyterian-St. Luke's Medical Center Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor
US4391797A (en) 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4176177A (en) 1978-11-16 1979-11-27 Rush-Presbyterian-St. Luke's Medical Center Inhibition of bone resorption
US4416877A (en) 1979-02-13 1983-11-22 Symphar S.A. Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds
US4300244A (en) 1979-09-19 1981-11-17 Carbomedics, Inc. Cardiovascular grafts
US4356261A (en) 1980-04-22 1982-10-26 Rush-Presbyterian-St. Luke's Medical Center Anti-invasion factor containing cultures
US4531936A (en) * 1981-01-29 1985-07-30 Gordon Robert T Device and method for the selective delivery of drugs to the myocardium
US4768523A (en) 1981-04-29 1988-09-06 Lifecore Biomedical, Inc. Hydrogel adhesive
US4357312A (en) 1981-07-16 1982-11-02 The Children's Hospital Medical Center Method of making prolonged release body
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US5441745A (en) 1982-03-30 1995-08-15 Vestar, Inc. Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body
US4542025A (en) 1982-07-29 1985-09-17 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US5286763A (en) 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
US4834755A (en) 1983-04-04 1989-05-30 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
US4959358A (en) 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US4500676A (en) 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
GB8334484D0 (en) 1983-12-24 1984-02-01 Smith & Nephew Ass Surgical dressing
US4591496A (en) 1984-01-16 1986-05-27 Massachusetts Institute Of Technology Process for making systems for the controlled release of macromolecules
IL74715A0 (en) 1984-03-27 1985-06-30 Univ New Jersey Med Biodegradable matrix and methods for producing same
US4779806A (en) 1984-07-23 1988-10-25 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4789501A (en) 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4916219A (en) 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
US4824436A (en) * 1985-04-09 1989-04-25 Harvey Wolinsky Method for the prevention of restenosis
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4771042A (en) 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
GB8601100D0 (en) 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4806621A (en) 1986-01-21 1989-02-21 Massachusetts Institute Of Technology Biocompatible, bioerodible, hydrophobic, implantable polyimino carbonate article
DE3786721D1 (de) * 1986-02-24 1993-09-02 Fischell Robert Vorrichtung zum aufweisen von blutgefaessen, sowie system zu deren einfuehrung.
US4966890A (en) 1986-04-04 1990-10-30 Angiogenics, Ltd. Method and composition for arresting angiogenesis and capillary, cell or membrane leakage
US4955878A (en) * 1986-04-04 1990-09-11 Biotechnology, Inc. Kit for preventing or treating arterial dysfunction resulting from angioplasty procedures
US4746729A (en) 1986-07-30 1988-05-24 Kuettner Klaus E Cartilage-derived leukocyte elastase-inhibitor
US4882168A (en) 1986-09-05 1989-11-21 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
GB2194885A (en) 1986-09-10 1988-03-23 Ephraim Kaplan Pharmaceutical compositions containing vanadium
US4893623A (en) 1986-12-09 1990-01-16 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
CH673117A5 (fr) 1986-12-10 1990-02-15 Ajinomoto Kk
US5092885A (en) * 1987-02-12 1992-03-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Peptides with laminin activity
US5084441A (en) 1987-03-04 1992-01-28 Shaw Jack M Acetylated low density lipoproteins: a delivery system to phagocytic cells for stimulating immunologic response and host resistance
US5041126A (en) 1987-03-13 1991-08-20 Cook Incorporated Endovascular stent and delivery system
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4861627A (en) 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US4808402A (en) 1987-05-29 1989-02-28 Northwestern University Method and compositions for modulating neovascularization
NL8701337A (nl) 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US4829099A (en) 1987-07-17 1989-05-09 Bioresearch, Inc. Metabolically acceptable polyisocyanate adhesives
US5019379A (en) 1987-07-31 1991-05-28 Massachusetts Institute Of Technology Unsaturated polyanhydrides
GB8720440D0 (en) 1987-08-28 1987-10-07 Smith & Nephew Ass Curable compositions
US5001009A (en) 1987-09-02 1991-03-19 Sterilization Technical Services, Inc. Lubricious hydrophilic composite coated on substrates
US5059189A (en) 1987-09-08 1991-10-22 E. R. Squibb & Sons, Inc. Method of preparing adhesive dressings containing a pharmaceutically active ingredient
US4983395A (en) 1987-11-12 1991-01-08 Theratech Inc. Device for administering an active agent to the skin or mucosa
US5460817A (en) 1988-01-19 1995-10-24 Allied Colloids Ltd. Particulate composition comprising a core of matrix polymer with active ingredient distributed therein
DE68910113T2 (de) * 1988-01-19 1994-03-17 Childrens Hospital Corp Wachstuminhibierendes mittel und dessen verwendung.
US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US4942184A (en) 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
JPH0722576B2 (ja) 1988-04-11 1995-03-15 三菱電機株式会社 磁気共鳴装置
US4989601A (en) * 1988-05-02 1991-02-05 Medical Engineering & Development Institute, Inc. Method, apparatus, and substance for treating tissue having neoplastic cells
ATE145337T1 (de) 1988-05-02 1996-12-15 Phanos Tech Inc Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen
US5096892A (en) 1988-05-27 1992-03-17 The Children's Medical Center Corporation Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin
US5100668A (en) 1988-06-14 1992-03-31 Massachusetts Institute Of Technology Controlled release systems containing heparin and growth factors
JPH0643336B2 (ja) 1988-06-30 1994-06-08 呉羽化学工業株式会社 血管増殖抑制剤
DE3825374A1 (de) * 1988-07-26 1990-02-01 Schwendener Reto Dipl Apotheke Komplex aus mindestens einer lipophilen saeure und mitoxantron und/oder bisantren
US4966605A (en) 1988-07-28 1990-10-30 Thieler William R Method for opening and closing surgical wounds
JPH0255064A (ja) * 1988-08-03 1990-02-23 Toa O カテーテルを用いた血管内血栓の血栓除去装置
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5019090A (en) * 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US5252713A (en) * 1988-09-23 1993-10-12 Neorx Corporation Polymeric carriers for non-covalent drug conjugation
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5091176A (en) 1988-11-02 1992-02-25 W. R. Grace & Co.-Conn. Polymer-modified peptide drugs having enhanced biological and pharmacological activities
US5211657A (en) * 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
LU87410A1 (fr) 1988-12-20 1990-07-10 Cird Composition cosmetique ou pharmaceutique contenant des microspheres de polymeres ou de corps gras chargees d'au moins un produit actif
US5086164A (en) 1989-01-10 1992-02-04 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US4905694A (en) 1989-04-04 1990-03-06 Ethicon, Inc. Intracorporeal temporary wound closure
WO1990013332A1 (fr) * 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Support pour medicaments a liberation progressive
US5132315A (en) 1989-05-19 1992-07-21 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic application of an anti-invasive compound
AU648505B2 (en) * 1989-05-19 1994-04-28 Amgen, Inc. Metalloproteinase inhibitor
US4990155A (en) * 1989-05-19 1991-02-05 Wilkoff Howard M Surgical stent method and apparatus
US5171262A (en) 1989-06-15 1992-12-15 Cordis Corporation Non-woven endoprosthesis
CA2015946A1 (fr) * 1989-06-27 1990-12-27 Lawrence P. Klemann Diols analogues de lipides pouvant remplacer les matieres grasses comestibles
US5290807A (en) 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
EP0415294A3 (en) * 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
CA1340994C (fr) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Traitement de maladies et d'etats pathologiques
JPH03109324A (ja) 1989-09-22 1991-05-09 Microbial Chem Res Found 血管新生阻害剤
US5461081A (en) 1989-09-28 1995-10-24 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
US5525348A (en) 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5527532A (en) 1989-11-13 1996-06-18 President And Fellows Of Harvard College Extraluminal regulation of the growth and repair of tubular structures in vivo
WO1991007154A1 (fr) 1989-11-13 1991-05-30 President And Fellows Of Harvard College REGULATION EXTRALUMINALE DE LA CROISSANCE ET DE LA REPARATION DE STRUCTURES TUBULAIRES ιIN VIVO
US5059166A (en) 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5176617A (en) * 1989-12-11 1993-01-05 Medical Innovative Technologies R & D Limited Partnership Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct
US5439446A (en) 1994-06-30 1995-08-08 Boston Scientific Corporation Stent and therapeutic delivery system
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5192744A (en) * 1990-01-12 1993-03-09 Northwestern University Method of inhibiting angiogenesis of tumors
EP0512071B1 (fr) * 1990-01-25 1996-10-30 Children's Hospital Procede et compositions destines a inhiber l'angiogenese
DE69108423T2 (de) 1990-02-08 1995-07-27 Howmedica Aufblasbarer Dilatator.
US5075112A (en) 1990-02-12 1991-12-24 Cartilage Technologies Inc. Method of and dosage unit for inhibiting angiogenesis or vascularization in an animal using shark cartilage
US5200397A (en) 1990-02-22 1993-04-06 W. R. Grace & Co.-Conn. Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
EP0470246B1 (fr) 1990-02-28 1995-06-28 Medtronic, Inc. Prothese pour l'elution intraluminale d'un medicament
DE4006609A1 (de) 1990-03-02 1991-09-26 Max Planck Gesellschaft Inhibitor der proliferation von endothelzellen
US5052998A (en) 1990-04-04 1991-10-01 Zimmon David S Indwelling stent and method of use
EP0528971B1 (fr) 1990-05-14 1999-09-01 JERNBERG, Gary R. Procede et implant chirurgical utilisant des agents chimiotherapeutiques
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5092841A (en) * 1990-05-17 1992-03-03 Wayne State University Method for treating an arterial wall injured during angioplasty
WO1991017724A1 (fr) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Polymere utilise dans un dispositif medical
US5407683A (en) 1990-06-01 1995-04-18 Research Corporation Technologies, Inc. Pharmaceutical solutions and emulsions containing taxol
DE69110467T2 (de) * 1990-06-15 1996-02-01 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5462751A (en) 1990-06-22 1995-10-31 The Regeants Of The University Of California Biological and pharmaceutical agents having a nanomeric biodegradable core
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
EP0470569B1 (fr) * 1990-08-08 1995-11-22 Takeda Chemical Industries, Ltd. Agent embolisant instravasculaire contenant une substance inhibitrice de l'angiogénésis
JP3120187B2 (ja) * 1990-08-08 2000-12-25 武田薬品工業株式会社 血管新生阻害物質を含む血管内塞栓剤
US5210155A (en) * 1990-08-24 1993-05-11 Exxon Chemical Patents Inc. Phenol terminated diester compositions derived from dicarboxylic acids, polyester polymers or alkyd polymers, and curable compositions containing same
US5278324A (en) 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
ZA918168B (en) 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
DE69116130T2 (de) * 1990-10-18 1996-05-15 Ho Young Song Selbstexpandierender, endovaskulärer dilatator
WO1992006701A1 (fr) 1990-10-18 1992-04-30 Huffstutler, M., Conrad, Jr. Preparations d'extraits de symphytum fluide concentre, formes therapeutiques et procedes d'utilisation
US5360789A (en) 1990-11-20 1994-11-01 Kowa Co., Ltd. Therapeutic agent for skin or corneal disease
US5268384A (en) 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
JP2928892B2 (ja) 1990-11-27 1999-08-03 三洋化成工業株式会社 外科用接着剤
US5149368A (en) 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
WO1992012717A2 (fr) * 1991-01-15 1992-08-06 Composition contenant une tetracycline et utilisation pour inhiber l'angiogenese
AU1579092A (en) * 1991-02-27 1992-10-06 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
US5540928A (en) 1991-02-27 1996-07-30 President And Fellows Of Harvard College Extraluminal regulation of the growth and repair of tubular structures in vivo
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
KR0177492B1 (ko) * 1991-03-08 1999-05-01 케이지 이가키 맥관 스텐트, 맥관 스텐트 유지 구조체 및 맥관 스텐트 삽입 고착장치
IT1250421B (it) 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5330768A (en) 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
FR2678833B1 (fr) 1991-07-08 1995-04-07 Rhone Poulenc Rorer Sa Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes.
US5344644A (en) 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release
JPH0558882A (ja) * 1991-09-04 1993-03-09 Yoshiaki Kawashima ナノカプセルの製造法
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1993006792A1 (fr) * 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Extenseur vasculaire biodegradable pour administration d'un medicament
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
CA2079417C (fr) 1991-10-28 2003-01-07 Lilip Lau Empreintes extensibles et leur methode de fabrication
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
JPH05131753A (ja) * 1991-11-15 1993-05-28 Fujicopian Co Ltd 多数回使用可能な熱転写インクシート
US5302397A (en) 1991-11-19 1994-04-12 Amsden Brian G Polymer-based drug delivery system
US5270047A (en) * 1991-11-21 1993-12-14 Kauffman Raymond F Local delivery of dipyridamole for the treatment of proliferative diseases
WO1993010076A1 (fr) 1991-11-22 1993-05-27 The University Of Mississippi Synthese et resolution optique de la chaine laterale de taxol et composes apparentes
CA2124329C (fr) * 1991-11-27 2008-11-18 Gregory A. Kopia Composes, compositions et methodes de fixation de substances bio-actives aux membranes de surface de bio-particules
US5260002A (en) 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
CA2086642C (fr) 1992-01-09 2004-06-15 Randall E. Morris Methode de traitement des maladies vasculaires hyperproliferatives
US5516781A (en) 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
US5176626A (en) 1992-01-15 1993-01-05 Wilson-Cook Medical, Inc. Indwelling stent
US5260066A (en) 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
US6080777A (en) 1992-01-31 2000-06-27 The Trustees Of Columbia University In The City Of New York Taxol as a radiation sensitizer
US5301664A (en) 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
DE69326631T2 (de) 1992-03-19 2000-06-08 Medtronic, Inc. Intraluminales Erweiterungsgerät
DK0706373T3 (da) 1992-03-23 2000-09-18 Univ Georgetown Liposomindkapslet taxol og en fremgangsmåde til anvendelse heraf
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
AU670937B2 (en) 1992-04-28 1996-08-08 Wyeth Method of treating hyperproliferative vascular disease
DE4214215A1 (de) * 1992-04-30 1993-11-04 Behringwerke Ag Verwendung von inhibitoren von plasminogenaktivatoren zur behandlung von entzuendungen
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
WO1993023075A1 (fr) * 1992-05-14 1993-11-25 Oncologix, Inc. Traitement du syndrome de permeabilite capillaire diffuse et des maladies induites par la collagenase par administration d'inhibiteurs de la metalloproteinase matricielle
JPH08500973A (ja) 1992-05-21 1996-02-06 ザ ペン ステイト リサーチ ファウンデーション タキソール、関連タキサン及び他の新規な抗癌／抗ウイルス性化合物原料としてのイチイ培養組織
WO1993024476A1 (fr) 1992-06-04 1993-12-09 Clover Consolidated, Limited Vehicules polymeres solubles dans l'eau servant a la liberation de medicaments
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
GB9213077D0 (en) 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
US5274137A (en) 1992-06-23 1993-12-28 Nicolaou K C Intermediates for preparation of taxols
US5294637A (en) 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5273965A (en) 1992-07-02 1993-12-28 Cambridge Biotech Corporation Methods for enhancing drug delivery with modified saponins
FR2693193B1 (fr) * 1992-07-03 1994-09-02 Rhone Poulenc Rorer Sa Nouveaux dérivés de la désacétyl-10 baccatine III, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5472954A (en) 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
US5202448A (en) 1992-08-14 1993-04-13 Napro Biotherapeutics, Inc. Processes of converting taxanes into baccatin III
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
WO1994005282A1 (fr) 1992-09-04 1994-03-17 The Scripps Research Institute Derives de taxol hydrosolubles
US5342621A (en) 1992-09-15 1994-08-30 Advanced Cardiovascular Systems, Inc. Antithrombogenic surface
CA2145093C (fr) 1992-09-25 2007-04-10 Lawrence Leroy Kunz Inhibiteur therapeutique des cellules musculaires lisses
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2100808A1 (fr) 1992-10-01 1994-04-02 Vittorio Farina Desoxytaxols
FR2696464B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696463B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2696461B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
FR2696462B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2698543B1 (fr) 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5342348A (en) 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5279949A (en) 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
EP0604022A1 (fr) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Endoprothèse résorbable, à plusieurs couches, pour le maintien des vaisseaux, et sa méthode de fabrication
US5419760A (en) * 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US5378456A (en) * 1993-03-25 1995-01-03 American Cyanamid Company Antitumor mitoxantrone polymeric compositions
WO1994024961A1 (fr) 1993-04-23 1994-11-10 Schneider (Usa) Inc. Extenseur recouvert et dispositif pour son introduction
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
JPH08510209A (ja) * 1993-05-13 1996-10-29 ネオルックス コーポレイション 血管平滑筋細胞の治療阻害因子
IT1276342B1 (it) 1993-06-04 1997-10-30 Ist Naz Stud Cura Dei Tumori Stent metallico rivestito con materiale polimerico biocompatibile
US5468769A (en) 1993-07-15 1995-11-21 Abbott Laboratories Paclitaxel derivatives
AU728873B2 (en) 1993-07-19 2001-01-18 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
AU771815B2 (en) 1993-07-19 2004-04-01 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
NZ533467A (en) * 1993-07-19 2006-02-24 Angiotech Pharm Inc Anti-angiogenic compositions and methods of use
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
WO1995003795A1 (fr) 1993-07-29 1995-02-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Procede de traitement de l'atherosclerose ou de la restenose au moyen d'un agent de stabilisation des microtubules
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5455046A (en) 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5457113A (en) 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
JPH09508892A (ja) 1993-11-17 1997-09-09 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼを用いる血管形成の阻害方法
US5462726A (en) 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
CA2147813A1 (fr) 1994-04-28 1995-10-29 Richard Dixon Prothese intravasculaire a enrobage anti-thrombogenique
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5489589A (en) 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
JP3224121B2 (ja) 1995-04-24 2001-10-29 ヤマハ発動機株式会社 自動二輪車用ステアリングヘッド部材
US5801191A (en) 1995-06-01 1998-09-01 Biophysica Foundation Taxoids
US5766584A (en) 1995-06-02 1998-06-16 Massachusetts Institute Of Technology Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
NZ505584A (en) * 1996-05-24 2002-04-26 Univ British Columbia Delivery of a therapeutic agent to the smooth muscle cells of a body passageway via an adventia
CA2288198A1 (fr) 1997-03-25 1998-10-01 Daniel I. Simon Modulation du retablissement vasculaire par inhibition de l'adhesion des leucocytes et de la fonction leucocytaire
ATE278397T1 (de) 1997-03-31 2004-10-15 Boston Scient Ltd Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
US6273908B1 (en) * 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
IL133053A0 (en) 1998-03-23 2001-03-19 Conjuchem Inc Local delivery of long lasting therapeutic agents
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
EP1132058A1 (fr) 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Prothèse intravasculaire
US6395326B1 (en) 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
AU2002235175A1 (en) 2000-12-06 2002-06-18 Tularik, Inc. Lometrexol combination therapy
JP3502053B2 (ja) 2001-03-15 2004-03-02 パナソニック コミュニケーションズ株式会社 複合機
WO2004001780A2 (fr) * 2002-06-20 2003-12-31 Federal-Mogul Powertrain, Inc. Gaine isolante multicouche
JP3990961B2 (ja) * 2002-09-09 2007-10-17 株式会社コナミデジタルエンタテインメント ゲーム機およびビンゴゲーム機
US20040127976A1 (en) 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20070003636A1 (en) * 2003-01-22 2007-01-04 Francois Mach Statins (HMG-COA reductase inhibitors) as a novel type of immunomodulator, immunosuppressor and anti-inflammatory agent
US20050100577A1 (en) 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system

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